Giuseppe Lippi

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..These results demonstrate that activated partial thromboplastin time has an excellent diagnostic sensitivity and a satisfactory specificity for identifying isolated von Willebrand factor deficiencies...

..According to our experimental conditions, a 5-10 min centrifuge time at 1500 x g may be suitable for primary tubes collected for routine coagulation testing...

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..Although there is information on biochemical markers of muscle and cardiac damage following strenuous exercise, little is known about the kinetics of these markers in athletes performing sub-maximal exercise...

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..In this review, the most recent advances in our understanding of the mechanisms by which ABO blood group determines plasma VWF levels and their clinical impact will be discussed...

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..To investigate the relationship between thyroid and kidney function...

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..Although creatinine-based estimates of glomerular filtration rate (GFR) overcome some shortcomings of serum creatinine, there is scarce information on their use in endurance athletes...

..Several Olympic records are regularly broken during the Olympics. Will this be the case for Beijing?..

..These results attest that medium to high strains of running in healthy, middle-aged, trained individuals do not cause renal damage, but a limited and temporary decline in renal function...

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..The diagnostic approach to haemostatic defects in the newborn is challenging and requires appropriate interpretation of coagulation tests according to reference values dependent on the postnatal age...

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..However, little information is available on the interaction between GGT activity and traditional or emerging markers of cardiovascular risk...

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..Since the FVIII activity is frequently normal in patients with mild type 1 or 2 von Willebrand disease (VWD), there is controversy whether FVIII testing should accompany VWF Antigen (VWF:Ag) assay...

..Critical values' reporting is an essential requisite for clinical laboratories. Local policies were investigated within an indicative cohort of Italian laboratories to monitor the situation and establish a performance benchmark...

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..Pharmacies were historically involved in clinical chemistry. At the European level, the existing pharmacy syllabus gives to students and postgraduates the physiopathological knowledge a good basis for such an evolution...

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..A strong independent association has been recently observed between elevated red blood cell distribution width (RDW) and increased incidence of cardiovascular events...

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..12; P = 0.24). Taken together, these results support the existence of an epidemiologic association between air pollution and acute cardiovascular events...

..We assessed whether there is an association between RDW at admission and cardiac troponin T (cTnT) elevation in patients with chest pain...

..Despite remarkable progress, the diagnosis of acute coronary syndromes (ACS) is still challenging...

..Safety transport boxes are increasingly used to ship laboratory specimens but there is little information on their capacity to maintain suitable transportation temperatures...

..To evaluate feasibility and reliability of measuring saliva cortisol in athletes...

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..Should these findings be confirmed, consideration should be given to prevent thrombotic complications in patients with hyperthyroidism...

..Results of studies on Lp(a) in patients with impaired renal function are contradictory, and no information is available on the association between Lp(a) and estimated glomerular filtration rate and cystatin C...

..Moreover, in those patients presenting with high serum GGT activity, it would not be necessary to reduce the dosage, discontinue the drug or change to a different anti-epileptic medication...

..To investigate the relationship between fasting plasma glucose (FPG) and shortened activated partial thromboplastin time (APTT), an independent risk factor for thrombosis...

..Because of its potential value in the diagnosis of the thalassaemia syndromes, the effective separation of HbA(2) from HbE can provide clinical laboratories with a valuable information for the diagnostic reasoning...

..However, the mechanism(s) underlying this association remains unclear. Since impaired kidney function is a well-known risk factor for cardiovascular disease, we assessed whether RDW is associated with decreased kidney function...

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..Although there is no definitive evidence, the use of small-gauge needles for venipuncture is usually discouraged to reduce the chance of producing unsuitable specimens...

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..However, misuse of iron therapy, occasionally resulting in iron overload, is not free from metabolic risks...

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..This article aims to provide a comprehensive review of the current literature on this topic, attempting to suggest a suitable approach to the puzzling issue of preoperative laboratory testing...

..It is traditionally accepted that hemolytic samples are unsuitable for coagulation assays because of the release of hemoglobin, intracellular components, and thromboplastic substances from damaged blood cells...

..The results of this investigation suggest that, within certain limitations for parameters derived or calculated from cellular volumes, blood specimens stored for as long as 24 hours at 4 degrees C may be suitable for hematologic testing...

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..If ongoing and future studies confirm their role in probability-based models risk assessment, a new era in the diagnostic approach to ACS may be dawning...

..Despite the acceptable analytical performances, we demonstrated that standardization and harmonization of results in SMBG have not been fully achieved...

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..This rightward shift is usually considered a helpful adaptation, enabling a relatively more efficiently mechanism of oxygen delivery to the peripheral tissues, enabling physiological advantages during exercise and improved recovery...

..Therefore, the present investigation evaluated the influence of in vitro blood cell lysis on routine clinical chemistry testing...

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..Although there is as yet no direct or anecdotal evidence of cobalt chloride administration to athletes, its use should be warned against as being not only unfair but potentially dangerous...

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..Increased levels of troponins, especially TnT, are frequently observed in patients on chronic hemodialysis (HD), reflecting ongoing and subclinical myocardial damage...

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..Particularly, biochemical risk factors and markers play a crucial role in all steps of atherosclerosis process, and entail a great relevance in risk stratification and early prevention...

..Moreover, IMA might be reliably applied to stratify the long-term risk of these patients, but not for diagnosing an ACS during or immediately post-HD...

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..These adaptive changes might be beneficial in the long term, offering some protection against the risk of thrombosis and adverse cardiovascular events in physically active individuals...

..The aim of this study was the evaluation of the early subclinical cardiac involvement in patients with systemic sclerosis by means of non-invasive laboratory cardiac markers...

..The present survey investigated the development of several pre-analytical processes within a representative cohort of Italian clinical laboratories...

..The aim of this review is to discuss the biochemistry, physiology, and complications of blood doping and to provide an update on current antidoping policies...

..These findings suggest that obesity itself may not be a sufficient risk factor for atherogenic dyslipidemia or poor glycemic control in people with type 2 diabetes...

..It is unclear whether they are independent risk factors or simply markers, reflecting association with other traditional risk factors...

..To evaluate the efficacy and safety of the factor VIII/von Willebrand factor concentrate Haemate-P as replacement therapy in patients with von Willebrand's disease (VWD) undergoing surgical or invasive procedures...

..For the time being, the storage of athletes' blood samples to allow testing and sanctioning of guilty athletes once a definitive test has been introduced may represent a reliable deterrent policy...

..The clinical significance of this finding deserves further investigation, especially in patients at higher risk of heart failure...

..The introduction of early and reliable biomarkers of AMI should hence be acknowledged, since they would increase the efficiency of the diagnostic process...

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..Little is known so far on the lipid profile of these patients...

..We believe that, due to the adverse effect on haemostasis, the administration of third-generation oral contraceptives should be carefully considered in women carrying prothrombotic abnormalities...

..To assess the association between circulating levels of soluble CD40 ligand (sCD40L), an emerging cardiovascular risk factor, and gamma-glutamyltransferase (GGT) activity concentrations in Type 1 diabetic subjects...

..We hypothesize that neither a heavy and regular physical exercise nor the extensive and prolonged mechanical involvement of the prostate region by the bicycle riding have significant influence on release of both PSA and fPSA...

..Cost-effectiveness suggests that this parameter should be a first-line tool to monitor iron requirements in clinical practice...

..We have prospectively assessed the effects of plasma HDL-C levels on the incidence of CKD in a large cohort of type 2 diabetic patients...

..The VWF-containing concentrates Fanhdi and Haemate-P, added to FVIII-deficient plasma with the presence of inhibitor, generate more thrombin than do the purified concentrates Hemofil-M and Kogenate Bayer...

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..Thereby, the inclusion of those tests, along with the TC/HDL ratio and other more conventional analyses in panels for the evaluation of the cardiovascular risk might be profitable in terms of effectual prevention...

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..We conclude that TG parameters tentatively could be a tool to tailor the global haemostatic capacity in haemophilic patients...

..These simple assays can supplement classical coagulation test methods to identify most inappropriate blood collections and validate sample rejection...

..Besides age and blood group, the variability introduced by the presence of an acute phase response might contribute to decrease the clinical usefulness of this measurement...

..There is debate on the influence of haemodialysis (HD) on lipoprotein(a)...

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