Giovambattista De Sarro

Summary

Affiliation: Magna Graecia University
Country: Italy

Publications

  1. doi request reprint Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice
    Giovambattista De Sarro
    Clinical Pharmacology Unit, Science of Health Department, School of Medicine, University Magna Graecia of Catanzaro, Viale Europa, LocalitàGermaneto, 88100 Catanzaro, Italy
    Pharmacol Res 65:285-96. 2012
  2. ncbi request reprint Effects of adenosine receptor agonists and antagonists on audiogenic seizure-sensible DBA/2 mice
    G De Sarro
    Department of Experimental and Clinical Medicine, School of Medicine, University of Catanzaro, Italy
    Eur J Pharmacol 371:137-45. 1999
  3. ncbi request reprint Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice
    Giovambattista De Sarro
    Department of Experimental and Clinical Medicine G Salvatore, School of Medicine, University of Catanzaro, Policlinico Mater Domini, Via T Campanella, 115, 88100 Catanzaro, Italy
    Pharmacol Biochem Behav 77:761-6. 2004
  4. ncbi request reprint Amino acid levels in some brain areas of inducible nitric oxide synthase knock out mouse (iNOS-/-) before and after pentylenetetrazole kindling
    Grazia De Luca
    Department of Biochemical, Physiological and Nutritional Sciences, School of Medicine, University of Messina, Messina, Italy
    Pharmacol Biochem Behav 85:804-12. 2006
  5. ncbi request reprint Comparative anticonvulsant activity of some 2,3-benzodiazepine derivatives in rodents
    Giovambattista De Sarro
    Department of Experimental and Clinical Medicine, School of Medicine at Catanzaro, Policlinico Mater Domini, Via T Campanella, 115, 88100, Catanzaro, Italy
    Pharmacol Biochem Behav 74:595-602. 2003
  6. ncbi request reprint Influence of some beta-adrenoceptor antagonists on the anticonvulsant potency of antiepileptic drugs against audiogenic seizures in DBA/2 mice
    Giovambattista De Sarro
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Via T Campanella, 115 Policlinico Mater Domini, 88100 Catanzaro, Italy
    Eur J Pharmacol 442:205-13. 2002
  7. ncbi request reprint Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice
    G De Sarro
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Cantanzaro, Policlinico Mater Domini, Italy
    Naunyn Schmiedebergs Arch Pharmacol 363:330-6. 2001
  8. ncbi request reprint NMDA and AMPA/kainate receptors are involved in the anticonvulsant activity of riluzole in DBA/2 mice
    G De Sarro
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro Magna Graecia, Policlinico Mater Domini, Via T Campanella, 88100 Catanzaro, Italy
    Eur J Pharmacol 408:25-34. 2000
  9. ncbi request reprint Effects of compounds acting on GABA(B) receptors in the pentylenetetrazole kindling model of epilepsy in mice
    G De Sarro
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro Magna Grecia, Policlinico Mater Domini, Via T Campanella, 88100 Catanzaro, Italy
    Neuropharmacology 39:2147-61. 2000
  10. ncbi request reprint Influence of D-cycloserine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice
    G De Sarro
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Policlinico Mater Domini, Via T Campanella 115, 88100, Catanzaro, Italy
    Epilepsy Res 40:109-21. 2000

Collaborators

Detail Information

Publications75

  1. doi request reprint Fosinopril and zofenopril, two angiotensin-converting enzyme (ACE) inhibitors, potentiate the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice
    Giovambattista De Sarro
    Clinical Pharmacology Unit, Science of Health Department, School of Medicine, University Magna Graecia of Catanzaro, Viale Europa, LocalitàGermaneto, 88100 Catanzaro, Italy
    Pharmacol Res 65:285-96. 2012
    ....
  2. ncbi request reprint Effects of adenosine receptor agonists and antagonists on audiogenic seizure-sensible DBA/2 mice
    G De Sarro
    Department of Experimental and Clinical Medicine, School of Medicine, University of Catanzaro, Italy
    Eur J Pharmacol 371:137-45. 1999
    ..CGS 15943, 0.29 mg/kg i.p., KF 17837, 0.57 mg/kg, i.p., CSC 0.12 mg/kg, i.p. and SCH 58261 0.07 mg/kg, i.p., respectively. These data suggest that stimulation of adenosine A1 and A2A receptors is involved in the suppression of seizures...
  3. ncbi request reprint Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice
    Giovambattista De Sarro
    Department of Experimental and Clinical Medicine G Salvatore, School of Medicine, University of Catanzaro, Policlinico Mater Domini, Via T Campanella, 115, 88100 Catanzaro, Italy
    Pharmacol Biochem Behav 77:761-6. 2004
    ..The present data suggest that IL-6(-/-) mice might be a valid novel epileptic model for the study of pathophysiology and pharmacology of epileptic seizures...
  4. ncbi request reprint Amino acid levels in some brain areas of inducible nitric oxide synthase knock out mouse (iNOS-/-) before and after pentylenetetrazole kindling
    Grazia De Luca
    Department of Biochemical, Physiological and Nutritional Sciences, School of Medicine, University of Messina, Messina, Italy
    Pharmacol Biochem Behav 85:804-12. 2006
    ....
  5. ncbi request reprint Comparative anticonvulsant activity of some 2,3-benzodiazepine derivatives in rodents
    Giovambattista De Sarro
    Department of Experimental and Clinical Medicine, School of Medicine at Catanzaro, Policlinico Mater Domini, Via T Campanella, 115, 88100, Catanzaro, Italy
    Pharmacol Biochem Behav 74:595-602. 2003
    ....
  6. ncbi request reprint Influence of some beta-adrenoceptor antagonists on the anticonvulsant potency of antiepileptic drugs against audiogenic seizures in DBA/2 mice
    Giovambattista De Sarro
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Via T Campanella, 115 Policlinico Mater Domini, 88100 Catanzaro, Italy
    Eur J Pharmacol 442:205-13. 2002
    ....
  7. ncbi request reprint Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice
    G De Sarro
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Cantanzaro, Policlinico Mater Domini, Italy
    Naunyn Schmiedebergs Arch Pharmacol 363:330-6. 2001
    ..In conclusion, retigabine showed an additive effect when administered in combination with classical anticonvulsants, most notably diazepam, phenobarbital, phenytoin and valproate...
  8. ncbi request reprint NMDA and AMPA/kainate receptors are involved in the anticonvulsant activity of riluzole in DBA/2 mice
    G De Sarro
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro Magna Graecia, Policlinico Mater Domini, Via T Campanella, 88100 Catanzaro, Italy
    Eur J Pharmacol 408:25-34. 2000
    ..Our findings suggest that the anticonvulsant properties of riluzole depend upon its interaction with neurotransmission mediated by both the glycine/NMDA and the AMPA/kainate receptor complex...
  9. ncbi request reprint Effects of compounds acting on GABA(B) receptors in the pentylenetetrazole kindling model of epilepsy in mice
    G De Sarro
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro Magna Grecia, Policlinico Mater Domini, Via T Campanella, 88100 Catanzaro, Italy
    Neuropharmacology 39:2147-61. 2000
    ....
  10. ncbi request reprint Influence of D-cycloserine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice
    G De Sarro
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Policlinico Mater Domini, Via T Campanella 115, 88100, Catanzaro, Italy
    Epilepsy Res 40:109-21. 2000
    ..In conclusion, DCS potentiates the anticonvulsant action of some classical antiepileptic drugs, most notably diazepam, phenobarbital, phenytoin and valproate...
  11. ncbi request reprint Topiramate potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice
    G De Sarro
    Chair of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Policlinico Mater Domini, Via T Campanella, 88100, Catanzaro, Italy
    Eur J Pharmacol 388:163-70. 2000
    ..In conclusion, topiramate showed an additive effect when administered in combination with some classical anticonvulsants, most notably diazepam, phenobarbital, lamotrigine, phenytoin and valproate...
  12. ncbi request reprint Seizure susceptibility to various convulsant stimuli in dystrophin-deficient mdx mice
    Giovambattista De Sarro
    Department of Experimental and Clinical Medicine G Salvatore, School of Medicine, University Magna Graecia of Catanzaro, Policlinico Mater Domini, Via T Campanella, 115, 88100 Catanzaro, Italy
    Neurosci Res 50:37-44. 2004
    ..The present data suggests that the dystrophin deficiency in mdx mice affects the pathophysiology and pharmacology of acute and chronic epileptic seizures in an opposite manner...
  13. ncbi request reprint 3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents
    Laura De Luca
    Dipartimento Farmaco Chimico, Universita di Messina, Messina, Italy
    Arch Pharm (Weinheim) 339:388-400. 2006
    ..Moreover, in order to explain the different degree of efficacy of the newly designed N-substituted derivatives, excluded volumes were also considered...
  14. doi request reprint Enhancement of anti-absence effects of ethosuximide by low doses of a noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist in a genetic animal model of absence epilepsy
    Emilio Russo
    Chair of Pharmacology, Department of Experimental and Clinical Medicine, School of Medicine, University of Catanzaro, Catanzaro, Italy
    Epilepsy Behav 13:295-9. 2008
    ....
  15. ncbi request reprint Effects of non-competitive AMPA receptor antagonists injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy
    Rita Citraro
    Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, School of Medicine at Catanzaro, Policlinico Mater Domini, Via Tommaso Campanella, 115, 88100 Catanzaro, Italy
    Neuropharmacology 51:1058-67. 2006
    ..These findings suggest that AMPA receptor antagonists might play a role in absence epilepsies and that it might depend on the involvement of specific neuronal areas...
  16. doi request reprint Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model
    Emilio Russo
    Department of Experimental and Clinical Medicine, School of Medicine, University of Catanzaro, Via T Campanella 115, Catanzaro, Italy
    Epilepsia 52:1341-50. 2011
    ..Here, we examined the effects of long-term treatment with several AEDs on absence seizure development and onset of depressive-like behavior in WAG/Rij rats at different ages, using a forced swimming test (FST)...
  17. ncbi request reprint Susceptibility to audiogenic seizure and neurotransmitter amino acid levels in different brain areas of IL-6-deficient mice
    Grazia De Luca
    Department of Biochemical, Physiological and Nutritional Sciences, AOU G Martino via Consolare Valeria, 98125 Messina, Italy
    Pharmacol Biochem Behav 78:75-81. 2004
    ..The present data support the validity of IL-6(-/-) mice as a novel epileptic model for the study of the pathophysiology and pharmacology of epilepsy...
  18. doi request reprint Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures
    Emilio Russo
    Science of Health Department, School of Medicine, University of Catanzaro, Italy
    Epilepsy Behav 28:232-40. 2013
    ....
  19. doi request reprint CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations
    Rita Citraro
    Chair of Pharmacology, Department of Health Science, School of Medicine and Surgery, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Epilepsy Res 106:74-82. 2013
    ..In conclusion, our result might be useful for the identification of future drug therapies in absence epilepsy...
  20. ncbi request reprint New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists
    Maria Zappala
    Dipartimento Farmaco Chimico, Universita di Messina, Viale Annunziata 98168, Messina, Italy
    Bioorg Med Chem Lett 16:167-70. 2006
    ..Functional tests were performed to evaluate the antagonistic activity at the AMPA and kainate receptors...
  21. doi request reprint Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy
    Emilio Russo
    Department of Experimental and Clinical Medicine, School of Medicine, University of Catanzaro, Catanzaro, Italy
    Epilepsia 51:1560-9. 2010
    ....
  22. ncbi request reprint Amino acid levels in some lethargic mouse brain areas before and after pentylenetetrazole kindling
    Grazia De Luca
    Department of Biochemical, Physiological and Nutritional Sciences, School of Medicine, University of Messina, AOU G Martino via Consolare Valeria, 98125 Messina, Italy
    Pharmacol Biochem Behav 81:47-53. 2005
    ..In conclusion, our results indicate that lethargic mice show a range of biochemical and behavioral changes, correlated in particular with a higher susceptibility to develop kindled seizures...
  23. ncbi request reprint Influence of levetiracetam on the anticonvulsant efficacy of conventional antiepileptic drugs against audiogenic seizures in DBA/2 mice
    Eugenio Donato Di Paola
    Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Catanzaro, Italy
    Epilepsy Res 75:112-21. 2007
    ....
  24. doi request reprint Pharmacodynamic potentiation of antiepileptic drugs' effects by some HMG-CoA reductase inhibitors against audiogenic seizures in DBA/2 mice
    Emilio Russo
    Science of Health Department, Clinical Pharmacology Unit, School of Medicine, University Magna Graecia of Catanzaro, Viale Europa, Germaneto, 88100 Catanzaro, Italy
    Pharmacol Res 70:1-12. 2013
    ..The present results suggest that statins, besides the beneficial cardiovascular effects, might be able to affect brain areas, which might participate in the regulation of seizure susceptibility...
  25. doi request reprint mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy
    Emilio Russo
    Science of Health Department, School of Medicine, University Magna Graecia of Catanzaro, Viale Europa Germaneto, 88100 Catanzaro, Italy
    Neuropharmacology 69:25-36. 2013
    ..Our experiments here suggest new insights into this intriguing field, which deserves to be further explored. This article is part of the Special Issue entitled 'New Targets and Approaches to the Treatment of Epilepsy'...
  26. ncbi request reprint Influence of carbenoxolone on the anticonvulsant efficacy of conventional antiepileptic drugs against audiogenic seizures in DBA/2 mice
    Pietro Gareri
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, School of Medicine at Catanzaro, Policlinico Mater Domini, Via T Campanella, 88100, Catanzaro, Italy
    Eur J Pharmacol 484:49-56. 2004
    ....
  27. ncbi request reprint Comparative anticonvulsant activity of N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives in rodents
    Guido Ferreri
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, School of Medicine at Catanzaro, University of Catanzaro, Policlinico Mater Domini, Via T Campanella, 115, 88100, Catanzaro, Italy
    Pharmacol Biochem Behav 77:85-94. 2004
    ....
  28. doi request reprint Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists
    Rosaria Gitto
    Dipartimento Farmaco Chimico, Universita di Messina, Messina, Italy
    Bioorg Med Chem 17:1640-7. 2009
    ..The most active of them (3d) showed NR2B binding affinity equipotent to that of ifenprodil. These results were also corroborated by computational studies...
  29. ncbi request reprint Antiabsence effects of carbenoxolone in two genetic animal models of absence epilepsy (WAG/Rij rats and lh/lh mice)
    Pietro Gareri
    Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Via T Campanella 115, 88100 Catanzaro, Italy
    Neuropharmacology 49:551-63. 2005
    ..No effects were observed in both animal models following systemic or focal administration of glycyrrhizin into the same brain areas where CBX was shown to be effective...
  30. ncbi request reprint Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives
    Rosaria Gitto
    Dipartimento Farmaco Chimico, Universita di Messina, Viale Annunziata, 98168, Messina, Italy
    Farmaco 59:7-12. 2004
    ..When tested for their ability to prevent sound-induced seizures in DBA/2 mice, some of these novel compounds showed high anticonvulsant potency...
  31. doi request reprint Vigabatrin has antiepileptogenic and antidepressant effects in an animal model of epilepsy and depression comorbidity
    Emilio Russo
    Chair of Pharmacology, Department of Experimental and Clinical Medicine, School of Medicine, University of Catanzaro, Italy
    Behav Brain Res 225:373-6. 2011
    ....
  32. ncbi request reprint Effects of some neurosteroids injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy
    Rita Citraro
    Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Policlinico Mater Domini, Via T Campanella, 115, 88100 Catanzaro, Italy
    Neuropharmacology 50:1059-71. 2006
    ..These findings suggest that neurosteroids might play a role in absence epilepsies and that it might depend on the involvement of specific neuronal areas...
  33. doi request reprint Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy
    Rita Citraro
    Chair of Pharmacology, Department of Experimental and Clinical Medicine, School of Medicine, University Magna Graecia of Catanzaro, Via T Campanella 115, Catanzaro, Italy
    Epilepsy Res 95:60-9. 2011
    ..To evaluate the potential anticonvulsant activity of α-lactalbumin (ALAC), a whey protein rich in tryptophan (TRP) relative to other large neutral amino acids (LNAAs), in rodent models of seizures and epilepsy...
  34. ncbi request reprint Nifedipine affects the anticonvulsant activity of topiramate in various animal models of epilepsy
    Emilio Russo
    Department of Experimental and Clinical Medicine G Salvatore, Faculty of Medicine and Surgery, University of Catanzaro Magna Graecia, School of Medicine, Catanzaro, Policlinico Mater Domini, 115 Via Tommaso Campanella, 88100 Catanzaro, Italy
    Neuropharmacology 46:865-78. 2004
    ..These results confirm TPM's broad spectrum of anticonvulsant activity and support the proposal that a modulation of neuronal L-type Ca(2+) channel activity plays an important role in its antiepileptic activity...
  35. doi request reprint Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidity
    Emilio Russo
    Science of Health Department, School of Medicine, University Magna Graecia of Catanzaro, Via T Campanella, 115, 88100 Catanzaro, Italy
    Neuropharmacology 64:371-9. 2013
    ..This article is part of a Special Issue entitled 'Cognitive Enhancers'...
  36. doi request reprint Effects of ethanol on the development of genetically determined epilepsies in rats
    Emilio Russo
    Department of Experimental and Clinical Medicine, School of Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Int J Dev Neurosci 26:739-44. 2008
    ....
  37. ncbi request reprint Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions
    Emilio Russo
    Science of Health Department, School of Medicine, University of Catanzaro, Catanzaro, Italy Pharmacovigilance s Center Region Calabria, University Hospital Mater Domini, Catanzaro, Italy
    Phytother Res 28:643-55. 2014
    ....
  38. doi request reprint Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically
    Michele Ammendola
    Department of Medical and Surgical Sciences, University of Catanzaro Magna Graecia Medical School, Catanzaro, Italy
    Oncology 85:111-6. 2013
    ..Tryptase is a serine protease stored in mast cell (MC) granules, which plays a role in tumor angiogenesis. MCs can release tryptase following c-Kit receptor activation...
  39. ncbi request reprint Enantioseparation, absolute configuration determination, and anticonvulsant activity of (+/-)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-one
    Maria Luisa Calabrò
    Dipartimento Farmaco Chimico, Universita di Messina, Messina, Italy
    Chirality 19:16-21. 2007
    ..The in vivo anticonvulsant activity of the enantiomers (+)-(R)-2 and (-)-(S)-2 is reported. It has been also demonstrated that compound (+/-)-(R,S)-2 in vivo undergoes oxidative metabolism to derivative 1...
  40. ncbi request reprint AMPA receptor antagonists as potential anticonvulsant drugs
    Giovambattista De Sarro
    Department of Experimental and Clinical Medicine, University of Catanzaro, Italy
    Curr Top Med Chem 5:31-42. 2005
    ..In particular, extensive work was addressed to the discovery of selective antagonists some of which proved to be potent anticonvulsant agents...
  41. ncbi request reprint Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents
    Rosaria Gitto
    Department of Medicinal Chemistry, Faculty of Pharmacy, Universita di Messina, Messina, Italy
    Chem Pharm Bull (Tokyo) 56:181-4. 2008
    ..The activity against audiogenic seizures in DBA/2 mice of the newly synthesized compounds has also been evaluated...
  42. ncbi request reprint Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs)
    Pietro Gareri
    Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, 88100 Catanzaro, Italy
    Neuropharmacology 47:1205-16. 2004
    ..No anticonvulsant effects were observed following focal bilateral microinjections of glycyrrhizin into the same brain areas where CBX was shown to be effective...
  43. doi request reprint New AMPA antagonists in epilepsy
    Emilio Russo
    University Magna Graecia of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy
    Expert Opin Investig Drugs 21:1371-89. 2012
    ..Evidences support their role during seizures and neurodegeneration. Development of AMPAR ligands has led to two different branches of research, with the identification of competitive and noncompetitive antagonists...
  44. doi request reprint Venlafaxine-propafenone interaction resulting in hallucinations and psychomotor agitation
    Pietro Gareri
    Faculty of Medicine and Surgery, University Magna Graecia of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini University Hospital, Operative Unit Elderly Health Care, Catanzaro, Italy
    Ann Pharmacother 42:434-8. 2008
    ..To report a case of visual hallucinations and psychomotor agitation probably induced by an interaction between venlafaxine and propafenone...
  45. ncbi request reprint The safety of clozapine in the elderly
    Pietro Gareri
    University Magna Graecia of Catanzaro, Mater Domini University Hospital, Clinical Pharmacology and Pharmacovigilance Unit, Faculty of Medicine and Surgery, Department of Experimental and Clinical Medicine, Catanzaro, Italy
    Expert Opin Drug Saf 7:525-38. 2008
    ..It is also effective for the treatment of aggressive behaviour in schizophrenic and demented patients and in the management of psychosis and aggression in Parkinson's disease and Lewy body dementia...
  46. ncbi request reprint Apomorphine-induced neurodegeneration in Mongolian gerbil hippocampus
    Emilio Russo
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Catanzaro, Italy
    Schizophr Res 95:223-7. 2007
    ....
  47. pmc Pharmacovigilance and drug safety 2011 in Calabria (Italy): Adverse events analysis
    Francesca Scicchitano
    Department of Science of Health, School of Medicine, University of Catanzaro, Italy and Pharmacovigilance s Centre Calabria Region, University Hospital Mater Domini, Catanzaro, Italy
    J Res Med Sci 17:872-5. 2012
    ..The Italian Drug Agency (AIFA; Agenzia Italiana del Farmaco) is financing several projects to the aim of increasing reporting, and in Calabria a Pharmacovigilance Information Centre has been created...
  48. ncbi request reprint Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agents
    Nicola Micale
    Dipartimento Farmaco Chimico, Universita di Messina, Viale Annunziata 98168, Messina, Italy
    Bioorg Med Chem 12:3703-9. 2004
    ..The new compounds possess anticonvulsant properties lower than those of prototype 5 but, in some instances, comparable to that of GYKI 52466, a well-known noncompetitive AMPA receptor antagonist...
  49. ncbi request reprint Group III mGlu receptor agonists potentiate the anticonvulsant effect of AMPA and NMDA receptor block
    Giovambattista De Sarro
    Cattedra di Farmacologia, Dipartimento di Medicina Sperimentale e Clinica, Universita di Catanzaro, Catanzaro, Italy
    Eur J Pharmacol 451:55-61. 2002
    ..p.) administered intraperitoneally. We conclude that modest reduction of synaptic glutamate release by activation of Group III metabotropic receptors potentiates the anticonvulsant effect of AMPA and NMDA receptor blockade...
  50. pmc Muscular damage during telbivudine treatment in a chronic hepatitis B patient
    Benedetto Caroleo
    Department of Health Science School of Medicine, University Magna Graecia of Catanzaro, Italy
    Muscles Ligaments Tendons J 1:57-60. 2011
    ....
  51. doi request reprint Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy
    Rita Citraro
    Department of Health Science, School of Medicine and Surgery, University Magna Graecia of Catanzaro, Viale Europa Germaneto, 88100 Catanzaro, Italy
    Neuropharmacology 69:115-26. 2013
    ..This article is part of the Special Issue entitled 'New Targets and Approaches to the Treatment of Epilepsy'...
  52. doi request reprint The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis
    Emilio Russo
    Science of Health Department, School of Medicine, University Magna Graecia of Catanzaro, Viale Europa, Germaneto, 88100 Catanzaro, Italy
    Mol Neurobiol 46:662-81. 2012
    ....
  53. ncbi request reprint Hepatotoxicity induced by methimazole in a previously healthy patient
    Luca Gallelli
    Clinical Pharmacology Unit, Chair of Pharmacology, Department of Experimental and Clinical Medicine, School of Medicine and Surgery, University Magna Graecia of Catanzaro, Mater Domini University Hospital, Via T Campanella 115, 88100 Catanzaro, Italy
    Curr Drug Saf 4:204-6. 2009
    ..Naranjo probability scale indicated a probable relationship between hepatotoxicity and methimazole therapy. In conclusion physicians should be aware the risk of hepatotoxicity related with methimazole...
  54. doi request reprint Effects of acetaminophen and ibuprofen in children with migraine receiving preventive treatment with magnesium
    Luca Gallelli
    Department of Health Science, School of Medicine, University of Catanzaro, Catanzaro, Italy
    Headache 54:313-24. 2014
    ..The purpose of this study was to evaluate both the effects of ibuprofen and/or acetaminophen for the acute treatment of primary migraine in children in or out prophylactic treatment with magnesium...
  55. doi request reprint Targeting α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors in epilepsy
    Rita Citraro
    University Magna Graecia of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy
    Expert Opin Ther Targets 18:319-34. 2014
    ..Glutamate activation of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPARs) have long ago been identified as suitable targets for the development of anti seizure drugs...
  56. doi request reprint Perspective on the use of perampanel and intravenous carbamazepine for generalized seizures
    Valentina Franco
    University of Pavia, Department of Internal Medicine and Therapeutics, Clinical Pharmacology Unit, Pavia, Italy
    Expert Opin Pharmacother 15:637-44. 2014
    ..Several antiepileptic drugs are available for the treatment of epileptic patients. However, the treatment of some seizure types and novel drug formulations deserve further advances in epilepsy research...
  57. ncbi request reprint Sodium valproate induced tremor in a patient with epilepsy and Down's syndrome
    Antonio Siniscalchi
    Department of Neuroscience, Neurology Division, Annunziata Hospital, Cosenza, Italy
    Curr Drug Saf 8:69-71. 2013
    ....
  58. ncbi request reprint Adverse effects of atypical antipsychotics in the elderly: a review
    Pietro Gareri
    Department of Experimental and Clinical Medicine Gaetano Salvatore, Faculty of Medicine and Surgery, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Drugs Aging 23:937-56. 2006
    ..Such effects may be partly explained by age-related changes in pharmacokinetics and pharmacodynamics, and partly by the characteristics of the drugs themselves and their different receptor binding profiles...
  59. ncbi request reprint A case of neuroleptic malignant syndrome induced by risperidone in a schizophrenic woman
    Luca Gallelli
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University Magna Graecia of Catanzaro, Via T Campanella 115, 88100 Catanzaro, Italy
    Curr Drug Saf 4:119-20. 2009
    ..We report a case of neuroleptic malignant syndrome in a woman who assumed risperidone for schizoaffective disorders...
  60. doi request reprint Sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities
    Pietro Gareri
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University Magna Graecia of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini University Hospital, Catanzaro, Italy
    Ann Pharmacother 43:1354-9. 2009
    ..To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities...
  61. ncbi request reprint Rosacea-like facial rash related to metformin administration in a young woman
    Laura Mumoli
    Department of Medical and Surgical Science, Division of Internal Medicine, University Magna Graecia Mater Domini Hospital of Catanzaro, Catanzaro, Italy
    BMC Pharmacol Toxicol 15:3. 2014
    ..Since the skin represents a common site of adverse drug reactions, few data are reported at this time regarding the development of skin rash during the treatment with antidiabetic drugs...
  62. doi request reprint Use and safety of antipsychotics in behavioral disorders in elderly people with dementia
    Pietro Gareri
    From the Elderly Health Care, Ambulatory Center for Dementia, ASP Catanzaro Department of Science of Health, School of Medicine and Surgery, University Magna Græcia of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, and Psychiatry Unit, Mater Domini University Hospital, Catanzaro, Italy
    J Clin Psychopharmacol 34:109-23. 2014
    ..Use of antipsychotics in dementia needs a careful case-by-case assessment, together with the possible drug-drug, drug-disease, and drug-food interactions...
  63. doi request reprint Hepatitis C virus infection in an endemic area of Southern Italy 14 years later: evidence for a vanishing infection
    Vincenzo Guadagnino
    Chair of Infectious Diseases, School of Medicine and Surgery, University of Catanzaro, Italy
    Dig Liver Dis 45:403-7. 2013
    ..In a 1996 survey, prevalence of hepatitis C virus antibodies (anti-HCV) in a southern Italian town was 12.6%...
  64. pmc Interactions among Low Dose of Methotrexate and Drugs Used in the Treatment of Rheumatoid Arthritis
    Marinella Patanè
    Department of Health Science, School of Medicine, University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy Pharmacovigilance s Center Regione Calabria, University Hospital Mater Domini, 88100 Catanzaro, Italy
    Adv Pharmacol Sci 2013:313858. 2013
    ..In conclusion, during the treatment with MTX, DDIs play an important role in both the development of ADRs and therapeutic failure...
  65. doi request reprint Tryptase-positive mast cells and angiogenesis in keloids: a new possible post-surgical target for prevention
    Michele Ammendola
    University of Catanzaro, Catanzaro, Italy
    Updates Surg 65:53-7. 2013
    ..In this context, several tryptase inhibitors might be clinically evaluated as a possible new anti-angiogenetic approach to prevent keloid formation after surgery...
  66. doi request reprint Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes
    Luca Gallelli
    School of Medicine and Surgery, Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Mater Domini University Hospital, Catanzaro, Italy
    Eur J Clin Pharmacol 66:137-44. 2010
    ..Our aim was to compare the efficacy and tolerability of loperamide and racecadotril in elderly patients with acute diarrhea...
  67. doi request reprint Determinants of health-related quality of life in pharmacoresistant epilepsy: results from a large multicenter study of consecutively enrolled patients using validated quantitative assessments
    Chiara Luoni
    Clinical Pharmacology Unit, University of Pavia, Pavia, Italy
    Epilepsia 52:2181-91. 2011
    ....
  68. doi request reprint Role of CYP3A5 in abnormal clearance of methadone
    Salvatore De Fazio
    Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University Magna Graecia of Catanzaro, Mater Domini University Hospital, Catanzaro, Italy
    Ann Pharmacother 42:893-7. 2008
    ..To report a case of unusually low concentrations of methadone in a polydrug abuser during maintenance treatment with methadone...
  69. pmc The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis
    Eusebio Chiefari
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Catanzaro, Italy
    BMC Biol 7:24. 2009
    ..Also, the hypothesis that increased insulin sensitivity in Hmga1-deficient mice could be related to the deficit of an insulin resistance factor is discussed...
  70. pmc Laxative-induced rhabdomyolysis
    Alfonso Merante
    Geriatrist, Geriatric Unit, Pugliese Ciaccio Hospital, Catanzaro, Italy
    Clin Interv Aging 5:71-3. 2010
    ..A careful monitoring of all the drugs taken by the elderly is one of the most important duties of a physician since drug interactions and their secondary effects may be fatal...
  71. doi request reprint Phthalates: European regulation, chemistry, pharmacokinetic and related toxicity
    Pasquale Ventrice
    Chair of Pharmacology, Science of Health Department, School of Medicine, University of Catanzaro, Italy
    Environ Toxicol Pharmacol 36:88-96. 2013
    ..This article discusses the molecular and cellular mechanisms involved in organ toxicity of phthalates; furthermore, pharmacokinetic, chemistry and the European regulation are summarized...
  72. pmc A questionnaire-based study on prevalence and treatment of headache in young children
    Luca Gallelli
    Clinical Pharmacology and Pharmacovigilance Unit, Department of Experimental and Clinical Medicine, Faculty of Medicine, University Magna Graecia of Catanzaro, Via T Campanella 115, I 88100, Catanzaro, Italy
    J Headache Pain 6:277-80. 2005
    ..These data showed that morbidity from headache is often unrecognised and undertreated. Better management of headache symptoms and therapy could reduce the frequency of headache episodes, with a reduction of adverse drug reactions...