Sebastiano Mercadante

Summary

Affiliation: La Maddalena Cancer Center
Country: Italy

Publications

  1. ncbi Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 30:485-91. 2005
  2. ncbi Medical treatment for inoperable malignant bowel obstruction: a qualitative systematic review
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, and Department of Anesthesiology, University of Palermo, Palermo, Italy
    J Pain Symptom Manage 33:217-23. 2007
  3. ncbi Dialogues on complex analgesic strategies for difficult pain syndromes
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90146 Palermo, Italy
    Support Care Cancer 12:599-603. 2004
  4. ncbi A model of acute symptom control unit: Pain Relief and Palliative Care Unit of La Maddalena Cancer Center
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo Colli 312, 90146 Palermo, Italy
    Support Care Cancer 11:114-9. 2003
  5. ncbi Factors involved in gastrointestinal bleeding in advanced cancer patients followed at home
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 12:95-8. 2004
  6. ncbi Opioids and renal function
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain 5:2-19. 2004
  7. doi A randomized-controlled study of intrathecal versus epidural thoracic analgesia in patients undergoing abdominal cancer surgery
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    J Clin Monit Comput 22:293-8. 2008
  8. ncbi World Health Organization guidelines for cancer pain: a reappraisal
    S Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    Ann Oncol 16:iv132-135. 2005
  9. ncbi Randomized double-blind, double-dummy crossover clinical trial of oral tramadol versus rectal tramadol administration in opioid-naive cancer patients with pain
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, 90146 Palermo, Italy
    Support Care Cancer 13:702-7. 2005
  10. ncbi Sleep disorders in advanced cancer patients: prevalence and factors associated
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo Colli 312, 90146, Palermo, Italy
    Support Care Cancer 12:355-9. 2004

Detail Information

Publications104 found, 100 shown here

  1. ncbi Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 30:485-91. 2005
    ..These intensive treatments should be reserved for a very selected population and initiated in an appropriate setting with frequent monitoring facilities and skilled nursing...
  2. ncbi Medical treatment for inoperable malignant bowel obstruction: a qualitative systematic review
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, and Department of Anesthesiology, University of Palermo, Palermo, Italy
    J Pain Symptom Manage 33:217-23. 2007
    ..Data on CSs are less convincing, due to the methodological weakness of existing studies. This review confirms the difficulties in conducting randomized controlled trials in this population...
  3. ncbi Dialogues on complex analgesic strategies for difficult pain syndromes
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90146 Palermo, Italy
    Support Care Cancer 12:599-603. 2004
    ..Three case reports illustrate how complex could be the analgesic approach using multiple analgesic regimens and different routes of administration to effectively manage complex pain syndromes commonly defined as unresponsive...
  4. ncbi A model of acute symptom control unit: Pain Relief and Palliative Care Unit of La Maddalena Cancer Center
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo Colli 312, 90146 Palermo, Italy
    Support Care Cancer 11:114-9. 2003
    ....
  5. ncbi Factors involved in gastrointestinal bleeding in advanced cancer patients followed at home
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 12:95-8. 2004
    ..However, no clear relationship between age, gender, and the use of offender drugs with gastrointestinal bleeding was found. Liver involvement was frequently associated with the risk of developing gastrointestinal bleeding...
  6. ncbi Opioids and renal function
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain 5:2-19. 2004
    ....
  7. doi A randomized-controlled study of intrathecal versus epidural thoracic analgesia in patients undergoing abdominal cancer surgery
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    J Clin Monit Comput 22:293-8. 2008
    ....
  8. ncbi World Health Organization guidelines for cancer pain: a reappraisal
    S Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    Ann Oncol 16:iv132-135. 2005
  9. ncbi Randomized double-blind, double-dummy crossover clinical trial of oral tramadol versus rectal tramadol administration in opioid-naive cancer patients with pain
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, 90146 Palermo, Italy
    Support Care Cancer 13:702-7. 2005
    ..0002) and patients (P=0.002). Rectal administration of tramadol appears a reliable, noninvasive alternative method of pain control for patients no longer responsive to non-opioid analgesics, unable to take oral tramadol...
  10. ncbi Sleep disorders in advanced cancer patients: prevalence and factors associated
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo Colli 312, 90146, Palermo, Italy
    Support Care Cancer 12:355-9. 2004
    ..However, the prevalence of this problem in advanced cancer patients has never been assessed. The aim of this study was to evaluate the frequency of sleep disturbances in terms of quantity and quality, and possible associated factors...
  11. doi Frequency, indications, outcomes, and predictive factors of opioid switching in an acute palliative care unit
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, University of Palermo, Palermo, Italy
    J Pain Symptom Manage 37:632-41. 2009
    ..The presence of both poor pain relief and adverse effects is a negative factor for switching prognosis, whereas renal failure is not...
  12. ncbi Cancer pain management in children
    Sebastiano Mercadante
    La Maddalena Cancer Center, Palermo, Italy
    Palliat Med 18:654-62. 2004
    ....
  13. ncbi Addition of a second opioid may improve opioid response in cancer pain: preliminary data
    Sebastiano Mercadante
    La Maddalena Cancer Center, Palliative Medicine Chair of Anesthesia, Intensive Care and Emergency, Palermo, Italy
    Support Care Cancer 12:762-6. 2004
    ..It allowed for a regaining of analgesia, regardless of the opioid combination used. These preliminary observations should be confirmed in further studies...
  14. ncbi Opioid switching: a systematic and critical review
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Cancer Treat Rev 32:304-15. 2006
    ..The process of reaching an optimal dose should be highly individualized, particularly when patients are switched from high doses of opioids, given the wide conversion ratios reported in literature...
  15. ncbi Management of painful bone metastases
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit La Maddalena Cancer Center, University of Palermo, Palermo, Italy
    Curr Opin Oncol 19:308-14. 2007
    ..This review examines recent data on the pathophysiology and mechanisms of bone pain; it highlights the use of multiple and interdisciplinary treatments rather than sole use of traditional analgesics...
  16. ncbi Opioid-induced or pain relief-reduced symptoms in advanced cancer patients?
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit La Maddalena Cancer Center, Via San Lorenzo Colli 312, 90146 Palermo, Italy
    Eur J Pain 10:153-9. 2006
    ..Moreover, in the clinical setting symptomatic treatment and illness may balance the outcome of opioid titration. Some adverse effects may tend to disappear continuing the treatment in a long-term period...
  17. ncbi Opioid plasma concentrations during a switch from transdermal fentanyl to methadone
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Palliat Med 10:338-44. 2007
    ....
  18. ncbi A prospective randomized study of corticosteroids as adjuvant drugs to opioids in advanced cancer patients
    Sebastiano L Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Am J Hosp Palliat Care 24:13-9. 2007
    ..Corticosteroid-related toxicity was minimal. Further studies with an increased sample size are necessary to detect any minimal difference in analgesia between the two groups...
  19. ncbi Opioid titration in cancer pain: a critical review
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Eur J Pain 11:823-30. 2007
    ..This review assesses the principal titration methods and outcomes regarding the different opioid drugs and their modalities of administration, in different clinical contexts...
  20. ncbi Why are our patients still suffering pain?
    Sebastiano Mercadante
    La Maddalena Cancer Center, Via San Lorenzo 312, 90145 Palermo, Italy
    Nat Clin Pract Oncol 4:138-9. 2007
  21. ncbi Is there a ceiling effect of transdermal buprenorphine? Preliminary data in cancer patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 15:441-4. 2007
    ....
  22. ncbi Opioid escalation in patients with cancer pain: the effect of age
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    J Pain Symptom Manage 32:413-9. 2006
    ..However, the group of patients over 75 was relatively small and data should be interpreted with caution. Careful titration based on the individual response seems appropriate irrespective of age...
  23. ncbi Rapid switching between transdermal fentanyl and methadone in cancer patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    J Clin Oncol 23:5229-34. 2005
    ..The aim of this study was to examine the clinical effects of switching from transdermal (TTS) fentanyl to methadone, or vice versa, in patients with a poor response to the previous opioid...
  24. ncbi Opioid plasma concentration during switching from morphine to methadone: preliminary data
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90146 Palermo, Italy
    Support Care Cancer 11:326-31. 2003
    ..Opioid plasma changes substantially overlap the clinical changes observed in these patients, in terms of benefit between analgesia and adverse effects...
  25. ncbi Safety and effectiveness of intravenous morphine for episodic breakthrough pain in patients receiving transdermal buprenorphine
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 32:175-9. 2006
    ..The occurrence of adverse effects for each episode treated was not frequent and intensity was not relevant. IV-MO was effective and safe in most cancer patients receiving TTS-BUP who experienced pain exacerbation...
  26. ncbi Scoring the effect of radiotherapy for painful bone metastases
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Via San Lorenzo, Palermo, Italy
    Support Care Cancer 14:967-9. 2006
    ..An integration of competences in monitoring the pain response and modifying the opioid treatment according to changes of the clinical condition is mandatory...
  27. doi Breakthrough pain in advanced cancer patients followed at home: a longitudinal study
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 38:554-60. 2009
    ..This helps explain the different incidences reported in previous studies performed in different settings and conditions...
  28. doi Sustained-release oral morphine versus transdermal fentanyl and oral methadone in cancer pain management
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Eur J Pain 12:1040-6. 2008
    ....
  29. doi Palliative sedation in advanced cancer patients followed at home: a retrospective analysis
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 43:1126-30. 2012
    ..Data regarding palliative sedation at home in dying patients are lacking...
  30. ncbi Switching from transdermal drugs: an observational "N of 1" study of fentanyl and buprenorphine
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 34:532-8. 2007
    ..Further studies should be performed to gather data about the use of TTS BU with other opioids, at different doses, and in different clinical conditions...
  31. doi Opioid switching in patients with advanced cancer followed at home. A retrospective analysis
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 45:298-304. 2013
    ..Opioid switching has been found to improve opioid responsiveness in different conditions. However, data on opioid switching performed at home are almost nonexistent, despite the fact that most patients are followed at home...
  32. ncbi Intrathecal treatment in cancer patients unresponsive to multiple trials of systemic opioids
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Clin J Pain 23:793-8. 2007
    ....
  33. doi Opioid switching from and to tapentadol extended release in cancer patients: conversion ratio with other opioids
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 29:661-6. 2013
    ..The aim of this exploratory study was to assess the conversion ratios between tapentadol and other opioids in patients requiring an opioid switching...
  34. doi Prognostic factors of survival in patients with advanced cancer admitted to home care
    Sebastiano Mercadante
    Pain Relief and Supportive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 45:56-62. 2013
    ..Data regarding prognostication of life expectancy in patients with advanced cancer are of paramount importance to patients, families, and clinicians. However, data regarding patients followed at home are lacking...
  35. ncbi Amitriptyline in neuropathic cancer pain in patients on morphine therapy: a randomized placebo-controlled, double-blind crossover study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Home Palliative Care Program, Società Assistenza Malato Oncologico Terminale, Palermo, Italy
    Tumori 88:239-42. 2002
    ..A randomized placebo-controlled, double-blind crossover study was designed to evidence the effects of amitriptyline in patients with neuropathic cancer pain...
  36. doi Does pain intensity predict a poor opioid response in cancer patients?
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Italy
    Eur J Cancer 47:713-7. 2011
    ..The aim of this study was to test the hypothesis that initial pain intensity is not a predictive factor of poor opioid response in advanced cancer patients, as suggested by a recent work...
  37. doi The effects of low doses of pregabalin on morphine analgesia in advanced cancer patients
    Sebastiano Mercadante
    La Maddalena Cancer Center, Pain Relief and Palliative Care Unit, University of Palermo, Italy
    Clin J Pain 29:15-9. 2013
    ..The aim of this study was to evaluate the opioid response in patients receiving morphine and pregabalin, independently from the presumed pain mechanisms, in comparison with patients receiving morphine treatment only...
  38. doi How do cancer patients receiving palliative care at home die? A descriptive study
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 42:702-9. 2011
    ..Data regarding the circumstances of the process of death of terminally ill patients followed at home are lacking...
  39. doi The use of opioids for breakthrough pain in acute palliative care unit by using doses proportional to opioid basal regimen
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Clin J Pain 26:306-9. 2010
    ..To determine the efficacy and safety of different opioids used in doses proportional to the basal opioid regimen for the management of breakthrough pain (BP)...
  40. doi Tools for identifying cancer pain of predominantly neuropathic origin and opioid responsiveness in cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain 10:594-600. 2009
    ..05), and patients with "definite NP" required more intensive treatment. Patients requiring more aggressive treatment showed significantly higher values of Opioid Escalation Index (OEI)mg...
  41. doi When the progression of disease lowers opioid requirement in cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, Palermo, Italy
    Clin J Pain 26:56-7. 2010
    ..To describe 2 cases in which an abrupt progression of disease compromising pain pathways and inducing some relief of existing pain or limiting drug delivery to central nervous system...
  42. doi Tapentadol in cancer pain management: a prospective open-label study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, 90146 Palermo, Italy
    Curr Med Res Opin 28:1775-9. 2012
    ..The aim of this prospective, open-label study was to evaluate the efficacy and tolerability of tapentadol (TP) in the management of cancer pain...
  43. doi Controlled sedation for refractory symptoms in dying patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 37:771-9. 2009
    ..This study also points to the importance of palliative care and the experience of professionals skilled in both symptom control and end-of-life care...
  44. ncbi Low morphine doses in opioid-naive cancer patients with pain
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Clinic for Cancer, and Department of Anesthesiology and Intensive Care, University of Palermo, Palermo, Italy
    J Pain Symptom Manage 31:242-7. 2006
    ....
  45. doi Emergencies in patients with advanced cancer followed at home
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 44:295-300. 2012
    ..Caregivers may call medical services for an emergency, which can result in patients being admitted to the hospital. No data exist on emergencies in patients followed by a home care team...
  46. ncbi Morphine versus oxycodone in pancreatic cancer pain: a randomized controlled study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Clin J Pain 26:794-7. 2010
    ..It was hypothesized that OX could have some advantages over MO in terms of efficacy and dose escalation in pancreatic cancer pain...
  47. doi Breakthrough pain in oncology: a longitudinal study
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 40:183-90. 2010
    ..These studies have used cross-sectional designs, and the relationship of BP with analgesic treatment has not been evaluated...
  48. ncbi Safety and effectiveness of intravenous morphine for episodic (breakthrough) pain using a fixed ratio with the oral daily morphine dose
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 27:352-9. 2004
    ..v.-M at a dose equivalent to 20% of the basal oral dosage is safe and effective in the majority of patients experiencing pain exacerbation. This treatment is inexpensive and can be used at little risk to patients...
  49. doi Intravenous morphine for breakthrough (episodic-) pain in an acute palliative care unit: a confirmatory study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, University of Palermo, Palermo, Italy
    J Pain Symptom Manage 35:307-13. 2008
    ..The role of nurses is of paramount importance in monitoring and collecting data and gathering information for audit purposes on the unit...
  50. ncbi Hyperalgesia and opioid switching
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Department of Palliative Medicine, University of Palermo, Palermo, Italy
    Am J Hosp Palliat Care 22:291-4. 2005
    ....
  51. ncbi Rapid titration with intravenous morphine for severe cancer pain and immediate oral conversion
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Cancer 95:203-8. 2002
    ..The aim of the current study was to evaluate a method of rapid titration with intravenous morphine to achieve relief of cancer pain of severe intensity...
  52. doi Relationship between background cancer pain, breakthrough pain, and analgesic treatment: a preliminary study for a better interpretation of epidemiological and clinical studies
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 29:667-71. 2013
    ..The different operational definitions of breakthrough cancer pain (BTcP) has generated unclear epidemiological data...
  53. doi Switching from oxycodone to methadone in advanced cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Support Care Cancer 20:191-4. 2012
    ..The aim of this study was to prospectively evaluate the outcomes and the conversion ratio of switching from oxycodone to methadone in advanced cancer patients admitted to an acute palliative care unit...
  54. doi Equipotent doses to switch from high doses of opioids to transdermal buprenorphine
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center and University of Palermo, Via San Lorenzo 312, 90146 Palermo, Italy
    Support Care Cancer 17:715-8. 2009
    ....
  55. doi Palliative sedation in patients with advanced cancer followed at home: a systematic review
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 41:754-60. 2011
    ..Palliative sedation (PS) is considered to be an effective treatment modality for these refractory symptoms when aggressive efforts fail to provide relief...
  56. doi Low doses of transdermal fentanyl in opioid-naive patients with cancer pain
    Sebastiano Mercadante
    Anaesthesia and Intensive Care Unit, and Pain Relief and Palliative Care Unit, La Maddalena Cancer Centre, Palermo, Italy
    Curr Med Res Opin 26:2765-8. 2010
    ..The aim of this study was to evaluate the effect and tolerability of low doses of transdermal (TD) fentanyl patches in opioid-naive patients with cancer pain...
  57. doi The use of fentanyl buccal tablets as breakthrough medication in patients receiving chronic methadone therapy: an open label preliminary study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Support Care Cancer 19:435-8. 2011
    ..Whether methadone produces tolerance to other opioids, other opioids should be less effective when administered as a BTcP medication...
  58. doi The use of high doses of oxycodone in an acute palliative care unit
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Am J Hosp Palliat Care 28:242-4. 2011
    ..This study demonstrated that CRO administered in larger doses was safe and effective, showing versatility and flexibility similar to morphine...
  59. ncbi Aggressive pharmacological treatment for reversing malignant bowel obstruction
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 28:412-6. 2004
    ..It suggests that the most important mechanism in these circumstances is functional and can be reversible, if an aggressive treatment is initiated early before fecal impaction and edema render bowel obstruction irreversible...
  60. doi Dosing fentanyl buccal tablet for breakthrough cancer pain: dose titration versus proportional doses
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 28:963-8. 2012
    ....
  61. doi Opioid switching and burst ketamine to improve the opioid response in patients with movement-related pain due to bone metastases
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo Colli 312, 90146 Palermo, Italy
    Clin J Pain 25:648-9. 2009
    ..To improve opioid repsonse in patients with movement-related pain by using opioid switching adding a burst of ketamine...
  62. doi Sexuality in patients with advanced cancer: a prospective study in a population admitted to an acute pain relief and palliative care unit
    Valentina Vitrano
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Am J Hosp Palliat Care 28:198-202. 2011
    ....
  63. doi The use of opioids in the last week of life in an acute palliative care unit
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Am J Hosp Palliat Care 27:514-7. 2010
    ..Doses increases prevalently observed in sedated patients were performed before starting sedation with the purpose to treat concomitant distressing symptoms, such as dyspnoea...
  64. ncbi Surgical treatment of early breast cancer in day surgery
    Antonio Marrazzo
    Department of Experimental Oncology and Clinical Application, University of Palermo, Palermo
    Chir Ital 59:687-91. 2007
    ..Moreover, when performing quadrantectomy with SLNB in day surgery fewer than 50% of breast cancer patients (40% in our experience) require another surgical treatment, concluding the surgery in a single session...
  65. doi Meaningful cut-off pain intensity for breakthrough pain changes in advanced cancer patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 29:93-7. 2013
    ....
  66. doi Intravenous morphine for management of cancer pain
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center and Palliative Medicine, Department of Anesthesia and Intensive Care, University of Palermo, Palermo, Italy
    Lancet Oncol 11:484-9. 2010
    ..I.v. morphine is advantageous in specific clinical situations and should be part of armamentarium of all physicians treating pain in patients with cancer...
  67. doi High doses of oxycodone-naloxone combination may provide poor analgesia
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Support Care Cancer 19:1471-2. 2011
    ..The substitution with the same doses (240 mg/day) of regular controlled-release oxycodone was effective in regaining adequate analgesia...
  68. doi Pain in patients with lung cancer: pathophysiology and treatment
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90145 Palermo, Italy
    Lung Cancer 68:10-5. 2010
    ..More complex strategies, such as interventional procedures, are seldom necessary and require an appropriate selection of patients...
  69. doi Prevalence of opioid-related dysuria in patients with advanced cancer having pain
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Am J Hosp Palliat Care 28:27-30. 2011
    ....
  70. ncbi Treatment strategies for cancer patients with breakthrough pain
    Alessandra Casuccio
    University of Palermo, Department of Clinical Neuroscience, Palermo, Italy
    Expert Opin Pharmacother 10:947-53. 2009
    ..It is normally severe in intensity, has a rapid onset, has a variable duration (on average 30 min) and is considered a negative prognostic factor...
  71. doi High-dose furosemide and small-volume hypertonic saline solution infusion for the treatment of leg edema in advanced cancer patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 37:419-23. 2009
    ..These observations suggest that high-dose furosemide and small-volume saline may be an effective strategy for the treatment of peripheral edema in patients with advanced cancer...
  72. ncbi Optimization of opioid therapy for preventing incident pain associated with bone metastases
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 28:505-10. 2004
    ..This approach is based on experimental bone models showing a hypersensitivity to some innocuous stimuli, such as movement, requiring pre-emptive higher doses of basal opioid medication to reduce the increased pain input...
  73. ncbi Video-thoracoscopic surgical pleurodesis in the management of malignant pleural effusion: the importance of an early intervention
    Antonio Marrazzo
    Department of Experimental Oncology and Clinical Application, University of Palermo, Italy
    J Pain Symptom Manage 30:75-9. 2005
    ..Early use of talc insufflated by video-thoracoscopic surgery is an effective and relatively safe method for treating pleural effusion, and preventing recurrence, in advanced cancer patients...
  74. ncbi Celiac plexus block for pancreatic cancer pain: factors influencing pain, symptoms and quality of life
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 26:1140-7. 2003
    ..Outcomes are strongly based on individual variation...
  75. doi Prevalence and treatment of cancer pain in Italian oncological wards centres: a cross-sectional survey
    Sebastiano Mercadante
    La Maddalena Cancer Center, Palermo, Italy
    Support Care Cancer 16:1203-11. 2008
    ....
  76. ncbi Episodic (breakthrough) pain: consensus conference of an expert working group of the European Association for Palliative Care
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Cancer 94:832-9. 2002
    ..The wide differences in estimation of incidence reported in literature are probably because of different settings and meanings attributed to the definition of breakthrough pain...
  77. doi Intravenous patient-controlled analgesia and management of pain in post-surgical elderly with cancer
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Surg Oncol 19:173-7. 2010
    ..The success of such a technique depends on close evaluation of all preoperative and intraoperative factors that can cause or contribute to acute delirium. In the present paper we review the literature on this pivotal field...
  78. ncbi Pharmacological management of cancer pain in the elderly
    Sebastiano Mercadante
    Anesthesia and Intensive Care Pain Unit, La Maddalena Cancer Center, and Palliative Medicine, University of Palermo, Palermo, Italy
    Drugs Aging 24:761-76. 2007
    ..Older patients with cancer should be continuously assessed for cancer pain, both before and after analgesic treatment...
  79. ncbi Injustifiable use of gastroprotection in advanced cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Palliat Med 21:631-3. 2007
    ....
  80. ncbi Patients' and relatives' perceptions about intravenous and subcutaneous hydration
    Sebastiano Mercadante
    Pain Relief and Palliative Care, University of Palermo, Palermo, Italy
    J Pain Symptom Manage 30:354-8. 2005
    ..Most patients and relatives surveyed accepted and were in favor of intravenous hydration...
  81. ncbi Pain mechanisms involved and outcome in advanced cancer patients with possible indications for celiac plexus block and superior hypogastric plexus block
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Home Palliative Care Program, SAMOT Società per l Assistenza al Malato Oncologico Terminale, Palermo, Italy
    Tumori 88:243-5. 2002
    ....
  82. ncbi Hyperalgesia: an emerging iatrogenic syndrome
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 26:769-75. 2003
    ..Alternative procedures should be taken into consideration to break this cycle, should it occur. More data are needed to detect this condition, as currently no diagnostic information on specific markers, clinical or biochemical, exists...
  83. ncbi The use of bisphosphonates in the management of bone metastatic prostate cancer
    Sebastiano Mercadante
    Anestesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, Palermo, 90146, Italy
    Curr Urol Rep 3:244-9. 2002
    ..Studies of the efficacy of lower doses to prevent skeletal morbidity in patients without metastases or with asymptomatic bone lesions are warranted...
  84. doi Peritoneal catheter for continuous drainage of ascites in advanced cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Support Care Cancer 16:975-8. 2008
    ..A continuous peritoneal drainage by an indwelling catheter has been reported to be hugely beneficial symptomatically, avoiding the hazards and disadvantages of multiple repeated procedures and direct and indirect costs...
  85. doi Sexual issues in early and late stage cancer: a review
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Support Care Cancer 18:659-65. 2010
    ..The aim of this review was to examine the literature regarding sexuality in advanced cancer patients, after taking into consideration the principal changes produced by the disease and its treatment...
  86. ncbi Looking for the role of NSAIDs in cancer pain
    Sebastiano Mercadante
    J Clin Oncol 23:2442-3; author reply 2443. 2005
  87. ncbi CT-guided neurolytic splanchnic nerve block by an anterior approach
    Sebastiano Mercadante
    J Pain Symptom Manage 23:268-70. 2002
  88. ncbi Opioid prescription in Italy: new law, no effect
    Sebastiano Mercadante
    Lancet 360:1254-5. 2002
  89. ncbi Itraconazole-fentanyl interaction in a cancer patient
    Sebastiano Mercadante
    J Pain Symptom Manage 24:284-6. 2002
  90. ncbi Burst ketamine to reverse opioid tolerance in cancer pain
    Sebastiano Mercadante
    J Pain Symptom Manage 25:302-5. 2003
  91. ncbi Naloxone in treating central adverse effects during opioid titration for cancer pain
    Sebastiano Mercadante
    J Pain Symptom Manage 26:691-3. 2003
  92. doi Fatigue in palliative care patients -- an EAPC approach
    Lukas Radbruch
    Department of Palliative Medicine, RWTH Aachen University, Aachen, Germany
    Palliat Med 22:13-32. 2008
    ..Identification of the time point, where treatment of fatigue is no longer indicated is important to alleviate distress at the end of life...
  93. ncbi Switching to methadone: 'ad libitum' or fixed dose ratio?
    Sebastiano Mercadante
    Palliat Med 18:71; author reply 72. 2004
  94. ncbi Re: Rauck et al. Long-term intrathecal opioid therapy with a patient-activated, implanted delivery system for the treatment of refractory cancer pain. J Pain. 2003 Oct;4(8):441-7
    Sebastiano Mercadante
    J Pain 5:138-9. 2004
  95. ncbi Epidural treatment in advanced cancer patients
    Sebastiano Mercadante
    Anesth Analg 98:1503; auhtor reply 1503-4. 2004
  96. doi Bedside anesthesia for painful procedures in onco-hematology
    Sebastiano Mercadante
    J Palliat Med 11:8-9. 2008
  97. ncbi Local anesthetics for breakthrough pain in patients receiving intrathecal treatment for cancer pain management
    Sebastiano Mercadante
    Anesth Analg 100:1540. 2005
  98. ncbi How to use octreotide for malignant bowel obstruction
    Carla Ripamonti
    Rehabilitation and Palliative Care Operative Unit, National Cancer Institute of Milan, Italy
    J Support Oncol 2:357-64. 2004
  99. ncbi Prolonged uncontrolled pain, psychological distress, and opioid escalation
    Sebastiano Mercadante
    J Pain Symptom Manage 28:1-3. 2004
  100. ncbi Problematic discharge from hospital for patients prescribed opioids for cancer pain
    Sebastiano Mercadante
    J Pain Symptom Manage 29:433-4. 2005
  101. ncbi Opioid consumption in Italy: industry is not necessarily business--look at the effects
    Sebastiano Mercadante
    J Pain Symptom Manage 27:391-2. 2004