Sebastiano Mercadante

Summary

Affiliation: La Maddalena Cancer Center
Country: Italy

Publications

  1. ncbi request reprint A comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: an open-label, randomised, crossover trial
    S Mercadante
    Dipartimento Oncologico, Casa di Cura ad alta specialità Pain relief and Palliative Care Unit, La Maddalena, Via S Lorenzo Colli 312, Palermo, Italy
    Curr Med Res Opin 25:2805-15. 2009
  2. ncbi request reprint New opioids
    Sebastiano Mercadante
    Sebastiano Mercadante and Vittorio Gebbia, La Maddalena Cancer Center, Palermo and Giampiero Porzio, University of L Aquila, L Aquila, Italy
    J Clin Oncol 32:1671-6. 2014
  3. ncbi request reprint Pharmacological management of cancer pain in children
    Sebastiano Mercadante
    Anesthesia and Intensive Care and Pain Relief and Supportive Care Unit, La Maddalena Cancer Center, Italy Chair of Anesthesiology, University of Palermo, Italy Electronic address
    Crit Rev Oncol Hematol 91:93-7. 2014
  4. ncbi request reprint Intranasal fentanyl versus fentanyl pectin nasal spray for the management of breakthrough cancer pain in doses proportional to basal opioid regimen
    Sebastiano Mercadante
    Anesthesia and intensive Care and Pain Relief and Supportive Care, La Maddalena Cancer Center, Palermo, Italy Electronic address
    J Pain 15:602-7. 2014
  5. doi request reprint Changes of QTc interval after opioid switching to oral methadone
    Sebastiano Mercadante
    Cancer Pain and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Support Care Cancer 21:3421-4. 2013
  6. doi request reprint Cancer pain management in an oncological ward in a comprehensive cancer center with an established palliative care unit
    Sebastiano Mercadante
    Anesthesia and Intensive Care and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, and Palliative Medicine, University of Palermo, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 21:3287-92. 2013
  7. doi request reprint The long and winding road of non steroidal antinflammatory drugs and paracetamol in cancer pain management: a critical review
    Sebastiano Mercadante
    La Maddalena Cancer Center, Palermo, Italy
    Crit Rev Oncol Hematol 87:140-5. 2013
  8. ncbi request reprint The use of fentanyl buccal tablets for breakthrough pain by using doses proportional to opioid basal regimen in a home care setting
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 21:2335-9. 2013
  9. ncbi request reprint The poor use of methadone in Italian hospices
    Sebastiano Mercadante
    Anesthesia and Intensive Care and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center and University of Palermo, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 21:2225-8. 2013
  10. doi request reprint Relationship between background cancer pain, breakthrough pain, and analgesic treatment: a preliminary study for a better interpretation of epidemiological and clinical studies
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 29:667-71. 2013

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint A comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: an open-label, randomised, crossover trial
    S Mercadante
    Dipartimento Oncologico, Casa di Cura ad alta specialità Pain relief and Palliative Care Unit, La Maddalena, Via S Lorenzo Colli 312, Palermo, Italy
    Curr Med Res Opin 25:2805-15. 2009
    ..The efficacy of intranasal fentanyl spray (INFS) was compared with that of oral transmucosal fentanyl citrate (OTFC) for the relief of cancer-related breakthrough pain (BTP) in an open-label, crossover trial...
  2. ncbi request reprint New opioids
    Sebastiano Mercadante
    Sebastiano Mercadante and Vittorio Gebbia, La Maddalena Cancer Center, Palermo and Giampiero Porzio, University of L Aquila, L Aquila, Italy
    J Clin Oncol 32:1671-6. 2014
    ....
  3. ncbi request reprint Pharmacological management of cancer pain in children
    Sebastiano Mercadante
    Anesthesia and Intensive Care and Pain Relief and Supportive Care Unit, La Maddalena Cancer Center, Italy Chair of Anesthesiology, University of Palermo, Italy Electronic address
    Crit Rev Oncol Hematol 91:93-7. 2014
    ....
  4. ncbi request reprint Intranasal fentanyl versus fentanyl pectin nasal spray for the management of breakthrough cancer pain in doses proportional to basal opioid regimen
    Sebastiano Mercadante
    Anesthesia and intensive Care and Pain Relief and Supportive Care, La Maddalena Cancer Center, Palermo, Italy Electronic address
    J Pain 15:602-7. 2014
    ..Both delivery systems, in doses proportional to the basal opioid regimen, provided significant analgesia within 10 minutes, without producing relevant adverse effects...
  5. doi request reprint Changes of QTc interval after opioid switching to oral methadone
    Sebastiano Mercadante
    Cancer Pain and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Support Care Cancer 21:3421-4. 2013
    ..A larger number of patients should be assessed to quantify the risk of serious arrhythmia. ..
  6. doi request reprint Cancer pain management in an oncological ward in a comprehensive cancer center with an established palliative care unit
    Sebastiano Mercadante
    Anesthesia and Intensive Care and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, and Palliative Medicine, University of Palermo, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 21:3287-92. 2013
    ..This survey was performed to draw information on pain prevalence, intensity, and management from a sample of patients who were admitted to an oncologic center where a palliative care unit (PCU) has been established for 13 years...
  7. doi request reprint The long and winding road of non steroidal antinflammatory drugs and paracetamol in cancer pain management: a critical review
    Sebastiano Mercadante
    La Maddalena Cancer Center, Palermo, Italy
    Crit Rev Oncol Hematol 87:140-5. 2013
    ....
  8. ncbi request reprint The use of fentanyl buccal tablets for breakthrough pain by using doses proportional to opioid basal regimen in a home care setting
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 21:2335-9. 2013
    ..This study suggests that FBT given in doses proportional to the basal opioid regimen for the management of BTcP is very effective and safe in clinical practice in the home care setting...
  9. ncbi request reprint The poor use of methadone in Italian hospices
    Sebastiano Mercadante
    Anesthesia and Intensive Care and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center and University of Palermo, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 21:2225-8. 2013
    ..The aim of this survey was to investigate the frequency of the use of methadone in Italian hospices and how it is used...
  10. doi request reprint Relationship between background cancer pain, breakthrough pain, and analgesic treatment: a preliminary study for a better interpretation of epidemiological and clinical studies
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 29:667-71. 2013
    ..The different operational definitions of breakthrough cancer pain (BTcP) has generated unclear epidemiological data...
  11. ncbi request reprint Opioid use and effectiveness of its prescription at discharge in an acute pain relief and palliative care unit
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Support Care Cancer 21:1853-9. 2013
    ....
  12. doi request reprint Opioid switching from and to tapentadol extended release in cancer patients: conversion ratio with other opioids
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 29:661-6. 2013
    ..The aim of this exploratory study was to assess the conversion ratios between tapentadol and other opioids in patients requiring an opioid switching...
  13. doi request reprint Tapentadol in cancer pain management: a prospective open-label study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, 90146 Palermo, Italy
    Curr Med Res Opin 28:1775-9. 2012
    ..The aim of this prospective, open-label study was to evaluate the efficacy and tolerability of tapentadol (TP) in the management of cancer pain...
  14. doi request reprint Pattern and characteristics of advanced cancer patients admitted to hospices in Italy
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Support Care Cancer 21:935-9. 2013
    ..Data from hospice activities in Italy strongly suggest to spread palliative care in other settings, other than home care and hospice, to intercept oncologic patients in their disease trajectory early...
  15. doi request reprint The effects of low doses of pregabalin on morphine analgesia in advanced cancer patients
    Sebastiano Mercadante
    La Maddalena Cancer Center, Pain Relief and Palliative Care Unit, University of Palermo, Italy
    Clin J Pain 29:15-9. 2013
    ..The aim of this study was to evaluate the opioid response in patients receiving morphine and pregabalin, independently from the presumed pain mechanisms, in comparison with patients receiving morphine treatment only...
  16. doi request reprint Opioid switching in patients with advanced cancer followed at home. A retrospective analysis
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 45:298-304. 2013
    ..Opioid switching has been found to improve opioid responsiveness in different conditions. However, data on opioid switching performed at home are almost nonexistent, despite the fact that most patients are followed at home...
  17. doi request reprint US Food and Drug Administration's Risk Evaluation and Mitigation Strategy for extended-release and long-acting opioids: pros and cons, and a European perspective
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Drugs 72:2327-32. 2012
    ....
  18. doi request reprint Meaningful cut-off pain intensity for breakthrough pain changes in advanced cancer patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 29:93-7. 2013
    ....
  19. doi request reprint Prognostic factors of survival in patients with advanced cancer admitted to home care
    Sebastiano Mercadante
    Pain Relief and Supportive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 45:56-62. 2013
    ..Data regarding prognostication of life expectancy in patients with advanced cancer are of paramount importance to patients, families, and clinicians. However, data regarding patients followed at home are lacking...
  20. doi request reprint Combined oral prolonged-release oxycodone and naloxone in chronic pain management
    Sebastiano Mercadante
    University of Palermo, La Maddalena Cancer Center, Anesthesia and Intensive Care and Pain Relief and Supportive Care Unit, Via San Lorenzo 312, 90146 Palermo, Italy
    Expert Opin Investig Drugs 22:161-6. 2013
    ..The most common drugs used for relieving OIC are laxatives, which do not address the opioid receptor-mediated bowel dysfunction and do not provide sufficient relief...
  21. doi request reprint Octreotide for malignant bowel obstruction: twenty years after
    Sebastiano Mercadante
    Pain Relief and Palliative Care, La Maddalena Cancer Center, Palermo, Italy
    Crit Rev Oncol Hematol 83:388-92. 2012
    ..As such, octreotide is the only drug approved by the health-care system in Italy for this treatment...
  22. doi request reprint Emergencies in patients with advanced cancer followed at home
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 44:295-300. 2012
    ..Caregivers may call medical services for an emergency, which can result in patients being admitted to the hospital. No data exist on emergencies in patients followed by a home care team...
  23. doi request reprint Dosing fentanyl buccal tablet for breakthrough cancer pain: dose titration versus proportional doses
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 28:963-8. 2012
    ....
  24. doi request reprint Palliative sedation in advanced cancer patients followed at home: a retrospective analysis
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 43:1126-30. 2012
    ..Data regarding palliative sedation at home in dying patients are lacking...
  25. doi request reprint Spinal analgesia for advanced cancer patients: an update
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Crit Rev Oncol Hematol 82:227-32. 2012
    ..In complex pain situations, spinal analgesia should not be negated to cancer patients, and oncologists should address this group of patients to other specialists...
  26. doi request reprint Switching methadone: a 10-year experience of 345 patients in an acute palliative care unit
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Pain Med 13:399-404. 2012
    ..The aim of this study was to retrospectively review the chart of cancer patients switched to methadone for unfavorable response to the previous opioid...
  27. doi request reprint The effect of age on opioid switching to methadone: a systematic review
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center and Palliative Medicine, University of Palermo, Palermo, Italy
    J Palliat Med 15:347-51. 2012
    ..The aim of this review was to assess from the existing literature the effect of age on the outcome of opioid switching to methadone, and the possible influence on conversions ratios...
  28. doi request reprint Outcome of opioid switching 4 weeks after discharge from a palliative care unit
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, University of Palermo, Palermo, Italy
    Curr Med Res Opin 27:2357-60. 2011
    ..Despite the favorable effects reported with opioid switching performed in a specialized unit in the short term, data on long-term basis are poor, particularly after discharging patients home or in other settings...
  29. doi request reprint Oral trasmucosal fentanyl citrate for breakthrough pain treatment in cancer patients
    Sebastiano Mercadante
    University of Palermo, La Maddalena Cancer Center, Palermo and Department of Anesthesia, Intensive Care and Emergencies, Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, Via San Lorenzo 312, 90145 Palermo, Italy
    Expert Opin Pharmacother 13:873-8. 2012
    ..The availability of supplemental doses of oral opioids, in addition to the continuous analgesic medication, is the main treatment suggested to manage pain flares...
  30. doi request reprint Pharmacotherapy for breakthrough cancer pain
    Sebastiano Mercadante
    Pain Relief and Supportive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Drugs 72:181-90. 2012
    ..Long-term studies have confirmed their efficacy and safety...
  31. doi request reprint Sexual issues in early and late stage cancer: a review
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Support Care Cancer 18:659-65. 2010
    ..The aim of this review was to examine the literature regarding sexuality in advanced cancer patients, after taking into consideration the principal changes produced by the disease and its treatment...
  32. doi request reprint Effectiveness and tolerability of amidotrizoate for the treatment of constipation resistant to laxatives in advanced cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 41:421-5. 2011
    ..Constipation is a common problem for advanced cancer patients, and is generally inadequately treated...
  33. doi request reprint The use of high doses of oxycodone in an acute palliative care unit
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Am J Hosp Palliat Care 28:242-4. 2011
    ..This study demonstrated that CRO administered in larger doses was safe and effective, showing versatility and flexibility similar to morphine...
  34. doi request reprint Prevalence of opioid-related dysuria in patients with advanced cancer having pain
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Am J Hosp Palliat Care 28:27-30. 2011
    ....
  35. ncbi request reprint Palliative care in Italy: problem areas emerging from the literature
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Minerva Anestesiol 76:1060-71. 2010
    ..The development of a range of palliative care programs integrating primary territorial care and specialized palliative services may constitute the ideal synthesis to respond to patients' needs...
  36. doi request reprint An Italian survey on the attitudes in treating breakthrough cancer pain in hospice
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Support Care Cancer 19:979-83. 2011
    ..The choice of BcP medications should be based on the best cost-efficacy ratio rather than solely on economical considerations...
  37. doi request reprint Breakthrough pain in oncology: a longitudinal study
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 40:183-90. 2010
    ..These studies have used cross-sectional designs, and the relationship of BP with analgesic treatment has not been evaluated...
  38. doi request reprint The use of opioids in the last week of life in an acute palliative care unit
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Am J Hosp Palliat Care 27:514-7. 2010
    ..Doses increases prevalently observed in sedated patients were performed before starting sedation with the purpose to treat concomitant distressing symptoms, such as dyspnoea...
  39. doi request reprint Intravenous morphine for management of cancer pain
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center and Palliative Medicine, Department of Anesthesia and Intensive Care, University of Palermo, Palermo, Italy
    Lancet Oncol 11:484-9. 2010
    ..I.v. morphine is advantageous in specific clinical situations and should be part of armamentarium of all physicians treating pain in patients with cancer...
  40. doi request reprint The use of opioids for breakthrough pain in acute palliative care unit by using doses proportional to opioid basal regimen
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Clin J Pain 26:306-9. 2010
    ..To determine the efficacy and safety of different opioids used in doses proportional to the basal opioid regimen for the management of breakthrough pain (BP)...
  41. doi request reprint Intravenous patient-controlled analgesia and management of pain in post-surgical elderly with cancer
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Surg Oncol 19:173-7. 2010
    ..The success of such a technique depends on close evaluation of all preoperative and intraoperative factors that can cause or contribute to acute delirium. In the present paper we review the literature on this pivotal field...
  42. doi request reprint Management of cancer pain
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Intern Emerg Med 5:S31-5. 2010
    ..This review will offer an update on these problems and the existing therapeutic opportunities...
  43. doi request reprint The use of fentanyl buccal tablets as breakthrough medication in patients receiving chronic methadone therapy: an open label preliminary study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Support Care Cancer 19:435-8. 2011
    ..Whether methadone produces tolerance to other opioids, other opioids should be less effective when administered as a BTcP medication...
  44. ncbi request reprint Morphine versus oxycodone in pancreatic cancer pain: a randomized controlled study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Clin J Pain 26:794-7. 2010
    ..It was hypothesized that OX could have some advantages over MO in terms of efficacy and dose escalation in pancreatic cancer pain...
  45. doi request reprint Switching from oxycodone to methadone in advanced cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Support Care Cancer 20:191-4. 2012
    ..The aim of this study was to prospectively evaluate the outcomes and the conversion ratio of switching from oxycodone to methadone in advanced cancer patients admitted to an acute palliative care unit...
  46. ncbi request reprint Prospects and challenges in opioid analgesia for pain management
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 27:1741-3. 2011
    ..New delivery systems have been developed for a more effective management of breakthrough pain. Pharmacogenetics could play a critical role in personalizing pain management in the future...
  47. doi request reprint Conversion ratios for opioid switching in the treatment of cancer pain: a systematic review
    Sebastiano Mercadante
    University of Palermo, 90146 Palermo, Italy
    Palliat Med 25:504-15. 2011
    ..The derived ratios are influenced by several factors, including the reasons for switching and previous opioid doses. An individual treatment decision and strict monitoring is recommended for patients considered at risk...
  48. ncbi request reprint High doses of oxycodone-naloxone combination may provide poor analgesia
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Support Care Cancer 19:1471-2. 2011
    ..The substitution with the same doses (240 mg/day) of regular controlled-release oxycodone was effective in regaining adequate analgesia...
  49. doi request reprint How do cancer patients receiving palliative care at home die? A descriptive study
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 42:702-9. 2011
    ..Data regarding the circumstances of the process of death of terminally ill patients followed at home are lacking...
  50. doi request reprint Fentanyl buccal tablets for breakthrough pain in highly tolerant cancer patients: preliminary data on the proportionality between breakthrough pain dose and background dose
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 42:464-9. 2011
    ....
  51. doi request reprint Managing breakthrough pain
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90145 Palermo, Italy
    Curr Pain Headache Rep 15:244-9. 2011
    ..The need of titrating opioid doses for BTcP has been commonly recommended in all the controlled studies, but never has been substantiated in appropriate studies...
  52. doi request reprint Does pain intensity predict a poor opioid response in cancer patients?
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Italy
    Eur J Cancer 47:713-7. 2011
    ..The aim of this study was to test the hypothesis that initial pain intensity is not a predictive factor of poor opioid response in advanced cancer patients, as suggested by a recent work...
  53. doi request reprint Palliative sedation in patients with advanced cancer followed at home: a systematic review
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 41:754-60. 2011
    ..Palliative sedation (PS) is considered to be an effective treatment modality for these refractory symptoms when aggressive efforts fail to provide relief...
  54. doi request reprint Refractory death rattle: deep aspiration facilitates the effects of antisecretory agents
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 41:637-9. 2011
    ..This preliminary experience may help further research on the best treatment at the end of life...
  55. doi request reprint The use of high doses of OROS hydromorphone in an acute palliative care unit
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 27:2373-6. 2011
    ....
  56. doi request reprint When the progression of disease lowers opioid requirement in cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, Palermo, Italy
    Clin J Pain 26:56-7. 2010
    ..To describe 2 cases in which an abrupt progression of disease compromising pain pathways and inducing some relief of existing pain or limiting drug delivery to central nervous system...
  57. doi request reprint Pain in patients with lung cancer: pathophysiology and treatment
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90145 Palermo, Italy
    Lung Cancer 68:10-5. 2010
    ..More complex strategies, such as interventional procedures, are seldom necessary and require an appropriate selection of patients...
  58. pmc Transmucosal fentanyl vs intravenous morphine in doses proportional to basal opioid regimen for episodic-breakthrough pain
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Br J Cancer 96:1828-33. 2007
    ..Future comparative studies with appropriate design should compare titration methods and proportional methods of OTFC dosing...
  59. doi request reprint Prevalence and treatment of cancer pain in Italian oncological wards centres: a cross-sectional survey
    Sebastiano Mercadante
    La Maddalena Cancer Center, Palermo, Italy
    Support Care Cancer 16:1203-11. 2008
    ....
  60. doi request reprint Peritoneal catheter for continuous drainage of ascites in advanced cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Support Care Cancer 16:975-8. 2008
    ..A continuous peritoneal drainage by an indwelling catheter has been reported to be hugely beneficial symptomatically, avoiding the hazards and disadvantages of multiple repeated procedures and direct and indirect costs...
  61. doi request reprint Sustained-release oral morphine versus transdermal fentanyl and oral methadone in cancer pain management
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Eur J Pain 12:1040-6. 2008
    ....
  62. doi request reprint Intravenous morphine for breakthrough (episodic-) pain in an acute palliative care unit: a confirmatory study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, University of Palermo, Palermo, Italy
    J Pain Symptom Manage 35:307-13. 2008
    ..The role of nurses is of paramount importance in monitoring and collecting data and gathering information for audit purposes on the unit...
  63. ncbi request reprint Intrathecal treatment in cancer patients unresponsive to multiple trials of systemic opioids
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Clin J Pain 23:793-8. 2007
    ....
  64. ncbi request reprint Injustifiable use of gastroprotection in advanced cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Palliat Med 21:631-3. 2007
    ....
  65. ncbi request reprint Pharmacological management of cancer pain in the elderly
    Sebastiano Mercadante
    Anesthesia and Intensive Care Pain Unit, La Maddalena Cancer Center, and Palliative Medicine, University of Palermo, Palermo, Italy
    Drugs Aging 24:761-76. 2007
    ..Older patients with cancer should be continuously assessed for cancer pain, both before and after analgesic treatment...
  66. ncbi request reprint Clinical and financial analysis of an acute palliative care unit in an oncological department
    S Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Palliat Med 22:760-7. 2008
    ..Our findings also suggest both a cost and quality incentive for oncological departments to develop APC...
  67. doi request reprint High-dose furosemide and small-volume hypertonic saline solution infusion for the treatment of leg edema in advanced cancer patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 37:419-23. 2009
    ..These observations suggest that high-dose furosemide and small-volume saline may be an effective strategy for the treatment of peripheral edema in patients with advanced cancer...
  68. doi request reprint Controlled sedation for refractory symptoms in dying patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 37:771-9. 2009
    ..This study also points to the importance of palliative care and the experience of professionals skilled in both symptom control and end-of-life care...
  69. doi request reprint Equipotent doses to switch from high doses of opioids to transdermal buprenorphine
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center and University of Palermo, Via San Lorenzo 312, 90146 Palermo, Italy
    Support Care Cancer 17:715-8. 2009
    ....
  70. doi request reprint Tools for identifying cancer pain of predominantly neuropathic origin and opioid responsiveness in cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain 10:594-600. 2009
    ..05), and patients with "definite NP" required more intensive treatment. Patients requiring more aggressive treatment showed significantly higher values of Opioid Escalation Index (OEI)mg...
  71. doi request reprint Effects of red blood cell transfusion on anemia-related symptoms in patients with cancer
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Palliat Med 12:60-3. 2009
    ..However, the effects on dyspnea and fatigue tend to decrease within 15 days, despite the maintenance of hemoglobin values attained after transfusions, suggesting that other factors may play a role...
  72. doi request reprint Opioid switching and burst ketamine to improve the opioid response in patients with movement-related pain due to bone metastases
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo Colli 312, 90146 Palermo, Italy
    Clin J Pain 25:648-9. 2009
    ..To improve opioid repsonse in patients with movement-related pain by using opioid switching adding a burst of ketamine...
  73. ncbi request reprint Switching from transdermal drugs: an observational "N of 1" study of fentanyl and buprenorphine
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 34:532-8. 2007
    ..Further studies should be performed to gather data about the use of TTS BU with other opioids, at different doses, and in different clinical conditions...
  74. ncbi request reprint Safety and effectiveness of intravenous morphine for episodic breakthrough pain in patients receiving transdermal buprenorphine
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 32:175-9. 2006
    ..The occurrence of adverse effects for each episode treated was not frequent and intensity was not relevant. IV-MO was effective and safe in most cancer patients receiving TTS-BUP who experienced pain exacerbation...
  75. ncbi request reprint Breakthrough pain in advanced cancer patients followed at home: a longitudinal study
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 38:554-60. 2009
    ..This helps explain the different incidences reported in previous studies performed in different settings and conditions...
  76. ncbi request reprint Addition of a second opioid may improve opioid response in cancer pain: preliminary data
    Sebastiano Mercadante
    La Maddalena Cancer Center, Palliative Medicine Chair of Anesthesia, Intensive Care and Emergency, Palermo, Italy
    Support Care Cancer 12:762-6. 2004
    ..It allowed for a regaining of analgesia, regardless of the opioid combination used. These preliminary observations should be confirmed in further studies...
  77. ncbi request reprint Randomized double-blind, double-dummy crossover clinical trial of oral tramadol versus rectal tramadol administration in opioid-naive cancer patients with pain
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, 90146 Palermo, Italy
    Support Care Cancer 13:702-7. 2005
    ..0002) and patients (P=0.002). Rectal administration of tramadol appears a reliable, noninvasive alternative method of pain control for patients no longer responsive to non-opioid analgesics, unable to take oral tramadol...
  78. ncbi request reprint Low morphine doses in opioid-naive cancer patients with pain
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Clinic for Cancer, and Department of Anesthesiology and Intensive Care, University of Palermo, Palermo, Italy
    J Pain Symptom Manage 31:242-7. 2006
    ....
  79. ncbi request reprint Amitriptyline in neuropathic cancer pain in patients on morphine therapy: a randomized placebo-controlled, double-blind crossover study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Home Palliative Care Program, Società Assistenza Malato Oncologico Terminale, Palermo, Italy
    Tumori 88:239-42. 2002
    ..A randomized placebo-controlled, double-blind crossover study was designed to evidence the effects of amitriptyline in patients with neuropathic cancer pain...
  80. ncbi request reprint Opioid plasma concentrations during a switch from transdermal fentanyl to methadone
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Palliat Med 10:338-44. 2007
    ....
  81. doi request reprint Frequency, indications, outcomes, and predictive factors of opioid switching in an acute palliative care unit
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, University of Palermo, Palermo, Italy
    J Pain Symptom Manage 37:632-41. 2009
    ..The presence of both poor pain relief and adverse effects is a negative factor for switching prognosis, whereas renal failure is not...
  82. ncbi request reprint Dialogues on complex analgesic strategies for difficult pain syndromes
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90146 Palermo, Italy
    Support Care Cancer 12:599-603. 2004
    ..Three case reports illustrate how complex could be the analgesic approach using multiple analgesic regimens and different routes of administration to effectively manage complex pain syndromes commonly defined as unresponsive...
  83. ncbi request reprint Hyperalgesia and opioid switching
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Department of Palliative Medicine, University of Palermo, Palermo, Italy
    Am J Hosp Palliat Care 22:291-4. 2005
    ....
  84. ncbi request reprint Safety and effectiveness of intravenous morphine for episodic (breakthrough) pain using a fixed ratio with the oral daily morphine dose
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 27:352-9. 2004
    ..v.-M at a dose equivalent to 20% of the basal oral dosage is safe and effective in the majority of patients experiencing pain exacerbation. This treatment is inexpensive and can be used at little risk to patients...
  85. doi request reprint Low doses of transdermal fentanyl in opioid-naive patients with cancer pain
    Sebastiano Mercadante
    Anaesthesia and Intensive Care Unit, and Pain Relief and Palliative Care Unit, La Maddalena Cancer Centre, Palermo, Italy
    Curr Med Res Opin 26:2765-8. 2010
    ..The aim of this study was to evaluate the effect and tolerability of low doses of transdermal (TD) fentanyl patches in opioid-naive patients with cancer pain...
  86. ncbi request reprint Rapid switching between transdermal fentanyl and methadone in cancer patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    J Clin Oncol 23:5229-34. 2005
    ..The aim of this study was to examine the clinical effects of switching from transdermal (TTS) fentanyl to methadone, or vice versa, in patients with a poor response to the previous opioid...
  87. ncbi request reprint Rapid titration with intravenous morphine for severe cancer pain and immediate oral conversion
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Cancer 95:203-8. 2002
    ..The aim of the current study was to evaluate a method of rapid titration with intravenous morphine to achieve relief of cancer pain of severe intensity...
  88. ncbi request reprint Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 30:485-91. 2005
    ..These intensive treatments should be reserved for a very selected population and initiated in an appropriate setting with frequent monitoring facilities and skilled nursing...
  89. ncbi request reprint Factors involved in gastrointestinal bleeding in advanced cancer patients followed at home
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 12:95-8. 2004
    ..However, no clear relationship between age, gender, and the use of offender drugs with gastrointestinal bleeding was found. Liver involvement was frequently associated with the risk of developing gastrointestinal bleeding...
  90. ncbi request reprint Is there a ceiling effect of transdermal buprenorphine? Preliminary data in cancer patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 15:441-4. 2007
    ....
  91. ncbi request reprint Opioid-induced or pain relief-reduced symptoms in advanced cancer patients?
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit La Maddalena Cancer Center, Via San Lorenzo Colli 312, 90146 Palermo, Italy
    Eur J Pain 10:153-9. 2006
    ..Moreover, in the clinical setting symptomatic treatment and illness may balance the outcome of opioid titration. Some adverse effects may tend to disappear continuing the treatment in a long-term period...
  92. ncbi request reprint Cancer pain management in children
    Sebastiano Mercadante
    La Maddalena Cancer Center, Palermo, Italy
    Palliat Med 18:654-62. 2004
    ....
  93. ncbi request reprint Scoring the effect of radiotherapy for painful bone metastases
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Via San Lorenzo, Palermo, Italy
    Support Care Cancer 14:967-9. 2006
    ..An integration of competences in monitoring the pain response and modifying the opioid treatment according to changes of the clinical condition is mandatory...
  94. ncbi request reprint Opioid escalation in patients with cancer pain: the effect of age
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    J Pain Symptom Manage 32:413-9. 2006
    ..However, the group of patients over 75 was relatively small and data should be interpreted with caution. Careful titration based on the individual response seems appropriate irrespective of age...
  95. ncbi request reprint Treatment strategies for cancer patients with breakthrough pain
    Alessandra Casuccio
    University of Palermo, Department of Clinical Neuroscience, Palermo, Italy
    Expert Opin Pharmacother 10:947-53. 2009
    ..It is normally severe in intensity, has a rapid onset, has a variable duration (on average 30 min) and is considered a negative prognostic factor...
  96. ncbi request reprint Episodic (breakthrough) pain: consensus conference of an expert working group of the European Association for Palliative Care
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Cancer 94:832-9. 2002
    ..The wide differences in estimation of incidence reported in literature are probably because of different settings and meanings attributed to the definition of breakthrough pain...
  97. ncbi request reprint Management of painful bone metastases
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit La Maddalena Cancer Center, University of Palermo, Palermo, Italy
    Curr Opin Oncol 19:308-14. 2007
    ..This review examines recent data on the pathophysiology and mechanisms of bone pain; it highlights the use of multiple and interdisciplinary treatments rather than sole use of traditional analgesics...
  98. ncbi request reprint Why are our patients still suffering pain?
    Sebastiano Mercadante
    La Maddalena Cancer Center, Via San Lorenzo 312, 90145 Palermo, Italy
    Nat Clin Pract Oncol 4:138-9. 2007
  99. ncbi request reprint Optimization of opioid therapy for preventing incident pain associated with bone metastases
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 28:505-10. 2004
    ..This approach is based on experimental bone models showing a hypersensitivity to some innocuous stimuli, such as movement, requiring pre-emptive higher doses of basal opioid medication to reduce the increased pain input...
  100. ncbi request reprint A model of acute symptom control unit: Pain Relief and Palliative Care Unit of La Maddalena Cancer Center
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo Colli 312, 90146 Palermo, Italy
    Support Care Cancer 11:114-9. 2003
    ....
  101. ncbi request reprint Opioid switching: a systematic and critical review
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Cancer Treat Rev 32:304-15. 2006
    ..The process of reaching an optimal dose should be highly individualized, particularly when patients are switched from high doses of opioids, given the wide conversion ratios reported in literature...