Research Topics
Species | Giovambattista De SarroSummaryAffiliation: Magna Graecia University Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 miceGiovambattista De Sarro
Clinical Pharmacology Unit, Science of Health Department, School of Medicine, University Magna Graecia of Catanzaro, Viale Europa, LocalitàGermaneto, 88100 Catanzaro, Italy
Pharmacol Res 65:285-96. 2012....
Effects of adenosine receptor agonists and antagonists on audiogenic seizure-sensible DBA/2 miceG De Sarro
Department of Experimental and Clinical Medicine, School of Medicine, University of Catanzaro, Italy
Eur J Pharmacol 371:137-45. 1999..CGS 15943, 0.29 mg/kg i.p., KF 17837, 0.57 mg/kg, i.p., CSC 0.12 mg/kg, i.p. and SCH 58261 0.07 mg/kg, i.p., respectively. These data suggest that stimulation of adenosine A1 and A2A receptors is involved in the suppression of seizures...- Seizure susceptibility to various convulsant stimuli in dystrophin-deficient mdx miceGiovambattista De Sarro
Department of Experimental and Clinical Medicine G Salvatore, School of Medicine, University Magna Graecia of Catanzaro, Policlinico Mater Domini, Via T Campanella, 115, 88100 Catanzaro, Italy
Neurosci Res 50:37-44. 2004..The present data suggests that the dystrophin deficiency in mdx mice affects the pathophysiology and pharmacology of acute and chronic epileptic seizures in an opposite manner... - Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 miceGiovambattista De Sarro
Department of Experimental and Clinical Medicine G Salvatore, School of Medicine, University of Catanzaro, Policlinico Mater Domini, Via T Campanella, 115, 88100 Catanzaro, Italy
Pharmacol Biochem Behav 77:761-6. 2004..The present data suggest that IL-6(-/-) mice might be a valid novel epileptic model for the study of pathophysiology and pharmacology of epileptic seizures... - Amino acid levels in some brain areas of inducible nitric oxide synthase knock out mouse (iNOS-/-) before and after pentylenetetrazole kindlingGrazia De Luca
Department of Biochemical, Physiological and Nutritional Sciences, School of Medicine, University of Messina, Messina, Italy
Pharmacol Biochem Behav 85:804-12. 2006.... - Comparative anticonvulsant activity of some 2,3-benzodiazepine derivatives in rodentsGiovambattista De Sarro
Department of Experimental and Clinical Medicine, School of Medicine at Catanzaro, Policlinico Mater Domini, Via T Campanella, 115, 88100, Catanzaro, Italy
Pharmacol Biochem Behav 74:595-602. 2003.... - Influence of some beta-adrenoceptor antagonists on the anticonvulsant potency of antiepileptic drugs against audiogenic seizures in DBA/2 miceGiovambattista De Sarro
Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Via T Campanella, 115 Policlinico Mater Domini, 88100 Catanzaro, Italy
Eur J Pharmacol 442:205-13. 2002.... - Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 miceG De Sarro
Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Cantanzaro, Policlinico Mater Domini, Italy
Naunyn Schmiedebergs Arch Pharmacol 363:330-6. 2001..In conclusion, retigabine showed an additive effect when administered in combination with classical anticonvulsants, most notably diazepam, phenobarbital, phenytoin and valproate... - NMDA and AMPA/kainate receptors are involved in the anticonvulsant activity of riluzole in DBA/2 miceG De Sarro
Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro Magna Graecia, Policlinico Mater Domini, Via T Campanella, 88100 Catanzaro, Italy
Eur J Pharmacol 408:25-34. 2000..Our findings suggest that the anticonvulsant properties of riluzole depend upon its interaction with neurotransmission mediated by both the glycine/NMDA and the AMPA/kainate receptor complex... - Effects of compounds acting on GABA(B) receptors in the pentylenetetrazole kindling model of epilepsy in miceG De Sarro
Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro Magna Grecia, Policlinico Mater Domini, Via T Campanella, 88100 Catanzaro, Italy
Neuropharmacology 39:2147-61. 2000.... - Influence of D-cycloserine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 miceG De Sarro
Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Policlinico Mater Domini, Via T Campanella 115, 88100, Catanzaro, Italy
Epilepsy Res 40:109-21. 2000..In conclusion, DCS potentiates the anticonvulsant action of some classical antiepileptic drugs, most notably diazepam, phenobarbital, phenytoin and valproate... - Topiramate potentiates the antiseizure activity of some anticonvulsants in DBA/2 miceG De Sarro
Chair of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Policlinico Mater Domini, Via T Campanella, 88100, Catanzaro, Italy
Eur J Pharmacol 388:163-70. 2000..In conclusion, topiramate showed an additive effect when administered in combination with some classical anticonvulsants, most notably diazepam, phenobarbital, lamotrigine, phenytoin and valproate... - 3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agentsLaura De Luca
Dipartimento Farmaco Chimico, Universita di Messina, Messina, Italy
Arch Pharm (Weinheim) 339:388-400. 2006..Moreover, in order to explain the different degree of efficacy of the newly designed N-substituted derivatives, excluded volumes were also considered... - Enhancement of anti-absence effects of ethosuximide by low doses of a noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist in a genetic animal model of absence epilepsyEmilio Russo
Chair of Pharmacology, Department of Experimental and Clinical Medicine, School of Medicine, University of Catanzaro, Catanzaro, Italy
Epilepsy Behav 13:295-9. 2008.... - Effects of non-competitive AMPA receptor antagonists injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsyRita Citraro
Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, School of Medicine at Catanzaro, Policlinico Mater Domini, Via Tommaso Campanella, 115, 88100 Catanzaro, Italy
Neuropharmacology 51:1058-67. 2006..These findings suggest that AMPA receptor antagonists might play a role in absence epilepsies and that it might depend on the involvement of specific neuronal areas... - Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy modelEmilio Russo
Department of Experimental and Clinical Medicine, School of Medicine, University of Catanzaro, Via T Campanella 115, Catanzaro, Italy
Epilepsia 52:1341-50. 2011..Here, we examined the effects of long-term treatment with several AEDs on absence seizure development and onset of depressive-like behavior in WAG/Rij rats at different ages, using a forced swimming test (FST)... - Susceptibility to audiogenic seizure and neurotransmitter amino acid levels in different brain areas of IL-6-deficient miceGrazia De Luca
Department of Biochemical, Physiological and Nutritional Sciences, AOU G Martino via Consolare Valeria, 98125 Messina, Italy
Pharmacol Biochem Behav 78:75-81. 2004..The present data support the validity of IL-6(-/-) mice as a novel epileptic model for the study of the pathophysiology and pharmacology of epilepsy... - Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsyEmilio Russo
Department of Experimental and Clinical Medicine, School of Medicine, University of Catanzaro, Catanzaro, Italy
Epilepsia 51:1560-9. 2010.... - Amino acid levels in some lethargic mouse brain areas before and after pentylenetetrazole kindlingGrazia De Luca
Department of Biochemical, Physiological and Nutritional Sciences, School of Medicine, University of Messina, AOU G. Martino via Consolare Valeria, 98125 Messina, Italy
Pharmacol Biochem Behav 81:47-53. 2005..In conclusion, our results indicate that lethargic mice show a range of biochemical and behavioral changes, correlated in particular with a higher susceptibility to develop kindled seizures... - New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonistsMaria Zappala
Dipartimento Farmaco Chimico, Universita di Messina, Viale Annunziata 98168, Messina, Italy
Bioorg Med Chem Lett 16:167-70. 2006..Functional tests were performed to evaluate the antagonistic activity at the AMPA and kainate receptors... - Influence of levetiracetam on the anticonvulsant efficacy of conventional antiepileptic drugs against audiogenic seizures in DBA/2 miceEugenio Donato Di Paola
Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Catanzaro, Italy
Epilepsy Res 75:112-21. 2007.... - Influence of carbenoxolone on the anticonvulsant efficacy of conventional antiepileptic drugs against audiogenic seizures in DBA/2 micePietro Gareri
Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, School of Medicine at Catanzaro, Policlinico Mater Domini, Via T. Campanella, 88100, Catanzaro, Italy
Eur J Pharmacol 484:49-56. 2004.... - Antiabsence effects of carbenoxolone in two genetic animal models of absence epilepsy (WAG/Rij rats and lh/lh mice)Pietro Gareri
Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Via T. Campanella 115, 88100 Catanzaro, Italy
Neuropharmacology 49:551-63. 2005..No effects were observed in both animal models following systemic or focal administration of glycyrrhizin into the same brain areas where CBX was shown to be effective... - Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonistsRosaria Gitto
Dipartimento Farmaco Chimico, Universita di Messina, Messina, Italy
Bioorg Med Chem 17:1640-7. 2009..The most active of them (3d) showed NR2B binding affinity equipotent to that of ifenprodil. These results were also corroborated by computational studies... - Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivativesRosaria Gitto
Dipartimento Farmaco Chimico, Universita di Messina, Viale Annunziata, 98168, Messina, Italy
Farmaco 59:7-12. 2004..When tested for their ability to prevent sound-induced seizures in DBA/2 mice, some of these novel compounds showed high anticonvulsant potency... - Comparative anticonvulsant activity of N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives in rodentsGuido Ferreri
Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, School of Medicine at Catanzaro, University of Catanzaro, Policlinico Mater Domini, Via T. Campanella, 115, 88100, Catanzaro, Italy
Pharmacol Biochem Behav 77:85-94. 2004.... - Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidityEmilio Russo
Chair of Pharmacology, Department of Experimental and Clinical Medicine, School of Medicine, University of Catanzaro, Italy
Behav Brain Res 225:373-6. 2011.... - Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsyRita Citraro
Chair of Pharmacology, Department of Experimental and Clinical Medicine, School of Medicine, University Magna Graecia of Catanzaro, Via T Campanella 115, Catanzaro, Italy
Epilepsy Res 95:60-9. 2011..To evaluate the potential anticonvulsant activity of α-lactalbumin (ALAC), a whey protein rich in tryptophan (TRP) relative to other large neutral amino acids (LNAAs), in rodent models of seizures and epilepsy... - Effects of some neurosteroids injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsyRita Citraro
Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Policlinico Mater Domini, Via T. Campanella, 115, 88100 Catanzaro, Italy
Neuropharmacology 50:1059-71. 2006..These findings suggest that neurosteroids might play a role in absence epilepsies and that it might depend on the involvement of specific neuronal areas... - Nifedipine affects the anticonvulsant activity of topiramate in various animal models of epilepsyEmilio Russo
Department of Experimental and Clinical Medicine G. Salvatore, Faculty of Medicine and Surgery, University of Catanzaro Magna Graecia, School of Medicine, Catanzaro, Policlinico Mater Domini, 115 Via Tommaso Campanella, 88100 Catanzaro, Italy
Neuropharmacology 46:865-78. 2004..These results confirm TPM's broad spectrum of anticonvulsant activity and support the proposal that a modulation of neuronal L-type Ca(2+) channel activity plays an important role in its antiepileptic activity... - Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidityEmilio Russo
Science of Health Department, School of Medicine, University Magna Graecia of Catanzaro, Via T Campanella, 115, 88100 Catanzaro, Italy
Neuropharmacology 64:371-9. 2013..This article is part of a Special Issue entitled 'Cognitive Enhancers'... - Effects of ethanol on the development of genetically determined epilepsies in ratsEmilio Russo
Department of Experimental and Clinical Medicine, School of Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
Int J Dev Neurosci 26:739-44. 2008.... - Enantioseparation, absolute configuration determination, and anticonvulsant activity of (+/-)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-oneMaria Luisa Calabrò
Dipartimento Farmaco Chimico, Universita di Messina, Messina, Italy
Chirality 19:16-21. 2007..The in vivo anticonvulsant activity of the enantiomers (+)-(R)-2 and (-)-(S)-2 is reported. It has been also demonstrated that compound (+/-)-(R,S)-2 in vivo undergoes oxidative metabolism to derivative 1... - Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs)Pietro Gareri
Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, 88100 Catanzaro, Italy
Neuropharmacology 47:1205-16. 2004..No anticonvulsant effects were observed following focal bilateral microinjections of glycyrrhizin into the same brain areas where CBX was shown to be effective... - AMPA receptor antagonists as potential anticonvulsant drugsGiovambattista De Sarro
Department of Experimental and Clinical Medicine, University of Catanzaro, Italy
Curr Top Med Chem 5:31-42. 2005..In particular, extensive work was addressed to the discovery of selective antagonists some of which proved to be potent anticonvulsant agents... - Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agentsRosaria Gitto
Department of Medicinal Chemistry, Faculty of Pharmacy, Universita di Messina, Messina, Italy
Chem Pharm Bull (Tokyo) 56:181-4. 2008..The activity against audiogenic seizures in DBA/2 mice of the newly synthesized compounds has also been evaluated... - New AMPA antagonists in epilepsyEmilio Russo
University Magna Graecia of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy
Expert Opin Investig Drugs 21:1371-89. 2012.... - Pharmacodynamic potentiation of antiepileptic drugs' effects by some HMG-CoA reductase inhibitors against audiogenic seizures in DBA/2 miceEmilio Russo
Science of Health Department, Clinical Pharmacology Unit, School of Medicine, University Magna Graecia of Catanzaro, Viale Europa, Germaneto, 88100 Catanzaro, Italy
Pharmacol Res 70:1-12. 2013..The present results suggest that statins, besides the beneficial cardiovascular effects, might be able to affect brain areas, which might participate in the regulation of seizure susceptibility... - Venlafaxine-propafenone interaction resulting in hallucinations and psychomotor agitationPietro Gareri
Faculty of Medicine and Surgery, University Magna Graecia of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini University Hospital, Operative Unit Elderly Health Care, Catanzaro, Italy
Ann Pharmacother 42:434-8. 2008..To report a case of visual hallucinations and psychomotor agitation probably induced by an interaction between venlafaxine and propafenone... - The safety of clozapine in the elderlyPietro Gareri
University Magna Graecia of Catanzaro, Mater Domini University Hospital, Clinical Pharmacology and Pharmacovigilance Unit, Faculty of Medicine and Surgery, Department of Experimental and Clinical Medicine, Catanzaro, Italy
Expert Opin Drug Saf 7:525-38. 2008..It is also effective for the treatment of aggressive behaviour in schizophrenic and demented patients and in the management of psychosis and aggression in Parkinson's disease and Lewy body dementia... - Apomorphine-induced neurodegeneration in Mongolian gerbil hippocampusEmilio Russo
Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Catanzaro, Italy
Schizophr Res 95:223-7. 2007.... - mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsyEmilio Russo
Science of Health Department, School of Medicine, University Magna Graecia of Catanzaro, Viale Europa Germaneto, 88100 Catanzaro, Italy
Neuropharmacology 69:25-36. 2013..Our experiments here suggest new insights into this intriguing field, which deserves to be further explored. This article is part of the Special Issue entitled 'New Targets and Approaches to the Treatment of Epilepsy'... - Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agentsNicola Micale
Dipartimento Farmaco-Chimico, , Viale Annunziata 98168, Messina, Italy
Bioorg Med Chem 12:3703-9. 2004..The new compounds possess anticonvulsant properties lower than those of prototype 5 but, in some instances, comparable to that of GYKI 52466, a well-known noncompetitive AMPA receptor antagonist... - Group III mGlu receptor agonists potentiate the anticonvulsant effect of AMPA and NMDA receptor blockGiovambattista De Sarro
Cattedra di Farmacologia, Dipartimento di Medicina Sperimentale e Clinica, , Catanzaro, Italy
Eur J Pharmacol 451:55-61. 2002..p.) administered intraperitoneally. We conclude that modest reduction of synaptic glutamate release by activation of Group III metabotropic receptors potentiates the anticonvulsant effect of AMPA and NMDA receptor blockade... - Hepatotoxicity induced by methimazole in a previously healthy patientLuca Gallelli
Clinical Pharmacology Unit, Chair of Pharmacology, Department of Experimental and Clinical Medicine, School of Medicine and Surgery, University Magna Graecia of Catanzaro, Mater Domini University Hospital, Via T Campanella 115, 88100 Catanzaro, Italy
Curr Drug Saf 4:204-6. 2009..Naranjo probability scale indicated a probable relationship between hepatotoxicity and methimazole therapy. In conclusion physicians should be aware the risk of hepatotoxicity related with methimazole... - The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and EpileptogenesisEmilio Russo
Science of Health Department, School of Medicine, University Magna Graecia of Catanzaro, Viale Europa, Germaneto, 88100, Catanzaro, Italy
Mol Neurobiol 46:662-81. 2012.... - Sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbiditiesPietro Gareri
Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University Magna Graecia of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini University Hospital, Catanzaro, Italy
Ann Pharmacother 43:1354-9. 2009..To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities... - A case of neuroleptic malignant syndrome induced by risperidone in a schizophrenic womanLuca Gallelli
Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University Magna Graecia of Catanzaro, Via T Campanella 115, 88100 Catanzaro, Italy
Curr Drug Saf 4:119-20. 2009..We report a case of neuroleptic malignant syndrome in a woman who assumed risperidone for schizoaffective disorders... - Adverse effects of atypical antipsychotics in the elderly: a reviewPietro Gareri
Department of Experimental and Clinical Medicine Gaetano Salvatore, Faculty of Medicine and Surgery, University of Catanzaro Magna Graecia, Catanzaro, Italy
Drugs Aging 23:937-56. 2006..Such effects may be partly explained by age-related changes in pharmacokinetics and pharmacodynamics, and partly by the characteristics of the drugs themselves and their different receptor binding profiles... - Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsyRita Citraro
Department of Health Science, School of Medicine and Surgery, University Magna Graecia of Catanzaro, Viale Europa Germaneto, 88100 Catanzaro, Italy
Neuropharmacology 69:115-26. 2013..This article is part of the Special Issue entitled 'New Targets and Approaches to the Treatment of Epilepsy'... - Tryptase-positive mast cells and angiogenesis in keloids: a new possible post-surgical target for preventionMichele Ammendola
University of Catanzaro, Catanzaro, Italy
Updates Surg 65:53-7. 2013..In this context, several tryptase inhibitors might be clinically evaluated as a possible new anti-angiogenetic approach to prevent keloid formation after surgery... - Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homesLuca Gallelli
School of Medicine and Surgery, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Mater Domini University Hospital, Catanzaro, Italy
Eur J Clin Pharmacol 66:137-44. 2010..Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea... - Determinants of health-related quality of life in pharmacoresistant epilepsy: results from a large multicenter study of consecutively enrolled patients using validated quantitative assessmentsChiara Luoni
Clinical Pharmacology Unit, University of Pavia, Pavia, Italy
Epilepsia 52:2181-91. 2011.... 
Laxative-induced rhabdomyolysisAlfonso Merante
Geriatrist, Geriatric Unit, Pugliese Ciaccio Hospital, Catanzaro, Italy
Clin Interv Aging 5:71-3. 2010..A careful monitoring of all the drugs taken by the elderly is one of the most important duties of a physician since drug interactions and their secondary effects may be fatal...- Role of CYP3A5 in abnormal clearance of methadoneSalvatore De Fazio
Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University Magna Graecia of Catanzaro, Mater Domini University Hospital, Catanzaro, Italy
Ann Pharmacother 42:893-7. 2008..To report a case of unusually low concentrations of methadone in a polydrug abuser during maintenance treatment with methadone... - The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasisEusebio Chiefari
Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Catanzaro, Italy
BMC Biol 7:24. 2009..Also, the hypothesis that increased insulin sensitivity in Hmga1-deficient mice could be related to the deficit of an insulin resistance factor is discussed... - A questionnaire-based study on prevalence and treatment of headache in young childrenLuca Gallelli
Clinical Pharmacology and Pharmacovigilance Unit, Department of Experimental and Clinical Medicine, Faculty of Medicine, University Magna Graecia of Catanzaro, Via T Campanella 115, I 88100, Catanzaro, Italy
J Headache Pain 6:277-80. 2005..These data showed that morbidity from headache is often unrecognised and undertreated. Better management of headache symptoms and therapy could reduce the frequency of headache episodes, with a reduction of adverse drug reactions...