Research Topics
| M MaggioSummaryCountry: Italy Publications
| Collaborators
|
Detail Information
Publications
Sex hormones and sarcopenia in older personsMarcello Maggio
Department of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, Parma, Italy
Curr Opin Clin Nutr Metab Care 16:3-13. 2013..The aim of this review is to highlight the effects of DHEAS and testosterone treatment to counteract sarcopenia, especially in older men...- Is the haematopoietic effect of testosterone mediated by erythropoietin? The results of a clinical trial in older menM Maggio
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Via Gramsci 14, Parma, Italy
Andrology 1:24-8. 2013..The haematopoietic effect of testosterone does not appear to be mediated by stimulation of erythropoietin production... - The relationship between sex hormones, sex hormone binding globulin and peripheral artery disease in older personsM Maggio
Department of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, Italy
Atherosclerosis 225:469-74. 2012..The protective effect of testosterone and sex hormone binding globulin (SHBG) for diabetes in men suggests that the biological activity of sex hormones may affect PAD, especially in older populations... 
Dietary habits in women with recurrent idiopathic calcium nephrolithiasisTiziana Meschi
Department of Clinical Sciences, University of Parma, Via A Gramsci 14, Parma, Italy
J Transl Med 10:63. 2012....- Estradiol and inflammatory markers in older menMarcello Maggio
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University Hospital of Parma, Parma, Italy
J Clin Endocrinol Metab 94:518-22. 2009..It is still unclear whether estradiol (E2), which generally has biological activities complementary to testosterone, affects inflammation... 
The impact of omega-3 fatty acids on osteoporosisM Maggio
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
Curr Pharm Des 15:4157-64. 2009....- Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: the InCHIANTI studyMarcello Maggio
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
Clin Nutr 29:674-7. 2010..However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown... - Gonadal status and physical performance in older menMarcello Maggio
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Italy
Aging Male 14:42-7. 2011..To test the relationship between gonadal status and objective measures and determinants of physical performance in older men and their determinants... - SHBG, sex hormones, and inflammatory markers in older womenMarcello Maggio
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, 43100 Parma, Italy
J Clin Endocrinol Metab 96:1053-9. 2011..In premenopausal and older women, high testosterone and estradiol (E2) and low SHBG levels are associated with insulin resistance and diabetes, conditions characterized by low-grade inflammation... - Magnesium and anabolic hormones in older menM Maggio
Section of Geriatrics, Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy
Int J Androl 34:e594-600. 2011..4 ± 4.9; p = 0.01). In a cohort of older men, magnesium levels are strongly and independently associated with the anabolic hormones testosterone and IGF-1... - The hormonal pathway to cognitive impairment in older menM Maggio
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
J Nutr Health Aging 16:40-54. 2012..Then, giving the contradictory data of the literature and the multi-factorial origin of dementia, we will introduce the hypothesis of multiple hormonal derangement as a better determinant of cognitive decline in older men... - Estradiol and metabolic syndrome in older italian men: The InCHIANTI StudyMarcello Maggio
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, 43100 Parma, Italy
J Androl 31:155-62. 2010..Whether confirmed in other studies, assessment of E2 should be also considered in older men. Whether changes in this hormonal pattern play a role in the development of MS should be further tested in longitudinal studies... - Relationship between testosterone deficiency and cardiovascular risk and mortality in adult menC Cattabiani
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
J Endocrinol Invest 35:104-20. 2012..Finally we will detail the emerging relationship between low T and mortality in men addressing also the reverse hypothesis that low T has a protective role by turning off T-dependent functions... - Dehydroepiandrosterone sulfate and cognitive function in the elderly: The InCHIANTI StudyG Valenti
Department of Internal Medicine and Medical Sciences, Section of Geriatrics, University of Parma, Parma 43100, Italy
J Endocrinol Invest 32:766-72. 2009..004+/-0.002, p<0.03). Our data show a significant and positive association between DHEAS and cognitive function, assessed by MMSE test. Low DHEAS levels predict accelerated decline in MMSE score during the 3-yr follow-up period... - Sex hormone binding globulin levels across the adult lifespan in women--the role of body mass index and fasting insulinM Maggio
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, School of Endocrinology, University of Parma, Parma, Italy
J Endocrinol Invest 31:597-601. 2008..00039 to 0.00028). SHBG levels show an age-related U-shaped trajectory. These changes mirror the age-related changes in BMI and fasting insulin, suggesting that BMI and insulin negatively influence SHBG concentration... - Omega-3 and renal function in older adultsF Lauretani
Geriatric Unit, Geriatric Rehabilitation Department, University Hospital of Parma, Parma, Italy
Curr Pharm Des 15:4149-56. 2009..These findings suggest that a higher dietary intake of PUFA may be protective against progression to chronic kidney disease... - Decreased DHEAS secretion in patients with chronic inflammatory diseases treated with glucocorticoidsM Maggio
University of Parma, Italy
J Endocrinol Invest 25:87-8. 2002 - Thyroid disease in the elderly: sex-related differences in clinical expressionS Morganti
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, Endocrine-Metabolic Unit, University of Parma, 43100 Parma, Italy
J Endocrinol Invest 28:101-4. 2005..However, male sex may represent a risk factor for thyroid cancer in elderly population and this observation should be carefully considered in the evaluation of thyroid nodules in the elderly... - Clinical implications of the reduced activity of the GH-IGF-I axis in older menG P Ceda
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, 43100 Parma, Italy
J Endocrinol Invest 28:96-100. 2005..In conclusion, IGF-I is a pleiotropic hormone that in older persons may positively affect the cardiovascular system, the central nervous system and physical function... - Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older menMarcello Maggio
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
J Clin Endocrinol Metab 91:345-7. 2006..05). T was not correlated with any other inflammatory marker. CONCLUSIONS: These preliminary findings suggest an inverse relationship between T and sIL-6r. Longitudinal studies are needed to establish the causality of this association... - Welcoming low testosterone as a cardiovascular risk factorM Maggio
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Parma, Parma, Italy
Int J Impot Res 21:261-4. 2009..Recent studies have shown low serum testosterone levels to be an independent risk factor of cardiovascular and all-cause mortality. It is time to welcome low serum testosterone levels as a cardiovascular risk factor... - Effects of vitamin A administration on serum thyrotropin concentrations in healthy human subjectsG Ceresini
Department of Internal Medicine, Section of Geriatrics, University of Parma, Parma, Italy
Metabolism 51:691-4. 2002..These results suggest that TSH secretion is poorly affected by vit A administration in healthy human subjects; the data also indicate that any cooperation between T(3) and vit A is unlikely to occur in the regulation of TSH secretion... - Effects of ACE-inhibition on IGF-1 and IGFBP-3 concentrations in older adults with high cardiovascular risk profileS Giovannini
Dept of Aging and Geriatric Research, Division of Biology of Aging, University of Florida, Institute on Aging, 1600 SW Archer Road, PO Box 100143, Gainesville, FL 32610, USA
J Nutr Health Aging 14:457-60. 2010..The present study evaluates the effects of a 6-month treatment with an ACE-inhibitor (ie, fosinopril) on serum concentrations of total IGF-1 and IGF binding protein (IGFBP)-3 in older adults at high risk for cardiovascular disease... - Androgen deficiency in older menG Valenti
Section of Geriatrics, Department of Internal Medicine and Biomedical Sciences, University of Parma, Via Gramsi 14, 42100 Parma, Italy
Minerva Ginecol 59:43-9. 2007..New compounds designed to target androgen receptors in specific tissues are promising options as anabolic agents... - Interleukin-6 in aging and chronic disease: a magnificent pathwayMarcello Maggio
Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
J Gerontol A Biol Sci Med Sci 61:575-84. 2006.... - Low testosterone levels and the risk of anemia in older men and womenLuigi Ferrucci
Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21225, USA
Arch Intern Med 166:1380-8. 2006..Anemia is a frequent feature of male hypogonadism and anti-androgenic treatment. We hypothesized that the presence of low testosterone levels in older persons is a risk factor for anemia... - Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI studyMarcello Maggio
National Institute on Aging, NIH, NIA ASTRA Unit at Harbor Hospital, 3001 S Hanover St, Baltimore, MD 21225, USA
Am J Physiol Endocrinol Metab 292:E353-8. 2007..Further studies are needed to support the notion that raising SHBG is a potential therapeutic target for prevention and treatment of MetS... - Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) studyMarcello Maggio
National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
Arch Intern Med 167:2249-54. 2007..We hypothesized that in older men a parallel age-associated decline in bioavailable testosterone, IGF-1, and DHEA-S secretion is associated with higher mortality independent of potential confounders... - Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI studySari Stenholm
Clinical Research Branch, National Institute on Aging, 3001 S Hanover Street, Baltimore, MD 21225, USA
Clin Endocrinol (Oxf) 73:55-65. 2010..The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons... - Uric acid and inflammatory markersCarmelinda Ruggiero
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, MD, USA
Eur Heart J 27:1174-81. 2006..Epidemiological studies have recently shown that UA may be a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure... - The concept of multiple hormonal dysregulationMarcello Maggio
Department of Internal and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
Acta Biomed 81:19-29. 2010.... - Association between hormones and metabolic syndrome in older Italian menMarcello Maggio
Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
J Am Geriatr Soc 54:1832-8. 2006.... - Effects of high-dose isoflavones on metabolic and inflammatory markers in healthy postmenopausal womenCornelia Charles
Laboratory of Clinical Investigation, Diabetes Section, National Institute on Aging, Baltimore, MD, USA
Menopause 16:395-400. 2009..However, the effect of isoflavones on adipokines/cytokines remains unclear. The purpose of this study was to evaluate the effect of high-dose isoflavones on inflammatory and metabolic markers in postmenopausal women... - Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 yearsCarmelinda Ruggiero
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
Am J Cardiol 100:115-21. 2007..In conclusion, our study suggests that in a population-based cohort, baseline UA and changes in circulating UA during 3 years of follow-up predict changes in circulating CRP independent of relevant confounders, including baseline IL-6... - Relation of angiotensin-converting enzyme inhibitor treatment to insulin-like growth factor-1 serum levels in subjects >65 years of age (the InCHIANTI study)Marcello Maggio
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA
Am J Cardiol 97:1525-9. 2006..This may be 1 of the mechanisms by which ACE inhibitors might slow the decreases in muscle strength and physical function that are often observed in older subjects... - Glucose and insulin measurements from the oral glucose tolerance test and mortality predictionE Jeffrey Metter
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
Diabetes Care 31:1026-30. 2008..To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality... - Anabolic and catabolic biomarkers as predictors of muscle strength decline: the InCHIANTI studySari Stenholm
National Institute on Aging, Clinical Research Branch, Longitudinal Studies Section, Baltimore, Maryland 21225, USA
Rejuvenation Res 13:3-11. 2010..This study aims to examine whether high levels of multiple catabolic and low levels of multiple anabolic biomarkers predict accelerated decline of muscle strength... - Consensus Document on substitution therapy with DHEA in the elderlyGiorgio Valenti
Dipartimento di Medicina Interna e Scienze Biomediche, Sezione Geriatria, , Via Gramsci 14, 43100 Parma, Italy
Aging Clin Exp Res 18:277-300. 2006 - Relationship between higher estradiol levels and 9-year mortality in older women: the Invecchiare in Chianti studyMarcello Maggio
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
J Am Geriatr Soc 57:1810-5. 2009..To investigate the relationship between total estradiol (E2) levels and 9-year mortality in older postmenopausal women not taking hormone replacement therapy (HRT)... - White blood cell count and mortality in the Baltimore Longitudinal Study of AgingCarmelinda Ruggiero
Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
J Am Coll Cardiol 49:1841-50. 2007..We investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002... - Update on new therapeutic options for the somatopauseGian Paolo Ceda
Section of Geriatrics, Department of Internal Medicine and Biomedical Sciences, School of Geriatrics, University of Parma, Italy
Acta Biomed 81:67-72. 2010..In this paper we will review the current evidence related to the use of GH and/or GH-secretagogues in normal and pathological aging...