Filippo Spreafico

Summary

Affiliation: Istituto Nazionale Tumori
Country: Italy

Publications

  1. doi request reprint Loss of heterozygosity analysis at different chromosome regions in Wilms tumor confirms 1p allelic loss as a marker of worse prognosis: a study from the Italian Association of Pediatric Hematology and Oncology
    Filippo Spreafico
    Pediatric Unit, Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    J Urol 189:260-6. 2013
  2. ncbi request reprint Wilms' tumor: past, present and (possibly) future
    Filippo Spreafico
    Pediatric Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy
    Expert Rev Anticancer Ther 6:249-58. 2006
  3. doi request reprint Treatment of relapsed Wilms tumors: lessons learned
    Filippo Spreafico
    Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G Venezian 1, 20133 Milano, Italy
    Expert Rev Anticancer Ther 9:1807-15. 2009
  4. doi request reprint Heterogeneity of disease classified as stage III in Wilms tumor: a report from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
    Filippo Spreafico
    Pediatric Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Int J Radiat Oncol Biol Phys 82:348-54. 2012
  5. doi request reprint Treatment of high-risk relapsed Wilms tumor with dose-intensive chemotherapy, marrow-ablative chemotherapy, and autologous hematopoietic stem cell support: experience by the Italian Association of Pediatric Hematology and Oncology
    Filippo Spreafico
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Pediatr Blood Cancer 51:23-8. 2008
  6. doi request reprint Renal cell carcinoma in children and adolescents
    Filippo Spreafico
    Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Expert Rev Anticancer Ther 10:1967-78. 2010
  7. ncbi request reprint Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumors
    Filippo Spreafico
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 70:1011-9. 2008
  8. doi request reprint No salvage using high-dose chemotherapy plus/minus reirradiation for relapsing previously irradiated medulloblastoma
    Maura Massimino
    Division of Pediatrics, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 73:1358-63. 2009
  9. ncbi request reprint Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy
    Maura Massimino
    Neuro Oncology Functional Unit, Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 64:1031-7. 2006
  10. doi request reprint Hyperfractionated accelerated radiotherapy in the Milan strategy for metastatic medulloblastoma
    Lorenza Gandola
    Radiotherapy Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milano, Italy
    J Clin Oncol 27:566-71. 2009

Detail Information

Publications73

  1. doi request reprint Loss of heterozygosity analysis at different chromosome regions in Wilms tumor confirms 1p allelic loss as a marker of worse prognosis: a study from the Italian Association of Pediatric Hematology and Oncology
    Filippo Spreafico
    Pediatric Unit, Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    J Urol 189:260-6. 2013
    ..The specific aims of the AIEOP-TW-2003 protocol included prospectively investigating a possible association of tumor loss of heterozygosity with outcomes in children treated for Wilms tumor...
  2. ncbi request reprint Wilms' tumor: past, present and (possibly) future
    Filippo Spreafico
    Pediatric Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy
    Expert Rev Anticancer Ther 6:249-58. 2006
    ..This review covers current concepts on treatment strategies for Wilms' tumor, with an overview of the results and achievements of the important clinical trials...
  3. doi request reprint Treatment of relapsed Wilms tumors: lessons learned
    Filippo Spreafico
    Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G Venezian 1, 20133 Milano, Italy
    Expert Rev Anticancer Ther 9:1807-15. 2009
    ..The authors have reviewed the available experiences concerning the treatment of recurrent WT, and have attempted to provide the most up-to-date recommendations regarding the optimal risk-based treatment for these patients...
  4. doi request reprint Heterogeneity of disease classified as stage III in Wilms tumor: a report from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
    Filippo Spreafico
    Pediatric Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Int J Radiat Oncol Biol Phys 82:348-54. 2012
    ..We analyzed whether the prognosis can differ among Wilms tumors (WT) labeled as Stage III according to currently adopted classification systems...
  5. doi request reprint Treatment of high-risk relapsed Wilms tumor with dose-intensive chemotherapy, marrow-ablative chemotherapy, and autologous hematopoietic stem cell support: experience by the Italian Association of Pediatric Hematology and Oncology
    Filippo Spreafico
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Pediatr Blood Cancer 51:23-8. 2008
    ..We evaluated an intensified chemotherapy strategy in children with Wilms tumor who relapsed with high-risk features...
  6. doi request reprint Renal cell carcinoma in children and adolescents
    Filippo Spreafico
    Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Expert Rev Anticancer Ther 10:1967-78. 2010
    ..On the other hand, the utility of targeted therapies in the adjuvant setting remains to be seen for both adults and children...
  7. ncbi request reprint Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumors
    Filippo Spreafico
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 70:1011-9. 2008
    ..Brain necrosis or other subacute iatrogenic reactions has been recognized as a potential complication of radiotherapy (RT), although the possible synergistic effects of high-dose chemotherapy and RT might have been underestimated...
  8. doi request reprint No salvage using high-dose chemotherapy plus/minus reirradiation for relapsing previously irradiated medulloblastoma
    Maura Massimino
    Division of Pediatrics, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 73:1358-63. 2009
    ..Myeloablative regimens were frequently used for medulloblastoma relapsing after craniospinal irradiation (CSI): in 1997-2002, we used repeated surgery, standard-dose and myeloablative chemotherapy, and reirradiation...
  9. ncbi request reprint Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy
    Maura Massimino
    Neuro Oncology Functional Unit, Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 64:1031-7. 2006
    ..Supratentorial primitive neuroectodermal tumors (S-PNET) are rare and have a grim prognosis, frequently taking an aggressive course with local relapse and metastatic spread. We report the results of a mono-institutional therapeutic trial...
  10. doi request reprint Hyperfractionated accelerated radiotherapy in the Milan strategy for metastatic medulloblastoma
    Lorenza Gandola
    Radiotherapy Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milano, Italy
    J Clin Oncol 27:566-71. 2009
    ..With a view to improving the prognosis for patients with metastatic medulloblastoma, we tested the efficacy and toxicity of a hyperfractionated accelerated radiotherapy (HART) regimen delivered after intensive sequential chemotherapy...
  11. doi request reprint Evolving of therapeutic strategies for CNS-PNET
    Maura Massimino
    Department of Pediatrics, Fond IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Pediatr Blood Cancer 60:2031-5. 2013
    ..Efforts were subsequently made to improve the prognosis and to de-escalate the treatment for selected patient groups...
  12. ncbi request reprint Evolving treatment strategies for parameningeal rhabdomyosarcoma: the experience of the Istituto Nazionale Tumori of Milan
    Cristina Meazza
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milano MI, Italy
    Head Neck 27:49-57. 2005
    ..Ninety pediatric patients with parameningeal rhabdomyosarcoma (PM-RMS) were treated between 1970 and 2002 at the Istituto Nazionale Tumori, Milan...
  13. doi request reprint Long-term results of combined preradiation chemotherapy and age-tailored radiotherapy doses for childhood medulloblastoma
    Maura Massimino
    Pediatric Oncology Unit, Fondazione IRCCS, Istituto Nazionale Tumori, Via Venezian, 1 20133, Milan, Italy
    J Neurooncol 108:163-71. 2012
    ....
  14. ncbi request reprint Papillary thyroid carcinoma of childhood and adolescence: a 30-year experience at the Istituto Nazionale Tumori in Milan
    Paola Collini
    Department of Anatomical Pathology, Istituto Nazionale Tumori, Milan, Italy
    Pediatr Blood Cancer 46:300-6. 2006
    ..The aim of this study was to verify this assumption in a single-institution series spanning a 30-year period with a very long follow-up...
  15. doi request reprint A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma
    Maura Massimino
    Division of Paediatrics, Fond IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133, Milan, Italy
    J Neurooncol 100:65-71. 2010
    ..023), with three-year PFS and OS rates of 70 and 100%, respectively. Lower doses of cisplatin/etoposide are still effective in progressive low-grade glioma, with less acute and persistent morbidity...
  16. ncbi request reprint Clinical stage I nonseminomatous germ cell tumors of the testis in childhood and adolescence: an analysis of 31 cases
    Monica Terenziani
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    J Pediatr Hematol Oncol 24:454-8. 2002
    ..A conservative approach is the best option in children, while adolescent NSGCTT behaves like the adult disease and management must include similar treatment strategies...
  17. ncbi request reprint Survival of adults treated for medulloblastoma using paediatric protocols
    Filippo Spreafico
    Paediatric Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Eur J Cancer 41:1304-10. 2005
    ....
  18. doi request reprint Comparison of the prognostic value of assessing tumor diameter versus tumor volume at diagnosis or in response to initial chemotherapy in rhabdomyosarcoma
    Andrea Ferrari
    Pediatric Oncology Unit, Division of Medical Statistics and Biometry, Radiology and Radiotherapy Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 28:1322-8. 2010
    ....
  19. ncbi request reprint Clinical experience with psychological aspects in pediatric patients amputated for malignancies
    Carlo Alfredo Clerici
    Pediatric Oncology Unit, Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 90:399-404. 2004
    ..Studies addressing the psychological aspects of limb amputation in childhood cancer are still relatively limited, and the results have sometimes been contradictory...
  20. doi request reprint Synchronous bilateral Wilms tumor: a report from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)
    Paolo Indolfi
    Pediatric Oncology Unit, Department of Pediatrics, II University, Naples, Italy
    Cancer 119:1586-92. 2013
    ..The optimal management of bilateral Wilms tumor (BWT) is challenging, and their survival is lower than for unilateral tumors. This report discusses a large series of BWTs treated in Italy in the last 2 decades...
  21. ncbi request reprint [Adolescents with cancer: the "Youth Project" at the Istituto Nazionale Tumori in Milan]
    Andrea Ferrari
    Struttura Complessa di Oncologia Pediatrica, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
    Recenti Prog Med 104:10-6. 2013
    ..The paper also describes the activity of the Adolescent Commission established by the Italian Pediatric Hematology Oncology (AIEOP)...
  22. ncbi request reprint Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor
    Maura Massimino
    Department of Pediatrics, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 69:404-10. 2007
    ..Hence, our study was launched in 1998 to evaluate the protective effect of TSH suppression during CSI for medulloblastoma/primitive neuroectodermal tumor...
  23. ncbi request reprint Assistance to parents who have lost their child with cancer
    Carlo Alfredo Clerici
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    Tumori 92:306-10. 2006
    ..To assess the psychological needs of parents after the death of their child from cancer...
  24. pmc Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma
    Maura Massimino
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    Neuro Oncol 7:41-8. 2005
    ..Sequential and high-dose chemotherapy can be afforded in front-line therapy of childhood malignant glioma without excessive morbidity and rather encouraging results...
  25. ncbi request reprint Adult Wilms' tumor: A monoinstitutional experience and a review of the literature
    Monica Terenziani
    Unità di Oncologia Pediatrica, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 101:289-93. 2004
    ..The authors reviewed their institutional experience regarding adult patients with Wilms' tumor (WT) to assess their clinical characteristics and compliance with respect to children's treatment guidelines...
  26. ncbi request reprint Rhabdomyosarcoma of the head and neck region: experience at the pediatric unit of the Istituto Nazionale Tumori, Milan
    Cristina Meazza
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan
    J Otolaryngol 35:53-9. 2006
    ..This study aims to describe the clinical features and outcome of pediatric patients with head and neck rhabdomyosarcoma (RMS), which can be divided into parameningeal, orbital, or nonorbital, nonparameningeal...
  27. ncbi request reprint Salvage treatment for childhood ependymoma after surgery only: Pitfalls of omitting "at once" adjuvant treatment
    Maura Massimino
    Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 65:1440-5. 2006
    ..To discuss the results obtained by giving adjuvant treatment for childhood ependymoma (EPD) at relapse after complete surgery only...
  28. ncbi request reprint Adult-type soft tissue sarcomas in pediatric-age patients: experience at the Istituto Nazionale Tumori in Milan
    Andrea Ferrari
    Pediatric Oncology Unit, Department of Pathology, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milano, Italy
    J Clin Oncol 23:4021-30. 2005
    ..We report on a large group of 182 patients younger than 18 years old treated at a single institution over a 25-year period...
  29. doi request reprint Soft tissue sarcomas of childhood and adolescence: the prognostic role of tumor size in relation to patient body size
    Andrea Ferrari
    Pediatric Oncology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milano, Italy
    J Clin Oncol 27:371-6. 2009
    ....
  30. doi request reprint The Youth Project at the Istituto Nazionale Tumori in Milan
    Andrea Ferrari
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Tumori 98:399-407. 2012
    ..The location of the pediatric unit within a cancer referral center and the cooperation with divisions dedicated to adults have played an important role in the project's creation...
  31. ncbi request reprint Wilms tumor in monozygous twins: clinical, pathological, cytogenetic and molecular case report
    Daniela Perotti
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Milan, Italy
    J Pediatr Hematol Oncol 27:521-5. 2005
    ..To the authors' knowledge, this is the first report describing at both the clinical and genetic level a couple of monozygotic twins concordant for WT development...
  32. ncbi request reprint Etoposide, cisplatin, epirubicin chemotherapy in the treatment of pediatric liver tumors
    Michela Casanova
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Via Venezian, 1 20133 Milano, Italy
    Pediatr Hematol Oncol 22:189-98. 2005
    ..EPE chemotherapy seems to be effective in the treatment of childhood malignant liver tumors. Etoposide could be suggested as part of intensive multidrug regimens for HCC and high-risk HB...
  33. ncbi request reprint Neuroblastoma in patients over 12 years old: a 20-year experience at the Istituto Nazionale Tumori of Milan
    Marta Giorgia Podda
    Department of Paediatric Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 96:684-9. 2010
    ..As neuroblastoma is rare in adolescents and exceedingly rare in adults, few series are reported in the literature. In the present study, we analyzed the outcomes and clinical characteristics of a mono-institutional series...
  34. ncbi request reprint Intensive, very short-term chemotherapy for advanced Burkitt's lymphoma in children
    Filippo Spreafico
    Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 20:2783-8. 2002
    ..To improve the 63% event-free survival (EFS) achieved before 1986 in Murphy's stage III to IV Burkitt's lymphoma (BL), both chemotherapy and supportive care were intensified...
  35. doi request reprint Diffuse pontine gliomas in children: changing strategies, changing results? A mono-institutional 20-year experience
    Maura Massimino
    Pediatric Oncology Unit, Fondazione IRRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    J Neurooncol 87:355-61. 2008
    ..Despite improved diagnostic, therapeutic, and supportive tools in pediatric neuro-oncology, little has been achieved for patients with diffuse pontine tumors...
  36. ncbi request reprint WT1 gene analysis in sporadic early-onset and bilateral wilms tumor patients without associated abnormalities
    Daniela Perotti
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, 20133 Milan, Italy
    J Pediatr Hematol Oncol 27:197-201. 2005
    ..These results suggest that early age of diagnosis and bilaterality are not by themselves efficient predictors of germline WT1 alterations in WT patients without associated abnormalities...
  37. ncbi request reprint The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors
    Francesca Di Renzo
    Department of Biology, University of Milan, Milan, Italy
    J Pediatr Hematol Oncol 28:791-7. 2006
    ....
  38. doi request reprint Genomic profiling by whole-genome single nucleotide polymorphism arrays in Wilms tumor and association with relapse
    Daniela Perotti
    Department of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Genes Chromosomes Cancer 51:644-53. 2012
    ..Our study, besides confirming the role of 1q gains, identified a number of additional candidate genetic markers, warranting further molecular investigations...
  39. doi request reprint End of life in children with cancer: experience at the pediatric oncology department of the istituto nazionale tumori in Milan
    Silvia Beretta
    Struttura Complessa di Oncologia Pediatrica, Istituto Nazionale Tumori, Milano, Italy
    Pediatr Blood Cancer 54:88-91. 2010
    ..Coping with end-stage pediatric cancer patients and the related bereavement is a challenge for all the caregivers involved...
  40. ncbi request reprint Endodermal sinus tumor of the vagina
    Monica Terenziani
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milano, Italy
    Pediatr Blood Cancer 48:577-8. 2007
    ..Both patients remained alive and disease-free, without having had surgical procedures except for biopsies. Platinum-based chemotherapy is able to achieve complete remissions and should be considered for vaginal endodermal sinus tumors...
  41. ncbi request reprint Immunomodulation in a treatment program including pre- and post-operative interleukin-2 and chemotherapy for childhood osteosarcoma
    Roberto Luksch
    Department of Medical Oncology, Pediatric Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 89:263-8. 2003
    ..An additional aim was to assess whether any correlation between the immune modifications and the clinical outcome could be found...
  42. ncbi request reprint Non-chromosome 11-p syndromes in Wilms tumor patients: Clinical and cytogenetic report of two Down syndrome cases and one Turner syndrome case
    Filippo Spreafico
    Unit of Pediatric Oncology, Istituto Nazionale Tumori, Milano, Italy
    Am J Med Genet A 143:85-8. 2007
  43. ncbi request reprint Five questions for assessing psychological problems in pediatric patients cured of neoplastic disease
    Carlo Alfredo Clerici
    Istituto Nazionale Tumori, Milan, Italy
    Pediatr Hematol Oncol 21:481-7. 2004
    ..Experience drawn from pediatric oncology might suggest an approach based on a physician-patient relationship that could provide the means for identifying patients' psychological needs and problems...
  44. doi request reprint A novel WT1 mutation in a 46,XY boy with congenital bilateral cryptorchidism, nystagmus and Wilms tumor
    Monica Terenziani
    Department of Medical Oncology, Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Pediatr Nephrol 24:1413-7. 2009
    ....
  45. ncbi request reprint High response rate to cisplatin/etoposide regimen in childhood low-grade glioma
    Maura Massimino
    Pediatric Oncology, Radiodiagnostic E and Radiotherapy Unit, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 20:4209-16. 2002
    ..The aim of this study was to avoid radiotherapy and to induce an objective response in children with low-grade glioma (LGG) using a simple chemotherapy regimen based on cisplatin and etoposide...
  46. ncbi request reprint Results of nimotuzumab and vinorelbine, radiation and re-irradiation for diffuse pontine glioma in childhood
    Maura Massimino
    Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori INT, Via Venezian 1, 20133, Milano, Italy
    J Neurooncol 118:305-12. 2014
    ..5 and 15 months, respectively. This strategy generated interesting results and warrants further investigation. ..
  47. doi request reprint Histological variants of medulloblastoma are the most powerful clinical prognostic indicators
    Maura Massimino
    Department of Pediatrics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Pediatr Blood Cancer 60:210-6. 2013
    ..We centrally reviewed medulloblastoma cases from past 10 years reassessing their histology to ascertain its prognostic significance...
  48. doi request reprint Occurrence of breast cancer after chest wall irradiation for pediatric cancer, as detected by a multimodal screening program
    Monica Terenziani
    Pediatric Oncology Unit, Radiology Department, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Int J Radiat Oncol Biol Phys 85:35-9. 2013
    ..To assess the occurrence of breast cancer (BC) after exposure to ionizing radiation for pediatric cancer, by means of a multimodal screening program...
  49. ncbi request reprint Adult-type soft tissue sarcomas in paediatric age: a nomogram-based prognostic comparison with adult sarcoma
    Andrea Ferrari
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Eur J Cancer 43:2691-7. 2007
    ..The study compares the outcome of paediatric patients with adult-type soft tissue sarcomas with that reported for adults, taking into account the effect of established prognostic factors...
  50. doi request reprint Mirror therapy for phantom limb pain in an adolescent cancer survivor
    Carlo Alfredo Clerici
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Tumori 98:e27-30. 2012
    ..Here we discuss the advantages of an unconventional rehabilitation technique, the recently reported mirror therapy, whose positive effects might be due, according to some researchers, to neuronal plasticity mechanisms...
  51. ncbi request reprint Vinorelbine in previously treated advanced childhood sarcomas: evidence of activity in rhabdomyosarcoma
    Michela Casanova
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    Cancer 94:3263-8. 2002
    ..Vinca alkaloids have proved active against a number of pediatric malignancies. The aim of this study was to assess the feasibility and effectiveness of using vinorelbine in previously treated pediatric patients with advanced sarcomas...
  52. ncbi request reprint Hyperfractionated radiotherapy and chemotherapy for childhood ependymoma: final results of the first prospective AIEOP (Associazione Italiana di Ematologia-Oncologia Pediatrica) study
    Maura Massimino
    Department of Pediatric Oncology, Istituto Nazionale Tumori, Milano, Italy
    Int J Radiat Oncol Biol Phys 58:1336-45. 2004
    ..A postsurgical "stage-based" protocol for ependymoma was designed...
  53. ncbi request reprint Telomere maintenance in Wilms tumors: first evidence for the presence of alternative lengthening of telomeres mechanism
    Lorenza Venturini
    Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Genes Chromosomes Cancer 50:823-9. 2011
    ..The study provides the first evidence of the presence of ALT in WT, and indicates that in a small but defined fraction of cases (about 15%) ALT is the only TMM that supports the development of WT...
  54. ncbi request reprint Psychological assessment of women on an early breast screening program after radiotherapy to the chest wall for childhood cancer
    Carlo Alfredo Clerici
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 94:568-73. 2008
    ..This study investigates the psychological status in a population of female patients who received chest irradiation for a childhood cancer and were screened for second primary breast cancer...
  55. ncbi request reprint Celiac disease and childhood cancer
    Stefano Cereda
    Pediatric Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    J Pediatr Hematol Oncol 28:346-9. 2006
    ..The association between celiac disease and childhood cancer is not clear. Few cases are reported in the literature. Here, we report the cases referred to our pediatric oncology unit with a review of the literature...
  56. doi request reprint Teratoma with a malignant somatic component in pediatric patients: the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience
    Monica Terenziani
    Pediatric Oncology Unit, Fondazione IRCCS National Cancer Institute, Milano, Italy
    Pediatr Blood Cancer 54:532-7. 2010
    ..Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse...
  57. doi request reprint Clinical and molecular description of a Wilms tumor in a patient with tuberous sclerosis complex
    Filippo Spreafico
    Pediatric Oncology Unit, Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Am J Med Genet A 155:1419-24. 2011
    ..To the best of our knowledge, this is the second report of a patient with tuberous sclerosis who developed a WT, and it represents the first case in which a detailed clinical and molecular description is provided...
  58. doi request reprint Axial skeletal osteosarcoma: a 25-year monoinstitutional experience in children and adolescents
    Cristina Meazza
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G Venezian 1, 20133, Milan, Italy
    Med Oncol 31:875. 2014
    ..Adequacy of local treatment and pathological response influenced the prognosis for axial OS, which remained dismal. A high incidence of p53 mutation emerged in our series of patients...
  59. doi request reprint Prognostic determinants in epithelioid sarcoma
    Patrizia Gasparini
    Unit of Molecular Cytogenetics, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Eur J Cancer 47:287-95. 2011
    ....
  60. pmc A female survivor of childhood medulloblastoma presenting with growth-hormone-induced edema and inflammatory lesions: a case report
    Veronica Biassoni
    Department of Pediatric Oncology, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy
    J Med Case Reports 3:17. 2009
    ..There are few reports, however, on the "in-vivo" induction of edema and symptomatic inflammatory lesions during replacement therapy...
  61. ncbi request reprint Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14
    Daniela Perotti
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Milan, Italy
    Hum Mutat 24:400-7. 2004
    ..Together with the finding of the expression of the POU6F2 mouse homolog in both fetal and adult kidney, our observations suggest that the gene is a tumor suppressor and is involved in hereditary predisposition to WT...
  62. ncbi request reprint Conservative surgical approach for thyroid and lymph-node involvement in papillary thyroid carcinoma of childhood and adolescence
    Maura Massimino
    Unit of Pediatrics, Istituto Nazionale Tumori, Milan, Italy
    Pediatr Blood Cancer 46:307-13. 2006
    ..The aim of this study is to outline the possibility of a conservative approach (hemithyroidectomy plus selective neck dissection of clinically involved nodes, followed by TSH-suppressive therapy) in a selected group of patients...
  63. doi request reprint Radiation-induced thyroid changes: a retrospective and a prospective view
    Maura Massimino
    Department of Medical Oncology, Paediatrics Unit, Istituto Nazionale Tumori, Via Venezian, 1, Milan 20133, Italy
    Eur J Cancer 45:2546-51. 2009
    ..Increasing numbers of children are being cured of cancers by treatments that include radiation also involving the thyroid bed: these children warrant an early diagnosis and treatment of any radiation-related thyroid changes...
  64. ncbi request reprint Unusual primary secreting germ cell tumor of the spine. Case report
    Maura Massimino
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan Italy
    J Neurosurg Spine 5:65-7. 2006
    ..The occurrence of this rare tumor located primarily in the spine warrants attention in pathological studies of spinal tumors in young patients...
  65. ncbi request reprint Psychological support in children and adolescents with cancer when amputation is required
    Andrea Ferrari
    Pediatric Oncology Unit, Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy
    Med Pediatr Oncol 38:261-5. 2002
  66. ncbi request reprint Bilateral preaxial polydactyly in a WAGR syndrome patient
    Siranoush Manoukian
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Am J Med Genet A 134:426-9. 2005
    ..These observations indicate that preaxial polydactyly may be another feature of the WAGR syndrome and suggest the existence of a related gene in the WAGR critical region or in its proximity...
  67. doi request reprint Rectal burkitt lymphoma in childhood
    Francesca Favini
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Istituti Clinici di Perfezionamento, Milano, Italy
    J Pediatr Hematol Oncol 30:176-8. 2008
    ..The role of surgery for this tumor is limited nowadays, except for surgical emergencies, biopsies, and second-look surgery in selected cases...
  68. ncbi request reprint Brain tumors in children and adolescents: cognitive and psychological disorders at different ages
    Geraldina Poggi
    IRCCS Eugenio Medea, Via Don Luigi Monza 23842, Bosisio Parini LC, Italy
    Psychooncology 14:386-95. 2005
    ..These findings are relevant as they point out the long-term outcome of brain tumor survivors. Hence, the recommendation to diversify psychological interventions and rehabilitation plans according to the patients' age...
  69. doi request reprint Molecular evidence of the independent origin of multiple Wilms tumors in a case of WAGR syndrome
    Stefania Uccini
    Department of Experimental Medicine and Pathology, La Sapienza University, Rome, Italy
    Pediatr Blood Cancer 51:344-8. 2008
    ..This study investigated the genetic events leading to tumorigenesis in a patient affected with WAGR syndrome who developed multiple distinct Wilms tumors (WTs)...
  70. ncbi request reprint Revised SIOP working classification of renal tumors of childhood
    Filippo Spreafico
    Med Pediatr Oncol 41:102. 2003
  71. ncbi request reprint Local lymph node involvement in pediatric renal cell carcinoma: a report from the Italian TREP project
    Paolo Indolfi
    Pediatric Oncology Service, Pediatric Department, Second University of Napoli, Napoli, Italy
    Pediatr Blood Cancer 51:475-8. 2008
    ..The aim of this article is to study the prognostic significance of local lymph node involvement in pediatric RCC and the role of retroperitoneal lymph node dissection (RLND) at diagnosis...
  72. ncbi request reprint Malignant renal tumours incidence and survival in European children (1978-1997): report from the Automated Childhood Cancer Information System project
    Guido Pastore
    Childhood Cancer Registry of Piedmont, Cancer Epidemiology Unit of the Centre for Cancer Epidemiology and Prevention, CERMS and University of Torino, Torino, Italy
    Eur J Cancer 42:2103-14. 2006
    ..Further development and exploitation of the ACCIS database will benefit clinical management and aetiological studies...
  73. pmc Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer
    Adele Murrell
    Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Cambridge, United Kingdom
    PLoS ONE 3:e1849. 2008
    ..This DMR, known as DMR0, has been shown to be methylated on the silent maternal IGF2 allele presumably with a role in repression. The effect of IGF2 DMR0 methylation changes in the aetiology of BWS or SRS is unknown...