Research Topics
| Antonella ViolaSummaryAffiliation: Istituto Clinico Humanitas Country: Italy Publications
| Collaborators
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Detail Information
Publications
Lipid rafts and T cell receptor signaling: a critical re-evaluationPaola Pizzo
Department of Biomedical Sciences, University of Padova, Padova, Italy
Eur J Immunol 32:3082-91. 2002..These results indicate that, while signaling through GPI-anchored proteins requires lipid raft integrity, CD3-dependent TCR activation occurs independently of cholesterol extraction...- Metabolic mechanisms of cancer-induced inhibition of immune responsesAntonella Viola
Venetian Institute of Molecular Medicine, Padua, Italy Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
Semin Cancer Biol 17:309-16. 2007..The knowledge of these complex and partially interconnected metabolic pathways is offering new targets for an integrated pharmacological approach aiming at freeing tumor-specific T lymphocytes from the latches of cancer influence... - Chemokines and their receptors: drug targets in immunity and inflammationAntonella Viola
Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Milan, Italy
Annu Rev Pharmacol Toxicol 48:171-97. 2008..In this review, we examine the role of chemokines in health and diseases and discuss strategies to target the chemokine system... - Tether and trap: regulation of membrane-raft dynamics by actin-binding proteinsAntonella Viola
Istituto Clinico Humanitas IRCCS, Via Manzoni 113, 20089 Rozzano, Milan, Italy University of Milan, Faculty of Medicine, Italy
Nat Rev Immunol 7:889-96. 2007..This new and dynamic view of the plasma membrane may improve our understanding of the complex process leading to cell polarization during lymphocyte migration and activation... - Chemokines: coded messages for T-cell missionsAntonella Viola
Istituto Clinico Humanitas I R C C S, Via Manzoni 56, 20089 Rozzano, Milan, Italy
Front Biosci 13:6341-53. 2008..In this review we will discuss the role of chemokines in T-cell biology, following an ideal pilgrimage that spans the key steps of the T-cell life... 
Signaling amplification at the immunological synapseAntonella Viola
Laboratory of Adaptive Immunity, Department of Translational Medicine, University of Milan, I R C C S Istituto Clinico Humanitas, 20089, Rozzano, Milan, Italy
Curr Top Microbiol Immunol 340:109-22. 2010..In this review, we discuss some strategies used by membrane receptors to tune activation signals in T cells...
Agrin is required for survival and function of monocytic cellsCristina Mazzon
Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico, Rozzano, Milan, Italy
Blood 119:5502-11. 2012..Altogether, these data identify agrin as a novel player of innate immunity...- Regulatory T cells target chemokine secretion by dendritic cells independently of their capacity to regulate T cell proliferationSara Morlacchi
Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
J Immunol 186:6807-14. 2011..Overall, our results shed some light on the different aspects that need to be considered when attempting to modulate Tregs for clinical purposes... - The pros and cons of chemokines in tumor immunologyAntonella Viola
Istituto Clinico Humanitas IRCCS and Department of Translational Medicine, University of Milan, Via Manzoni 113, 20089 Rozzano, Milan, Italy
Trends Immunol 33:496-504. 2012..Although the field is in its infancy, we also highlight how targeting chemokines offers a tool to modulate the tumor environment with the aim of enhancing immune-mediated rejection of cancer... - The critical role of agrin in the hematopoietic stem cell nicheCristina Mazzon
Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
Blood 118:2733-42. 2011..These data unveil a crucial role of agrin in the hematopoietic niches and in the cross-talk between stromal and hematopoietic stem cells... - Self-antigen presentation by mouse B cells results in regulatory T-cell induction rather than anergy or clonal deletionSara Morlacchi
Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Milan, Italy
Blood 118:984-91. 2011..The results presented in this study underline the role of B cells in Treg induction and may have important implications in clinical protocols aimed at the peripheral expansion of Tregs in patients... - Tunable chemokine production by antigen presenting dendritic cells in response to changes in regulatory T cell frequency in mouse reactive lymph nodesValentina Dal Secco
Istituto Clinico Humanitas IRCCS, Milan, Italy
PLoS ONE 4:e7696. 2009..Recent experiments using two photon laser microscopy indicate that dendritic cells (DCs) are central to Treg cell function and that the in vivo mechanisms of T cell regulation are more complex than those described in vitro... - Serotonin-mediated tuning of human helper T cell responsiveness to the chemokine CXCL12Elena Magrini
Humanitas Clinical Institute IRCCS, Rozzano, Milan, Italy
PLoS ONE 6:e22482. 2011..Our data suggest that the reduced T cell responsiveness to CXCL12 induced by 5-HT may occur to facilitate T cell extravasation and migration into inflamed tissues... - Adhesion shapes T cells for prompt and sustained T-cell receptor signallingRita Lucia Contento
Department of Translational Medicine, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
EMBO J 29:4035-47. 2010..Our data show that the initial adhesive signals delivered by chemokines and LFA-1 shape and prepare T cells for antigen recognition... - From tango to quadrilla: current views of the immunological synapseCristina Mazzon
Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
Cell Adh Migr 1:7-12. 2007..In this review, we present the current views on the immunological synapse and discuss about some interesting unresolved questions... - CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapseRegina Tavano
Venetian Institute of Molecular Medicine, Department of Biomedical Science, University of Padua, 35100 Padua, Italy
Nat Cell Biol 8:1270-6. 2006..Together, our data indicate that CD28 binding to FLNa is required to induce the T-cell cytoskeletal rearrangements leading to recruitment of lipid microdomains and signalling mediators into the immunological synapse... - Lymphocyte lipid rafts: structure and functionPaola Pizzo
Department of Biomedical Sciences, University of Padova, Via G Colombo 3, 35121 Padova, Italy
Curr Opin Immunol 15:255-60. 2003.... - Physiological T cell activation starts and propagates in lipid raftsPaola Pizzo
Department of Biomedical Sciences, University of Padova, Via G Colombo 3, 35121 Padova, Italy
Immunol Lett 91:3-9. 2004..Moreover, T cell stimulation by pulsed EBV-B cells, but not by anti-CD3 antibodies, induced recruitment of active Lck in detergent-resistant membranes, where the signal transduction is organized and amplified... - T cell costimulation by chemokine receptorsBarbara Molon
Venetian Institute of Molecular Medicine and Department of Biomedical Science, University of Padua, 35100 Padua, Italy
Nat Immunol 6:465-71. 2005.... - CXCR4-CCR5: a couple modulating T cell functionsRita Lucia Contento
Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy
Proc Natl Acad Sci U S A 105:10101-6. 2008..We suggest that cooperation between receptors represents one key strategy for the functional plasticity of chemokines... - Lipid rafts in lymphocyte activationPaola Pizzo
Department of Biomedical Sciences, University of Padova, Viale Giuseppe Colombo 3, I 35121, Italy
Microbes Infect 6:686-92. 2004..In this review, we discuss the recent literature suggesting that, during lymphocyte activation and chemotaxis, lipid rafts act as platforms to compartmentalise signalling and facilitate specific protein-protein interactions... - The inner side of T cell lipid raftsGiorgia Gri
Department of Biomedical Sciences, Venetian Institute of Molecular Medicine, University of Padua, 35129 Padua, Italy
Immunol Lett 94:247-52. 2004..Interestingly, TCR/CD3 cross-linking induces co-capping of the raft bilayer independently of cholesterol or signaling events, indicating that cholesterol-extracting drugs are unable to destroy TCR-lipid rafts interaction... - CD28 and lipid rafts coordinate recruitment of Lck to the immunological synapse of human T lymphocytesRegina Tavano
Venetian Institute of Molecular Medicine and Department of Biomedical Science, University of Padua, Padua, Italy
J Immunol 173:5392-7. 2004..These results indicate that CD28 signaling orchestrates both Lck and lipid raft recruitment to the IS to amplify T cell activation... - Filamin-A regulates actin-dependent clustering of HIV receptorsSonia Jimenez-Baranda
Department of Immunology and Oncology Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas CSIC, Darwin 3, Campus de Cantoblanco, 28049 Madrid, Spain
Nat Cell Biol 9:838-46. 2007..Our results thus identify filamin-A as an adaptor protein that links HIV-1 receptors to the actin cytoskeleton remodelling machinery, which may facilitate virus infection... - Flying kites on slippery slopes at Keystone. Symposium on Lipid Rafts and Cell FunctionSatvajit Mayor
National Centre for Biological Science (NCBS, Bellary Road, Bangalore 560 065, India
EMBO Rep 7:1089-93. 2006 - T cells and their partners: The chemokine dating agencyAntonella Viola
Department of Biomedical Science, University of Padua and Venetian Institute of Molecular Medicine, 35129 Padua, Italy
Trends Immunol 27:421-7. 2006..These findings identify new roles for chemokines in T-cell triggering and activation of effector functions, and suggest that these small cytokines represent key conductors of adaptive immunity... - Lipid rafts in lymphocyte activation and migrationSantos Manes
Department of Immunology and Oncology, National Center of Biotechnology Consejo Superior de Investigaciones Científicas, Madrid, Spain
Mol Membr Biol 23:59-69. 2006..In this review we discuss the roles of lipid rafts as organizers of T lymphocyte polarity during cell activation and migration... - Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1Barbara Marinari
Department of Cellular and Developmental Biology, University of Rome La Sapienza, Via del Sardi 70, I-00185 Rome, Italy
Eur J Immunol 32:447-56. 2002..These results identify Vav, Rac-1 and MEKK1 as components of a common pathway regulating both NF-kappaB and AP-1 that contributes to full activation of the CD28 response element (CD28RE)...