Marcello Maggiolini

Summary

Country: Italy

Publications

  1. ncbi request reprint The unfolding stories of GPR30, a new membrane-bound estrogen receptor
    Marcello Maggiolini
    Department of Pharmaco Biology, University of Calabria, 87030 Rende, Italy
    J Endocrinol 204:105-14. 2010
  2. pmc The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes
    Rosamaria Lappano
    Department of Pharmaco Biology, University of Calabria, Rende, Italy
    PLoS ONE 6:e16631. 2011
  3. pmc Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts
    Marco Pupo
    Department of Pharmaco Biology, University of Calabria, Rende, Italy
    Environ Health Perspect 120:1177-82. 2012
  4. pmc MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells
    Rosamaria Lappano
    Dipartimento Farmaco Biologico, Universita della Calabria, via Bucci, 87036 Rende, Italy
    Breast Cancer Res 14:R12. 2012
  5. ncbi request reprint Two novel GPER agonists induce gene expression changes and growth effects in cancer cells
    R Lappano
    Dipartimento Farmaco Biologico, Universita della Calabria, Rende, Italy
    Curr Cancer Drug Targets 12:531-42. 2012
  6. ncbi request reprint The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells
    Marcello Maggiolini
    Department of Pharmaco Biology, University of Calabria, 87030 Rende CS, Italy
    J Biol Chem 279:27008-16. 2004
  7. ncbi request reprint 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30
    Adele Vivacqua
    Department of Pharmaco Biology, University of Calabria, 87030 Rende CS, Italy
    Mol Pharmacol 70:1414-23. 2006
  8. ncbi request reprint The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells
    Adele Vivacqua
    Department of Pharmaco Biology, University of Calabria, 87030 Rende CS, Italy
    Mol Endocrinol 20:631-46. 2006
  9. doi request reprint 17 beta-estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ER alpha
    Adele Chimento
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende CS, Italy
    Mol Cell Endocrinol 320:136-44. 2010
  10. pmc G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells
    Lidia Albanito
    Department of Pharmaco Biology, University of Calabria, Rende, Italy
    Environ Health Perspect 116:1648-55. 2008

Collaborators

Detail Information

Publications56

  1. ncbi request reprint The unfolding stories of GPR30, a new membrane-bound estrogen receptor
    Marcello Maggiolini
    Department of Pharmaco Biology, University of Calabria, 87030 Rende, Italy
    J Endocrinol 204:105-14. 2010
    ..Here, we review the history of the discovery of this new ER, the evidence for the claim that it is an ER, its signal transduction, and its potential functions in physiology and disease...
  2. pmc The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes
    Rosamaria Lappano
    Department of Pharmaco Biology, University of Calabria, Rende, Italy
    PLoS ONE 6:e16631. 2011
    ..In addition, the levels of oxysterols, including 25 HC, have been found to be elevated in hypercholesterolemic serum...
  3. pmc Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts
    Marco Pupo
    Department of Pharmaco Biology, University of Calabria, Rende, Italy
    Environ Health Perspect 120:1177-82. 2012
    ..In this regard, recent studies have shown that GPER was involved in the proliferative effects induced by BPA in both normal and tumor cells...
  4. pmc MIBE acts as antagonist ligand of both estrogen receptor α and GPER in breast cancer cells
    Rosamaria Lappano
    Dipartimento Farmaco Biologico, Universita della Calabria, via Bucci, 87036 Rende, Italy
    Breast Cancer Res 14:R12. 2012
    ..We synthesized a novel compound (ethyl 3-[5-(2-ethoxycarbonyl-1-methylvinyloxy)-1-methyl-1H-indol-3-yl]but-2-enoate), referred to as MIBE, and investigated its properties elicited through ERα and GPER in breast cancer cells...
  5. ncbi request reprint Two novel GPER agonists induce gene expression changes and growth effects in cancer cells
    R Lappano
    Dipartimento Farmaco Biologico, Universita della Calabria, Rende, Italy
    Curr Cancer Drug Targets 12:531-42. 2012
    ....
  6. ncbi request reprint The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells
    Marcello Maggiolini
    Department of Pharmaco Biology, University of Calabria, 87030 Rende CS, Italy
    J Biol Chem 279:27008-16. 2004
    ..The ability of E2 and phytoestrogens to regulate the expression of growth-related genes such as c-fos even in the absence of ER has interesting implications for understanding breast cancer progression...
  7. ncbi request reprint 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30
    Adele Vivacqua
    Department of Pharmaco Biology, University of Calabria, 87030 Rende CS, Italy
    Mol Pharmacol 70:1414-23. 2006
    ..Our findings provide new insight into the molecular mechanisms through which estrogens may induce the progression of TC...
  8. ncbi request reprint The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells
    Adele Vivacqua
    Department of Pharmaco Biology, University of Calabria, 87030 Rende CS, Italy
    Mol Endocrinol 20:631-46. 2006
    ..Our data demonstrate a new mode of action of E2 and OHT in endometrial cancer cells, contributing to a better understanding of the molecular mechanisms involved in their uterine agonistic activity...
  9. doi request reprint 17 beta-estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ER alpha
    Adele Chimento
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende CS, Italy
    Mol Cell Endocrinol 320:136-44. 2010
    ..These data demonstrate that E2, working through both ER alpha and/or GPR30, activates in PS the rapid EGFR/ERK/c-Jun pathway, modulating the expression of genes involved in the balance between cellular proliferation and apoptosis...
  10. pmc G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells
    Lidia Albanito
    Department of Pharmaco Biology, University of Calabria, Rende, Italy
    Environ Health Perspect 116:1648-55. 2008
    ..Recent investigations have demonstrated that the orphan G-protein-coupled receptor 30 (GPR30), which is structurally unrelated to the ER, mediates rapid actions of 17beta-estradiol and environmental estrogens...
  11. ncbi request reprint Fibronectin and type IV collagen activate ERalpha AF-1 by c-Src pathway: effect on breast cancer cell motility
    Diego Sisci
    Dipartimento Farmaco Biologico, Universita della Calabria, Arcavacata di Rende, Italy
    Oncogene 23:8920-30. 2004
    ..These findings address the integrated role of ECM proteins and ERalpha in influencing breast cancer cell motility through a mechanism that involves c-Src and seems not to be related to a specific cell type...
  12. pmc Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells--identification of a novel androgen response element
    Marilena Lanzino
    Dipartimento Farmaco Biologico, University of Calabria, Arcavacata di Rende CS 87036, Italy
    Nucleic Acids Res 38:5351-65. 2010
    ....
  13. ncbi request reprint Oestrogen receptor beta is required for androgen-stimulated proliferation of LNCaP prostate cancer cells
    Marcello Maggiolini
    Department of Pharmaco Biology, University of Calabria, 87036 Rende CS, Italy
    J Mol Endocrinol 32:777-91. 2004
    ..Thus our findings implicate ERbeta as a potential target for the treatment of prostate tumours...
  14. doi request reprint SLC37A1 gene expression is up-regulated by epidermal growth factor in breast cancer cells
    Domenico Iacopetta
    Department of Pharmaco Biology, University of Calabria, 87036 Rende CS, Italy
    Breast Cancer Res Treat 122:755-64. 2010
    ..In addition, further studies are required to provide evidence concerning the potential role of EGF-mediated SLC37A1 induction in breast tumor cells...
  15. ncbi request reprint G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells
    Adele Vivacqua
    Department of Pharmaco Biology, University of Calabria, 87030 Rende, Italy
    Mol Endocrinol 23:1815-26. 2009
    ..Our results emphasize the need for new endocrine agents able to block widespread actions of estrogen without exerting any stimulatory activity on transduction pathways shared by the steroid and growth factor-signaling networks...
  16. doi request reprint 17β-estradiol enhances α(5) integrin subunit gene expression through ERα-Sp1 interaction and reduces cell motility and invasion of ERα-positive breast cancer cells
    Diego Sisci
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende, Italy
    Breast Cancer Res Treat 124:63-77. 2010
    ....
  17. ncbi request reprint G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells
    Lidia Albanito
    Departments of Pharmaco Biology and Cell Biology, University of Calabria, 87030 Rende Cosenza, Italy
    Cancer Res 67:1859-66. 2007
    ....
  18. pmc Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells
    Lidia Albanito
    Department Pharmaco Biology, University of Calabria, 87030 Rende Cosenze, Italy
    Endocrinology 149:3799-808. 2008
    ..On the basis of our results, the action of EGF may include the up-regulation of GPR30 in facilitating a stimulatory role of estrogen, even in ER-negative breast tumor cells...
  19. doi request reprint E-cadherin mediates the aggregation of breast cancer cells induced by tamoxifen and epidermal growth factor
    Loredana Mauro
    Department Cellular Biology, University of Calabria, Cosenza, Arcavacata Rende CS, 87030, Italy
    Breast Cancer Res Treat 121:79-89. 2010
    ..Thus, the potential ability of tamoxifen to induce cell-cell aggregation may contribute to the biologic response of pharmacologic intervention in patients with breast cancer...
  20. doi request reprint Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells
    Rosamaria Lappano
    Dipartimento Farmaco Biologico, Universita della Calabria, Rende CS, Italy
    Mol Cell Endocrinol 320:162-70. 2010
    ....
  21. doi request reprint The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line
    Rosa Sirianni
    Department of Pharmaco Biology, Universita della Calabria, 87036 Rende, Italy
    Endocrinology 149:5043-51. 2008
    ..Further studies to elucidate the involvement of rapid estrogen signaling pathways in the regulation of male fertility are warranted...
  22. ncbi request reprint Oleuropein and hydroxytyrosol inhibit MCF-7 breast cancer cell proliferation interfering with ERK1/2 activation
    Rosa Sirianni
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende CS, Italy
    Mol Nutr Food Res 54:833-40. 2010
    ..Our study demonstrated that HT and OL can have a chemo-preventive role in breast cancer cell proliferation through the inhibition of estrogen-dependent rapid signals involved in uncontrolled tumor cell growth...
  23. doi request reprint Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts
    Antonio Madeo
    Department of Pharmaco Biology, University of Calabria, Rende, Cosenza, Italy
    Cancer Res 70:6036-46. 2010
    ..More generally, they define estrogenic GPR30 signaling as a functionally important component of the tumor microenvironment...
  24. doi request reprint The nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts (CAFs)
    Marco Pupo
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy
    Mol Cell Endocrinol 376:23-32. 2013
    ..Our data provide novel insights into the nuclear localization and function of GPER in CAFs toward a better understanding of the estrogen action elicited through these key players of the tumor microenvironment. ..
  25. ncbi request reprint The food contaminants bisphenol A and 4-nonylphenol act as agonists for estrogen receptor alpha in MCF7 breast cancer cells
    Adele Vivacqua
    Department of Pharmaco Biology, University of Calabria, 87036 Rende CS, Italy
    Endocrine 22:275-84. 2003
    ..The estrogenic effects of such industrial agents together with an increasing widespread human exposure should be taken into account for the potential influence also on hormone-dependent breast cancer disease...
  26. pmc G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17β-estradiol in cancer cells and cancer-associated fibroblasts
    Maria Francesca Santolla
    Department of Pharmaco Biology, University of Calabria, 87030 Rende, Italy
    J Biol Chem 287:43234-45. 2012
    ....
  27. ncbi request reprint Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells
    Stefania Catalano
    Centro Sanitario, University of Calabria, Arcavacata di Rende, Cosenza 87030, Italy
    J Biol Chem 279:19908-15. 2004
    ..Thus, we are able to demonstrate that the amplification of estrogen signal induced by leptin occurs through an enhancing in situ E(2) production as well as a direct functional activation of ERalpha...
  28. pmc The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytes
    Anna Grazia Recchia
    Department of Pharmaco Biology, University of Calabria, 87030 Rende Cosenza, Italy
    J Biol Chem 286:10773-82. 2011
    ..Taken together, our data suggest that the hypoxia-induced expression of GPER may be included among the mechanisms involved in the anti-apoptotic effects elicited by estrogens, particularly in a low oxygen microenvironment...
  29. doi request reprint 17β-Estradiol activates GPER- and ESR1-dependent pathways inducing apoptosis in GC-2 cells, a mouse spermatocyte-derived cell line
    Adele Chimento
    Department of Pharmaco Biology, University of Calabria, 87036 Arcavacata di Rende, Cosenza, Italy
    Mol Cell Endocrinol 355:49-59. 2012
    ....
  30. doi request reprint GPER mediates the Egr-1 expression induced by 17β-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells
    Adele Vivacqua
    Department of Pharmaco Biology, University of Calabria, 87030 Rende, CS, Italy
    Breast Cancer Res Treat 133:1025-35. 2012
    ..Therefore, Egr-1 may be included among the bio-markers of estrogen and antiestrogen actions and may be considered as a further therapeutic target in both breast and endometrial tumors...
  31. pmc Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells
    Rosa Sirianni
    Department of Pharmaco Biology, University of Calabria, 87036 Arcavacata di Rende CS, Italy
    J Biol Chem 284:28905-16. 2009
    ..These novel findings clarify the mechanisms involved in the growth of Leydig cell tumors and should be taken into account in determining new therapeutic approaches...
  32. ncbi request reprint Differential expression of estrogen receptors (ERalpha/ERbeta) in testis of mature and immature pigs
    Vittoria Rago
    Department of Cell Biology, University of Calabria, 87030 Arcavacata di Rendi, Cosenza, Italy
    Anat Rec A Discov Mol Cell Evol Biol 281:1234-9. 2004
    ..The differential ERalpha/ERbeta expression in germ and somatic cells of the gonads suggest a role of estrogens in function and in development of pig testis...
  33. doi request reprint A sexually dimorphic distribution pattern of the novel estrogen receptor G-protein-coupled receptor 30 in some brain areas of the hamster
    Marcello Canonaco
    Comparative Neuroanatomy and Cytology Laboratory and Pharmaco Biology Department, University of Calabria, 87030 Arcavacata di Rende, Cosenza, Italy
    J Endocrinol 196:131-8. 2008
    ....
  34. pmc Metformin inhibits androgen-induced IGF-IR up-regulation in prostate cancer cells by disrupting membrane-initiated androgen signaling
    Roberta Malaguarnera
    Endocrinology R M, A s, A Morc, A B, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy Endocrinology S S, Department of Clinical and Molecular Biomedicine, University of Catania, Garibaldi Nesima Hospital, 95125 Catania, Italy Department of General Pathology A Mi, II University of Naples, Via L De Crecchio, 7 80138 Naples, Italy Department of Urology and Biology of Prostate Cancer Program A Morr, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia 19107 and Department of Pharmaco Biology M M, University of Calabria, 87030 Rende, Italy
    Endocrinology 155:1207-21. 2014
    ....
  35. doi request reprint Endothelin-1 induces connective tissue growth factor expression in cardiomyocytes
    Anna Grazia Recchia
    Department of Pharmaco Biology, Cell Biology, University of Calabria, 87036 Rende CS, Italy
    J Mol Cell Cardiol 46:352-9. 2009
    ..CTGF inhibitors should be considered in setting a comprehensive pharmacological approach towards ET-1 induced cardiovascular diseases...
  36. ncbi request reprint Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells
    Marcello Maggiolini
    Department of Pharmaco Biology, University of Calabria, 87036 Rende CS, Italy
    J Steroid Biochem Mol Biol 82:315-22. 2002
    ..Thus, the activity of ISL and the balance between risk or chemopreventive factor for estrogen-dependent breast cancer may depend on dietary intake...
  37. doi request reprint Structure-activity relationships of resveratrol and derivatives in breast cancer cells
    Rosamaria Lappano
    Dipartimento Farmaco Biologico, Universita della Calabria, Rende, CS, Italy
    Mol Nutr Food Res 53:845-58. 2009
    ..Our data suggest that subtle changes in the structure of the RSV derivatives examined may be responsible for the different ERalpha-mediated biological responses observed in estrogen-sensitive cancer cells...
  38. ncbi request reprint The mutant androgen receptor T877A mediates the proliferative but not the cytotoxic dose-dependent effects of genistein and quercetin on human LNCaP prostate cancer cells
    Marcello Maggiolini
    Department of Pharmaco Biology, University of Calabria, Rende, Italy
    Mol Pharmacol 62:1027-35. 2002
    ..The results of our study provide evidence that phytoestrogens may regulate several signaling processes in LNCaP cells; however, further studies are needed to assess their potential capability to restrain prostate tumor progression...
  39. pmc GPER mediates cardiotropic effects in spontaneously hypertensive rat hearts
    Ernestina Marianna De Francesco
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Cosenza, Italy
    PLoS ONE 8:e69322. 2013
    ..Hence, GPER may be considered as a useful target in the treatment of some cardiac dysfunctions associated with stressful conditions like the essential hypertension. ..
  40. pmc Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes
    Vittoria Rago
    Department of Cell Biology, Faculty of Pharmacy, University of Calabria, Italy
    Reprod Biol Endocrinol 9:135. 2011
    ..Recently, a G-protein-coupled-receptor (GPER) has been suggested as being involved in rapid responses to estrogens in different normal and tumor cells...
  41. doi request reprint A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to p38MAPK-dependent activation of mTOR and cyclinD1 expression in prostate and lung cancer cells
    Anna Grazia Recchia
    Department of Pharmaco Biology, University of Calabria, 87036 Rende CS, Italy
    Int J Biochem Cell Biol 41:603-14. 2009
    ..Hence, our data suggest that p38MAPK-dependent activation of the mTOR/CD1 pathway may represent a mechanism through which AR and EGFR cross-talk contributes to prostate and lung cancer progression...
  42. ncbi request reprint Tamoxifen through GPER upregulates aromatase expression: a novel mechanism sustaining tamoxifen-resistant breast cancer cell growth
    Stefania Catalano
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Arcavacata di Rende, CS, Italy
    Breast Cancer Res Treat 146:273-85. 2014
    ..Blocking estrogen production and/or GPER signaling activation may represent a valid option to overcome tamoxifen-resistance in breast cancers. ..
  43. doi request reprint Crucial role of phospholamban phosphorylation and S-nitrosylation in the negative lusitropism induced by 17β-estradiol in the male rat heart
    Elisabetta Filice
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende, Italy
    Cell Physiol Biochem 28:41-52. 2011
    ....
  44. ncbi request reprint Differential expression of steroidogenic factor-1/adrenal 4 binding protein and liver receptor homolog-1 (LRH-1)/fetoprotein transcription factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression
    Vincenzo Pezzi
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende 87036 CS, Italy
    Endocrinology 145:2186-96. 2004
    ..The colocalization of LRH-1 and aromatase to multiple testis cell types suggests that LRH-1 may have important effects on estrogen production, testis development, spermatogenesis, and testicular carcinogenesis...
  45. doi request reprint Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells
    Adele Chimento
    Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, Cosenza, Italy
    Mol Nutr Food Res 58:478-89. 2014
    ..Using the ER-negative and GPER-positive SKBR3 BC cells as experimental model, we investigated the effects of OL and HT on GPER-mediated activation of downstream pathways...
  46. ncbi request reprint GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens
    Ernestina Marianna De Francesco
    Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, Rende CS, Italy
    Cancer Res 74:4053-64. 2014
    ..Our findings offer important new insights into the ability of estrogenic GPER signaling to trigger HIF1α-dependent VEGF expression that supports angiogenesis and progression in breast cancer. Cancer Res; 74(15); 4053-64. ©2014 AACR. ..
  47. ncbi request reprint Niacin activates the G protein estrogen receptor (GPER)-mediated signalling
    Maria Francesca Santolla
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Cosenza, Italy
    Cell Signal 26:1466-75. 2014
    ....
  48. ncbi request reprint Peroxisome proliferator-activated receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappaB sequence in human MCF7 breast cancer cells
    Daniela Bonofiglio
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende, Italy
    Mol Endocrinol 20:3083-92. 2006
    ....
  49. ncbi request reprint Glycerophospholipid synthesis as a novel drug target against cancer
    Vincenza Dolce
    Department of Pharmaco Biology, University of Calabria, 87036 Rende CS, Italy
    Curr Mol Pharmacol 4:167-75. 2011
    ..This review presents an overview of mammalian glycerophospholipid synthesis, signal transduction and cellular distribution of the biochemical activities that produce distinct membrane lipid molecular species...
  50. ncbi request reprint Aromatase overexpression enhances the stimulatory effects of adrenal androgens on MCF7 breast cancer cells
    Marcello Maggiolini
    Department of Pharmaco Biology, Facolta di Farmacia, University of Calabria, I 87036 Rende, CS, Italy
    Mol Cell Endocrinol 193:13-8. 2002
    ..Our results suggest that in postmenopausal women aromatase inhibitors might be considered as an adjuvant approach to the treatment of hormone-dependent breast tumors that overexpress aromatase...
  51. doi request reprint New advances on the functional cross-talk between insulin-like growth factor-I and estrogen signaling in cancer
    Viviana Bartella
    Department of Pharmaco Biology, University of Calabria, 87030 Rende, Italy
    Cell Signal 24:1515-21. 2012
    ..These studies offer hope for new strategies aimed at the treatment of estrogen related cancers in order to prevent an estrogen-independent and more aggressive tumor progression...
  52. doi request reprint GPER activates Notch signaling in breast cancer cells and cancer-associated fibroblasts (CAFs)
    Marco Pupo
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy
    Int J Biochem Cell Biol 46:56-67. 2014
    ..Taken together, our results prove the involvement of the Notch signaling pathway in mediating the effects of estrogenic GPER signaling in breast cancer cells and CAFs. ..
  53. doi request reprint Rhenium(IV) compounds inducing apoptosis in cancer cells
    José Martínez-Lillo
    Centro di Eccellenza CEMIF CAL, Dipartimento di Chimica, Universita della Calabria, via P Bucci 14 c, 87030 Arcavacata di Rende, Cosenza, Italy
    Chem Commun (Camb) 47:5283-5. 2011
    ..All compounds displayed potent in vitro antiproliferative activity against selected cancer cells...
  54. doi request reprint GPCRs and cancer
    Rosamaria Lappano
    Department of Pharmaco Biology, University of Calabria, Rende, Italy
    Acta Pharmacol Sin 33:351-62. 2012
    ..These findings provide a broad overview on the biological activity elicited by GPCRs in tumor cells and contribute to the identification of novel pharmacological approaches for cancer patients...
  55. ncbi request reprint Negative charged threonine 95 of c-Jun is essential for c-Jun N-terminal kinase-dependent phosphorylation of threonine 91/93 and stress-induced c-Jun biological activity
    Maria Vinciguerra
    Dipartimento Farmaco Biologico, Universita della Calabria, 87036 Rende CS, Italy
    Int J Biochem Cell Biol 40:307-16. 2008
    ..Hence, our study suggests that c-Jun may sense the strength of genotoxic stress through DNA-damage dependent phosphorylation of T95, which in turn augments c-Jun transactivation by JNKs...
  56. doi request reprint G protein-coupled receptors: novel targets for drug discovery in cancer
    Rosamaria Lappano
    Department of Pharmaco Biology, University of Calabria, 87030 Rende, Cosenza, Italy
    Nat Rev Drug Discov 10:47-60. 2011
    ..We also discuss current data regarding novel GPCR targets that may provide promising opportunities for drug discovery in cancer prevention and treatment...