- Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapyRoberta Lanzillo
Federico University, Neurological Sciences Department, Naples, Italy
Mult Scler 16:450-4. 2010..At survival analysis, the risk for a 1-point EDSS increase was slightly higher in group B than in group A (p = 0.053). Low-dose atorvastatin may be beneficial, as add-on therapy, in poor responders to high-dose interferon beta-1a alone...
- Neuropsychological assessment, quantitative MRI and ApoE gene polymorphisms in a series of MS patients treated with IFN beta-1bRoberta Lanzillo
Department of Neurological Sciences, Federico II University, Via Pansini, 5 80131 Naples, Italy
J Neurol Sci 245:141-5. 2006..This ongoing trial suggests a possible beneficial effect of IFN beta-1b treatment on cognitive functions in RRMS patients. Extension of follow-up and further data analyses are needed to confirm and clarify these findings...
- Natalizumab is effective in multiple sclerosis patients switching from other disease modifying therapies in clinical practiceR Lanzillo
Neurological Sciences Department, Federico II University, Via Pansini 5, 80131 Naples, Italy
Neurol Sci 34:521-8. 2013..Natalizumab showed to decrease ARR, stabilize EDSS, increase the percentage of CELs free patients and decrease the number of CELs in a group of 50 poor responders to classical DMT, after the first 12 months of therapy...
- Natalizumab vs interferon beta 1a in relapsing-remitting multiple sclerosis: a head-to-head retrospective studyR Lanzillo
Neurological Sciences Department, Federico II University, Naples, Italy
Acta Neurol Scand 126:306-14. 2012..No head-to-head study has been performed yet to assess whether natalizumab is more effective than classical immunomodulators in multiple sclerosis (MS)...
- Insulin-like growth factor (IGF)-I and IGF-binding protein-3 serum levels in relapsing-remitting and secondary progressive multiple sclerosis patientsR Lanzillo
Neurology, Hermitage Capodimonte Hospital, Naples, Italy
Eur J Neurol 18:1402-6. 2011..A role of IGFBP-3 in multiple sclerosis (MS) progression was hypothesized in patients with primary progressive (PP) MS...
- Multiple sclerosis and headache co-morbidity. A case-control studyG Vacca
Dipartimento di Scienze Neurologiche, Universita degli Studi di Napoli Federico II, Naples, Italy
Neurol Sci 28:133-5. 2007..First symptoms of headache preceded those of MS in two thirds of cases. Headache features did not significantly change after MS onset. Comorbidity of MS and PH could be explained by some common clinical and biological traits...
- Predictive factors of neutralizing antibodies development in relapsing-remitting multiple sclerosis patients on interferon Beta-1b therapyR Lanzillo
Department of Neurological Sciences, Federico II University, Via Pansini 5, Naples, Italy
Neurol Sci 32:287-92. 2011..0 and 5.6, respectively). Our study suggests that NAbs development might be a marker of a more aggressive disease and that worse outcome in NAbs producers might be biased by baseline condition...
- Early onset calpainopathy with normal non-functional calpain 3 levelR Lanzillo
Department of Neurological Sciences, Federico II University, Naples, Italy
Dev Med Child Neurol 48:304-6. 2006..This is the first genetically confirmed case of very early onset calpainopathy with a normal amount of protein at WB. Molecular analysis is also suggested in very young patients with normal WB...
- Chronic cerebrospinal venous insufficiency in multiple sclerosis: a highly prevalent age-dependent phenomenonRoberta Lanzillo
Department of Neurological Sciences, Federico II University School of Medicine, Naples, Italy
BMC Neurol 13:20. 2013..This study aimed to investigate the prevalence and clinical relevance of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis (MS) patients and healthy controls using extra- and intracranial colour Doppler sonography...
- Multiple sclerosis: cerebral circulation timeMarcello Mancini
Institute of Biostructure and Bioimaging, National Research Council of Italy, Federico II University School of Medicine, Via Pansini 5, Edificio 10, 80131 Naples, Italy
Radiology 262:947-55. 2012..To assess cerebral circulation times (CCTs) in patients with multiple sclerosis (MS) and control subjects by using contrast material-enhanced ultrasonography (US) to determine whether vascular abnormalities can be detected in this disease...
- Brain tissue volume changes in relapsing-remitting multiple sclerosis: correlation with lesion loadMario Quarantelli
Biostructure and Bioimaging Institute, National Council for Research, Building 10, Via Pansini 5, 80131 Naples, Italy
Neuroimage 18:360-6. 2003..Brain atrophy in RR-MS is mainly related to GM loss, which correlates with faWM. Both measures do not appear to significantly affect EDSS, which correlates to disease duration...
- Modifications of brain tissue volumes in facioscapulohumeral dystrophyMario Quarantelli
Biostructure and Bioimaging Institute, National Council for Research, Naples, Italy
Neuroimage 32:1237-42. 2006..10(-3)). To the best of our knowledge, this is the first study to demonstrate a reduction in GM volume in FSHD. We hypothesize that localized GM loss in FSHD is the consequence of a selective involvement of specific CNS structures...
- A new POLG1 mutation with peo and severe axonal and demyelinating sensory-motor neuropathyL Santoro
Dipartimento di Scienze Neurologiche, Universita degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131, Napoli, Italia
J Neurol 253:869-74. 2006..Recent positional cloning studies have linked the disease to four different chromosomal loci. Mutations in POLG1 are a frequent cause of this disorder...
- Analysis of dystrophin gene deletions indicates that the hinge III region of the protein correlates with disease severityA Carsana
Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, and CEINGE Biotecnologie Avanzate, Via S Pansini 5, 80131 Napoli, Italy
Ann Hum Genet 69:253-9. 2005..Our data obtained in BMD patients, by confirming inferences arising from minigene transfection experiments in mdx mice, represent an important contribution to gene therapy approaches...
- Epileptic seizures in multiple sclerosis: clinical and EEG correlationsP Striano
Department of Neurological Sciences, Federico II University of Naples, Via Pansini 5, I 80131 Naples, Italy
Neurol Sci 24:322-8. 2003..Prognosis of epilepsy during the course of MS is usually good but the choice of AEDs remains a matter of debate...
- Aphasia as a rare presentation of monosymptomatic demyelinating disease: case report and review of the literatureL Di Majo
Department of Neurological Sciences, Federico II University, Via Pansini 5, I 80131 Naples, Italy
Neurol Sci 23:79-82. 2002..The clinical and radiological differences between multiple sclerosis and acute disseminated encephalomyelitis are discussed. Although aphasia has already been described in demyelinating diseases, we underline its rarity as onset symptom...
- The glycopeptide CSF114(Glc) detects serum antibodies in multiple sclerosisFrancesco Lolli
Dipartimento di Scienze Neurologiche e Psichiatriche, Universita degli Studi di Firenze, Viale Morgagni 85, I 50134 Firenze, Italy
J Neuroimmunol 167:131-7. 2005..The study of antibodies to CSF114(Glc) is a new, potential immunological marker of MS...