Giuseppe Viglietto

Summary

Affiliation: Istituto di Chimica Biomolecolare
Country: Italy

Publications

  1. pmc Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization
    Maria Letizia Motti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Am J Pathol 166:737-49. 2005
  2. ncbi request reprint The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib
    Nicola Normanno
    Cell Biology and Preclinical Models Unit, INT Fondazione Pascale, Naples, Italy
    J Cell Physiol 207:420-7. 2006
  3. ncbi request reprint Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
    Giuseppe Viglietto
    Istituto di Endocrinologia ed Oncologia Sperimentale, CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Naples, Italy
    Nat Med 8:1136-44. 2002
  4. ncbi request reprint Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization
    Giuseppe Viglietto
    Instituto di Endocrinologia ed Oncologia Sperimentale, CNR and Dipartimento di Biologia e Patologie Cellulare e Molecolare, Naples, Italy
    Cell Cycle 1:394-400. 2002
  5. ncbi request reprint Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells
    Donata Vitagliano
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II c o Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy
    Cancer Res 64:3823-9. 2004
  6. ncbi request reprint Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1)
    Gustavo Baldassarre
    Istituto Nazionale Tumori, Via M Semmola, 80131, Naples, Italy
    Oncogene 21:1739-49. 2002
  7. doi request reprint The role of CD133 in the identification and characterisation of tumour-initiating cells in non-small-cell lung cancer
    Virginia Tirino
    Department of Experimental Oncology, National Cancer Institute, Naples, Italy
    Eur J Cardiothorac Surg 36:446-53. 2009
  8. pmc A new mechanism of BRAF activation in human thyroid papillary carcinomas
    Alfredo Fusco
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    J Clin Invest 115:20-3. 2005
  9. ncbi request reprint Therapy of human pancreatic carcinoma based on suppression of HMGA1 protein synthesis in preclinical models
    Francesco Trapasso
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, c o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Universita di Napoli Federico II, Naples, Italy
    Cancer Gene Ther 11:633-41. 2004
  10. ncbi request reprint The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins
    Angela Iervolino
    Naples Oncogenomic Center Centro di Ricerca per l Ingegneria Genetica, Biotecnologie Avanzate, Italy
    Cancer Res 66:6280-7. 2006

Collaborators

  • Carlo Croce
  • P Chieffi
  • Alfredo Fusco
  • Takashi Watanabe
  • Renato Franco
  • Manuela Campiglio
  • Sai Yendamuri
  • Marina N Nikiforova
  • Gustavo Baldassarre
  • Rami I Aqeilan
  • Alfonso Bellacosa
  • Mario Mancino
  • M Santoro
  • Y E Nikiforov
  • Gennaro Chiappetta
  • Maria Letizia Motti
  • Donatella Malanga
  • Francesco Trapasso
  • Carmela De Marco
  • Daniela Califano
  • Rodolfo Iuliano
  • Virginia Tirino
  • Fernanda Fabiani
  • Giancarlo Troncone
  • Monica Fedele
  • Ilaria Le Pera
  • Francesca Pentimalli
  • Gaetano Rocco
  • Giuseppe Pirozzi
  • Silvia De Gisi
  • Angela Iervolino
  • Nicola Normanno
  • Maria Napolitano
  • Francesca Carlomagno
  • Barbara Tavernise
  • Dolores Di Vizio
  • Rosa Marina Melillo
  • Filippo Schepis
  • Letizia Cito
  • Lorenzo Chiariotti
  • Rosa Visone
  • Sabrina Battista
  • Donata Vitagliano
  • Lucio Palombini
  • Angelo Boccia
  • Kristoffel R Dumon
  • Giovanna Maria Pierantoni
  • Rosa Camerlingo
  • Antonello La Rocca
  • Rocco Savino
  • Nicla De Rosa
  • Natalia Malara
  • Marianna Scrima
  • Angela Persico
  • Simona Losito
  • Adele Carotenuto
  • Monica R Maiello
  • Antonella De Luca
  • Sylvie Menard
  • Salvatore Venuta
  • Lawrence Kenyon
  • Francesco Merolla
  • Luciano Pezzullo
  • Wanda D'Amico
  • Floriana Forzati
  • Gennaro Schettini
  • Tullio Florio
  • Guido Pettinato
  • Christiane Susini
  • Emiliano Palmieri
  • Andres J P Klein-Szanto
  • Ivana De Martino
  • Andrea Ciarmiello
  • Angela Celetti
  • Ilenia Migliaccio
  • Claudio Arra
  • Luigi Insabato
  • Anderson J Ryan
  • Jerome M Hershman
  • Nobutsugu Abe
  • Hansjuerg Alder
  • Rossano Cesari
  • Manuela Sarti
  • Luisa Infante
  • Mario Monaco
  • Irene Samà
  • Paola Bruni
  • Antonella Federico
  • Alessandra Clodomiro
  • Barbara Belletti

Detail Information

Publications20

  1. pmc Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization
    Maria Letizia Motti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Am J Pathol 166:737-49. 2005
    ..Thus the PI3/AKT pathway and its effector p27(kip1) play major roles in thyroid carcinogenesis...
  2. ncbi request reprint The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib
    Nicola Normanno
    Cell Biology and Preclinical Models Unit, INT Fondazione Pascale, Naples, Italy
    J Cell Physiol 207:420-7. 2006
    ..Taken together, these data strongly support the role of the MEK/MAPK pathway in the resistance to gefitinib, and provide the rationale for novel therapeutic approaches based on combinations of signal transduction inhibitors...
  3. ncbi request reprint Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
    Giuseppe Viglietto
    Istituto di Endocrinologia ed Oncologia Sperimentale, CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Naples, Italy
    Nat Med 8:1136-44. 2002
    ....
  4. ncbi request reprint Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization
    Giuseppe Viglietto
    Instituto di Endocrinologia ed Oncologia Sperimentale, CNR and Dipartimento di Biologia e Patologie Cellulare e Molecolare, Naples, Italy
    Cell Cycle 1:394-400. 2002
    ..Finally, we review the possible clinical implications of these observations with respect to prognosis and novel anticancer therapies...
  5. ncbi request reprint Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells
    Donata Vitagliano
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II c o Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy
    Cancer Res 64:3823-9. 2004
    ..Therefore, in thyroid cancer, RET/PTC-mediated MAPK activation contributes to p27Kip1 deregulation. This pathway is implicated in cell cycle progression and in response to small molecule kinase inhibitors...
  6. ncbi request reprint Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1)
    Gustavo Baldassarre
    Istituto Nazionale Tumori, Via M Semmola, 80131, Naples, Italy
    Oncogene 21:1739-49. 2002
    ..Both DNA synthesis inhibition and SSEA-3 down-regulation are prevented if p27(kip1) expression is blocked by an antisense construct, which demonstrates that RET-triggered effects are mediated by p27(kip1)...
  7. doi request reprint The role of CD133 in the identification and characterisation of tumour-initiating cells in non-small-cell lung cancer
    Virginia Tirino
    Department of Experimental Oncology, National Cancer Institute, Naples, Italy
    Eur J Cardiothorac Surg 36:446-53. 2009
    ..This study aimed at isolating and characterising the population of tumour-initiating cells in non-small-cell lung cancer (NSCLC)...
  8. pmc A new mechanism of BRAF activation in human thyroid papillary carcinomas
    Alfredo Fusco
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    J Clin Invest 115:20-3. 2005
    ..The resulting AKAP9-BRAF fusion protein shows constitutive kinase activity, and it is able to transmit mitogenic signals to the MAPK pathways and to promote malignant transformation of NIH3T3 cells...
  9. ncbi request reprint Therapy of human pancreatic carcinoma based on suppression of HMGA1 protein synthesis in preclinical models
    Francesco Trapasso
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, c o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Universita di Napoli Federico II, Naples, Italy
    Cancer Gene Ther 11:633-41. 2004
    ..Therefore, suppression of HMGA1 protein synthesis by an HMGA1 antisense approach seems to be a feasible treatment strategy in pancreatic carcinomas...
  10. ncbi request reprint The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins
    Angela Iervolino
    Naples Oncogenomic Center Centro di Ricerca per l Ingegneria Genetica, Biotecnologie Avanzate, Italy
    Cancer Res 66:6280-7. 2006
    ..On the other hand, resistance to PTPRJ may be part of the mechanism of RET oncogenic conversion secondary to the M918T mutation...
  11. ncbi request reprint An adenovirus carrying the rat protein tyrosine phosphatase eta suppresses the growth of human thyroid carcinoma cell lines in vitro and in vivo
    Rodolfo Iuliano
    Dipartimento di Medicina Sperimentale e Clinica, Facolta di Medicina e Chirurgia di Catanzaro, Università degli Studi di Catanzaro Magna Graecia, 88100 Catanzaro, Italy
    Cancer Res 63:882-6. 2003
    ..These data suggest that gene therapy based on restoration of PTPeta function has potential in the treatment of human thyroid malignant neoplasias...
  12. ncbi request reprint Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors
    Dolores Di Vizio
    Dipartimento di Scienze Biomorfologiche e Funzionali, Facolta di Medicina e Chirurgia, Universita di Napoli Federico II, Via S Pansini, 5, 80131 Napoli, Italy
    Oncogene 24:1882-94. 2005
    ....
  13. ncbi request reprint Reduced E-cadherin expression contributes to the loss of p27kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas
    Maria Letizia Motti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano Facoltà di Medicina e Chirurgia, Universita Federico II, Via S Pansini 5, 80131, Napoli, Italy
    Carcinogenesis 26:1021-34. 2005
    ..In summary, our data indicate that the altered response to contact inhibition exhibited by thyroid anaplastic cancer cells is due to the failure to upregulate p27(Kip1) in response to cell-cell interactions...
  14. ncbi request reprint Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer
    Maria Letizia Motti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano Facoltà di Medicina e Chirurgia, Universita Federico II, Via S Pansini 5, Napoli, Italy
    Cell Cycle 3:1074-80. 2004
    ..We conclude that in breast cancer cells p27(kip1) is phosphorylated at T198 in a PI3K/Akt dependent manner and that this phosphorylation may contribute to p27(kip1) cytoplasmic mislocalization observed in breast cancer...
  15. ncbi request reprint The rat tyrosine phosphatase eta increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue
    Ilaria Le Pera
    Department of Experimental and Clinical Medicine, Medical School of Catanzaro, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy
    Oncogene 24:3187-95. 2005
    ..Interestingly, the extent of both c-Src dephosphorylation at Tyr 529, FAK and paxillin phosphorylation, and the increased cell adhesion were associated with the degree of r-PTPeta expression...
  16. ncbi request reprint A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas
    Giovanna Maria Pierantoni
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Via Pansini 5, I 80131 Naples, Italy
    Carcinogenesis 24:1861-9. 2003
    ..These results suggest a critical role played by HMGA1 rearrangements in the generation of human lipomas...
  17. ncbi request reprint Critical role of cyclin D3 in TSH-dependent growth of thyrocytes and in hyperproliferative diseases of the thyroid gland
    Maria Letizia Motti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita Federico II, Via S Pansini 5, 80131 Naples, Italy
    Oncogene 22:7576-86. 2003
    ..Finally, we found that cyclin D3 protein is expressed in a fraction of human goiters but it is strongly overexpressed in most follicular adenomas...
  18. ncbi request reprint Loss of p27 expression through RAS-->BRAF-->MAP kinase-dependent pathway in human thyroid carcinomas
    Maria Letizia Motti
    Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Universita Parthenope, Napoli, Italy
    Cell Cycle 6:2817-25. 2007
    ....
  19. ncbi request reprint Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung
    Donatella Malanga
    Laboratorio di Oncologia Molecolare, BioGem s c a r l, Ariano Irpino AV, Italy
    Cell Cycle 7:665-9. 2008
    ..Our data provide evidence that, although AKT1 mutations are apparently rare in lung cancer (1.9%), the oncogenic properties of E17K-AKT1 may contribute to the development of a fraction of lung carcinoma with squamous histotype (5.5%)...
  20. ncbi request reprint Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas
    Monica Fedele
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 80131 Naples, Italy
    Oncogene 24:3427-35. 2005
    ..Taken together, these data indicate an oncogenic role of the HMGA1 gene also in vivo...