M Maggio

Summary

Country: Italy

Publications

  1. ncbi request reprint Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons
    Marcello Maggio
    Department of Clinical and Experimental Medicine, Section of Geriatrics via Gramsci 14, 43100, Parma, Italy
    Curr Pharm Des 20:3119-48. 2014
  2. ncbi request reprint Relationship between use of proton pump inhibitors and IGF system in older subjects
    M Maggio
    M Maggio, MD, PhD, Department of Clinical and Experimental Medicine, Geriatric Clinic, Food Sciences Unit and Endocrinology of Aging Unit, Via Gramsci 14, 43100, Parma, Italy Phone 0039 0521 703916 E Mail
    J Nutr Health Aging 18:420-3. 2014
  3. doi request reprint SHBG and endothelial function in older subjects
    Marcello Maggio
    Department of Clinical and Experimental Medicine, Section of Geriatrics, Andrology, Osteometabolic, Endocrinology Unit, University of Parma, Italy Geriatric Clinic Unit, Geriatric Rehabilitation Department, University Hospital of Parma, Parma, Italy Electronic address
    Int J Cardiol 168:2825-30. 2013
  4. pmc Insulin-like growth factor-1 bioactivity plays a prosurvival role in older participants
    Marcello Maggio
    Section of Geriatrics, Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    J Gerontol A Biol Sci Med Sci 68:1342-50. 2013
  5. ncbi request reprint Use of proton pump inhibitors is associated with lower trabecular bone density in older individuals
    Marcello Maggio
    Department of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, Via Gramsci, 14, 43126 Parma PR, Italy Geriatric Rehabilitation Department, University Hospital of Parma, Via Gramsci, 14, 43126 Parma PR, Italy Electronic address
    Bone 57:437-42. 2013
  6. doi request reprint Proton pump inhibitors and risk of 1-year mortality and rehospitalization in older patients discharged from acute care hospitals
    Marcello Maggio
    Department of Geriatric Rehabilitation, University Hospital of Parma, Parma, Italy
    JAMA Intern Med 173:518-23. 2013
  7. doi request reprint Sex hormones and sarcopenia in older persons
    Marcello Maggio
    Department of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, Parma, Italy
    Curr Opin Clin Nutr Metab Care 16:3-13. 2013
  8. doi request reprint Is the haematopoietic effect of testosterone mediated by erythropoietin? The results of a clinical trial in older men
    M Maggio
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Via Gramsci 14, Parma, Italy
    Andrology 1:24-8. 2013
  9. ncbi request reprint The relationship between sex hormones, sex hormone binding globulin and peripheral artery disease in older persons
    M Maggio
    Department of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, Italy
    Atherosclerosis 225:469-74. 2012
  10. pmc Dietary habits in women with recurrent idiopathic calcium nephrolithiasis
    Tiziana Meschi
    Department of Clinical Sciences, University of Parma, Via A Gramsci 14, Parma, Italy
    J Transl Med 10:63. 2012

Detail Information

Publications47

  1. ncbi request reprint Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons
    Marcello Maggio
    Department of Clinical and Experimental Medicine, Section of Geriatrics via Gramsci 14, 43100, Parma, Italy
    Curr Pharm Des 20:3119-48. 2014
    ....
  2. ncbi request reprint Relationship between use of proton pump inhibitors and IGF system in older subjects
    M Maggio
    M Maggio, MD, PhD, Department of Clinical and Experimental Medicine, Geriatric Clinic, Food Sciences Unit and Endocrinology of Aging Unit, Via Gramsci 14, 43100, Parma, Italy Phone 0039 0521 703916 E Mail
    J Nutr Health Aging 18:420-3. 2014
    ..to investigate the effects of proton pump inhibitors (PPIs) on the insulin-like-growth factor 1(IGF-1) system in the elderly...
  3. doi request reprint SHBG and endothelial function in older subjects
    Marcello Maggio
    Department of Clinical and Experimental Medicine, Section of Geriatrics, Andrology, Osteometabolic, Endocrinology Unit, University of Parma, Italy Geriatric Clinic Unit, Geriatric Rehabilitation Department, University Hospital of Parma, Parma, Italy Electronic address
    Int J Cardiol 168:2825-30. 2013
    ..However, the relationship between these hormones and endothelial function has never been addressed in the elderly...
  4. pmc Insulin-like growth factor-1 bioactivity plays a prosurvival role in older participants
    Marcello Maggio
    Section of Geriatrics, Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    J Gerontol A Biol Sci Med Sci 68:1342-50. 2013
    ..005), and independent of additional confounders (p = .037). High IGFBP-1 and low IGF-1/IGFBP-1 ratio are associated with all-cause mortality in older population. ..
  5. ncbi request reprint Use of proton pump inhibitors is associated with lower trabecular bone density in older individuals
    Marcello Maggio
    Department of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, Via Gramsci, 14, 43126 Parma PR, Italy Geriatric Rehabilitation Department, University Hospital of Parma, Via Gramsci, 14, 43126 Parma PR, Italy Electronic address
    Bone 57:437-42. 2013
    ..These findings suggest that PPI use might increase the risk of fractures in older subjects through its detrimental effects on trabecular bone. ..
  6. doi request reprint Proton pump inhibitors and risk of 1-year mortality and rehospitalization in older patients discharged from acute care hospitals
    Marcello Maggio
    Department of Geriatric Rehabilitation, University Hospital of Parma, Parma, Italy
    JAMA Intern Med 173:518-23. 2013
    ..The use of proton pump inhibitors (PPIs) has rapidly increased during the past several years. However, concern remains about risks associated with their long-term use in older populations...
  7. doi request reprint Sex hormones and sarcopenia in older persons
    Marcello Maggio
    Department of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, Parma, Italy
    Curr Opin Clin Nutr Metab Care 16:3-13. 2013
    ..The aim of this review is to highlight the effects of DHEAS and testosterone treatment to counteract sarcopenia, especially in older men...
  8. doi request reprint Is the haematopoietic effect of testosterone mediated by erythropoietin? The results of a clinical trial in older men
    M Maggio
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Via Gramsci 14, Parma, Italy
    Andrology 1:24-8. 2013
    ..The haematopoietic effect of testosterone does not appear to be mediated by stimulation of erythropoietin production...
  9. ncbi request reprint The relationship between sex hormones, sex hormone binding globulin and peripheral artery disease in older persons
    M Maggio
    Department of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma, Italy
    Atherosclerosis 225:469-74. 2012
    ..The protective effect of testosterone and sex hormone binding globulin (SHBG) for diabetes in men suggests that the biological activity of sex hormones may affect PAD, especially in older populations...
  10. pmc Dietary habits in women with recurrent idiopathic calcium nephrolithiasis
    Tiziana Meschi
    Department of Clinical Sciences, University of Parma, Via A Gramsci 14, Parma, Italy
    J Transl Med 10:63. 2012
    ....
  11. pmc SHBG, sex hormones, and inflammatory markers in older women
    Marcello Maggio
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, 43100 Parma, Italy
    J Clin Endocrinol Metab 96:1053-9. 2011
    ..In premenopausal and older women, high testosterone and estradiol (E2) and low SHBG levels are associated with insulin resistance and diabetes, conditions characterized by low-grade inflammation...
  12. ncbi request reprint The impact of omega-3 fatty acids on osteoporosis
    M Maggio
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
    Curr Pharm Des 15:4157-64. 2009
    ....
  13. doi request reprint Magnesium and anabolic hormones in older men
    M Maggio
    Section of Geriatrics, Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy
    Int J Androl 34:e594-600. 2011
    ..4 ± 4.9; p = 0.01). In a cohort of older men, magnesium levels are strongly and independently associated with the anabolic hormones testosterone and IGF-1...
  14. pmc Estradiol and metabolic syndrome in older italian men: The InCHIANTI Study
    Marcello Maggio
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, 43100 Parma, Italy
    J Androl 31:155-62. 2010
    ..Whether confirmed in other studies, assessment of E2 should be also considered in older men. Whether changes in this hormonal pattern play a role in the development of MS should be further tested in longitudinal studies...
  15. pmc Estradiol and inflammatory markers in older men
    Marcello Maggio
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University Hospital of Parma, Parma, Italy
    J Clin Endocrinol Metab 94:518-22. 2009
    ..It is still unclear whether estradiol (E2), which generally has biological activities complementary to testosterone, affects inflammation...
  16. doi request reprint Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: the InCHIANTI study
    Marcello Maggio
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
    Clin Nutr 29:674-7. 2010
    ..However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown...
  17. ncbi request reprint The hormonal pathway to cognitive impairment in older men
    M Maggio
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
    J Nutr Health Aging 16:40-54. 2012
    ..Then, giving the contradictory data of the literature and the multi-factorial origin of dementia, we will introduce the hypothesis of multiple hormonal derangement as a better determinant of cognitive decline in older men...
  18. pmc Gonadal status and physical performance in older men
    Marcello Maggio
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Italy
    Aging Male 14:42-7. 2011
    ..To test the relationship between gonadal status and objective measures and determinants of physical performance in older men and their determinants...
  19. doi request reprint Dehydroepiandrosterone sulfate and cognitive function in the elderly: The InCHIANTI Study
    G Valenti
    Department of Internal Medicine and Medical Sciences, Section of Geriatrics, University of Parma, Parma 43100, Italy
    J Endocrinol Invest 32:766-72. 2009
    ..004+/-0.002, p<0.03). Our data show a significant and positive association between DHEAS and cognitive function, assessed by MMSE test. Low DHEAS levels predict accelerated decline in MMSE score during the 3-yr follow-up period...
  20. doi request reprint Relationship between testosterone deficiency and cardiovascular risk and mortality in adult men
    C Cattabiani
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
    J Endocrinol Invest 35:104-20. 2012
    ..Finally we will detail the emerging relationship between low T and mortality in men addressing also the reverse hypothesis that low T has a protective role by turning off T-dependent functions...
  21. pmc Sex hormone binding globulin levels across the adult lifespan in women--the role of body mass index and fasting insulin
    M Maggio
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, School of Endocrinology, University of Parma, Parma, Italy
    J Endocrinol Invest 31:597-601. 2008
    ..00039 to 0.00028). SHBG levels show an age-related U-shaped trajectory. These changes mirror the age-related changes in BMI and fasting insulin, suggesting that BMI and insulin negatively influence SHBG concentration...
  22. pmc Omega-3 and renal function in older adults
    F Lauretani
    Geriatric Unit, Geriatric Rehabilitation Department, University Hospital of Parma, Parma, Italy
    Curr Pharm Des 15:4149-56. 2009
    ..These findings suggest that a higher dietary intake of PUFA may be protective against progression to chronic kidney disease...
  23. ncbi request reprint Clinical implications of the reduced activity of the GH-IGF-I axis in older men
    G P Ceda
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, 43100 Parma, Italy
    J Endocrinol Invest 28:96-100. 2005
    ..In conclusion, IGF-I is a pleiotropic hormone that in older persons may positively affect the cardiovascular system, the central nervous system and physical function...
  24. ncbi request reprint Decreased DHEAS secretion in patients with chronic inflammatory diseases treated with glucocorticoids
    M Maggio
    University of Parma, Italy
    J Endocrinol Invest 25:87-8. 2002
  25. ncbi request reprint Thyroid disease in the elderly: sex-related differences in clinical expression
    S Morganti
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, Endocrine Metabolic Unit, University of Parma, 43100 Parma, Italy
    J Endocrinol Invest 28:101-4. 2005
    ..However, male sex may represent a risk factor for thyroid cancer in elderly population and this observation should be carefully considered in the evaluation of thyroid nodules in the elderly...
  26. ncbi request reprint Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men
    Marcello Maggio
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Clin Endocrinol Metab 91:345-7. 2006
    ..An age-associated decline in testosterone (T) levels and an increase in proinflammatory cytokines contribute to chronic diseases in older men. Whether and how these changes are related is unclear...
  27. pmc Welcoming low testosterone as a cardiovascular risk factor
    M Maggio
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Parma, Parma, Italy
    Int J Impot Res 21:261-4. 2009
    ..Recent studies have shown low serum testosterone levels to be an independent risk factor of cardiovascular and all-cause mortality. It is time to welcome low serum testosterone levels as a cardiovascular risk factor...
  28. ncbi request reprint Androgen deficiency in older men
    G Valenti
    Section of Geriatrics, Department of Internal Medicine and Biomedical Sciences, University of Parma, Via Gramsi 14, 42100 Parma, Italy
    Minerva Ginecol 59:43-9. 2007
    ..New compounds designed to target androgen receptors in specific tissues are promising options as anabolic agents...
  29. ncbi request reprint Effects of vitamin A administration on serum thyrotropin concentrations in healthy human subjects
    G Ceresini
    Department of Internal Medicine, Section of Geriatrics, University of Parma, Parma, Italy
    Metabolism 51:691-4. 2002
    ..These results suggest that TSH secretion is poorly affected by vit A administration in healthy human subjects; the data also indicate that any cooperation between T(3) and vit A is unlikely to occur in the regulation of TSH secretion...
  30. ncbi request reprint Effects of ACE-inhibition on IGF-1 and IGFBP-3 concentrations in older adults with high cardiovascular risk profile
    S Giovannini
    Dept of Aging and Geriatric Research, Division of Biology of Aging, University of Florida, Institute on Aging, 1600 SW Archer Road, PO Box 100143, Gainesville, FL 32610, USA
    J Nutr Health Aging 14:457-60. 2010
    ..The present study evaluates the effects of a 6-month treatment with an ACE-inhibitor (ie, fosinopril) on serum concentrations of total IGF-1 and IGF binding protein (IGFBP)-3 in older adults at high risk for cardiovascular disease...
  31. pmc Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study
    Sari Stenholm
    Clinical Research Branch, National Institute on Aging, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Clin Endocrinol (Oxf) 73:55-65. 2010
    ..The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons...
  32. pmc Interleukin-6 in aging and chronic disease: a magnificent pathway
    Marcello Maggio
    Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 61:575-84. 2006
    ....
  33. pmc Low testosterone levels and the risk of anemia in older men and women
    Luigi Ferrucci
    Clinical Research Branch, Longitudinal Studies Section, National Institute on Aging, Baltimore, MD 21225, USA
    Arch Intern Med 166:1380-8. 2006
    ..Anemia is a frequent feature of male hypogonadism and anti-androgenic treatment. We hypothesized that the presence of low testosterone levels in older persons is a risk factor for anemia...
  34. pmc Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study
    Marcello Maggio
    National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Arch Intern Med 167:2249-54. 2007
    ..We hypothesized that in older men a parallel age-associated decline in bioavailable testosterone, IGF-1, and DHEA-S secretion is associated with higher mortality independent of potential confounders...
  35. pmc Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study
    Marcello Maggio
    National Institute on Aging, NIH, NIA ASTRA Unit at Harbor Hospital, 3001 S Hanover St, Baltimore, MD 21225, USA
    Am J Physiol Endocrinol Metab 292:E353-8. 2007
    ..Further studies are needed to support the notion that raising SHBG is a potential therapeutic target for prevention and treatment of MetS...
  36. pmc Effects of high-dose isoflavones on metabolic and inflammatory markers in healthy postmenopausal women
    Cornelia Charles
    Laboratory of Clinical Investigation, Diabetes Section, National Institute on Aging, Baltimore, MD, USA
    Menopause 16:395-400. 2009
    ..However, the effect of isoflavones on adipokines/cytokines remains unclear. The purpose of this study was to evaluate the effect of high-dose isoflavones on inflammatory and metabolic markers in postmenopausal women...
  37. pmc Uric acid and inflammatory markers
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, MD, USA
    Eur Heart J 27:1174-81. 2006
    ..Epidemiological studies have recently shown that UA may be a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure...
  38. pmc Relation of angiotensin-converting enzyme inhibitor treatment to insulin-like growth factor-1 serum levels in subjects >65 years of age (the InCHIANTI study)
    Marcello Maggio
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, USA
    Am J Cardiol 97:1525-9. 2006
    ..This may be 1 of the mechanisms by which ACE inhibitors might slow the decreases in muscle strength and physical function that are often observed in older subjects...
  39. pmc Association between hormones and metabolic syndrome in older Italian men
    Marcello Maggio
    Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 54:1832-8. 2006
    ....
  40. pmc Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Am J Cardiol 100:115-21. 2007
    ..In conclusion, our study suggests that in a population-based cohort, baseline UA and changes in circulating UA during 3 years of follow-up predict changes in circulating CRP independent of relevant confounders, including baseline IL-6...
  41. ncbi request reprint The concept of multiple hormonal dysregulation
    Marcello Maggio
    Department of Internal and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
    Acta Biomed 81:19-29. 2010
    ....
  42. pmc White blood cell count and mortality in the Baltimore Longitudinal Study of Aging
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Am Coll Cardiol 49:1841-50. 2007
    ..We investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002...
  43. ncbi request reprint Consensus Document on substitution therapy with DHEA in the elderly
    Giorgio Valenti
    Dipartimento di Medicina Interna e Scienze Biomediche, Sezione Geriatria, Universita degli Studi di Parma, Via Gramsci 14, 43100 Parma, Italy
    Aging Clin Exp Res 18:277-300. 2006
  44. pmc Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction
    E Jeffrey Metter
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
    Diabetes Care 31:1026-30. 2008
    ..To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality...
  45. pmc Anabolic and catabolic biomarkers as predictors of muscle strength decline: the InCHIANTI study
    Sari Stenholm
    National Institute on Aging, Clinical Research Branch, Longitudinal Studies Section, Baltimore, Maryland 21225, USA
    Rejuvenation Res 13:3-11. 2010
    ..This study aims to examine whether high levels of multiple catabolic and low levels of multiple anabolic biomarkers predict accelerated decline of muscle strength...
  46. ncbi request reprint Update on new therapeutic options for the somatopause
    Gian Paolo Ceda
    Section of Geriatrics, Department of Internal Medicine and Biomedical Sciences, School of Geriatrics, University of Parma, Italy
    Acta Biomed 81:67-72. 2010
    ..In this paper we will review the current evidence related to the use of GH and/or GH-secretagogues in normal and pathological aging...
  47. pmc Relationship between higher estradiol levels and 9-year mortality in older women: the Invecchiare in Chianti study
    Marcello Maggio
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy
    J Am Geriatr Soc 57:1810-5. 2009
    ..To investigate the relationship between total estradiol (E2) levels and 9-year mortality in older postmenopausal women not taking hormone replacement therapy (HRT)...