G Sesti

Summary

Affiliation: Magna Graecia University
Country: Italy

Publications

  1. ncbi request reprint The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia, Viale Europa, località Germaneto, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 91:2334-9. 2006
  2. ncbi request reprint Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals
    Elena Succurro
    1Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Obesity (Silver Spring) 16:1881-6. 2008
  3. pmc Decreased insulin clearance in individuals with elevated 1-h post-load plasma glucose levels
    Maria Adelaide Marini
    Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 8:e77440. 2013
  4. pmc Hypoglycemia assessed by continuous glucose monitoring is associated with preclinical atherosclerosis in individuals with impaired glucose tolerance
    Ersilia Castaldo
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 6:e28312. 2011
  5. pmc A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with insulin sensitivity
    Francesco Andreozzi
    Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy
    PLoS ONE 7:e36224. 2012
  6. pmc A fasting insulin-raising allele at IGF1 locus is associated with circulating levels of IGF-1 and insulin sensitivity
    Gaia Chiara Mannino
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy
    PLoS ONE 8:e85483. 2013
  7. pmc Association of insulin resistance indexes to carotid intima-media thickness
    Angela Sciacqua
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy
    PLoS ONE 8:e53968. 2013
  8. pmc Association between Noninvasive Fibrosis Markers and Chronic Kidney Disease among Adults with Nonalcoholic Fatty Liver Disease
    Giorgio Sesti
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy
    PLoS ONE 9:e88569. 2014
  9. ncbi request reprint Role of C Reactive Protein (CRP) in Leptin Resistance
    Marta Letizia Hribal
    Department of Medical and Surgical Sciences, University of Catanzaro Magna Graecia, Viale Europa, località Germaneto 88100 Catanzaro, Italy
    Curr Pharm Des 20:609-15. 2014
  10. doi request reprint A polymorphism at IGF1 locus is associated with carotid intima media thickness and endothelium-dependent vasodilatation
    Giorgio Sesti
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, Catanzaro 88100, Italy Electronic address
    Atherosclerosis 232:25-30. 2014

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia, Viale Europa, località Germaneto, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 91:2334-9. 2006
    ..Several studies suggest that genetic factors may play a role in the different responses to antidiabetic therapy; however, conclusive evidence is still lacking...
  2. ncbi request reprint Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals
    Elena Succurro
    1Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Obesity (Silver Spring) 16:1881-6. 2008
    ..Because these subjects also exhibited a worse metabolic risk profile, these findings may account for their increased risk for type 2 diabetes...
  3. pmc Decreased insulin clearance in individuals with elevated 1-h post-load plasma glucose levels
    Maria Adelaide Marini
    Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 8:e77440. 2013
    ....
  4. pmc Hypoglycemia assessed by continuous glucose monitoring is associated with preclinical atherosclerosis in individuals with impaired glucose tolerance
    Ersilia Castaldo
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    PLoS ONE 6:e28312. 2011
    ..252; P<0.0001), and ISI index (r(2) = 0.089; P = 0.004), accounting for 34.1% of the variation. Episodes of hypoglycemia may be considered as a new potential cardiovascular risk factor for IGT individuals...
  5. pmc A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with insulin sensitivity
    Francesco Andreozzi
    Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy
    PLoS ONE 7:e36224. 2012
    ..Examining data from the DIAGRAM+ (Diabetes Genetics Replication And Meta-analysis), we identified a variant (rs9267551) in the DDAH2 gene nominally associated with type 2 diabetes (P = 3 × 10(-5))...
  6. pmc A fasting insulin-raising allele at IGF1 locus is associated with circulating levels of IGF-1 and insulin sensitivity
    Gaia Chiara Mannino
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy
    PLoS ONE 8:e85483. 2013
    ..We investigated the effects of the rs35767 polymorphism on circulating IGF-1 levels, insulin sensitivity, and insulin clearance...
  7. pmc Association of insulin resistance indexes to carotid intima-media thickness
    Angela Sciacqua
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy
    PLoS ONE 8:e53968. 2013
    ....
  8. pmc Association between Noninvasive Fibrosis Markers and Chronic Kidney Disease among Adults with Nonalcoholic Fatty Liver Disease
    Giorgio Sesti
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy
    PLoS ONE 9:e88569. 2014
    ..94, 95%CI 1.11-14.05; P = 0.03) as compared with individuals at low probability. In conclusion, advanced liver fibrosis, determined by noninvasive fibrosis markers, is associated with CKD independently from other known factors. ..
  9. ncbi request reprint Role of C Reactive Protein (CRP) in Leptin Resistance
    Marta Letizia Hribal
    Department of Medical and Surgical Sciences, University of Catanzaro Magna Graecia, Viale Europa, località Germaneto 88100 Catanzaro, Italy
    Curr Pharm Des 20:609-15. 2014
    ....
  10. doi request reprint A polymorphism at IGF1 locus is associated with carotid intima media thickness and endothelium-dependent vasodilatation
    Giorgio Sesti
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, Catanzaro 88100, Italy Electronic address
    Atherosclerosis 232:25-30. 2014
    ..We investigated the effects of this polymorphism on circulating IGF-1 levels, carotid intima media thickness (cIMT) and endothelial-dependent vasodilation...
  11. ncbi request reprint A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease
    Giorgio Sesti
    Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Via Europa Località Germaneto, Catanzaro 88100, Italy Electronic address
    Atherosclerosis 231:141-4. 2013
    ....
  12. ncbi request reprint Association of hepatic insulin resistance indexes to nonalcoholic fatty liver disease and related biomarkers
    G Sesti
    Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Viale Europa, Catanzaro 88100, Italy Electronic address
    Nutr Metab Cardiovasc Dis 23:1182-7. 2013
    ....
  13. doi request reprint [Combination therapy with glucagon-like peptide-1 analogs and insulin: indications and contraindications in coronary artery disease patients]
    Giorgio Sesti
    Dipartimento di Scienze Mediche e Chirurgiche, Universita degli Studi Magna Graecia, Catanzano
    G Ital Cardiol (Rome) 13:9S-16S. 2012
    ..In this review, the pathophysiological rationale for using the combination of GLP-1 analogs is discussed, and data from clinical studies that have evaluated the efficacy of this treatment strategy are summarized...
  14. ncbi request reprint Insulin-like growth factor-I, inflammatory proteins, and fibrosis in subjects with nonalcoholic fatty liver disease
    Marta Letizia Hribal
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 98:E304-8. 2013
    ..Low circulating levels of the anti-inflammatory molecule IGF-I have been described in subjects with NAFLD...
  15. doi request reprint IGF-1 levels link estimated glomerular filtration rate to insulin resistance in obesity: a study in obese, but metabolically healthy, subjects and obese, insulin-resistant subjects
    G Sesti
    Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 21:933-40. 2011
    ..Metabolically healthy but obese (MHO) subjects have a favourable cardio-metabolic risk profile, but whether they are also at lower risk for kidney dysfunction is still questionable...
  16. doi request reprint [Effects of glucagon-like peptide-1 on appetite and body weight: preclinical and clinical data]
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinic, Universita degli Studi Magna Graecia, Catanzaro
    G Ital Cardiol (Rome) 12:10-6. 2011
    ..In this review, we discuss data of preclinical studies and clinical trials that evaluated the effects of liraglutide and exenatide, the two analogues of GLP-1 currently available in Italy, on body weight...
  17. pmc Cardiometabolic risk profiles and carotid atherosclerosis in individuals with prediabetes identified by fasting glucose, postchallenge glucose, and hemoglobin A1c criteria
    Maria A Marini
    Department of InternalMedicine, University of Rome Tor Vergata, Rome, Italy
    Diabetes Care 35:1144-9. 2012
    ..We evaluated whether cardiometabolic risk profiles differ for subjects identified as having prediabetes by A1C, fasting glucose (FPG), or 2-h postchallenge glucose (2-PG) criteria...
  18. pmc Insulin sensitivity, β-cell function, and incretin effect in individuals with elevated 1-hour postload plasma glucose levels
    Maria A Marini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetes Care 35:868-72. 2012
    ..Individuals with normal glucose tolerance (NGT), whose 1-h postload plasma glucose is ≥155 mg/dL (NGT 1h-high), have an increased risk of type 2 diabetes. The purpose of this study was to characterize their metabolic phenotype...
  19. ncbi request reprint Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance
    Giorgio Sesti
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes Care 28:120-5. 2005
    ..We studied the relationships between plasma IGF-I concentrations and insulin sensitivity in subjects with various degrees of glucose tolerance...
  20. ncbi request reprint Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database
    Giorgio Sesti
    Department of Experimental and Clinical Medicine, University of Catanzaro, Italy
    Diabetes Metab Res Rev 24:130-6. 2008
    ..We assessed the accuracy of the American Diabetes Association (ADA)2003 definition of impaired fasting glucose (IFG) in identifying subjects with low insulin sensitivity, and determined cardiovascular risk factors in ADA2003 IFG subjects...
  21. ncbi request reprint Impact of common polymorphisms in candidate genes for insulin resistance and obesity on weight loss of morbidly obese subjects after laparoscopic adjustable gastric banding and hypocaloric diet
    Giorgio Sesti
    Dipartimento Medicina Sperimentale e Clinica, Universita Magna Graecia di Catanzaro, Via Campanella, 115, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 90:5064-9. 2005
    ..It is unknown whether genetic factors that play an important role in body weight homeostasis influence the response to laparoscopic adjustable gastric banding (LAGB)...
  22. ncbi request reprint Pathophysiology of insulin resistance
    Giorgio Sesti
    Universita Magna Graecia di Catanzaro, Campus Universitario Germaneto di Catanzaro, 88100 Catanzaro, Italy
    Best Pract Res Clin Endocrinol Metab 20:665-79. 2006
    ..Inflammatory molecules and lipid metabolites inhibit insulin signalling by stimulating a number of different serine kinases which are responsible for serine phosphorylation of Insulin Receptor Substrate-1 (IRS-1)...
  23. ncbi request reprint The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia di Catanzaro Via Tommaso Campanella, 115 88100 Catanzaro, Italy
    Diabetes Care 27:1394-8. 2004
    ..The aim of this study was to investigate whether diabetic patients carrying the Arg(972) insulin receptor substrate-1 (IRS-1) variant are at increased risk for secondary failure to sulfonylurea...
  24. ncbi request reprint A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Via Tommaso Campanella, 115 11800 Catanzaro, Italy
    Diabetes 52:1280-3. 2003
    ..These results indicate that the common -866G/A polymorphism in the UCP2 gene may contribute to the biological variation of insulin secretion in humans...
  25. ncbi request reprint Harnessing the weight-regulating properties of glucagon-like peptide-1 in the treatment of type 2 diabetes
    G Sesti
    Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes Obes Metab 11:4-10. 2009
    ....
  26. ncbi request reprint Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes?
    Giorgio Sesti
    Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, IT 88100 Catanzaro, Italy
    Ann Med 34:444-50. 2002
    ....
  27. ncbi request reprint Searching for type 2 diabetes genes: prospects in pharmacotherapy
    G Sesti
    Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Pharmacogenomics J 2:25-9. 2002
  28. ncbi request reprint Defects of the insulin receptor substrate (IRS) system in human metabolic disorders
    G Sesti
    Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, 88100 Catanzaro, Italy
    FASEB J 15:2099-111. 2001
    ..In contrast, polymorphisms of the other IRS genes do not appear to contribute to type 2 diabetes...
  29. doi request reprint Elevated one-hour post-load plasma glucose levels identifies subjects with normal glucose tolerance but early carotid atherosclerosis
    E Succurro
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Italy
    Atherosclerosis 207:245-9. 2009
    ....
  30. doi request reprint One-hour post-load plasma glucose levels are associated with elevated liver enzymes
    E Succurro
    Department of Experimental and Clinical Medicine, Viale Europa, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 21:713-8. 2011
    ....
  31. ncbi request reprint The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets
    M Federici
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome-'Tor Vergata, 00133 Rome, Italy
    FASEB J 15:22-24. 2001
    ..These findings establish an important role for the insulin signaling in human b-cell survival and suggest that genetic defects in early steps of insulin signaling may contribute to b-cell failure...
  32. doi request reprint Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects
    E Succurro
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 19:713-9. 2009
    ..In this cross-sectional study, we analyzed the relationship between IGF-1 levels, insulin sensitivity and secretion in 110 nondiabetic subjects with a wide range of BMI to verify this hypothesis...
  33. ncbi request reprint Increased abundance of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of obese subjects is correlated with in vivo insulin sensitivity
    M Federici
    Department of Internal Medicine, University of Rome-Tor Vergata, Italy
    J Clin Endocrinol Metab 83:2911-5. 1998
    ..67; P < 0.016). These results indicate that downregulation of insulin receptors or upregulation of type 1 IGF receptors because of changes in plasma insulin and IGF-I levels may result in modifications in hybrid receptor abundance...
  34. doi request reprint Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion
    Marta L Hribal
    Department of Clinical and Experimental Medicine, University ofCatanzaro Magna Graecia, Catanzaro, Italy
    J Cell Mol Med 12:2096-106. 2008
    ..Furthermore, they may become an important tool to test novel tailored therapies...
  35. ncbi request reprint The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells
    M L Hribal
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    J Clin Endocrinol Metab 85:2004-13. 2000
    ..The present data indicate that the polymorphism at codon 972 of IRS-1 may contribute to the in vivo insulin resistance observed in carriers of this variant...
  36. ncbi request reprint Comparison of A1C, fasting and 2-h post-load plasma glucose criteria to diagnose diabetes in Italian Caucasians
    M A Marini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Nutr Metab Cardiovasc Dis 22:561-6. 2012
    ..5% in addition to criteria based on glucose levels. We compared A1C, fasting plasma glucose (FPG) or 2-h post-challenge glucose (2-hPG) criteria for the diagnosis of diabetes in a cohort of Italian Caucasians...
  37. ncbi request reprint Weight loss in combination with physical activity improves endothelial dysfunction in human obesity
    Angela Sciacqua
    Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes Care 26:1673-8. 2003
    ..To test whether weight loss may improve endothelial dysfunction in human obesity, we recruited 28 healthy obese subjects, aged 30-46 years, with BMI 30-43 kg/m(2)...
  38. doi request reprint Endothelial dysfunction and non-alcoholic liver steatosis in hypertensive patients
    A Sciacqua
    Department of Experimental and Clinical Medicine, G Salvatore, University Magna Græcia of Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 21:485-91. 2011
    ..The aim of this study was to test a possible association between non-alcoholic fatty liver disease and endothelium-dependent vasodilation in a group of hypertensive patients...
  39. ncbi request reprint Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of Italian-Caucasian nondiabetic subjects
    Francesco Andreozzi
    Dipartimento di Medicina Sperimentale e Clinica, Policlinico Mater Domini Via Tommaso Campanella 88100, Catanzaro, Italy
    Diabetes 55:2021-4. 2006
    ..0 and 5.2% of its variation. These data indicate that IL-6 is associated in a reciprocal manner with the two pathophysiological components of type 2 diabetes, i.e., insulin resistance and insulin secretion...
  40. pmc Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects
    M Federici
    Department of Internal Medicine, University of Rome, Tor Vergata, Italy
    J Clin Invest 98:2887-93. 1996
    ..Because IGF-I has been proposed as a hypoglycemic agent in NIDDM, these results are relevant to the development of new approaches to the treatment of insulin resistance of NIDDM...
  41. ncbi request reprint Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients
    M Federici
    Department of Internal Medicine, University of Rome-Tor Vergata, Italy
    Mol Cell Endocrinol 135:41-7. 1997
    ....
  42. ncbi request reprint Pulse pressure and endothelial dysfunction in never-treated hypertensive patients
    Roberto Ceravolo
    Internal Medicine and Cardiovascular Diseases Unit, Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
    J Am Coll Cardiol 41:1753-8. 2003
    ..This study sought to investigate whether pulse pressure (PP) is associated with endothelium-dependent vasodilation in a group of never-treated hypertensives...
  43. ncbi request reprint Role of PC-1 and ACE genes on insulin resistance and cardiac mass in never-treated hypertensive patients. Suggestive evidence for a digenic additive modulation
    Francesco Perticone
    Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 17:181-7. 2007
    ..The aim of this work was to investigate whether the PC-1 and ACE genes exert a polygenic control of insulin resistance and LVM in hypertensive patients...
  44. doi request reprint Kidney function and risk factors for left ventricular hypertrophy in untreated uncomplicated essential hypertension
    Francesco Perticone
    Department of Experimental and Clinical Medicine, G Salvatore, University Magna Graecia of Catanzaro, Reggio Calabria, Italy
    Am J Kidney Dis 52:74-84. 2008
    ..Left ventricular (LV) hypertrophy and decreased kidney function are well-established cardiovascular risk factors in hypertensive patients...
  45. pmc Reciprocal association of plasma IGF-1 and interleukin-6 levels with cardiometabolic risk factors in nondiabetic subjects
    Elena Succurro
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes Care 31:1886-8. 2008
    ....
  46. ncbi request reprint Molecular and functional characterization of pituitary adenylate cyclase-activating polypeptide (PACAP-38)/vasoactive intestinal polypeptide receptors in pancreatic beta-cells and effects of PACAP-38 on components of the insulin secretory system
    P Borboni
    Department of Internal Medicine, University of Rome Tor Vergata, Italy
    Endocrinology 140:5530-7. 1999
    ..Furthermore, we have demonstrated that PACAP exerts long-term effects on beta-cells, such as transcriptional regulation of the insulin gene and genes of the glucose-sensing system (GLUT1 and hexokinase 1)...
  47. pmc IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants
    E Morini
    IRCCS, Casa Sollievo della Sofferenza Mendel Institute, Viale Regina Margherita 261, Postal Code 00198, Rome, Italy
    Diabetologia 52:1852-7. 2009
    ..To obtain further insight into this topic, we performed a meta-analysis of all available case-control studies...
  48. doi request reprint Insulin sensitivity, and β-cell function in relation to hemoglobin A1C
    M A Marini
    Department of Systems Medicine, University of Rome Tor Vergata, Italy
    Nutr Metab Cardiovasc Dis 24:27-33. 2014
    ..7-6.4%...
  49. doi request reprint Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B
    M L Hribal
    Department of Experimental and Clinical Medicine, Viale Europa, Campus Germaneto, 88100 Catanzaro, Italy
    Diabetologia 54:795-802. 2011
    ..The aim of this study was to investigate the association of the rs10811661 polymorphism near the CDKN2B/CDKN2A genes with glucose tolerance, insulin sensitivity and insulin release in three samples of white people with European ancestry...
  50. ncbi request reprint C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport
    C D'Alessandris
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetologia 50:840-9. 2007
    ..However, it is unknown whether CRP directly affects insulin signalling action. To this aim, we determined the effects of human recombinant CRP (hrCRP) on insulin signalling involved in glucose transport in L6 myotubes...
  51. pmc Relation between serum uric acid and carotid intima-media thickness in healthy postmenopausal women
    T Montalcini
    Department of Clinical and Experimental Medicine, G Salvatore University of Catanzaro Magna Graecia, Viale Europa, I 88100, Catanzaro, Italy
    Intern Emerg Med 2:19-23. 2007
    ..We explored the association of the uric acid level with carotid intima-media thickness (IMT), a well known marker of CVD, in postmenopausal healthy women...
  52. ncbi request reprint Interaction between vascular dysfunction and cardiac mass increases the risk of cardiovascular outcomes in essential hypertension
    Angela Sciacqua
    Internal Medicine and Cardiovascular Diseases Unit, Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Italy
    Eur Heart J 26:921-7. 2005
    ..To investigate the additive prognostic impact of both forearm endothelial dysfunction and left ventricular mass (LVM) for future cardiovascular events...
  53. ncbi request reprint Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells
    Francesco Andreozzi
    Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Italy
    Circ Res 94:1211-8. 2004
    ....
  54. ncbi request reprint Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients
    Marina Cardellini
    Dipartimento di Medicina Sperimentale e Clinica, Policlinico Universitario Mater Domini, Via Europa, Campus Germaneto, 88100 Catanzaro, Italy
    Am J Physiol Endocrinol Metab 292:E347-52. 2007
    ..7% of its variation. These findings support the concept that insulin sensitivity, rather than plasma insulin levels, is associated with early atherosclerosis in nondiabetic normotensive offspring of type 2 diabetic patients...
  55. ncbi request reprint Dietary patterns and 1-h post-load glucose in essential hypertension
    A Sciacqua
    Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 24:547-53. 2014
    ..Specific dietary factors may affect insulin sensitivity and the risk of T2D. However, it is unknown whether dietary components affect 1-h PLG in hypertensive NGT. Therefore, we investigate the effect of dietary patterns on 1-h PLG...
  56. doi request reprint Low insulin-like growth factor-1 levels are associated with anaemia in adult non-diabetic subjects
    Elena Succurro
    Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Cantanzaro, Italy
    Thromb Haemost 105:365-70. 2011
    ..49-fold higher risk of having anaemia as compared with those in the fourth (odds ratio 2.70, 95% confidence interval 1.02-7.16). Our data suggest that low IGF-1 may be an important contributor to mild anaemia...
  57. ncbi request reprint Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells
    Francesco Andreozzi
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Via Tommaso Campanella, 115, 88100 Catanzaro, Italy
    Endocrinology 145:2845-57. 2004
    ..These changes result in impaired coupling of IRS-1 and PI 3-kinase, and activation of the Akt/mammalian target of rapamycin/phosphorylated heat- and acid-stable protein-1/p70S6 kinase pathway...
  58. pmc Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells
    Francesco Andreozzi
    Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Italy
    Mol Cell Biol 27:2372-83. 2007
    ..Our data suggest that IL-6 impairs the vasodilator effects of insulin that are mediated by the IRS-1/PI3-kinase/Akt/eNOS pathway through activation of JNK and ERK1/2...
  59. ncbi request reprint Metabolic and cardiovascular risk factors in subjects with impaired fasting glucose: the 100 versus 110 mg/dL threshold
    Francesco Andreozzi
    Department of Experimental and Clinical Medicine, University Magna Grzecia of Catanzaro, 88100 Catanzaro, Italy
    Diabetes Metab Res Rev 23:547-50. 2007
    ..This change was challenged as to its appropriateness. A few studies have examined the impact of the ADA(2003) threshold of IFG on metabolic and cardiovascular risk factors...
  60. ncbi request reprint Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects
    Daniela Scarpelli
    Dipartimento di Medicina Sperimentale e Clinica, Policlinico Mater Domini, University Magna Graecia of Catanzaro, Via Tommaso Campanella, 88100 Catanzaro, Italy
    Diabetes 55:1529-33. 2006
    ..31]; P = 0.01) and insulin resistance (1.99 [1.12-3.53]; P = 0.01). This study suggests that polymorphisms and haplotypes of the IL10 promoter may be associated with obesity and insulin resistance in a large sample of Italian Caucasians...
  61. ncbi request reprint Role of endogenous androgens on carotid atherosclerosis in non-obese postmenopausal women
    T Montalcini
    Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, U O Medicina Interna, Viale Europa, Germaneto, 88100 Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 17:705-11. 2007
    ..In particular androgens seem to have a protective role on atherosclerosis. The present study was performed to assess the role of endogenous sex hormones on carotid atherosclerosis in postmenopausal women...
  62. ncbi request reprint High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program
    M Federici
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    Diabetes 50:1290-301. 2001
    ..These data suggest that in human islets, high glucose may modulate the balance of proapoptotic and antiapoptotic Bcl proteins toward apoptosis, thus favoring beta-cell death...
  63. ncbi request reprint Carotid atherosclerosis associated to metabolic syndrome but not BMI in healthy menopausal women
    Tiziana Montalcini
    Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Viale Europa Germaneto, Catanzaro, Italy
    Diabetes Res Clin Pract 76:378-82. 2007
    ..The purpose of this study was to investigate whether the subclinical carotid atherosclerosis prevalence is different in obese postmenopausal women with and without the metabolic syndrome...
  64. doi request reprint Low-plasma insulin-like growth factor-I levels are associated with impaired endothelium-dependent vasodilatation in a cohort of untreated, hypertensive Caucasian subjects
    Francesco Perticone
    Department of Experimental and Clinical Medicine, Policlinico Mater Domini Viale Europa, Campus Germaneto, Catanzaro, Italy
    J Clin Endocrinol Metab 93:2806-10. 2008
    ..However, the relationship between plasma IGF-I levels and endothelium-dependent vasodilatation is still unsettled...
  65. ncbi request reprint Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension
    Francesco Perticone
    Internal Medicine and Cardiovascular Diseases Unit, Department of Medicina Sperimentale e Clinica G Salvatore, University Magna Graecia of Catanzaro, Catanzaro, Italy
    J Am Coll Cardiol 46:518-23. 2005
    ..We investigated the relationship between ADMA plasma levels and endothelium-dependent vasodilation in 36 never-treated essential hypertensives and in 8 normotensive healthy subjects...
  66. doi request reprint Endothelial dysfunction, ADMA and insulin resistance in essential hypertension
    Francesco Perticone
    Department of Medicina Sperimentale e Clinica G Salvatore, University Magna Graecia of Catanzaro, Italy
    Int J Cardiol 142:236-41. 2010
    ..In this study, we investigated, in 63 hypertensives and 21 normotensive healthy subjects, the relationship between ADMA and IR and their possible interaction on endothelial function...
  67. ncbi request reprint Effect of anti TNFalpha therapy on arterial diameter and wall shear stress and HDL cholesterol
    Concetta Irace
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Magna Graecia University, Catanzaro, Italy
    Atherosclerosis 177:113-8. 2004
    ..05 g/L versus 1.57 +/- 0.02 g/L, P <0.03). The present data show vasoconstriction and an increase of wall shear stress in studied arteries after infliximab. HDL cholesterol is reduced by treatment and does not seem to influence FMD...
  68. ncbi request reprint Renal function predicts cardiovascular outcomes in southern Italian postmenopausal women
    Francesco Perticone
    Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Italy
    Eur J Cardiovasc Prev Rehabil 16:481-6. 2009
    ..Postmenopausal women have an increased risk of adverse cardiovascular (CV) events. Similarly, chronic kidney disease (CKD) is a well established risk factor for CV disease and mortality...
  69. doi request reprint Differences in cardiovascular risk profile based on relationship between post-load plasma glucose and fasting plasma levels
    Elena Succurro
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes Metab Res Rev 25:351-6. 2009
    ..However, it is still unsettled whether individuals in Group II have a more atherogenic profile than Group I subjects...
  70. ncbi request reprint Endothelial dysfunction and C-reactive protein are risk factors for diabetes in essential hypertension
    Francesco Perticone
    Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes 57:167-71. 2008
    ..Type 2 diabetes and essential hypertension are major risk factors for cardiovascular diseases. Endothelial dysfunction is an early step in the development of atherosclerosis and has been demonstrated in hypertensive and diabetic patients...
  71. ncbi request reprint Effects of growth hormone and insulin-like growth factor-1 on cardiac hypertrophy of hypertensive patients
    Giorgio Sesti
    Unit of Internal Medicine, Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Italy
    J Hypertens 25:471-7. 2007
    ..We investigated the role of the GH/IGF-1 axis on LVM and ventricular geometry in a group of 230 never-treated hypertensive patients...
  72. ncbi request reprint Gly460Trp alpha-adducin gene polymorphism and endothelial function in untreated hypertensive patients
    Francesco Perticone
    Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy
    J Hypertens 25:2234-9. 2007
    ..The aim of the present study was to investigate the relationship between the 460Trp allele of ADD1 and endothelium-dependent vasodilation in 110 never-treated hypertensive patients...
  73. ncbi request reprint Endothelial dysfunction and subsequent decline in glomerular filtration rate in hypertensive patients
    Francesco Perticone
    Full Professor of Internal Medicine, Department of Medicina Sperimentale e Clinica, Campus Universitario Salvatore Venuta di Germaneto, Viale Europa, Catanzaro, Italy
    Circulation 122:379-84. 2010
    ..Thus, we prospectively evaluated the effect of endothelial function on estimated glomerular filtration rate (eGFR) in essential hypertension...
  74. ncbi request reprint Impaired endothelial function in never-treated hypertensive subjects carrying the Arg972 polymorphism in the insulin receptor substrate-1 gene
    Francesco Perticone
    Department of Experimental and Clinical Medicine, G Salvatore University Magna Graecia of Catanzaro, Policlinico Mater Domini Via Tommaso Campanella, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 89:3606-9. 2004
    ..4 vs. 13.3 +/- 3.5 ml/100 ml(-1) of tissue per min(-1)). Our data strongly suggest that, by inducing endothelial dysfunction, the Arg(972) IRS-1 polymorphism may contribute to the genetic predisposition to develop cardiovascular disease...
  75. ncbi request reprint New insights into body composition assessment in obese women
    A De Lorenzo
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    Can J Physiol Pharmacol 77:17-21. 1999
    ..In conclusion, evaluation of total body composition by means of bioelectric impedance analysis might be included in programs for the prevention of non-insulin-dependent diabetes and for monitoring weight loss during overt pathology...
  76. ncbi request reprint Insulin receptor substrate polymorphisms and type 2 diabetes mellitus
    G Sesti
    Department of Internal Medicine, University of Rome Tor Vergata, Italy
    Pharmacogenomics 1:343-57. 2000
    ..In contrast, polymorphisms of the other IRS genes do not appear to contribute to Type 2 diabetes...
  77. doi request reprint Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance
    F Andreozzi
    Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy
    Diabetologia 54:1879-87. 2011
    ..We measured the abundance of PHLPP in fat and skeletal muscle from obese participants. To study the effect of PHLPP on insulin signalling, PHLPP (also known as PHLPP1) was overexpressed in HepG2 and L6 cells...
  78. ncbi request reprint Endogenous testosterone and endothelial function in postmenopausal women
    Tiziana Montalcini
    Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Coron Artery Dis 18:9-13. 2007
    ..The role of androgens is still controversial. The aim of the present study was to investigate the relationship between endogenous sex hormones and endothelial function, measuring the brachial artery flow-mediated dilation...
  79. ncbi request reprint Components of the metabolic syndrome and carotid atherosclerosis: role of elevated blood pressure
    Concetta Irace
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Magna Graecia University, Catanzaro, Italy
    Hypertension 45:597-601. 2005
    ..The diagnosis of MetS per se might not adequately identify subjects at elevated cardiovascular risk...
  80. ncbi request reprint Insulin receptor variant forms and type 2 diabetes mellitus
    G Sesti
    Department of Internal Medicine, University of Rome, Tor Vergata, Italy
    Pharmacogenomics 1:49-61. 2000
    ..Mutations in the insulin receptor gene were identified in studies which examined an appropriately sized population of Type 2 diabetic patients. The prevalence of mutations in the insulin receptor gene ranged from 0.4 to 7.8%...
  81. ncbi request reprint Association of LDL cholesterol with carotid atherosclerosis in menopausal women affected by the metabolic syndrome
    Tiziana Montalcini
    Department of Clinical and Experimental Medicine G Salvatore, University of Catanzaro Magna Graecia, Via T Campanella, 88100 Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 15:368-72. 2005
    ..The metabolic syndrome is a highly prevalent condition associated with cardiovascular disease. However, the contribution of LDL to cardiovascular risk is not estimated since it is not part of ATP III criteria...
  82. ncbi request reprint Relation of fasting insulin related to insertion/deletion polymorphism of angiotensin-converting enzyme-gene and cardiac mass in never-treated patients with systemic hypertension
    Roberto Ceravolo
    Cardiovascular Diseases Unit, Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Am J Cardiol 92:1234-7. 2003
    ..Taken together, we investigated the growth effect of fasting insulin, associated with angiotensin-converting enzyme-gene polymorphism, on cardiac mass in a group of previously untreated hypertensive patients...
  83. ncbi request reprint Large brachial and common carotid artery diameter in postmenopausal women with carotid atherosclerosis
    Tiziana Montalcini
    Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Facoltà di Medicina Edificio Clinico A II livello, Viale Europa Loc Germaneto, 88100 Catanzaro, Italy
    Atherosclerosis 196:443-8. 2008
    ..We hypothesized that brachial and common carotid arteries diameters were larger in subjects with carotid atherosclerosis compared to subjects without these lesions...
  84. doi request reprint Leptin-stimulated endothelial nitric-oxide synthase via an adenosine 5'-monophosphate-activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein
    Cristina Procopio
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
    Endocrinology 150:3584-93. 2009
    ....
  85. doi request reprint Positive association between plasma IGF1 and high-density lipoprotein cholesterol levels in adult nondiabetic subjects
    Elena Succurro
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Via Europa, 88100 Catanzaro, Italy
    Eur J Endocrinol 163:75-80. 2010
    ..To address this issue, we evaluated the association between IGF1 levels and HDL-C in nondiabetic subjects...
  86. doi request reprint Nonalcoholic fatty liver disease is associated with low circulating levels of insulin-like growth factor-I
    Franco Arturi
    Dipartimento Medicina Sperimentale e Clinica, Universita Magna Graecia di Catanzaro, Viale Europa, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 96:E1640-4. 2011
    ..Among the potential factors that may account for the increased cardiometabolic risk, IGF-I is a plausible candidate because the liver is the main site of its production...
  87. ncbi request reprint Relation of low bone mineral density and carotid atherosclerosis in postmenopausal women
    Tiziana Montalcini
    Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Am J Cardiol 94:266-9. 2004
    ..We found a high prevalence of carotid atherosclerosis in subjects with high osteocalcin levels and low bone mineral density...
  88. ncbi request reprint Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient
    Francesca Bernassola
    Biochemistry Laboratory, IDI IRCCS, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    FASEB J 16:1371-8. 2002
    ..Collectively, these results identify TGase 2 as a potential candidate gene in type 2 diabetes...
  89. ncbi request reprint Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes
    Rossella D'Alfonso
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    J Clin Endocrinol Metab 88:317-22. 2003
    ..These results strongly argue against a major role of IRS-2 polymorphisms in the pathogenesis of type 2 diabetes...
  90. ncbi request reprint A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
    Harald Staiger
    Internal Medicine IV, Medical Clinic Tübingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Diabetes 57:514-7. 2008
    ..Based on HHEX's function during embryonic development of the ventral pancreas in mice, we investigated whether these SNPs affect beta-cell function in humans...
  91. ncbi request reprint Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Diabetes 51:1419-24. 2002
    ..These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)-->Arg amino acid polymorphism of IRS-1...
  92. ncbi request reprint Heterogeneous effect of peroxisome proliferator-activated receptor gamma2 Ala12 variant on type 2 diabetes risk
    Ornella Ludovico
    Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, Viale Cappuccini, S Giovanni Rotondo, 71013 Italy
    Obesity (Silver Spring) 15:1076-81. 2007
    ..It is greater in Asia than in Europe and, among Europeans, it is higher in Northern Europe, barely significant in Central Europe, and nonexistent in Southern Europe...
  93. ncbi request reprint Correspondence between the International Diabetes Federation criteria for metabolic syndrome and insulin resistance in a cohort of Italian nondiabetic Caucasians: the GISIR database
    Giorgio Sesti
    Diabetes Care 30:e33. 2007
  94. ncbi request reprint C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance
    Marina Cardellini
    Department of Internal Medicine, University of Rome, Italy
    Diabetes Care 28:2007-12. 2005
    ..We addressed the question of whether the C-174G IL-6 polymorphism contributes to variation of insulin sensitivity...
  95. ncbi request reprint Plasma interleukin-6 levels are increased in subjects with impaired glucose tolerance but not in those with impaired fasting glucose in a cohort of Italian Caucasians
    Marina Cardellini
    Department of Internal Medicine, University of Rome Tor, Vergata 00133, Rome, Italy
    Diabetes Metab Res Rev 23:141-5. 2007
    ..While the relationship between impaired glucose tolerance (IGT) and circulating interleukin-6 (IL-6) is well established, there is no information whether IL-6 levels are elevated in impaired fasting glucose (IFG)...
  96. ncbi request reprint Uric acid and endothelial dysfunction in essential hypertension
    Carmine Zoccali
    CNR IBIM Consiglio Nazionale delle Ricerche, Istituto di Biomedicina, delle Malattie Renali e dell Ipertensione Arteriosa, c o Divisione di Nefrologia e Dialisi, Ospedali Riuniti Via Vallone Petrara, Reggio Calabria, Italy
    J Am Soc Nephrol 17:1466-71. 2006
    ..Probably, the chronic inflammation that was documented in these patients may be considered the mechanistic link between serum UA and vascular damage...
  97. ncbi request reprint The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy
    Sabrina Prudente
    CSS Mendel Institute, Viale Regina Margherita 261, 00198 Rome, Italy
    Diabetes 54:2807-11. 2005
    ..05 vs. Q84 transfected and P < 0.01 vs. control cells). These data provide the first evidence that TRB3 gene plays a role in human insulin resistance and related clinical outcomes...
  98. pmc Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha
    Massimo Federici
    Center for Atherosclerosis, Policlinico Tor Vergata University Hospital, Rome, Italy
    J Clin Invest 115:3494-505. 2005
    ..Our results suggest that an interplay between reduced insulin action and unchecked TACE activity promotes diabetes and vascular inflammation...
  99. ncbi request reprint The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy
    Massimo Federici
    Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 56100 Rome, Italy
    Diabetes 52:887-90. 2003
    ..49 +/- 0.058, n = 34, and 0.76 +/- 0.066, n = 134, respectively [means +/- SE]; P = 0.051). Our findings suggest a role for Arg(972) IRS-1 in conferring risk for the development of type 1 diabetes...
  100. ncbi request reprint Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans
    Marta L Hribal
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    FASEB J 17:1340-2. 2003
    ..These data suggest that changes in early steps of insulin receptor signaling may play a role in determining beta-cell dysfunction caused by chronic hyperglycemia...