Annamaria Vezzani

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi request reprint Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y
    A Vezzani
    Department of Neurosciences, Istituo di Richerche Farmacologie Mario Negri, Milan, Italy
    Neuroscience 110:237-43. 2002
  2. ncbi request reprint Brain inflammation in epilepsy: experimental and clinical evidence
    Annamaria Vezzani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 46:1724-43. 2005
  3. ncbi request reprint Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy
    Teresa Ravizza
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Epilepsia 47:1160-8. 2006
  4. doi request reprint Epilepsy and brain inflammation
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Exp Neurol 244:11-21. 2013
  5. pmc The role of inflammation in epileptogenesis
    Annamaria Vezzani
    Laboratory Experimental Neurology, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Neuropharmacology 69:16-24. 2013
  6. pmc Significance of MDR1 and multiple drug resistance in refractory human epileptic brain
    Nicola Marchi
    Cerebrovascular Research Center, The Cleveland Clinic, Cleveland, OH 44195, USA
    BMC Med 2:37. 2004
  7. pmc The role of inflammation in epilepsy
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Nat Rev Neurol 7:31-40. 2011
  8. ncbi request reprint ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy
    Annamaria Vezzani
    Mario Negri Institute for Pharmacological Research, Laboratory of Experimental Neurology, Department of Neuroscience, Via Giuseppe La Masa 19, 20156 Milano, Italy
    Curr Opin Investig Drugs 11:43-50. 2010
  9. doi request reprint The role of cytokines in the pathophysiology of epilepsy
    Annamaria Vezzani
    Mario Negri Institute for Pharmacological Research, Department of Neuroscience, Via G La Masa, 19 Milano, Italy
    Brain Behav Immun 22:797-803. 2008
  10. doi request reprint Glia as a source of cytokines: implications for neuronal excitability and survival
    Annamaria Vezzani
    Mario Negri Institute for Pharmacological Research, Milano, Italy
    Epilepsia 49:24-32. 2008

Detail Information

Publications61

  1. ncbi request reprint Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y
    A Vezzani
    Department of Neurosciences, Istituo di Richerche Farmacologie Mario Negri, Milan, Italy
    Neuroscience 110:237-43. 2002
    ....
  2. ncbi request reprint Brain inflammation in epilepsy: experimental and clinical evidence
    Annamaria Vezzani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 46:1724-43. 2005
    ..The elucidation of this aspect may open new perspectives for the pharmacologic treatment of seizures...
  3. ncbi request reprint Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy
    Teresa Ravizza
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Epilepsia 47:1160-8. 2006
    ..In this study, we investigated whether seizures can be effectively inhibited by blocking the brain production of IL-1beta, by using selective inhibitors of interleukin-converting enzyme (ICE/caspase-1) or through caspase-1 gene deletion...
  4. doi request reprint Epilepsy and brain inflammation
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Exp Neurol 244:11-21. 2013
    ..Finally, we will report on the anti-inflammatory treatments with anticonvulsant actions in experimental models highlighting possible therapeutic options for treating drug-resistant seizures and for prevention of epileptogenesis...
  5. pmc The role of inflammation in epileptogenesis
    Annamaria Vezzani
    Laboratory Experimental Neurology, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Neuropharmacology 69:16-24. 2013
    ..This article is part of the Special Issue entitled 'New Targets and Approaches to the Treatment of Epilepsy'...
  6. pmc Significance of MDR1 and multiple drug resistance in refractory human epileptic brain
    Nicola Marchi
    Cerebrovascular Research Center, The Cleveland Clinic, Cleveland, OH 44195, USA
    BMC Med 2:37. 2004
    ..Since various antiepileptic drugs (AEDs) can act as substrates for MDR1, the enhanced expression/function of this protein may increase their active extrusion from the brain, resulting in decreased responsiveness to AEDs...
  7. pmc The role of inflammation in epilepsy
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Nat Rev Neurol 7:31-40. 2011
    ....
  8. ncbi request reprint ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy
    Annamaria Vezzani
    Mario Negri Institute for Pharmacological Research, Laboratory of Experimental Neurology, Department of Neuroscience, Via Giuseppe La Masa 19, 20156 Milano, Italy
    Curr Opin Investig Drugs 11:43-50. 2010
    ....
  9. doi request reprint The role of cytokines in the pathophysiology of epilepsy
    Annamaria Vezzani
    Mario Negri Institute for Pharmacological Research, Department of Neuroscience, Via G La Masa, 19 Milano, Italy
    Brain Behav Immun 22:797-803. 2008
    ..These findings point out at novel glio-neuronal communications in diseased conditions and highlight potential new targets for therapeutic intervention...
  10. doi request reprint Glia as a source of cytokines: implications for neuronal excitability and survival
    Annamaria Vezzani
    Mario Negri Institute for Pharmacological Research, Milano, Italy
    Epilepsia 49:24-32. 2008
    ..This paper will provide an overview on the current knowledge in this field to discuss mechanistic hypotheses into the study of pathogenesis of epilepsy and recognize new potential therapeutic options...
  11. ncbi request reprint The promise of gene therapy for the treatment of epilepsy
    Annamaria Vezzani
    Mario Negri Institute for Pharmacological Research, Laboratory of Exp Neurology, Neuroscience Department, Via La Masa 19, 20156 Milano, Italy
    Expert Rev Neurother 7:1685-92. 2007
    ..The recent advances in refining gene therapy tools and in methods of gene delivery make this innovative approach a definite possibility for therapeutic intervention...
  12. ncbi request reprint Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy?
    Annamaria Vezzani
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacology Research, Via Eritrea 62, 20157 Milan, Italy
    Neuropeptides 38:245-52. 2004
    ..This concept is strongly supported by evidence that genetically modified rats overexpressing the NPY gene are less susceptible to seizures while deletion of NPY or Y2 receptor genes results in increased susceptibility to seizures...
  13. doi request reprint IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Brain Behav Immun 25:1281-9. 2011
    ..The anticonvulsant effects of inhibitors of the IL-1R/TLR signaling in various seizures models suggest that this system could be targeted to inhibit seizures in presently pharmaco-resistant epilepsies...
  14. doi request reprint Therapeutic potential of new antiinflammatory drugs
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, Milan, Italy
    Epilepsia 52:67-9. 2011
    ..This evidence highlights a new target system for pharmacological intervention to inhibit seizures by interfering with mechanisms involved in their genesis and recurrence...
  15. ncbi request reprint Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute of Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Epilepsia 43:30-5. 2002
    ....
  16. ncbi request reprint Inflammatory response and glia activation in developing rat hippocampus after status epilepticus
    Teresa Ravizza
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Epilepsia 46:113-7. 2005
    ..We investigated the activation of microglia and astrocytes, induction of cytokines, and hippocampal neuronal damage, 4 and 24 h after kainic acid-induced status epilepticus (SE) in postnatal day (PN) 9, 15, and 21 rats...
  17. ncbi request reprint Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development
    Nicola Marchi
    Dept Neuroscience, Mario Negri Inst for Pharmacol Res, Via Eritrea 62, 20157 Milano, Italy
    Neurobiol Dis 24:429-42. 2006
    ..Changes in BBB function may critically contribute to determine the brain uptake and distribution of P-gp substrates in epileptic tissue associated with developmental malformations...
  18. doi request reprint Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures
    Valentina Iori
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Neurobiol Dis 58:102-14. 2013
    ..These findings reveal new molecular mechanisms underlying seizures, cell loss and neurogenesis which involve inflammatory pathways upregulated in human epilepsy...
  19. ncbi request reprint Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development
    Massimo Rizzi
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, 20157 Milano, Italy
    Neurobiol Dis 14:494-503. 2003
    ..Thus, cytokine expression in immature brain is associated specifically with cell injury rather than with seizures per se, suggesting that proinflammatory cytokines may contribute to the occurence of SE-induced hippocampal damage...
  20. doi request reprint Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy
    Francesco Noe
    Department of Neuroscience, Mario Negri Inst for Pharmacol Res, Via G La Masa 19, 20156 Milano, Italy
    Brain 131:1506-15. 2008
    ..Our data show that this gene therapy strategy decreases spontaneous seizures and suppresses their progression in chronic epileptic rats, thus representing a promising new therapeutic strategy...
  21. ncbi request reprint Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus
    Cristina Richichi
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    J Neurosci 24:3051-9. 2004
    ..Thus, targeted NPY gene transfer provides a potential therapeutic principle for the treatment of drug-resistant partial epilepsies...
  22. ncbi request reprint Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis
    Jessica Marcon
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Neurobiol Dis 34:121-32. 2009
    ....
  23. doi request reprint Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    Mattia Maroso
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Nat Med 16:413-9. 2010
    ..Thus, HMGB1-TLR4 signaling may contribute to generating and perpetuating seizures in humans and might be targeted to attain anticonvulsant effects in epilepsies that are currently resistant to drugs...
  24. pmc A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta
    Silvia Balosso
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Brain 131:3256-65. 2008
    ....
  25. ncbi request reprint Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy
    Teresa Ravizza
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 29:142-60. 2008
    ..These data show that specific inflammatory pathways are chronically activated during epileptogenesis and they persist in chronic epileptic tissue, suggesting they may contribute to the etiopathogenesis of TLE...
  26. ncbi request reprint Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production
    Teresa Ravizza
    Department of Neuroscience, Laboratory of Experimental Neurology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 31:327-33. 2008
    ..These data indicate an antiepileptogenic effect mediated by ICE inhibition and suggest that specific anti-IL-1beta pharmacological strategies can be envisaged to interfere with epileptogenic mechanisms...
  27. ncbi request reprint Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors
    Silvia Balosso
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Ann Neurol 57:804-12. 2005
    ..This evidence highlights a novel function of TNF-alpha in brain and indicates a new system for anticonvulsive intervention...
  28. doi request reprint Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7 receptor-mediated IL-1beta release
    Liliana Bernardino
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Neurochem 106:271-80. 2008
    ..These mechanisms may contribute to determine cell death/survival in acute and chronic neurodegenerative conditions associated with inflammatory events...
  29. doi request reprint Neuropeptide Y overexpression using recombinant adeno-associated viral vectors
    Francesco Noe
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano 20156, Italy
    Neurotherapeutics 6:300-6. 2009
    ..These results establish a proof-of-principle evidence of the efficacy of gene therapy as anticonvulsant treatment. Additional investigations are required to address safety concerns and possible side effects in more detail...
  30. ncbi request reprint Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance
    Massimo Rizzi
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Neurosci 22:5833-9. 2002
    ..P-gp alterations significantly affect antiepileptic drugs concentrations in the brain, suggesting that seizure-induced mdr mRNA expression contributes to MDR in epilepsy...
  31. pmc Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice
    Mattia Maroso
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurotherapeutics 8:304-15. 2011
    ..These results support a new target system for anticonvulsant pharmacological intervention to control epileptic activity that does not respond to some common anticonvulsant drugs...
  32. ncbi request reprint Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis
    Costanza Savino
    Mario Negri Institute for Pharmacological Research, 20157, Milan, Italy
    J Neuroimmunol 172:27-37. 2006
    ..The possibility to dissociate the anti-neuroinflammatory action of EPO from its hematopoietic action, which may cause undesired side effects in non-anemic patients, present new avenues to the therapy of multiple sclerosis...
  33. ncbi request reprint A pilot study on brain-to-plasma partition of 10,11-dyhydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide and MDR1 brain expression in epilepsy patients not responding to oxcarbazepine
    Nicola Marchi
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Epilepsia 46:1613-9. 2005
    ....
  34. doi request reprint In vivo imaging of glia activation using 1H-magnetic resonance spectroscopy to detect putative biomarkers of tissue epileptogenicity
    Marta Filibian
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, Milan, Italy
    Epilepsia 53:1907-16. 2012
    ..Our aim was to explore if glia activation during epileptogenesis, or in the chronic epileptic phase, can be used as a biomarker of tissue epileptogenicity (i.e., a measure of epilepsy severity)...
  35. pmc Long-lasting pro-ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology
    Federica Frigerio
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, Milan, Italy
    Epilepsia 53:1887-97. 2012
    ..c.v.) albumin injection in naive rats; (3) measured electroencephalography (EEG) activity in these rats, their susceptibility to kainic acid (KA)-induced seizures, and their hippocampal afterdischarge threshold (ADT)...
  36. doi request reprint Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage
    Laura Librizzi
    Unit of Experimental Neurophysiology and Epileptology, Foundation Carlo Besta Neurological Institute, Milan, Italy
    Ann Neurol 72:82-90. 2012
    ..We addressed these questions by studying the relation between seizures, inflammation, and BBB permeability in a brain preparation isolated from extracerebral compartments...
  37. doi request reprint Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity
    Angelisa Frasca
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Neurobiol Dis 43:507-15. 2011
    ..Therefore, pharmacological targeting of misplaced NR2B-containing NMDARs, or prevention of these NMDAR changes, should be considered to block excitotoxicity which develops after various pro-epileptogenic brain injuries...
  38. ncbi request reprint Functional role of proinflammatory and anti-inflammatory cytokines in seizures
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacology Research, Milano, Italy
    Adv Exp Med Biol 548:123-33. 2004
    ..Furthermore, these studies suggest that other inflammatory and anti-inflammatory molecules produced in the CNS may have a role in the pathophysiology of seizure disorders...
  39. ncbi request reprint Immunity activation in brain cells in epilepsy: mechanistic insights and pathological consequences
    Teresa Ravizza
    Department of Neuroscience, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Neuropediatrics 44:330-5. 2013
    ....
  40. pmc Brain inflammation as a biomarker in epilepsy
    Annamaria Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Biomark Med 5:607-14. 2011
    ....
  41. doi request reprint Inflammation and prevention of epileptogenesis
    Teresa Ravizza
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa 19, 20156 Milano, Italy
    Neurosci Lett 497:223-30. 2011
    ..This emerging evidence predicts that pharmacological interventions targeting brain inflammation might provide a key to new antiepileptic drug design...
  42. doi request reprint Basic mechanisms of MCD in animal models
    Giorgio Battaglia
    Molecular Neuroanatomy and Pathogenesis Unit, IRCCS Foundation Neurological Institute Carlo Besta, Milano, Italy
    Epileptic Disord 11:206-14. 2009
    ..An improved understanding of relevant pathomechanisms will advance the development of targeted treatment strategies for epilepsy-associated malformations...
  43. ncbi request reprint Gene therapy in epilepsy: the focus on NPY
    Jari Nissinen
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milano, Italy
    Peptides 28:377-83. 2007
    ..Additional investigations are required to demonstrate a therapeutic role of gene therapy in chronic models of seizures and to address in more detail safety concerns and possible side-effects...
  44. ncbi request reprint Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons
    Silvia Balosso
    1 Department of Neuroscience, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Antioxid Redox Signal . 2014
    ..Antioxid. Redox Signal. 00, 000-000...
  45. ncbi request reprint Expression of glutamate receptor subtypes in the spinal cord of control and mnd mice, a model of motor neuron disorder
    Tiziana Mennini
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Neurosci Res 70:553-60. 2002
    ..These changes in ionotropic glutamate receptors may alter glutamatergic neurotransmission and play some role in the pathology of mnd mice...
  46. ncbi request reprint The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptors
    Bouchaib El Bahh
    Department of Pharmacology, University of Alberta Edmonton, Alberta, Canada T6G 2H7
    Eur J Neurosci 22:1417-30. 2005
    ..The results suggest that agonists targeting the Y2 receptor may be useful anticonvulsants...
  47. ncbi request reprint Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development
    En Ju D Lin
    Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, New Zealand
    Eur J Neurosci 18:2087-92. 2003
    ..The seizure suppression effect of galanin expression in the hippocampus by viral vectors may lead to novel therapeutic strategies for the treatment and management of intractable seizures with focal onset such as temporal lobe epilepsy...
  48. ncbi request reprint Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats
    Erwin A van Vliet
    Epilepsy Institute of the Netherlands SEIN, Heemstede, The Netherlands
    Epilepsia 47:672-80. 2006
    ..Here we tested whether P-gp contributes to pharmacoresistance to phenytoin (PHT) by using a specific P-gp inhibitor in a model of spontaneous seizures in rats...
  49. doi request reprint NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning
    Andreas T Sørensen
    Experimental Epilepsy Group, Wallenberg Neuroscience Center, BMC A 11, Lund University Hospital, Lund, Sweden
    Hippocampus 18:564-74. 2008
    ....
  50. ncbi request reprint Plasticity of somatostatin and somatostatin sst2A receptors in the rat dentate gyrus during kindling epileptogenesis
    Zsolt Csaba
    INSERM U549, IFR Broca Sainte Anne, Centre Paul Broca, 2ter rue d Alesia, 75014 Paris, France
    Eur J Neurosci 19:2531-8. 2004
    ..Because the sst2A receptor appears to mediate anticonvulsant and antiepileptogenic effects of somatostatin, this may represent a pivotal mechanism contributing to epileptogenesis...
  51. doi request reprint Fourth conference on epileptogenesis, May 23-26, 2007, Pisa, Italy
    Yuri Bozzi
    Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, Pisa, Italy
    Epilepsia 49:929-34. 2008
  52. ncbi request reprint Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain
    Anna L M Ferri
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Development 131:3805-19. 2004
    ..These findings highlight a crucial and unexpected role for Sox2 in the maintenance of neurones in selected brain areas, and suggest a contribution of neural cell proliferative defects to the pathological phenotype...
  53. ncbi request reprint Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures
    Liliana Bernardino
    Center for Neuroscience and Cell Biology, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    J Neurosci 25:6734-44. 2005
    ..Together, these findings are relevant for understanding the role of proinflammatory cytokines and microglia activation in acute and chronic excitotoxic conditions...
  54. ncbi request reprint Growth-associated protein 43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide
    Beatriz Longo
    Department of Physiology, UNIFESP EPM, Sao Paulo, Brazil
    Epilepsia 46:125-8. 2005
    ....
  55. ncbi request reprint Antiepileptic effects of botulinum neurotoxin E
    Laura Costantin
    Scuola Normale Superiore, Consiglio Nazionale delle Ricerche, 56100 Pisa, Italy
    J Neurosci 25:1943-51. 2005
    ..We conclude that BoNT/E delivery to the hippocampus is both antiictal and antiepileptogenic in experimental models of epilepsy...
  56. ncbi request reprint Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats
    Erwin van Vliet
    Stichting Epilepsie Instellingen Nederland, Achterweg 5, 2103 SW Heemstede, The Netherlands
    Epilepsy Res 60:203-13. 2004
    ..These findings show that both mdr1a and mdr1b are induced by SE, although the increase in mdr1b isoform was more persistent. More importantly, increased P-gp expression is still present in chronic epileptic rats...
  57. pmc Interleukin-1beta contributes to the generation of experimental febrile seizures
    Celine Dube
    Department of Anatomy and Neurobiology, University of California at Irvine, Medical Science I, ZOT 4475, Irvine, CA 92697 4475, USA
    Ann Neurol 57:152-5. 2005
    ..These data indicate that IL-1beta signaling contributes critically to fever-induced hyperexcitability underlying FS, constituting a potential target for their prevention...
  58. ncbi request reprint Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA
    Ann N Y Acad Sci 1113:173-7. 2007
    ..Selective induction or pharmacological application of IL-1ra may be sparing neurons in seizures and neurotrauma...
  59. ncbi request reprint Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors
    Alexandra Tschenett
    Departments of Pharmacology, University of Innsbruck, Peter Mayr Str 1 1a, 6020 Innsbruck, Austria
    Eur J Neurosci 18:143-8. 2003
    ..Taken together, deletion of the Y2 receptor has revealed an important role of Y2 receptors in the generation of anxiety-related and stress-related behaviours in mice...
  60. ncbi request reprint In vitro responsiveness of human-drug-resistant tissue to antiepileptic drugs: insights into the mechanisms of pharmacoresistance
    Emily Oby
    Cerebrovascular Research Center, The Cleveland Clinic, OH 44195, USA
    Brain Res 1086:201-13. 2006
    ..Taken together, our results support the hypothesis that multiple drug resistance to AEDs involves cerebrovascular changes that impede the achievement of appropriate drug levels in the central nervous system...
  61. ncbi request reprint Third conference on epileptogenesis. S Servolo Island, Venice, Italy, July 27-30, 2005
    Marco de Curtis
    Istituto Nazionale Neurologico Carlo Besta, Milano, Itlay
    Epilepsia 47:1243-6. 2006