A Lonardo

Summary

Country: Italy

Publications

  1. ncbi Intestinal Wegener's granulomatosis in a patient with severe alpha-1-antitrypsin deficiency resulting from a unique combination of two deficiency alleles (PiZ and PiMProcida)
    Amedeo Lonardo
    Division of Internal Medicine and Gastroenterology, Modena City Hospital, Italy
    Eur J Gastroenterol Hepatol 14:1389-92. 2002
  2. doi Potential for statins in the chemoprevention and management of hepatocellular carcinoma
    Amedeo Lonardo
    Department of Internal Medicine, Endocrinology, Metabolism and Geriatrics, University of Modena and Reggio Emilia and Nocsae Baggiovara, Modena, Italy
    J Gastroenterol Hepatol 27:1654-64. 2012
  3. ncbi Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study
    A Lonardo
    Department of Internal Medicine and Gastroenterology, City Hospital, Modena, Italy
    Dig Liver Dis 34:204-11. 2002
  4. ncbi The wide spectrum of steatohepatitis: a report of four cases and a review of the literature
    Amedeo Lonardo
    Unità Operativa di Medicina Interna e Gastroenterologia, Ospedale Civile di Modena, Universita di Modena e Reggio Emilia, Italy
    Eur J Gastroenterol Hepatol 16:1043-50. 2004
  5. ncbi [Hepatitis C virus-associated and metabolic steatosis. Different or overlapping diseases?]
    Amedeo Lonardo
    UO di Medicina Interna e Gastroenterologia, Ospedale Civile di Modena
    Ann Ital Med Int 20:10-22. 2005
  6. ncbi Review article: hepatic steatosis and insulin resistance
    A Lonardo
    Unità Operativa Medicina I Gastroenterologia, Ospedale Civile di Modena, Modena, Italy
    Aliment Pharmacol Ther 22:64-70. 2005
  7. ncbi Hepatic steatosis and insulin resistance: does etiology make a difference?
    Amedeo Lonardo
    Unità Operativa di Medicina Interna e Gastroenterologia, Nuovo Ospedale Civile Estense, Via Giardini, Baggiovara, Modena 41100, Italy
    J Hepatol 44:190-6. 2006
  8. ncbi Hepatitis C and steatosis: a reappraisal
    A Lonardo
    Unità Operativa di Medicina Interna e Gastroenterologia, Nuovo Ospedale Civile Estense di Baggiovara, Modena, Italy
    J Viral Hepat 13:73-80. 2006
  9. ncbi 'Endocrine NAFLD' a hormonocentric perspective of nonalcoholic fatty liver disease pathogenesis
    Amedeo Lonardo
    Dipartimento di Medicina Interna, Medicina III, Azienda Ospedaliero Universitaria, University of Modena and Reggio Emilia, Modena, Italy
    J Hepatol 44:1196-207. 2006
  10. doi Dysmetabolic changes associated with HCV: a distinct syndrome?
    Amedeo Lonardo
    Dipartimento Integrato di Medicina, Endocrinologia, Metabolismo e Geriatria, Universita degli Studi di Modena e Reggio Emilia, Nuovo Ospedale S Agostino Estense, Modena, Italy
    Intern Emerg Med 3:99-108. 2008

Collaborators

Detail Information

Publications44

  1. ncbi Intestinal Wegener's granulomatosis in a patient with severe alpha-1-antitrypsin deficiency resulting from a unique combination of two deficiency alleles (PiZ and PiMProcida)
    Amedeo Lonardo
    Division of Internal Medicine and Gastroenterology, Modena City Hospital, Italy
    Eur J Gastroenterol Hepatol 14:1389-92. 2002
    ..Our findings appear to support the concept that severe alpha-1-antitripsyn deficiency is implicated in the pathogenesis of the Crohn's disease-like milder intestinal manifestations belonging to the spectrum of Wegener's granulomatosis...
  2. doi Potential for statins in the chemoprevention and management of hepatocellular carcinoma
    Amedeo Lonardo
    Department of Internal Medicine, Endocrinology, Metabolism and Geriatrics, University of Modena and Reggio Emilia and Nocsae Baggiovara, Modena, Italy
    J Gastroenterol Hepatol 27:1654-64. 2012
    ..However, randomized controlled trials are necessary in order to investigate the role of statins in the chemoprevention of HCC and in slowing the course of otherwise incurable disease in humans...
  3. ncbi Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study
    A Lonardo
    Department of Internal Medicine and Gastroenterology, City Hospital, Modena, Italy
    Dig Liver Dis 34:204-11. 2002
    ..Non-alcoholic fatty liver disease is a common reason for hepatological consultation and may herald severe hepatic and extra-hepatic disease. The aetiopathogenesis of this condition is an area of increasing interest...
  4. ncbi The wide spectrum of steatohepatitis: a report of four cases and a review of the literature
    Amedeo Lonardo
    Unità Operativa di Medicina Interna e Gastroenterologia, Ospedale Civile di Modena, Universita di Modena e Reggio Emilia, Italy
    Eur J Gastroenterol Hepatol 16:1043-50. 2004
    ..These issues, which are worthy of future investigation, are reviewed...
  5. ncbi [Hepatitis C virus-associated and metabolic steatosis. Different or overlapping diseases?]
    Amedeo Lonardo
    UO di Medicina Interna e Gastroenterologia, Ospedale Civile di Modena
    Ann Ital Med Int 20:10-22. 2005
    ..Preliminary data suggest that the therapeutic options for NAFLD may also be useful to improve HCV-associated steatosis...
  6. ncbi Review article: hepatic steatosis and insulin resistance
    A Lonardo
    Unità Operativa Medicina I Gastroenterologia, Ospedale Civile di Modena, Modena, Italy
    Aliment Pharmacol Ther 22:64-70. 2005
    ..Insulin resistance represents the frame within which hepatic and extrahepatic non-alcoholic fatty liver disease-related clinical manifestations are to be anticipated and interpreted...
  7. ncbi Hepatic steatosis and insulin resistance: does etiology make a difference?
    Amedeo Lonardo
    Unità Operativa di Medicina Interna e Gastroenterologia, Nuovo Ospedale Civile Estense, Via Giardini, Baggiovara, Modena 41100, Italy
    J Hepatol 44:190-6. 2006
    ..To ascertain whether the etiology of hepatic steatosis modulates insulin resistance (IR) and to determine the predictors of IR...
  8. ncbi Hepatitis C and steatosis: a reappraisal
    A Lonardo
    Unità Operativa di Medicina Interna e Gastroenterologia, Nuovo Ospedale Civile Estense di Baggiovara, Modena, Italy
    J Viral Hepat 13:73-80. 2006
    ..These observations indicate the need to evaluate the efficacy of combined antiviral and 'metabolic' approaches vs standard antiviral regimes in patients with steatosis and HCV chronic infection...
  9. ncbi 'Endocrine NAFLD' a hormonocentric perspective of nonalcoholic fatty liver disease pathogenesis
    Amedeo Lonardo
    Dipartimento di Medicina Interna, Medicina III, Azienda Ospedaliero Universitaria, University of Modena and Reggio Emilia, Modena, Italy
    J Hepatol 44:1196-207. 2006
  10. doi Dysmetabolic changes associated with HCV: a distinct syndrome?
    Amedeo Lonardo
    Dipartimento Integrato di Medicina, Endocrinologia, Metabolismo e Geriatria, Universita degli Studi di Modena e Reggio Emilia, Nuovo Ospedale S Agostino Estense, Modena, Italy
    Intern Emerg Med 3:99-108. 2008
    ..Little is known about the possible role of HCV in further components of the metabolic syndrome such as atherosclerosis, obesity, arterial hypertension, hyperuricemia and thrombotic risk factors...
  11. ncbi Fatty liver, carotid disease and gallstones: a study of age-related associations
    Amedeo Lonardo
    University of Modena and Reggio Emilia Azienda USL, Department of Internal Medicine, Metabolism, Endocrinology and Geriatrics, Ospedale di Baggiovara, Via Giardini, 41100 Modena, Italy
    World J Gastroenterol 12:5826-33. 2006
    ..To evaluate carotid intima-media thickening (IMT) and plaques, gallstone disease (GD) and fatty liver (FL) as a function of age...
  12. ncbi HCV and diabetes. A two-question-based reappraisal
    A Lonardo
    University of Modena and Reggio Emilia, Department of Internal Medicine, Metabolism, Endocrinology and Geriatrics, Operating Unit Internal Medicine and Metabolism, Nuovo Ospedale Civile Estense di Baggiovara, Modena 41100, Italy
    Dig Liver Dis 39:753-61. 2007
    ..Glucose tolerance testing should best be performed in those with hepatitis C virus-related cirrhosis. However, additional studies are needed to support the cost-effectiveness of our conclusions...
  13. ncbi [Bleeding gastrointestinal angiodysplasias: our experience and a review of the literature]
    Amedeo Lonardo
    U O di Medicina Interna e Gastroenterologia, Ospedale Civile di Modena
    Ann Ital Med Int 19:122-7. 2004
    ..A better understanding of the clinical epidemiology of bleeding gastrointestinal angiodysplasias may facilitate their diagnosis and contribute to an effective clinical management...
  14. ncbi Of liver, whisky and plants: a requiem for colchicine in alcoholic cirrhosis?
    Amedeo Lonardo
    Unit of Internal Medicine and Gastroenterology, Modena City Hospital, P le S Agostino, 2 Modena 41100, Italy
    Eur J Gastroenterol Hepatol 14:355-8. 2002
    ..Were such a hypothesis confirmed, it would unify our view of the pathogenesis of alcoholic and non-alcoholic liver disease, with all its inherent therapeutic implications...
  15. ncbi Hereditary hemochromatosis masquerading as rheumatoid arthritis
    A Lonardo
    Divisione di Medicina Interna e Gastroenterologia, Ospedale Civile di Modena
    Ann Ital Med Int 16:46-9. 2001
    ..In male subjects with positive rheumatoid factor and joint and liver disease, hereditary hemochromatosis should be considered. More liberal use of genetic testing is justified in such cases...
  16. doi Insulin resistance in nonalcoholic steatohepatitis: necessary but not sufficient - death of a dogma from analysis of therapeutic studies?
    Amedeo Lonardo
    Universita di Modena e Reggio Emilia, Azienda USL di Modena, Modena, Italy
    Expert Rev Gastroenterol Hepatol 5:279-89. 2011
    ..If this hypothesis is true, we should try to tailor treatment to each subject...
  17. ncbi Are there any sex differences in fatty liver? A study of glucose metabolism and body fat distribution
    A Lonardo
    Division of Internal Medicine and Gastroenterology, Modena City Hospital, Modena, Italy
    J Gastroenterol Hepatol 15:775-82. 2000
    ..Whether sex differences affect its development is presently unknown. The hypothesis that glucose metabolism alterations or central body fat distribution are gender-related in fatty liver was investigated...
  18. pmc Hepatitis C virus-infected patients are 'spared' from the metabolic syndrome but not from insulin resistance. A comparative study of nonalcoholic fatty liver disease and hepatitis C virus-related steatosis
    Amedeo Lonardo
    Universita degli Studi di Modena e Reggio Emilia, Dipartimento di Medicina, Endocrinologia e Geriatria, Modena, Italy
    Can J Gastroenterol 23:273-8. 2009
    ..Nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C feature steatosis and insulin resistance (IR), conditions associated with the metabolic syndrome (MS)...
  19. doi Hepatitis C and diabetes: the inevitable coincidence?
    Amedeo Lonardo
    Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    Expert Rev Anti Infect Ther 7:293-308. 2009
    ....
  20. ncbi Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease
    Amedeo Lonardo
    Division of Internal Medicine and Gastroenterology, Modena City Hospital, Italy
    Gastroenterology 126:586-97. 2004
    ..Future therapy should be aimed at exploiting the interactions of HCV with host insulin and lipid metabolism, particularly in nonresponders to standard antiviral schedules...
  21. ncbi Genetic polymorphisms in non-alcoholic fatty liver disease: interleukin-6-174G/C polymorphism is associated with non-alcoholic steatohepatitis
    L Carulli
    Dipartimento di Medicina, Endocrinologia, Metabolismo e Geriatria, Nuvo Ospedale Civile S Agostino Estense, Via Giardini 1355, 41100 Modena, Italy
    Dig Liver Dis 41:823-8. 2009
    ..Environmental and genetic factors play a role in the pathogenesis and natural history of non-alcoholic fatty liver disease (NAFLD)...
  22. ncbi Review article: the metabolic syndrome and non-alcoholic fatty liver disease
    P Loria
    University of Modena and Reggio Emilia, Modena, Italy
    Aliment Pharmacol Ther 22:31-6. 2005
    ....
  23. ncbi Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease: an open question
    P Loria
    Department of Medicine, Endocrinology, Metabolism and Geriatrics, University of Modena and Reggio Emilia, Modena, Italy
    Nutr Metab Cardiovasc Dis 17:684-98. 2007
    ..To review available data concerning the basic science and epidemiological-clinical evidence for an association of NAFLD and cardiovascular disease...
  24. ncbi Gallstone disease in non-alcoholic fatty liver: prevalence and associated factors
    Paola Loria
    Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    J Gastroenterol Hepatol 20:1176-84. 2005
    ..Insulin resistance is a risk factors for non-alcoholic fatty liver disease (NAFLD) and for gallstone disease (GD). Aims of the present study were to assess the prevalence of and factors associated with GD in unselected patients with NAFLD...
  25. doi Practice guidelines for the diagnosis and management of nonalcoholic fatty liver disease. A decalogue from the Italian Association for the Study of the Liver (AISF) Expert Committee
    P Loria
    Dipartimento di Medicina Interna, Endocrinologia, Metabolismo e Geriatria, Universita di Modena e Reggio Emilia, Nuovo Ospedale Sant Agostino Estense di Baggiovara, Via del Pozzo 71, Modena, MO, Italy
    Dig Liver Dis 42:272-82. 2010
    ....
  26. ncbi Fatty liver and nonalcoholic steatohepatitis. Where do we stand and where are we going?
    A Lonardo
    Division of Internal Medicine and Gastroenterology, Modena City Hospital, Modena, Italy
    Dig Dis 17:80-9. 1999
    ..Nonalcoholic steatohepatitis (NASH) is increasingly recognized as a cause of liver failure, sometimes recurring following transplantation. Recent data on both conditions are critically reviewed...
  27. ncbi Is cholangiocarcinoma another complication of insulin resistance: a report of three cases
    E Michelini
    Dipartimento Integrato di Medicina, Endocrinologia, Metabolismo, e Geriatria Nuovo Ospedale Civile S Agostino Estense di Baggiovara, Modena, Italy
    Metab Syndr Relat Disord 5:194-202. 2007
    ..Studies are needed to confirm our hypothesis that IR is a risk factor for the development of ICC...
  28. ncbi Should nonalcoholic fatty liver disease be renamed?
    Paola Loria
    Dipartimento di Medicina Interna Università di Modena e Reggio Emilia, Modena, Italy
    Dig Dis 23:72-82. 2005
    ..None of the synonyms of nonalcoholic fatty liver disease (NAFLD) include clinical correlates nor do they mention insulin resistance, a recognized determinant of the etiopathogenesis and natural history of NAFLD...
  29. doi Is liver fat detrimental to vessels?: intersections in the pathogenesis of NAFLD and atherosclerosis
    Paola Loria
    Department of Internal Medicine, Metabolism, Endocrinology and Geriatrics, University of Modena and Reggio Emilia, Modena, Italy
    Clin Sci (Lond) 115:1-12. 2008
    ..On the research side, studies should focus on interventions aimed at restoring energy homoeostasis in lipotoxic tissues and at improving hepatic (micro)vascular blood supply...
  30. doi Endocrine and liver interaction: the role of endocrine pathways in NASH
    Paola Loria
    Dipartimento di Endocrinologia, Metabolismo e Geriatria, Universita degli Studi di Modena e Reggio Emilia, NOCSAE Baggiovara, Modena, MO, Italy
    Nat Rev Gastroenterol Hepatol 6:236-47. 2009
    ..Clinicians should, therefore, be aware of the potential role of endocrine disorders in patients with cryptogenic liver disease and of the effects of liver function on the endocrine system...
  31. ncbi Phenotypic expression of familial hypobetalipoproteinemia in three kindreds with mutations of apolipoprotein B gene
    P Tarugi
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, Via Campi 287, I 41100 Modena, Italy
    J Lipid Res 42:1552-61. 2001
    ....
  32. ncbi Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes
    Matteo Ricchi
    Dipartimento Integrato di Medicina Interna, Endocrinologia, Metabolismo and Geriatria, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy
    J Gastroenterol Hepatol 24:830-40. 2009
    ..However, to what degree these effects are mediated by steatosis extent is unknown...
  33. ncbi [Multifactorial hepatopathy in a patient with biliopancreatic diversion]
    Milena Greco
    Unità Operativa di Medicina Interna e Gastroenterologia, Ospedale Civile di Modena
    Ann Ital Med Int 18:99-103. 2003
    ..The multifactorial pathogenesis of the liver disease observed in our patient included obesity, antrectomy, heavy alcohol consumption, bacterial overgrowth, and protein malnutrition...
  34. ncbi Pediatric gallstone disease in familial hypobetalipoproteinemia
    Sandra Lancellotti
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    J Hepatol 43:188-91. 2005
    ..FHBL should be considered as a possible predisposing factor for cholesterol gallstones in children (190)...
  35. ncbi Non-organ-specific autoantibodies in nonalcoholic fatty liver disease: prevalence and correlates
    Paola Loria
    Dipartimento di Medicina Interna Medicina III, Universita degli Studi di Modena e Reggio Emilia, Policlinico, Via del Pozzo 71, 41100 Modena, MO, Italy
    Dig Dis Sci 48:2173-81. 2003
    ..In conclusion, NOSA positivity in NAFLD is more prevalent than in the general population. High-titre ANA but not SMA positivity is associated with insulin resistance...
  36. doi Statins in liver disease: a molehill, an iceberg, or neither?
    Curtis K Argo
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA, USA
    Hepatology 48:662-9. 2008
    ..Research using histological endpoints is urgently needed to determine the indications and contraindications of this extraordinary class of agents in patients with chronic liver disease...
  37. ncbi Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver
    Paola Loria
    Hepatology 39:1748; author reply 1749. 2004
  38. doi The hepatitis C virus-associated dysmetabolic syndrome
    Amedeo Lonardo
    Hepatology 48:1018-9; author reply 1019. 2008
  39. ncbi The prevalence of autoantibodies and autoimmune hepatitis in patients with nonalcoholic fatty liver disease
    Paolo Loria
    Am J Gastroenterol 100:1200-1; author reply 1201-2. 2005
  40. ncbi Gender, fatty liver and GGT
    Lucia Carulli
    Hepatology 44:278-9. 2006
  41. ncbi Apolipoprotein synthesis in nonalcoholic steatohepatitis
    Amedeo Lonardo
    Hepatology 36:514-5; author reply 515. 2002
  42. ncbi Growth hormone plasma levels in nonalcoholic fatty liver disease
    Amedeo Lonardo
    Am J Gastroenterol 97:1071-2. 2002
  43. ncbi The neck-liver axis. Madelung disease as further evidence for an impact of body fat distribution on hepatic histology
    Stefano Ballestri
    Hepatology 47:361-2. 2008
  44. ncbi Statins and HCV: a complex issue
    Amedeo Lonardo
    Hepatology 45:257. 2007