Antonella Viola

Summary

Affiliation: Istituto Clinico Humanitas
Country: Italy

Publications

  1. ncbi Lipid rafts and T cell receptor signaling: a critical re-evaluation
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Eur J Immunol 32:3082-91. 2002
  2. ncbi Metabolic mechanisms of cancer-induced inhibition of immune responses
    Antonella Viola
    Venetian Institute of Molecular Medicine, Padua, Italy Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Semin Cancer Biol 17:309-16. 2007
  3. ncbi Chemokines and their receptors: drug targets in immunity and inflammation
    Antonella Viola
    Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Milan, Italy
    Annu Rev Pharmacol Toxicol 48:171-97. 2008
  4. ncbi Tether and trap: regulation of membrane-raft dynamics by actin-binding proteins
    Antonella Viola
    Istituto Clinico Humanitas IRCCS, Via Manzoni 113, 20089 Rozzano, Milan, Italy University of Milan, Faculty of Medicine, Italy
    Nat Rev Immunol 7:889-96. 2007
  5. ncbi Chemokines: coded messages for T-cell missions
    Antonella Viola
    Istituto Clinico Humanitas I R C C S, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Front Biosci 13:6341-53. 2008
  6. doi Signaling amplification at the immunological synapse
    Antonella Viola
    Laboratory of Adaptive Immunity, Department of Translational Medicine, University of Milan, I R C C S Istituto Clinico Humanitas, 20089, Rozzano, Milan, Italy
    Curr Top Microbiol Immunol 340:109-22. 2010
  7. pmc Agrin is required for survival and function of monocytic cells
    Cristina Mazzon
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico, Rozzano, Milan, Italy
    Blood 119:5502-11. 2012
  8. doi Regulatory T cells target chemokine secretion by dendritic cells independently of their capacity to regulate T cell proliferation
    Sara Morlacchi
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    J Immunol 186:6807-14. 2011
  9. doi The pros and cons of chemokines in tumor immunology
    Antonella Viola
    Istituto Clinico Humanitas IRCCS and Department of Translational Medicine, University of Milan, Via Manzoni 113, 20089 Rozzano, Milan, Italy
    Trends Immunol 33:496-504. 2012
  10. doi Self-antigen presentation by mouse B cells results in regulatory T-cell induction rather than anergy or clonal deletion
    Sara Morlacchi
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Milan, Italy
    Blood 118:984-91. 2011

Collaborators

Detail Information

Publications29

  1. ncbi Lipid rafts and T cell receptor signaling: a critical re-evaluation
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Eur J Immunol 32:3082-91. 2002
    ..These results indicate that, while signaling through GPI-anchored proteins requires lipid raft integrity, CD3-dependent TCR activation occurs independently of cholesterol extraction...
  2. ncbi Metabolic mechanisms of cancer-induced inhibition of immune responses
    Antonella Viola
    Venetian Institute of Molecular Medicine, Padua, Italy Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Semin Cancer Biol 17:309-16. 2007
    ..The knowledge of these complex and partially interconnected metabolic pathways is offering new targets for an integrated pharmacological approach aiming at freeing tumor-specific T lymphocytes from the latches of cancer influence...
  3. ncbi Chemokines and their receptors: drug targets in immunity and inflammation
    Antonella Viola
    Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Milan, Italy
    Annu Rev Pharmacol Toxicol 48:171-97. 2008
    ..In this review, we examine the role of chemokines in health and diseases and discuss strategies to target the chemokine system...
  4. ncbi Tether and trap: regulation of membrane-raft dynamics by actin-binding proteins
    Antonella Viola
    Istituto Clinico Humanitas IRCCS, Via Manzoni 113, 20089 Rozzano, Milan, Italy University of Milan, Faculty of Medicine, Italy
    Nat Rev Immunol 7:889-96. 2007
    ..This new and dynamic view of the plasma membrane may improve our understanding of the complex process leading to cell polarization during lymphocyte migration and activation...
  5. ncbi Chemokines: coded messages for T-cell missions
    Antonella Viola
    Istituto Clinico Humanitas I R C C S, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Front Biosci 13:6341-53. 2008
    ..In this review we will discuss the role of chemokines in T-cell biology, following an ideal pilgrimage that spans the key steps of the T-cell life...
  6. doi Signaling amplification at the immunological synapse
    Antonella Viola
    Laboratory of Adaptive Immunity, Department of Translational Medicine, University of Milan, I R C C S Istituto Clinico Humanitas, 20089, Rozzano, Milan, Italy
    Curr Top Microbiol Immunol 340:109-22. 2010
    ..In this review, we discuss some strategies used by membrane receptors to tune activation signals in T cells...
  7. pmc Agrin is required for survival and function of monocytic cells
    Cristina Mazzon
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico, Rozzano, Milan, Italy
    Blood 119:5502-11. 2012
    ..Altogether, these data identify agrin as a novel player of innate immunity...
  8. doi Regulatory T cells target chemokine secretion by dendritic cells independently of their capacity to regulate T cell proliferation
    Sara Morlacchi
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    J Immunol 186:6807-14. 2011
    ..Overall, our results shed some light on the different aspects that need to be considered when attempting to modulate Tregs for clinical purposes...
  9. doi The pros and cons of chemokines in tumor immunology
    Antonella Viola
    Istituto Clinico Humanitas IRCCS and Department of Translational Medicine, University of Milan, Via Manzoni 113, 20089 Rozzano, Milan, Italy
    Trends Immunol 33:496-504. 2012
    ..Although the field is in its infancy, we also highlight how targeting chemokines offers a tool to modulate the tumor environment with the aim of enhancing immune-mediated rejection of cancer...
  10. doi Self-antigen presentation by mouse B cells results in regulatory T-cell induction rather than anergy or clonal deletion
    Sara Morlacchi
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Milan, Italy
    Blood 118:984-91. 2011
    ..The results presented in this study underline the role of B cells in Treg induction and may have important implications in clinical protocols aimed at the peripheral expansion of Tregs in patients...
  11. pmc The critical role of agrin in the hematopoietic stem cell niche
    Cristina Mazzon
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Blood 118:2733-42. 2011
    ..These data unveil a crucial role of agrin in the hematopoietic niches and in the cross-talk between stromal and hematopoietic stem cells...
  12. pmc Tunable chemokine production by antigen presenting dendritic cells in response to changes in regulatory T cell frequency in mouse reactive lymph nodes
    Valentina Dal Secco
    Istituto Clinico Humanitas IRCCS, Milan, Italy
    PLoS ONE 4:e7696. 2009
    ..Recent experiments using two photon laser microscopy indicate that dendritic cells (DCs) are central to Treg cell function and that the in vivo mechanisms of T cell regulation are more complex than those described in vitro...
  13. pmc The CXCR4 mutations in WHIM syndrome impair the stability of the T-cell immunologic synapse
    Marinos Kallikourdis
    Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    Blood 122:666-73. 2013
    ..These findings demonstrate that chemokine receptors can affect T-APC synapse stability and allow us to propose a novel mechanism that contributes to the adaptive immune response defects in WHIM patients. ..
  14. pmc Adhesion shapes T cells for prompt and sustained T-cell receptor signalling
    Rita Lucia Contento
    Department of Translational Medicine, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    EMBO J 29:4035-47. 2010
    ..Our data show that the initial adhesive signals delivered by chemokines and LFA-1 shape and prepare T cells for antigen recognition...
  15. pmc Serotonin-mediated tuning of human helper T cell responsiveness to the chemokine CXCL12
    Elena Magrini
    Humanitas Clinical Institute IRCCS, Rozzano, Milan, Italy
    PLoS ONE 6:e22482. 2011
    ..Our data suggest that the reduced T cell responsiveness to CXCL12 induced by 5-HT may occur to facilitate T cell extravasation and migration into inflamed tissues...
  16. pmc From tango to quadrilla: current views of the immunological synapse
    Cristina Mazzon
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Cell Adh Migr 1:7-12. 2007
    ..In this review, we present the current views on the immunological synapse and discuss about some interesting unresolved questions...
  17. ncbi CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse
    Regina Tavano
    Venetian Institute of Molecular Medicine, Department of Biomedical Science, University of Padua, 35100 Padua, Italy
    Nat Cell Biol 8:1270-6. 2006
    ..Together, our data indicate that CD28 binding to FLNa is required to induce the T-cell cytoskeletal rearrangements leading to recruitment of lipid microdomains and signalling mediators into the immunological synapse...
  18. ncbi Lymphocyte lipid rafts: structure and function
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Via G Colombo 3, 35121 Padova, Italy
    Curr Opin Immunol 15:255-60. 2003
    ....
  19. ncbi Lipid rafts in lymphocyte activation
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Viale Giuseppe Colombo 3, I 35121, Italy
    Microbes Infect 6:686-92. 2004
    ..In this review, we discuss the recent literature suggesting that, during lymphocyte activation and chemotaxis, lipid rafts act as platforms to compartmentalise signalling and facilitate specific protein-protein interactions...
  20. ncbi The inner side of T cell lipid rafts
    Giorgia Gri
    Department of Biomedical Sciences, Venetian Institute of Molecular Medicine, University of Padua, 35129 Padua, Italy
    Immunol Lett 94:247-52. 2004
    ..Interestingly, TCR/CD3 cross-linking induces co-capping of the raft bilayer independently of cholesterol or signaling events, indicating that cholesterol-extracting drugs are unable to destroy TCR-lipid rafts interaction...
  21. ncbi Physiological T cell activation starts and propagates in lipid rafts
    Paola Pizzo
    Department of Biomedical Sciences, University of Padova, Via G Colombo 3, 35121 Padova, Italy
    Immunol Lett 91:3-9. 2004
    ..Moreover, T cell stimulation by pulsed EBV-B cells, but not by anti-CD3 antibodies, induced recruitment of active Lck in detergent-resistant membranes, where the signal transduction is organized and amplified...
  22. ncbi CD28 and lipid rafts coordinate recruitment of Lck to the immunological synapse of human T lymphocytes
    Regina Tavano
    Venetian Institute of Molecular Medicine and Department of Biomedical Science, University of Padua, Padua, Italy
    J Immunol 173:5392-7. 2004
    ..These results indicate that CD28 signaling orchestrates both Lck and lipid raft recruitment to the IS to amplify T cell activation...
  23. ncbi T cell costimulation by chemokine receptors
    Barbara Molon
    Venetian Institute of Molecular Medicine and Department of Biomedical Science, University of Padua, 35100 Padua, Italy
    Nat Immunol 6:465-71. 2005
    ....
  24. pmc CXCR4-CCR5: a couple modulating T cell functions
    Rita Lucia Contento
    Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy
    Proc Natl Acad Sci U S A 105:10101-6. 2008
    ..We suggest that cooperation between receptors represents one key strategy for the functional plasticity of chemokines...
  25. ncbi Lipid rafts in lymphocyte activation and migration
    Santos Manes
    Department of Immunology and Oncology, National Center of Biotechnology Consejo Superior de Investigaciones Científicas, Madrid, Spain
    Mol Membr Biol 23:59-69. 2006
    ..In this review we discuss the roles of lipid rafts as organizers of T lymphocyte polarity during cell activation and migration...
  26. ncbi T cells and their partners: The chemokine dating agency
    Antonella Viola
    Department of Biomedical Science, University of Padua and Venetian Institute of Molecular Medicine, 35129 Padua, Italy
    Trends Immunol 27:421-7. 2006
    ..These findings identify new roles for chemokines in T-cell triggering and activation of effector functions, and suggest that these small cytokines represent key conductors of adaptive immunity...
  27. pmc Flying kites on slippery slopes at Keystone. Symposium on Lipid Rafts and Cell Function
    Satvajit Mayor
    National Centre for Biological Science NCBS, Bellary Road, Bangalore 560 065, India
    EMBO Rep 7:1089-93. 2006
  28. ncbi Filamin-A regulates actin-dependent clustering of HIV receptors
    Sonia Jimenez-Baranda
    Department of Immunology and Oncology Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas CSIC, Darwin 3, Campus de Cantoblanco, 28049 Madrid, Spain
    Nat Cell Biol 9:838-46. 2007
    ..Our results thus identify filamin-A as an adaptor protein that links HIV-1 receptors to the actin cytoskeleton remodelling machinery, which may facilitate virus infection...
  29. ncbi Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1
    Barbara Marinari
    Department of Cellular and Developmental Biology, University of Rome La Sapienza, Via del Sardi 70, I 00185 Rome, Italy
    Eur J Immunol 32:447-56. 2002
    ..These results identify Vav, Rac-1 and MEKK1 as components of a common pathway regulating both NF-kappaB and AP-1 that contributes to full activation of the CD28 response element (CD28RE)...