Gian Paolo Littarru

Summary

Country: Italy

Publications

  1. ncbi request reprint Coenzyme Q10 and statins: biochemical and clinical implications
    Gian Paolo Littarru
    Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, 60131 Ancona, Italy
    Mitochondrion 7:S168-74. 2007
  2. ncbi request reprint Bioenergetic and antioxidant properties of coenzyme Q10: recent developments
    Gian Paolo Littarru
    Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, Ancona 60131, Italy
    Mol Biotechnol 37:31-7. 2007
  3. doi request reprint Clinical aspects of coenzyme Q10: an update
    Gian Paolo Littarru
    Department of Biochemistry, Biology and Genetics, Polytechnic University of the Marche, Ancona, Italy
    Nutrition 26:250-4. 2010
  4. doi request reprint Coenzyme Q(10) , endothelial function, and cardiovascular disease
    Gian Paolo Littarru
    Department of Biochemistry, Biology and Genetics, Marche Polytechnic University, Ancona, Italy
    Biofactors 37:366-73. 2011
  5. ncbi request reprint Clinical aspects of coenzyme Q10: an update
    Gian Paolo Littarru
    Institute of Biochemistry, Polytechnic University of Marche, Via Ranieri, Ancona, Italy
    Curr Opin Clin Nutr Metab Care 8:641-6. 2005
  6. doi request reprint Prolonged coenzyme Q10 treatment in Down syndrome patients: effect on DNA oxidation
    Luca Tiano
    Department of Biochemistry Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
    Neurobiol Aging 33:626.e1-8. 2012
  7. ncbi request reprint Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study
    Luca Tiano
    Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, 60100 Ancona, Italy
    Eur Heart J 28:2249-55. 2007
  8. doi request reprint Olive oil supplemented with Coenzyme Q(10): effect on plasma and lipoprotein oxidative status
    Francesca Bruge
    Department of Clinical and Dental Sciences, Polytechnic University of Marche, Ancona, Italy
    Biofactors 38:249-56. 2012
  9. doi request reprint Nanostructured lipid carriers loaded with CoQ10: effect on human dermal fibroblasts under normal and UVA-mediated oxidative conditions
    Francesca Bruge
    Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Universita Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy
    Int J Pharm 455:348-56. 2013
  10. ncbi request reprint Assay of coenzyme Q10 in plasma by a single dilution step
    Gian Paolo Littarru
    Institute of Biochemistry, Universita Politecnica delle Marche, Ancona, Italy
    Methods Enzymol 378:170-6. 2004

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Coenzyme Q10 and statins: biochemical and clinical implications
    Gian Paolo Littarru
    Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, 60131 Ancona, Italy
    Mitochondrion 7:S168-74. 2007
    ....
  2. ncbi request reprint Bioenergetic and antioxidant properties of coenzyme Q10: recent developments
    Gian Paolo Littarru
    Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, Ancona 60131, Italy
    Mol Biotechnol 37:31-7. 2007
    ..The effect was more pronounced in patients with low basal values of ecSOD. Finally, we summarize the findings, also from our laboratory, on the implications of CoQ10 in seminal fluid integrity and sperm cell motility...
  3. doi request reprint Clinical aspects of coenzyme Q10: an update
    Gian Paolo Littarru
    Department of Biochemistry, Biology and Genetics, Polytechnic University of the Marche, Ancona, Italy
    Nutrition 26:250-4. 2010
    ..Moreover, for the first time CoQ(10) was found to decrease the incidence of preeclampsia in pregnancy. The ability of CoQ(10) to mitigate headache symptoms in adults was also verified in pediatric and adolescent populations...
  4. doi request reprint Coenzyme Q(10) , endothelial function, and cardiovascular disease
    Gian Paolo Littarru
    Department of Biochemistry, Biology and Genetics, Marche Polytechnic University, Ancona, Italy
    Biofactors 37:366-73. 2011
    ..The effect of CoQ(10) on endothelial dysfunction in ischemic heart disease is also reviewed together with recent data highlighting that treatment with CoQ(10) increases extracellular SOD activity...
  5. ncbi request reprint Clinical aspects of coenzyme Q10: an update
    Gian Paolo Littarru
    Institute of Biochemistry, Polytechnic University of Marche, Via Ranieri, Ancona, Italy
    Curr Opin Clin Nutr Metab Care 8:641-6. 2005
    ..These findings also give further insight into the biochemical mechanisms underlying clinical involvement of coenzyme Q10...
  6. doi request reprint Prolonged coenzyme Q10 treatment in Down syndrome patients: effect on DNA oxidation
    Luca Tiano
    Department of Biochemistry Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
    Neurobiol Aging 33:626.e1-8. 2012
    ..Our results highlight an age-specific reduction in the percentage of cells showing the highest amount of oxidized bases, indicating a potential role of CoQ(10) in modulating DNA repair mechanisms...
  7. ncbi request reprint Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study
    Luca Tiano
    Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, 60100 Ancona, Italy
    Eur Heart J 28:2249-55. 2007
    ..Moreover, there is a strong correlation between endothelium-bound ecSOD and the ED dilation of conduit arteries. CoQ(10) has been recently shown to improve the ED relaxation in diabetic patients...
  8. doi request reprint Olive oil supplemented with Coenzyme Q(10): effect on plasma and lipoprotein oxidative status
    Francesca Bruge
    Department of Clinical and Dental Sciences, Polytechnic University of Marche, Ancona, Italy
    Biofactors 38:249-56. 2012
    ..These changes are associated with a decreased susceptibility of plasma lipoproteins to peroxidation associated with a chain-breaking antioxidant activity of the formulation...
  9. doi request reprint Nanostructured lipid carriers loaded with CoQ10: effect on human dermal fibroblasts under normal and UVA-mediated oxidative conditions
    Francesca Bruge
    Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Universita Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy
    Int J Pharm 455:348-56. 2013
    ....
  10. ncbi request reprint Assay of coenzyme Q10 in plasma by a single dilution step
    Gian Paolo Littarru
    Institute of Biochemistry, Universita Politecnica delle Marche, Ancona, Italy
    Methods Enzymol 378:170-6. 2004
  11. ncbi request reprint Oxidative stress, endothelial function and coenzyme Q10
    Romualdo Belardinelli
    Cardiologia Riabilitativa Lancisi, Azienda Ospedali Riuniti, Ancona, Italy
    Biofactors 32:129-33. 2008
    ..Future studies are needed to inquire whether these effects may translate into benefits in clinical practice...
  12. doi request reprint Plasma coenzyme Q10 is increased during gestational diabetes
    Stefano Raffaele Giannubilo
    Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
    Diabetes Res Clin Pract 94:230-5. 2011
    ..To determine plasma CoQ(10) concentration in the course of gestational diabetes mellitus...
  13. doi request reprint Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation
    Francesca Bruge
    Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Via Ranieri, 60100 Ancona, Italy
    Br J Nutr 106:1058-62. 2011
    ..We conclude that regular consumption of MK-7-enriched olive oil may constitute a valid approach in order to preserve some key biochemical mechanisms controlling bone mineralisation...
  14. ncbi request reprint Coenzyme Q10 improves contractility of dysfunctional myocardium in chronic heart failure
    Romualdo Belardinelli
    Lancisi Heart Institute, Department of Cardiology and Cardiac Surgery, Ancona, Italy
    Biofactors 25:137-45. 2005
    ..There is evidence that plasma CoQ(10) levels decrease in patients with advanced chronic heart failure (CHF)...
  15. doi request reprint A novel Real Time PCR strategy to detect SOD3 SNP using LNA probes
    Francesca Bruge
    Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
    Mutat Res 669:80-4. 2009
    ..Moreover, identification of patients with lowered vascular antioxidant defences could address pharmacogenomical approaches to the therapy of cardiovascular diseases...
  16. ncbi request reprint Placental CoQ10 levels in HELLP syndrome
    Stefano R Giannubilo
    Department of Obstetrics and Gynecology, Polytechnic University of the Marche, Ancona, Italy
    Biofactors 25:159-63. 2005
    ..The increase in placental CoQ(10) in this syndrome might derive from a compensatory mechanism in a situation of increased oxidative stress...
  17. ncbi request reprint NAD(P)H:quinone oxidoreductase (NQO1) loss of function in Burkitt's lymphoma cell lines
    Francesca Bruge
    Institute of Biochemistry, Polytechnic University of the Marche, Ancona, Italy
    Biofactors 32:71-81. 2008
    ..On the other hand, this result suggests a careful re-evaluation of data concerning loss of NQO1 activity and polymorphisms in tumour cells...
  18. ncbi request reprint Assessment of DNA damage in Down Syndrome patients by means of a new, optimised single cell gel electrophoresis technique
    Luca Tiano
    Institute of Biochemistry, Polytechnic University of the Marche, Ancona, Italy
    Biofactors 25:187-95. 2005
    ....
  19. ncbi request reprint Assay of coenzyme Q(10) in plasma by a single dilution step
    Fabrizio Mosca
    Institute of Biochemistry, Institute of Biomedical Sciences, Faculty of Medicine, University of Ancona, Via Ranieri, 60131 Ancona, Italy
    Anal Biochem 305:49-54. 2002
    ..99 (P < 0.0001) was found with a reference electrochemical detection method. Within run precision showed a CV% of 1.6 for samples approaching normal values (1.02 microM). Day-to-day precision was also close to 2%...
  20. doi request reprint Fluorescence studies of the interactions of ubiquinol-10 with liposomes
    Rosamaria Fiorini
    Biochemistry Institute, Marche Polytechnic University, Ancona, Italy
    Photochem Photobiol 84:209-14. 2008
    ..The results indicate that ubiquinol-10 molecules are mainly located at the polar-lipid interface, inducing changes in the physico-chemical properties of the bilayer microenvironment...
  21. ncbi request reprint Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q10, nicotinamide, riboflavin and pantothenic acid in the rat
    Romina Vargiu
    Section of Human Physiology and Nutrition, Department of Applied Sciences to Biosystems, University of Cagliari, Via Porcell 4, I 09124, Cagliari, Italy
    Physiol Behav 76:257-63. 2002
    ..The present results indicate that supplementation with the combination of the above mentioned substances elicits positive functional changes on motor performance of skeletal, cardiac and smooth muscle of the rat...
  22. ncbi request reprint Coenzyme Q10: another biochemical alteration linked to infertility in varicocele patients?
    Antonio Mancini
    Institute of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy
    Metabolism 52:402-6. 2003
    ..These data suggest a pathophysiological role of CoQ10 in seminal plasma and a possible molecular defect in VAR...
  23. ncbi request reprint Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA
    Siro Passi
    Centro Invecchiamento Cellulare, I D I IRCCS, Roma, Italy
    Biofactors 18:113-24. 2003
    ....
  24. ncbi request reprint Lipophilic antioxidants in human sebum and aging
    Siro Passi
    IDI IRCCS, Rome, Italy
    Free Radic Res 36:471-7. 2002
    ..The same UV dose when applied in the absence of vit. E and CoQ10 produced a 90% decrease of squalene...
  25. ncbi request reprint Coenzyme Q10 and exercise training in chronic heart failure
    Romualdo Belardinelli
    Lancisi Heart Institute, Via Conca, 71 Torrette di Ancona, Italy
    Eur Heart J 27:2675-81. 2006
    ..However, it is not known whether oral CoQ(10) supplementation may improve cardiocirculatory efficiency and endothelial function in patients with CHF...
  26. ncbi request reprint The combined use of oral and topical lipophilic antioxidants increases their levels both in sebum and stratum corneum
    Siro Passi
    Centro Invecchiamento Cellulare, I D I IRCCS, Rome, Italy
    Biofactors 18:289-97. 2003
    ..Therefore topical application of the antioxidants was able to increase their level in sebum, while the concomitant oral administration also affected the levels of vit E and CoQ10 in the stratum corneum...
  27. doi request reprint Evaluation of antioxidant systems (coenzyme Q10 and total antioxidant capacity) in morbid obesity before and after biliopancreatic diversion
    Antonio Mancini
    Endocrinology, Catholic University of the Sacred Heart, 00135 Rome, Italy
    Metabolism 57:1384-9. 2008
    ..5 +/- 5.3 vs 66 +/- 5.3). The mechanisms of these phenomena remain to be established. These data suggest the importance of correcting postsurgical metabolic complications, in these clinical populations, with CoQ(10) supplementation...