G Sesti

Summary

Affiliation: Magna Graecia University
Country: Italy

Publications

  1. ncbi request reprint The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia, Viale Europa, località Germaneto, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 91:2334-9. 2006
  2. doi request reprint Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals
    Elena Succurro
    1Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Obesity (Silver Spring) 16:1881-6. 2008
  3. ncbi request reprint Role of C Reactive Protein (CRP) in Leptin Resistance
    Marta Letizia Hribal
    Department of Medical and Surgical Sciences, University of Catanzaro Magna Graecia, Viale Europa, località Germaneto 88100 Catanzaro, Italy
    Curr Pharm Des 20:609-15. 2014
  4. doi request reprint A polymorphism at IGF1 locus is associated with carotid intima media thickness and endothelium-dependent vasodilatation
    Giorgio Sesti
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, Catanzaro 88100, Italy Electronic address
    Atherosclerosis 232:25-30. 2014
  5. doi request reprint A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease
    Giorgio Sesti
    Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Via Europa Località Germaneto, Catanzaro 88100, Italy Electronic address
    Atherosclerosis 231:141-4. 2013
  6. doi request reprint Association of hepatic insulin resistance indexes to nonalcoholic fatty liver disease and related biomarkers
    G Sesti
    Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Viale Europa, Catanzaro 88100, Italy Electronic address
    Nutr Metab Cardiovasc Dis 23:1182-7. 2013
  7. doi request reprint [Combination therapy with glucagon-like peptide-1 analogs and insulin: indications and contraindications in coronary artery disease patients]
    Giorgio Sesti
    Dipartimento di Scienze Mediche e Chirurgiche, Universita degli Studi Magna Graecia, Catanzano
    G Ital Cardiol (Rome) 13:9S-16S. 2012
  8. doi request reprint Insulin-like growth factor-I, inflammatory proteins, and fibrosis in subjects with nonalcoholic fatty liver disease
    Marta Letizia Hribal
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 98:E304-8. 2013
  9. doi request reprint IGF-1 levels link estimated glomerular filtration rate to insulin resistance in obesity: a study in obese, but metabolically healthy, subjects and obese, insulin-resistant subjects
    G Sesti
    Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 21:933-40. 2011
  10. doi request reprint [Effects of glucagon-like peptide-1 on appetite and body weight: preclinical and clinical data]
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinic, Universita degli Studi Magna Graecia, Catanzaro
    G Ital Cardiol (Rome) 12:10-6. 2011

Detail Information

Publications91

  1. ncbi request reprint The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia, Viale Europa, località Germaneto, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 91:2334-9. 2006
    ..Several studies suggest that genetic factors may play a role in the different responses to antidiabetic therapy; however, conclusive evidence is still lacking...
  2. doi request reprint Insulin secretion in metabolically obese, but normal weight, and in metabolically healthy but obese individuals
    Elena Succurro
    1Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Obesity (Silver Spring) 16:1881-6. 2008
    ..Because these subjects also exhibited a worse metabolic risk profile, these findings may account for their increased risk for type 2 diabetes...
  3. ncbi request reprint Role of C Reactive Protein (CRP) in Leptin Resistance
    Marta Letizia Hribal
    Department of Medical and Surgical Sciences, University of Catanzaro Magna Graecia, Viale Europa, località Germaneto 88100 Catanzaro, Italy
    Curr Pharm Des 20:609-15. 2014
    ....
  4. doi request reprint A polymorphism at IGF1 locus is associated with carotid intima media thickness and endothelium-dependent vasodilatation
    Giorgio Sesti
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Viale Europa, Catanzaro 88100, Italy Electronic address
    Atherosclerosis 232:25-30. 2014
    ..We investigated the effects of this polymorphism on circulating IGF-1 levels, carotid intima media thickness (cIMT) and endothelial-dependent vasodilation...
  5. doi request reprint A functional variant of the dimethylarginine dimethylaminohydrolase-2 gene is associated with chronic kidney disease
    Giorgio Sesti
    Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Via Europa Località Germaneto, Catanzaro 88100, Italy Electronic address
    Atherosclerosis 231:141-4. 2013
    ....
  6. doi request reprint Association of hepatic insulin resistance indexes to nonalcoholic fatty liver disease and related biomarkers
    G Sesti
    Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Viale Europa, Catanzaro 88100, Italy Electronic address
    Nutr Metab Cardiovasc Dis 23:1182-7. 2013
    ....
  7. doi request reprint [Combination therapy with glucagon-like peptide-1 analogs and insulin: indications and contraindications in coronary artery disease patients]
    Giorgio Sesti
    Dipartimento di Scienze Mediche e Chirurgiche, Universita degli Studi Magna Graecia, Catanzano
    G Ital Cardiol (Rome) 13:9S-16S. 2012
    ..In this review, the pathophysiological rationale for using the combination of GLP-1 analogs is discussed, and data from clinical studies that have evaluated the efficacy of this treatment strategy are summarized...
  8. doi request reprint Insulin-like growth factor-I, inflammatory proteins, and fibrosis in subjects with nonalcoholic fatty liver disease
    Marta Letizia Hribal
    Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 98:E304-8. 2013
    ..Low circulating levels of the anti-inflammatory molecule IGF-I have been described in subjects with NAFLD...
  9. doi request reprint IGF-1 levels link estimated glomerular filtration rate to insulin resistance in obesity: a study in obese, but metabolically healthy, subjects and obese, insulin-resistant subjects
    G Sesti
    Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 21:933-40. 2011
    ..Metabolically healthy but obese (MHO) subjects have a favourable cardio-metabolic risk profile, but whether they are also at lower risk for kidney dysfunction is still questionable...
  10. doi request reprint [Effects of glucagon-like peptide-1 on appetite and body weight: preclinical and clinical data]
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinic, Universita degli Studi Magna Graecia, Catanzaro
    G Ital Cardiol (Rome) 12:10-6. 2011
    ..In this review, we discuss data of preclinical studies and clinical trials that evaluated the effects of liraglutide and exenatide, the two analogues of GLP-1 currently available in Italy, on body weight...
  11. pmc Cardiometabolic risk profiles and carotid atherosclerosis in individuals with prediabetes identified by fasting glucose, postchallenge glucose, and hemoglobin A1c criteria
    Maria A Marini
    Department of InternalMedicine, University of Rome Tor Vergata, Rome, Italy
    Diabetes Care 35:1144-9. 2012
    ..We evaluated whether cardiometabolic risk profiles differ for subjects identified as having prediabetes by A1C, fasting glucose (FPG), or 2-h postchallenge glucose (2-PG) criteria...
  12. pmc Insulin sensitivity, β-cell function, and incretin effect in individuals with elevated 1-hour postload plasma glucose levels
    Maria A Marini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetes Care 35:868-72. 2012
    ..Individuals with normal glucose tolerance (NGT), whose 1-h postload plasma glucose is ≥155 mg/dL (NGT 1h-high), have an increased risk of type 2 diabetes. The purpose of this study was to characterize their metabolic phenotype...
  13. ncbi request reprint The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia di Catanzaro Via Tommaso Campanella, 115 88100 Catanzaro, Italy
    Diabetes Care 27:1394-8. 2004
    ..The aim of this study was to investigate whether diabetic patients carrying the Arg(972) insulin receptor substrate-1 (IRS-1) variant are at increased risk for secondary failure to sulfonylurea...
  14. ncbi request reprint Defects of the insulin receptor substrate (IRS) system in human metabolic disorders
    G Sesti
    Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, 88100 Catanzaro, Italy
    FASEB J 15:2099-111. 2001
    ..In contrast, polymorphisms of the other IRS genes do not appear to contribute to type 2 diabetes...
  15. ncbi request reprint Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance
    Giorgio Sesti
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes Care 28:120-5. 2005
    ..We studied the relationships between plasma IGF-I concentrations and insulin sensitivity in subjects with various degrees of glucose tolerance...
  16. ncbi request reprint Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database
    Giorgio Sesti
    Department of Experimental and Clinical Medicine, University of Catanzaro, Italy
    Diabetes Metab Res Rev 24:130-6. 2008
    ..We assessed the accuracy of the American Diabetes Association (ADA)2003 definition of impaired fasting glucose (IFG) in identifying subjects with low insulin sensitivity, and determined cardiovascular risk factors in ADA2003 IFG subjects...
  17. ncbi request reprint Impact of common polymorphisms in candidate genes for insulin resistance and obesity on weight loss of morbidly obese subjects after laparoscopic adjustable gastric banding and hypocaloric diet
    Giorgio Sesti
    Dipartimento Medicina Sperimentale e Clinica, Universita Magna Graecia di Catanzaro, Via Campanella, 115, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 90:5064-9. 2005
    ..It is unknown whether genetic factors that play an important role in body weight homeostasis influence the response to laparoscopic adjustable gastric banding (LAGB)...
  18. ncbi request reprint Pathophysiology of insulin resistance
    Giorgio Sesti
    Universita Magna Graecia di Catanzaro, Campus Universitario Germaneto di Catanzaro, 88100 Catanzaro, Italy
    Best Pract Res Clin Endocrinol Metab 20:665-79. 2006
    ..Inflammatory molecules and lipid metabolites inhibit insulin signalling by stimulating a number of different serine kinases which are responsible for serine phosphorylation of Insulin Receptor Substrate-1 (IRS-1)...
  19. doi request reprint Harnessing the weight-regulating properties of glucagon-like peptide-1 in the treatment of type 2 diabetes
    G Sesti
    Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes Obes Metab 11:4-10. 2009
    ....
  20. ncbi request reprint Searching for type 2 diabetes genes: prospects in pharmacotherapy
    G Sesti
    Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Pharmacogenomics J 2:25-9. 2002
  21. ncbi request reprint Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes?
    Giorgio Sesti
    Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, IT 88100 Catanzaro, Italy
    Ann Med 34:444-50. 2002
    ....
  22. ncbi request reprint A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Via Tommaso Campanella, 115 11800 Catanzaro, Italy
    Diabetes 52:1280-3. 2003
    ..These results indicate that the common -866G/A polymorphism in the UCP2 gene may contribute to the biological variation of insulin secretion in humans...
  23. doi request reprint Elevated one-hour post-load plasma glucose levels identifies subjects with normal glucose tolerance but early carotid atherosclerosis
    E Succurro
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Italy
    Atherosclerosis 207:245-9. 2009
    ....
  24. doi request reprint One-hour post-load plasma glucose levels are associated with elevated liver enzymes
    E Succurro
    Department of Experimental and Clinical Medicine, Viale Europa, University Magna Græcia of Catanzaro, Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 21:713-8. 2011
    ....
  25. doi request reprint Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects
    E Succurro
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 19:713-9. 2009
    ..In this cross-sectional study, we analyzed the relationship between IGF-1 levels, insulin sensitivity and secretion in 110 nondiabetic subjects with a wide range of BMI to verify this hypothesis...
  26. ncbi request reprint Weight loss in combination with physical activity improves endothelial dysfunction in human obesity
    Angela Sciacqua
    Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes Care 26:1673-8. 2003
    ..To test whether weight loss may improve endothelial dysfunction in human obesity, we recruited 28 healthy obese subjects, aged 30-46 years, with BMI 30-43 kg/m(2)...
  27. doi request reprint Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion
    Marta L Hribal
    Department of Clinical and Experimental Medicine, University ofCatanzaro Magna Graecia, Catanzaro, Italy
    J Cell Mol Med 12:2096-106. 2008
    ..Furthermore, they may become an important tool to test novel tailored therapies...
  28. ncbi request reprint Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of Italian-Caucasian nondiabetic subjects
    Francesco Andreozzi
    Dipartimento di Medicina Sperimentale e Clinica, Policlinico Mater Domini Via Tommaso Campanella 88100, Catanzaro, Italy
    Diabetes 55:2021-4. 2006
    ..0 and 5.2% of its variation. These data indicate that IL-6 is associated in a reciprocal manner with the two pathophysiological components of type 2 diabetes, i.e., insulin resistance and insulin secretion...
  29. doi request reprint Endothelial dysfunction and non-alcoholic liver steatosis in hypertensive patients
    A Sciacqua
    Department of Experimental and Clinical Medicine, G Salvatore, University Magna Græcia of Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 21:485-91. 2011
    ..The aim of this study was to test a possible association between non-alcoholic fatty liver disease and endothelium-dependent vasodilation in a group of hypertensive patients...
  30. doi request reprint Kidney function and risk factors for left ventricular hypertrophy in untreated uncomplicated essential hypertension
    Francesco Perticone
    Department of Experimental and Clinical Medicine, G Salvatore, University Magna Graecia of Catanzaro, Reggio Calabria, Italy
    Am J Kidney Dis 52:74-84. 2008
    ..Left ventricular (LV) hypertrophy and decreased kidney function are well-established cardiovascular risk factors in hypertensive patients...
  31. ncbi request reprint Role of PC-1 and ACE genes on insulin resistance and cardiac mass in never-treated hypertensive patients. Suggestive evidence for a digenic additive modulation
    Francesco Perticone
    Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 17:181-7. 2007
    ..The aim of this work was to investigate whether the PC-1 and ACE genes exert a polygenic control of insulin resistance and LVM in hypertensive patients...
  32. ncbi request reprint Pulse pressure and endothelial dysfunction in never-treated hypertensive patients
    Roberto Ceravolo
    Internal Medicine and Cardiovascular Diseases Unit, Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
    J Am Coll Cardiol 41:1753-8. 2003
    ..This study sought to investigate whether pulse pressure (PP) is associated with endothelium-dependent vasodilation in a group of never-treated hypertensives...
  33. pmc Reciprocal association of plasma IGF-1 and interleukin-6 levels with cardiometabolic risk factors in nondiabetic subjects
    Elena Succurro
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes Care 31:1886-8. 2008
    ....
  34. pmc Relation between serum uric acid and carotid intima-media thickness in healthy postmenopausal women
    T Montalcini
    Department of Clinical and Experimental Medicine, G Salvatore University of Catanzaro Magna Graecia, Viale Europa, I 88100, Catanzaro, Italy
    Intern Emerg Med 2:19-23. 2007
    ..We explored the association of the uric acid level with carotid intima-media thickness (IMT), a well known marker of CVD, in postmenopausal healthy women...
  35. ncbi request reprint Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells
    Francesco Andreozzi
    Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Italy
    Circ Res 94:1211-8. 2004
    ....
  36. ncbi request reprint Interaction between vascular dysfunction and cardiac mass increases the risk of cardiovascular outcomes in essential hypertension
    Angela Sciacqua
    Internal Medicine and Cardiovascular Diseases Unit, Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Italy
    Eur Heart J 26:921-7. 2005
    ..To investigate the additive prognostic impact of both forearm endothelial dysfunction and left ventricular mass (LVM) for future cardiovascular events...
  37. ncbi request reprint Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients
    Marina Cardellini
    Dipartimento di Medicina Sperimentale e Clinica, Policlinico Universitario Mater Domini, Via Europa, Campus Germaneto, 88100 Catanzaro, Italy
    Am J Physiol Endocrinol Metab 292:E347-52. 2007
    ..7% of its variation. These findings support the concept that insulin sensitivity, rather than plasma insulin levels, is associated with early atherosclerosis in nondiabetic normotensive offspring of type 2 diabetic patients...
  38. doi request reprint Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B
    M L Hribal
    Department of Experimental and Clinical Medicine, Viale Europa, Campus Germaneto, 88100 Catanzaro, Italy
    Diabetologia 54:795-802. 2011
    ..The aim of this study was to investigate the association of the rs10811661 polymorphism near the CDKN2B/CDKN2A genes with glucose tolerance, insulin sensitivity and insulin release in three samples of white people with European ancestry...
  39. doi request reprint Low insulin-like growth factor-1 levels are associated with anaemia in adult non-diabetic subjects
    Elena Succurro
    Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Cantanzaro, Italy
    Thromb Haemost 105:365-70. 2011
    ..49-fold higher risk of having anaemia as compared with those in the fourth (odds ratio 2.70, 95% confidence interval 1.02-7.16). Our data suggest that low IGF-1 may be an important contributor to mild anaemia...
  40. ncbi request reprint Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells
    Francesco Andreozzi
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Via Tommaso Campanella, 115, 88100 Catanzaro, Italy
    Endocrinology 145:2845-57. 2004
    ..These changes result in impaired coupling of IRS-1 and PI 3-kinase, and activation of the Akt/mammalian target of rapamycin/phosphorylated heat- and acid-stable protein-1/p70S6 kinase pathway...
  41. ncbi request reprint Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects
    Daniela Scarpelli
    Dipartimento di Medicina Sperimentale e Clinica, Policlinico Mater Domini, University Magna Graecia of Catanzaro, Via Tommaso Campanella, 88100 Catanzaro, Italy
    Diabetes 55:1529-33. 2006
    ..31]; P = 0.01) and insulin resistance (1.99 [1.12-3.53]; P = 0.01). This study suggests that polymorphisms and haplotypes of the IL10 promoter may be associated with obesity and insulin resistance in a large sample of Italian Caucasians...
  42. ncbi request reprint Metabolic and cardiovascular risk factors in subjects with impaired fasting glucose: the 100 versus 110 mg/dL threshold
    Francesco Andreozzi
    Department of Experimental and Clinical Medicine, University Magna Grzecia of Catanzaro, 88100 Catanzaro, Italy
    Diabetes Metab Res Rev 23:547-50. 2007
    ..This change was challenged as to its appropriateness. A few studies have examined the impact of the ADA(2003) threshold of IFG on metabolic and cardiovascular risk factors...
  43. pmc Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells
    Francesco Andreozzi
    Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Italy
    Mol Cell Biol 27:2372-83. 2007
    ..Our data suggest that IL-6 impairs the vasodilator effects of insulin that are mediated by the IRS-1/PI3-kinase/Akt/eNOS pathway through activation of JNK and ERK1/2...
  44. ncbi request reprint Effect of anti TNFalpha therapy on arterial diameter and wall shear stress and HDL cholesterol
    Concetta Irace
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Magna Graecia University, Catanzaro, Italy
    Atherosclerosis 177:113-8. 2004
    ..05 g/L versus 1.57 +/- 0.02 g/L, P <0.03). The present data show vasoconstriction and an increase of wall shear stress in studied arteries after infliximab. HDL cholesterol is reduced by treatment and does not seem to influence FMD...
  45. ncbi request reprint Endothelial dysfunction and C-reactive protein are risk factors for diabetes in essential hypertension
    Francesco Perticone
    Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes 57:167-71. 2008
    ..Type 2 diabetes and essential hypertension are major risk factors for cardiovascular diseases. Endothelial dysfunction is an early step in the development of atherosclerosis and has been demonstrated in hypertensive and diabetic patients...
  46. ncbi request reprint Gly460Trp alpha-adducin gene polymorphism and endothelial function in untreated hypertensive patients
    Francesco Perticone
    Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy
    J Hypertens 25:2234-9. 2007
    ..The aim of the present study was to investigate the relationship between the 460Trp allele of ADD1 and endothelium-dependent vasodilation in 110 never-treated hypertensive patients...
  47. doi request reprint Endothelial dysfunction, ADMA and insulin resistance in essential hypertension
    Francesco Perticone
    Department of Medicina Sperimentale e Clinica G Salvatore, University Magna Graecia of Catanzaro, Italy
    Int J Cardiol 142:236-41. 2010
    ..In this study, we investigated, in 63 hypertensives and 21 normotensive healthy subjects, the relationship between ADMA and IR and their possible interaction on endothelial function...
  48. doi request reprint Differences in cardiovascular risk profile based on relationship between post-load plasma glucose and fasting plasma levels
    Elena Succurro
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes Metab Res Rev 25:351-6. 2009
    ..However, it is still unsettled whether individuals in Group II have a more atherogenic profile than Group I subjects...
  49. ncbi request reprint Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension
    Francesco Perticone
    Internal Medicine and Cardiovascular Diseases Unit, Department of Medicina Sperimentale e Clinica G Salvatore, University Magna Graecia of Catanzaro, Catanzaro, Italy
    J Am Coll Cardiol 46:518-23. 2005
    ..We investigated the relationship between ADMA plasma levels and endothelium-dependent vasodilation in 36 never-treated essential hypertensives and in 8 normotensive healthy subjects...
  50. doi request reprint Renal function predicts cardiovascular outcomes in southern Italian postmenopausal women
    Francesco Perticone
    Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Italy
    Eur J Cardiovasc Prev Rehabil 16:481-6. 2009
    ..Postmenopausal women have an increased risk of adverse cardiovascular (CV) events. Similarly, chronic kidney disease (CKD) is a well established risk factor for CV disease and mortality...
  51. ncbi request reprint Carotid atherosclerosis associated to metabolic syndrome but not BMI in healthy menopausal women
    Tiziana Montalcini
    Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Viale Europa Germaneto, Catanzaro, Italy
    Diabetes Res Clin Pract 76:378-82. 2007
    ..The purpose of this study was to investigate whether the subclinical carotid atherosclerosis prevalence is different in obese postmenopausal women with and without the metabolic syndrome...
  52. ncbi request reprint Effects of growth hormone and insulin-like growth factor-1 on cardiac hypertrophy of hypertensive patients
    Giorgio Sesti
    Unit of Internal Medicine, Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Italy
    J Hypertens 25:471-7. 2007
    ..We investigated the role of the GH/IGF-1 axis on LVM and ventricular geometry in a group of 230 never-treated hypertensive patients...
  53. doi request reprint Endothelial dysfunction and subsequent decline in glomerular filtration rate in hypertensive patients
    Francesco Perticone
    Full Professor of Internal Medicine, Department of Medicina Sperimentale e Clinica, Campus Universitario Salvatore Venuta di Germaneto, Viale Europa, Catanzaro, Italy
    Circulation 122:379-84. 2010
    ..Thus, we prospectively evaluated the effect of endothelial function on estimated glomerular filtration rate (eGFR) in essential hypertension...
  54. doi request reprint Low-plasma insulin-like growth factor-I levels are associated with impaired endothelium-dependent vasodilatation in a cohort of untreated, hypertensive Caucasian subjects
    Francesco Perticone
    Department of Experimental and Clinical Medicine, Policlinico Mater Domini Viale Europa, Campus Germaneto, Catanzaro, Italy
    J Clin Endocrinol Metab 93:2806-10. 2008
    ..However, the relationship between plasma IGF-I levels and endothelium-dependent vasodilatation is still unsettled...
  55. ncbi request reprint Impaired endothelial function in never-treated hypertensive subjects carrying the Arg972 polymorphism in the insulin receptor substrate-1 gene
    Francesco Perticone
    Department of Experimental and Clinical Medicine, G Salvatore University Magna Graecia of Catanzaro, Policlinico Mater Domini Via Tommaso Campanella, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 89:3606-9. 2004
    ..4 vs. 13.3 +/- 3.5 ml/100 ml(-1) of tissue per min(-1)). Our data strongly suggest that, by inducing endothelial dysfunction, the Arg(972) IRS-1 polymorphism may contribute to the genetic predisposition to develop cardiovascular disease...
  56. doi request reprint Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance
    F Andreozzi
    Department of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Viale Europa, 88100 Catanzaro, Italy
    Diabetologia 54:1879-87. 2011
    ..We measured the abundance of PHLPP in fat and skeletal muscle from obese participants. To study the effect of PHLPP on insulin signalling, PHLPP (also known as PHLPP1) was overexpressed in HepG2 and L6 cells...
  57. ncbi request reprint Endogenous testosterone and endothelial function in postmenopausal women
    Tiziana Montalcini
    Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Coron Artery Dis 18:9-13. 2007
    ..The role of androgens is still controversial. The aim of the present study was to investigate the relationship between endogenous sex hormones and endothelial function, measuring the brachial artery flow-mediated dilation...
  58. ncbi request reprint Components of the metabolic syndrome and carotid atherosclerosis: role of elevated blood pressure
    Concetta Irace
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Magna Graecia University, Catanzaro, Italy
    Hypertension 45:597-601. 2005
    ..The diagnosis of MetS per se might not adequately identify subjects at elevated cardiovascular risk...
  59. ncbi request reprint Role of endogenous androgens on carotid atherosclerosis in non-obese postmenopausal women
    T Montalcini
    Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, U O Medicina Interna, Viale Europa, Germaneto, 88100 Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 17:705-11. 2007
    ..In particular androgens seem to have a protective role on atherosclerosis. The present study was performed to assess the role of endogenous sex hormones on carotid atherosclerosis in postmenopausal women...
  60. ncbi request reprint Association of LDL cholesterol with carotid atherosclerosis in menopausal women affected by the metabolic syndrome
    Tiziana Montalcini
    Department of Clinical and Experimental Medicine G Salvatore, University of Catanzaro Magna Graecia, Via T Campanella, 88100 Catanzaro, Italy
    Nutr Metab Cardiovasc Dis 15:368-72. 2005
    ..The metabolic syndrome is a highly prevalent condition associated with cardiovascular disease. However, the contribution of LDL to cardiovascular risk is not estimated since it is not part of ATP III criteria...
  61. ncbi request reprint Large brachial and common carotid artery diameter in postmenopausal women with carotid atherosclerosis
    Tiziana Montalcini
    Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Facoltà di Medicina Edificio Clinico A II livello, Viale Europa Loc Germaneto, 88100 Catanzaro, Italy
    Atherosclerosis 196:443-8. 2008
    ..We hypothesized that brachial and common carotid arteries diameters were larger in subjects with carotid atherosclerosis compared to subjects without these lesions...
  62. ncbi request reprint Relation of fasting insulin related to insertion/deletion polymorphism of angiotensin-converting enzyme-gene and cardiac mass in never-treated patients with systemic hypertension
    Roberto Ceravolo
    Cardiovascular Diseases Unit, Department of Experimental and Clinical Medicine G Salvatore, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Am J Cardiol 92:1234-7. 2003
    ..Taken together, we investigated the growth effect of fasting insulin, associated with angiotensin-converting enzyme-gene polymorphism, on cardiac mass in a group of previously untreated hypertensive patients...
  63. doi request reprint Positive association between plasma IGF1 and high-density lipoprotein cholesterol levels in adult nondiabetic subjects
    Elena Succurro
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Via Europa, 88100 Catanzaro, Italy
    Eur J Endocrinol 163:75-80. 2010
    ..To address this issue, we evaluated the association between IGF1 levels and HDL-C in nondiabetic subjects...
  64. doi request reprint Leptin-stimulated endothelial nitric-oxide synthase via an adenosine 5'-monophosphate-activated protein kinase/Akt signaling pathway is attenuated by interaction with C-reactive protein
    Cristina Procopio
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
    Endocrinology 150:3584-93. 2009
    ....
  65. doi request reprint Nonalcoholic fatty liver disease is associated with low circulating levels of insulin-like growth factor-I
    Franco Arturi
    Dipartimento Medicina Sperimentale e Clinica, Universita Magna Graecia di Catanzaro, Viale Europa, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 96:E1640-4. 2011
    ..Among the potential factors that may account for the increased cardiometabolic risk, IGF-I is a plausible candidate because the liver is the main site of its production...
  66. ncbi request reprint Relation of low bone mineral density and carotid atherosclerosis in postmenopausal women
    Tiziana Montalcini
    Department of Medicina Sperimentale e Clinica G Salvatore, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Am J Cardiol 94:266-9. 2004
    ..We found a high prevalence of carotid atherosclerosis in subjects with high osteocalcin levels and low bone mineral density...
  67. ncbi request reprint Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells
    Massimo Federici
    Department of Internal Medicine, University of Tor Vergata, Rome, Italy
    Circulation 106:466-72. 2002
    ..We studied the effects of O-GlcNAcylation on insulin signaling in human coronary artery endothelial cells...
  68. ncbi request reprint Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes
    Rossella D'Alfonso
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    J Clin Endocrinol Metab 88:317-22. 2003
    ..These results strongly argue against a major role of IRS-2 polymorphisms in the pathogenesis of type 2 diabetes...
  69. pmc Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha
    Massimo Federici
    Center for Atherosclerosis, Policlinico Tor Vergata University Hospital, Rome, Italy
    J Clin Invest 115:3494-505. 2005
    ..Our results suggest that an interplay between reduced insulin action and unchecked TACE activity promotes diabetes and vascular inflammation...
  70. ncbi request reprint Uric acid and endothelial dysfunction in essential hypertension
    Carmine Zoccali
    CNR IBIM Consiglio Nazionale delle Ricerche, Istituto di Biomedicina, delle Malattie Renali e dell Ipertensione Arteriosa, c o Divisione di Nefrologia e Dialisi, Ospedali Riuniti Via Vallone Petrara, Reggio Calabria, Italy
    J Am Soc Nephrol 17:1466-71. 2006
    ..Probably, the chronic inflammation that was documented in these patients may be considered the mechanistic link between serum UA and vascular damage...
  71. ncbi request reprint The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy
    Massimo Federici
    Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 56100 Rome, Italy
    Diabetes 52:887-90. 2003
    ..49 +/- 0.058, n = 34, and 0.76 +/- 0.066, n = 134, respectively [means +/- SE]; P = 0.051). Our findings suggest a role for Arg(972) IRS-1 in conferring risk for the development of type 1 diabetes...
  72. ncbi request reprint G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells
    Massimo Federici
    Department of Medicine and Aging Sciences, Edificio CeSi, Room 271, University of Chieti, Via dei Vestini, 1, 66100 Chieti, Italy
    Circulation 109:399-405. 2004
    ....
  73. ncbi request reprint Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans
    Marta L Hribal
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    FASEB J 17:1340-2. 2003
    ..These data suggest that changes in early steps of insulin receptor signaling may play a role in determining beta-cell dysfunction caused by chronic hyperglycemia...
  74. ncbi request reprint Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Diabetes 51:1419-24. 2002
    ..These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)-->Arg amino acid polymorphism of IRS-1...
  75. ncbi request reprint Insulin resistance and increased intimal medial thickness in glucose tolerant offspring of type 2 diabetic subjects carrying the D298D genotype of endothelial nitric oxide synthase
    Stefano Rizza
    Arterioscler Thromb Vasc Biol 26:431-2. 2006
  76. ncbi request reprint Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient
    Francesca Bernassola
    Biochemistry Laboratory, IDI IRCCS, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    FASEB J 16:1371-8. 2002
    ..Collectively, these results identify TGase 2 as a potential candidate gene in type 2 diabetes...
  77. ncbi request reprint Plasma interleukin-6 levels are increased in subjects with impaired glucose tolerance but not in those with impaired fasting glucose in a cohort of Italian Caucasians
    Marina Cardellini
    Department of Internal Medicine, University of Rome Tor, Vergata 00133, Rome, Italy
    Diabetes Metab Res Rev 23:141-5. 2007
    ..While the relationship between impaired glucose tolerance (IGT) and circulating interleukin-6 (IL-6) is well established, there is no information whether IL-6 levels are elevated in impaired fasting glucose (IFG)...
  78. ncbi request reprint The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy
    Sabrina Prudente
    CSS Mendel Institute, Viale Regina Margherita 261, 00198 Rome, Italy
    Diabetes 54:2807-11. 2005
    ..05 vs. Q84 transfected and P < 0.01 vs. control cells). These data provide the first evidence that TRB3 gene plays a role in human insulin resistance and related clinical outcomes...
  79. ncbi request reprint A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study
    Harald Staiger
    Internal Medicine IV, Medical Clinic Tübingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Diabetes 57:514-7. 2008
    ..Based on HHEX's function during embryonic development of the ventral pancreas in mice, we investigated whether these SNPs affect beta-cell function in humans...
  80. ncbi request reprint The CCR2 promoter polymorphism T-960A, but not the serum MCP-1 level, is associated with endothelial function in prediabetic individuals
    Kilian Rittig
    Department of Endocrinology, Diabetes, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Germany
    Atherosclerosis 198:338-46. 2008
    ..This might be due to reduced subendothelial inflammation, mediated by reduced transendothelial monocyte-migration ability...
  81. ncbi request reprint Metabolically healthy but obese women have an intermediate cardiovascular risk profile between healthy nonobese women and obese insulin-resistant women
    Maria Adelaide Marini
    Department of Internal Medicine, University of Rome, Rome, Italy
    Diabetes Care 30:2145-7. 2007
  82. doi request reprint Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance
    Alena Stancakova
    Department of Medicine, University of Kuopio and University Hospital, 70210 Kuopio, Finland
    J Clin Endocrinol Metab 93:1924-30. 2008
    ..CDKAL1 is a recently discovered susceptibility gene for type 2 diabetes...
  83. ncbi request reprint Heterogeneous effect of peroxisome proliferator-activated receptor gamma2 Ala12 variant on type 2 diabetes risk
    Ornella Ludovico
    Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, Viale Cappuccini, S Giovanni Rotondo, 71013 Italy
    Obesity (Silver Spring) 15:1076-81. 2007
    ..It is greater in Asia than in Europe and, among Europeans, it is higher in Northern Europe, barely significant in Central Europe, and nonexistent in Southern Europe...
  84. ncbi request reprint Correspondence between the International Diabetes Federation criteria for metabolic syndrome and insulin resistance in a cohort of Italian nondiabetic Caucasians: the GISIR database
    Giorgio Sesti
    Diabetes Care 30:e33. 2007
  85. doi request reprint TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells
    Francesco Andreozzi
    Department of Medicine and Aging Sciences, Edificio CeSi, Room 271, University of Chieti, Via dei Vestini 1, 66100 Chieti, Italy
    Arterioscler Thromb Vasc Biol 28:1355-60. 2008
    ..We have recently described a Q84R gain-of-function polymorphism of TRIB3 with the R84 variant being associated with insulin resistance and an earlier age at myocardial infarction...
  86. ncbi request reprint C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance
    Marina Cardellini
    Department of Internal Medicine, University of Rome, Italy
    Diabetes Care 28:2007-12. 2005
    ..We addressed the question of whether the C-174G IL-6 polymorphism contributes to variation of insulin sensitivity...
  87. ncbi request reprint The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes
    Monica D'Adamo
    Laboratory of Molecular Medicine, University of Rome, Rome, Italy
    Diabetes 53:1905-10. 2004
    ..84, 95% CI 1.03-3.28; P = 0.037), but not in men. These results indicate that the -866A/A genotype of the UCP2 gene may contribute to diabetes susceptibility by affecting insulin sensitivity...
  88. ncbi request reprint Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells
    Cristina D'Alessandris
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    FASEB J 18:959-61. 2004
    ..Increased routing of glucose through this metabolic pathway results in impaired activation of the IR/IRSs/PI3-kinase/Akt survival pathway by induction of O-glycosylation of signaling molecules...
  89. ncbi request reprint Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes
    Salvatore De Cosmo
    Am J Kidney Dis 50:688-9. 2007
  90. ncbi request reprint The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients
    Maria Adelaide Marini
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    J Clin Endocrinol Metab 88:3368-71. 2003
    ..These results suggest that the Arg(972) IRS-1 variant could contribute to the risk for atherosclerotic cardiovascular diseases associated with type 2 diabetes by producing a cluster of insulin resistance-related metabolic abnormalities...
  91. doi request reprint PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes
    Agueda Gonzalez-Rodriguez
    Instituto de Investigaciones Biomedicas Alberto Sols, C Arturo Pérez Duperier 4, 28029 Madrid, Spain
    Am J Physiol Gastrointest Liver Physiol 295:G338-47. 2008
    ....