Giuseppe Lauria

Summary

Country: Italy

Publications

  1. doi Short- and intermediate-term efficacy of buprenorphine TDS in chronic painful neuropathies
    Paola Penza
    Neuromuscular Diseases Unit, Fondazione IRCCS National Neurological Institute Carlo Besta, Milan, Italy
    J Peripher Nerv Syst 13:283-8. 2008
  2. ncbi Small fibre neuropathies
    Giuseppe Lauria
    Immunology and Muscular Pathology Unit, National Neurological Institute Carlo Besta, Milan, Italy
    Curr Opin Neurol 18:591-7. 2005
  3. doi Docetaxel-induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model
    Ilaria Roglio
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    J Peripher Nerv Syst 14:36-44. 2009
  4. doi The neuroprotective effect of erythropoietin in docetaxel-induced peripheral neuropathy causes no reduction of antitumor activity in 13762 adenocarcinoma-bearing rats
    Ilaria Cervellini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Neurotox Res 18:151-60. 2010
  5. doi Continuous buprenorphine delivery effect in streptozotocine-induced painful diabetic neuropathy in rats
    Annalisa Canta
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Milan, Italy
    J Pain 10:961-8. 2009
  6. ncbi Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies
    Giuseppe Lauria
    Neuromuscular Diseases, National Neurological Institute Carlo Besta, Milan, Italy
    J Peripher Nerv Syst 11:262-71. 2006
  7. ncbi Cisplatin-induced peripheral neuropathy: neuroprotection by erythropoietin without affecting tumour growth
    Roberto Bianchi
    Mario Negri Institute of Pharmacological Research, Milan, Italy
    Eur J Cancer 43:710-7. 2007
  8. doi "Burning tongue" and "burning tip": the diagnostic challenge of the burning mouth syndrome
    Paola Penza
    Neuromuscular Diseases Unit, IRCCS Foundation Carlo Besta National Neurological Institute, Milan, Italy
    Clin J Pain 26:528-32. 2010
  9. ncbi Protective effect of erythropoietin and its carbamylated derivative in experimental Cisplatin peripheral neurotoxicity
    Roberto Bianchi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Clin Cancer Res 12:2607-12. 2006
  10. doi Small fiber neuropathy: is skin biopsy the holy grail?
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
    Curr Diab Rep 12:384-92. 2012

Collaborators

Detail Information

Publications32

  1. doi Short- and intermediate-term efficacy of buprenorphine TDS in chronic painful neuropathies
    Paola Penza
    Neuromuscular Diseases Unit, Fondazione IRCCS National Neurological Institute Carlo Besta, Milan, Italy
    J Peripher Nerv Syst 13:283-8. 2008
    ..In our study, which needs to be confirmed by a controlled trial, buprenorphine TDS induced clinically meaningful pain relief in about 40% of patients with chronic painful neuropathy, suggesting its use as a third-line treatment...
  2. ncbi Small fibre neuropathies
    Giuseppe Lauria
    Immunology and Muscular Pathology Unit, National Neurological Institute Carlo Besta, Milan, Italy
    Curr Opin Neurol 18:591-7. 2005
    ..To summarize the recent advances in aetiology, diagnostic assessment, and treatment of small fibre neuropathies...
  3. doi Docetaxel-induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model
    Ilaria Roglio
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    J Peripher Nerv Syst 14:36-44. 2009
    ..Our study confirmed that neuroactive steroids exert a protective effect on peripheral nerves at different levels, suggesting that they might represent a new therapeutic frontier for patients with chemotherapy-induced neuropathy...
  4. doi The neuroprotective effect of erythropoietin in docetaxel-induced peripheral neuropathy causes no reduction of antitumor activity in 13762 adenocarcinoma-bearing rats
    Ilaria Cervellini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Neurotox Res 18:151-60. 2010
    ..Since CINP induced by DOCE reproduces the clinical utility of taxane in humans, the findings reported might provide a basis for investigating EPO as a neuroprotective agent in patients receiving therapy with DOCE...
  5. doi Continuous buprenorphine delivery effect in streptozotocine-induced painful diabetic neuropathy in rats
    Annalisa Canta
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Milan, Italy
    J Pain 10:961-8. 2009
    ..Both doses of buprenorphine significantly reversed the diabetes-induced allodynia up to day 7 of treatment. Buprenorphine did not alter either thermal perception or NCV...
  6. ncbi Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies
    Giuseppe Lauria
    Neuromuscular Diseases, National Neurological Institute Carlo Besta, Milan, Italy
    J Peripher Nerv Syst 11:262-71. 2006
    ..Our findings demonstrated that TRPV1 is normally expressed throughout the nociceptive pathway of PNS and that TRPV1-positive peripheral nerve fibers degenerate in painful neuropathies...
  7. ncbi Cisplatin-induced peripheral neuropathy: neuroprotection by erythropoietin without affecting tumour growth
    Roberto Bianchi
    Mario Negri Institute of Pharmacological Research, Milan, Italy
    Eur J Cancer 43:710-7. 2007
    ..0 and 1.5 mg/kg twice a week for four weeks) was neuroprotective without influencing the effectiveness of the treatment or tumour growth. EPO thus appears to be an effective neuroprotectant that does not interfere with tumour treatment...
  8. doi "Burning tongue" and "burning tip": the diagnostic challenge of the burning mouth syndrome
    Paola Penza
    Neuromuscular Diseases Unit, IRCCS Foundation Carlo Besta National Neurological Institute, Milan, Italy
    Clin J Pain 26:528-32. 2010
    ..To investigate the clinical features of burning mouth syndrome (BMS) in a large cohort of patients and to correlate them with the results of tongue biopsy...
  9. ncbi Protective effect of erythropoietin and its carbamylated derivative in experimental Cisplatin peripheral neurotoxicity
    Roberto Bianchi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Clin Cancer Res 12:2607-12. 2006
    ..We have successfully identified derivatives of erythropoietin, including carbamylated erythropoietin, which do not raise the hematocrit but retain the neuroprotective action exerted by erythropoietin...
  10. doi Small fiber neuropathy: is skin biopsy the holy grail?
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
    Curr Diab Rep 12:384-92. 2012
    ..This paper reviews usefulness and limitations of skin biopsy and the relationship between degeneration and regeneration of small nerve fibers in patients with diabetes and metabolic syndrome...
  11. doi Painful neuropathy in subclinical hypothyroidism: clinical and neuropathological recovery after hormone replacement therapy
    Paola Penza
    Neuromuscular Diseases Unit, National Neurological Institute Carlo Besta, Via Celoria, 11, 20133, Milan, Italy
    Neurol Sci 30:149-51. 2009
    ..Subclinical hypothyroidism is a possible cause of sensory neuropathy and hormone replacement therapy can prompt nerve regeneration...
  12. doi Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy
    Giorgia Melli
    Neuromuscular Diseases Unit, IRCCS Foundation Neurological Institute Carlo Besta, Via Celoria, 11 20133, Milan, Italy
    Exp Neurol 214:276-84. 2008
    ..These findings suggest that alpha-lipoic acid might reduce the risk of developing peripheral nerve toxicity in patients undergoing chemotherapy and encourage further confirmatory clinical trials...
  13. doi Small fibre neuropathy
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
    Curr Opin Neurol 25:542-9. 2012
    ..This review summarizes the most recent advances in classification, diagnostic assessment, and treatment of small fibre neuropathy (SFN)...
  14. doi Electroacupuncture is not effective in chronic painful neuropathies
    Paola Penza
    Neuromuscular Disease Unit Anesthesiology Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Via Celoria 11, Milan, Italy
    Pain Med 12:1819-23. 2011
    ..To investigate the analgesic efficacy of electroacupuncture (EA) in patients with chronic painful neuropathy...
  15. pmc Foot pad skin biopsy in mouse models of hereditary neuropathy
    Patrizia Dacci
    Department of Neurology, Division of Neuroscience and INSPE, Neuropathology Unit, Milan, Italy
    Glia 58:2005-16. 2010
    ..Our data indicate that SB may reveal distal axonal pathology in mouse models and permits sequential follow-up of the neuropathy in an individual mouse, thereby reducing the number of mice necessary to document pathology of the PNS...
  16. ncbi Intraepidermal nerve fiber density in rat foot pad: neuropathologic-neurophysiologic correlation
    Giuseppe Lauria
    Immunology and Muscular Pathology Unit, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    J Peripher Nerv Syst 10:202-8. 2005
    ..Our study demonstrated that IENF density quantification correlates with SNCV changes and suggests that this might represent a useful outcome measurement in experimental neuropathies...
  17. doi Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy
    J Peripher Nerv Syst 15:202-7. 2010
    ..002). Height, weight, or BMI did not influence the calculated 5th percentile IENF normative densities in both genders. Our study provides IENF density normative reference values at the distal leg to be used in clinical practice...
  18. doi Altered peripheral myelination in mice lacking GABAB receptors
    Valerio Magnaghi
    Department of Endocrinology and Centre of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Mol Cell Neurosci 37:599-609. 2008
    ..In summary, our findings implicate GABA(B) receptors in the PNS myelination process and raise the possibility that PNS alterations contribute to the sensory phenotypes of GABA(B1)-deficient mice...
  19. doi Erythropoietin in amyotrophic lateral sclerosis: a pilot, randomized, double-blind, placebo-controlled study of safety and tolerability
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation, National Neurological Institute Carlo Besta, Via Celoria 11, Milan, Italy
    Amyotroph Lateral Scler 10:410-5. 2009
    ..RhEPO treatment was safe and well tolerated in ALS patients. Our results suggest that larger studies are warranted to confirm safety of treatment and to investigate different dose schedule and efficacy...
  20. pmc Skin biopsy: a new tool for diagnosing peripheral neuropathy
    Giuseppe Lauria
    Neuromuscular Diseases Unit, National Neurological Institute Carlo Besta, 20133, Milan, Italy
    BMJ 334:1159-62. 2007
  21. doi Erythropoietin in Friedreich ataxia: no effect on frataxin in a randomized controlled trial
    Caterina Mariotti
    SOSD Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy
    Mov Disord 27:446-9. 2012
    ..Recently, human recombinant erythropoietin was reported to increase frataxin levels in patients with Friedreich ataxia...
  22. ncbi Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome
    Giuseppe Lauria
    Immunology and Muscular Pathology Unit, National Neurological Institute Carlo Besta, Via Celoria, 11, 20133 Milan, Italy
    Pain 115:332-7. 2005
    ..These findings shed light into the pathogenesis of this common disorder and could contribute to evaluate targeted therapies in patients...
  23. ncbi Neuroactive steroids and peripheral neuropathy
    Ilaria Roglio
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Brain Res Rev 57:460-9. 2008
    ..Therefore, neuroactive steroids, pharmacological agents able to increase their local synthesis and synthetic ligands for their receptors have a promising potential for the treatment of different forms of peripheral neuropathy...
  24. ncbi Sensory neuron diseases
    Angelo Sghirlanzoni
    Neuro Oncology Unit, National Neurological Institute Carlo Besta, Milan, Italy
    Lancet Neurol 4:349-61. 2005
    ..Here we propose a comprehensive approach to the diagnosis of acquired and hereditary SND and discuss clinical, genetic, neurophysiological, neuroradiological, and neuropathological assessments...
  25. ncbi Skin biopsy as a diagnostic tool in peripheral neuropathy
    Giuseppe Lauria
    Neuromuscular Diseases Unit, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    Nat Clin Pract Neurol 3:546-57. 2007
    ....
  26. pmc Screening of the PFN1 gene in sporadic amyotrophic lateral sclerosis and in frontotemporal dementia
    Cinzia Tiloca
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Neurobiol Aging 34:1517.e9-10. 2013
    ..G15G in another patient, but none in a panel of 1512 control subjects. Our results suggest that PFN1 mutations in sporadic ALS and in FTD are rare, at least in the Italian population...
  27. doi Skin biopsy in painful and immune-mediated neuropathies
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRRCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, Milan, Italy
    J Peripher Nerv Syst 17:38-45. 2012
    ....
  28. ncbi Tubule and neurofilament immunoreactivity in human hairy skin: markers for intraepidermal nerve fibers
    Giuseppe Lauria
    Department of Clinical Neurosciences, Division of Neuromuscular Diseases, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    Muscle Nerve 30:310-6. 2004
    ..Double-staining studies confirmed that antibodies against cytoskeletal markers can be used to reliably stain skin nerve fibers, suggesting that they might provide insight into specific axonal impairment in peripheral neuropathies...
  29. ncbi Neurophysiological diagnosis of acquired sensory ganglionopathies
    Giuseppe Lauria
    Department of Clinical Neurosciences, National Neurological Institute Carlo Besta, Milan, Italy
    Eur Neurol 50:146-52. 2003
    ..We emphasize that distinct abnormalities allow to differentiate ganglionopathies from axonal sensory neuropathies on routine neurophysiological examination...
  30. pmc The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology
    Grazia Devigili
    Neurological Clinic, University of Ferrara, Italy
    Brain 131:1912-25. 2008
    ..6% of them the clinical picture did not change. Spontaneous remission of neuropathic pain occurred in 10.9% of SFN patients, while it worsened in 30.4% of them...
  31. ncbi Skin biopsy in the management of peripheral neuropathy
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Germany
    Lancet Neurol 6:632-42. 2007
    ..We also review the association between morphological measures of skin innervation and function and the limits of this method in the aetiological classification of peripheral neuropathies...
  32. pmc Erythropoietin both protects from and reverses experimental diabetic neuropathy
    Roberto Bianchi
    Mario Negri Institute of Pharmacological Research, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 101:823-8. 2004
    ..These observations suggest that administration of rhEPO or its analogues may be useful in the treatment of diabetic neuropathy...