Research Topics
Species | Gian Paolo LittarruSummaryCountry: Italy Publications
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Publications
Coenzyme Q10 and statins: biochemical and clinical implicationsGian Paolo Littarru
Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, 60131 Ancona, Italy
Mitochondrion 7:S168-74. 2007....- Bioenergetic and antioxidant properties of coenzyme Q10: recent developmentsGian Paolo Littarru
Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, Ancona 60131, Italy
Mol Biotechnol 37:31-7. 2007..The effect was more pronounced in patients with low basal values of ecSOD. Finally, we summarize the findings, also from our laboratory, on the implications of CoQ10 in seminal fluid integrity and sperm cell motility... 
Clinical aspects of coenzyme Q10: an updateGian Paolo Littarru
Department of Biochemistry, Biology and Genetics, Polytechnic University of the Marche, Ancona, Italy
Nutrition 26:250-4. 2010..Moreover, for the first time CoQ(10) was found to decrease the incidence of preeclampsia in pregnancy. The ability of CoQ(10) to mitigate headache symptoms in adults was also verified in pediatric and adolescent populations...- Coenzyme Q(10) , endothelial function, and cardiovascular diseaseGian Paolo Littarru
Department of Biochemistry, Biology and Genetics, Marche Polytechnic University, Ancona, Italy
Biofactors 37:366-73. 2011..The effect of CoQ(10) on endothelial dysfunction in ischemic heart disease is also reviewed together with recent data highlighting that treatment with CoQ(10) increases extracellular SOD activity... - Clinical aspects of coenzyme Q10: an updateGian Paolo Littarru
Institute of Biochemistry, Polytechnic University of Marche, Via Ranieri, Ancona, Italy
Curr Opin Clin Nutr Metab Care 8:641-6. 2005..These findings also give further insight into the biochemical mechanisms underlying clinical involvement of coenzyme Q10... - Prolonged coenzyme Q10 treatment in Down syndrome patients: effect on DNA oxidationLuca Tiano
Department of Biochemistry Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
Neurobiol Aging 33:626.e1-8. 2012..Our results highlight an age-specific reduction in the percentage of cells showing the highest amount of oxidized bases, indicating a potential role of CoQ(10) in modulating DNA repair mechanisms... - Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled studyLuca Tiano
Institute of Biochemistry, Polytechnic University of the Marche, Via Ranieri, 60100 Ancona, Italy
Eur Heart J 28:2249-55. 2007..Moreover, there is a strong correlation between endothelium-bound ecSOD and the ED dilation of conduit arteries. CoQ(10) has been recently shown to improve the ED relaxation in diabetic patients... - Olive oil supplemented with Coenzyme Q(10): effect on plasma and lipoprotein oxidative statusFrancesca Bruge
Department of Clinical and Dental Sciences, Polytechnic University of Marche, Ancona, Italy
Biofactors 38:249-56. 2012..These changes are associated with a decreased susceptibility of plasma lipoproteins to peroxidation associated with a chain-breaking antioxidant activity of the formulation... - Oxidative stress, endothelial function and coenzyme Q10Romualdo Belardinelli
Cardiologia Riabilitativa Lancisi, Azienda Ospedali Riuniti, Ancona, Italy
Biofactors 32:129-33. 2008..Future studies are needed to inquire whether these effects may translate into benefits in clinical practice... - Plasma coenzyme Q10 is increased during gestational diabetesStefano Raffaele Giannubilo
Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
Diabetes Res Clin Pract 94:230-5. 2011..To determine plasma CoQ(10) concentration in the course of gestational diabetes mellitus... - Coenzyme Q10 improves contractility of dysfunctional myocardium in chronic heart failureRomualdo Belardinelli
Lancisi Heart Institute, Department of Cardiology and Cardiac Surgery, Ancona, Italy
Biofactors 25:137-45. 2005..There is evidence that plasma CoQ(10) levels decrease in patients with advanced chronic heart failure (CHF)... - Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylationFrancesca Bruge
Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Via Ranieri, 60100 Ancona, Italy
Br J Nutr 106:1058-62. 2011..We conclude that regular consumption of MK-7-enriched olive oil may constitute a valid approach in order to preserve some key biochemical mechanisms controlling bone mineralisation... - A novel Real Time PCR strategy to detect SOD3 SNP using LNA probesFrancesca Bruge
Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
Mutat Res 669:80-4. 2009..Moreover, identification of patients with lowered vascular antioxidant defences could address pharmacogenomical approaches to the therapy of cardiovascular diseases... - NAD(P)H:quinone oxidoreductase (NQO1) loss of function in Burkitt's lymphoma cell linesFrancesca Bruge
Institute of Biochemistry, Polytechnic University of the Marche, Ancona, Italy
Biofactors 32:71-81. 2008..On the other hand, this result suggests a careful re-evaluation of data concerning loss of NQO1 activity and polymorphisms in tumour cells... - Assessment of DNA damage in Down Syndrome patients by means of a new, optimised single cell gel electrophoresis techniqueLuca Tiano
Institute of Biochemistry, Polytechnic University of the Marche, Ancona, Italy
Biofactors 25:187-95. 2005.... - Fluorescence studies of the interactions of ubiquinol-10 with liposomesRosamaria Fiorini
Biochemistry Institute, Marche Polytechnic University, Ancona, Italy
Photochem Photobiol 84:209-14. 2008..The results indicate that ubiquinol-10 molecules are mainly located at the polar-lipid interface, inducing changes in the physico-chemical properties of the bilayer microenvironment... - Placental CoQ10 levels in HELLP syndromeStefano R Giannubilo
Department of Obstetrics and Gynecology, Polytechnic University of the Marche, Ancona, Italy
Biofactors 25:159-63. 2005..The increase in placental CoQ(10) in this syndrome might derive from a compensatory mechanism in a situation of increased oxidative stress... - Assay of coenzyme Q10 in plasma by a single dilution stepGian Paolo Littarru
Institute of Biochemistry, , Ancona, Italy
Methods Enzymol 378:170-6. 2004 - Assay of coenzyme Q(10) in plasma by a single dilution stepFabrizio Mosca
Institute of Biochemistry, Institute of Biomedical Sciences, Faculty of Medicine, University of Ancona, Via Ranieri, 60131 Ancona, Italy
Anal Biochem 305:49-54. 2002..99 (P < 0.0001) was found with a reference electrochemical detection method. Within run precision showed a CV% of 1.6 for samples approaching normal values (1.02 microM). Day-to-day precision was also close to 2%... - Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q10, nicotinamide, riboflavin and pantothenic acid in the ratRomina Vargiu
Section of Human Physiology and Nutrition, Department of Applied Sciences to Biosystems, University of Cagliari, Via Porcell 4, I-09124, Cagliari, Italy
Physiol Behav 76:257-63. 2002..The present results indicate that supplementation with the combination of the above mentioned substances elicits positive functional changes on motor performance of skeletal, cardiac and smooth muscle of the rat... - Coenzyme Q10: another biochemical alteration linked to infertility in varicocele patients?Antonio Mancini
Institute of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy
Metabolism 52:402-6. 2003..These data suggest a pathophysiological role of CoQ10 in seminal plasma and a possible molecular defect in VAR... - Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFASiro Passi
Centro Invecchiamento Cellulare, I D I IRCCS, Roma, Italy
Biofactors 18:113-24. 2003.... - Lipophilic antioxidants in human sebum and agingSiro Passi
IDI-IRCCS, Rome, Italy
Free Radic Res 36:471-7. 2002..The same UV dose when applied in the absence of vit. E and CoQ10 produced a 90% decrease of squalene... - Coenzyme Q10 and exercise training in chronic heart failureRomualdo Belardinelli
Lancisi Heart Institute, Via Conca, 71 Torrette di Ancona, Italy
Eur Heart J 27:2675-81. 2006..However, it is not known whether oral CoQ(10) supplementation may improve cardiocirculatory efficiency and endothelial function in patients with CHF... - The combined use of oral and topical lipophilic antioxidants increases their levels both in sebum and stratum corneumSiro Passi
Centro Invecchiamento Cellulare, I D I IRCCS, Rome, Italy
Biofactors 18:289-97. 2003..Therefore topical application of the antioxidants was able to increase their level in sebum, while the concomitant oral administration also affected the levels of vit E and CoQ10 in the stratum corneum... - Evaluation of antioxidant systems (coenzyme Q10 and total antioxidant capacity) in morbid obesity before and after biliopancreatic diversionAntonio Mancini
Endocrinology, Catholic University of the Sacred Heart, 00135 Rome, Italy
Metabolism 57:1384-9. 2008..5 +/- 5.3 vs 66 +/- 5.3). The mechanisms of these phenomena remain to be established. These data suggest the importance of correcting postsurgical metabolic complications, in these clinical populations, with CoQ(10) supplementation...