Enea Spada

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. ncbi request reprint Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infection
    Silvia Guglietta
    Department of Cellular and Developmental Biology University of Rome La Sapienza, Rome, Italy
    Eur J Immunol 35:2627-37. 2005
  2. ncbi request reprint Changing epidemiology of parenterally transmitted viral hepatitis: results from the hepatitis surveillance system in Italy
    E Spada
    Clinical Epidemiology Unit, Laboratory of Epidemiology e Biostatistics, Istituto Superiore di Sanita, Rome, Italy
    Dig Liver Dis 33:778-84. 2001
  3. pmc Use of the minimum spanning tree model for molecular epidemiological investigation of a nosocomial outbreak of hepatitis C virus infection
    Enea Spada
    Istituto Superiore di Sanita, National Center of Epidemiology, Surveillance, and Health Promotion, Clinical Epidemiology Unit, via Regina Elena 299, 00161 Rome, Italy
    J Clin Microbiol 42:4230-6. 2004
  4. pmc Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance
    E Spada
    Istituto Superiore di Sanita, National Center of Epidemiology, Surveillance and Health Promotion, Clinical Epidemiology Unit, Viale Regina Elena 299, 00161 Rome, Italy
    Gut 53:1673-81. 2004
  5. ncbi request reprint An outbreak of hepatitis A virus infection with a high case-fatality rate among injecting drug users
    Enea Spada
    Istituto Superiore di Sanita, National Center of Epidemiology, Surveillance and Health Promotion, Clinical Epidemiology Unit, Viale Regina Elena 299, 00161 Rome, Italy
    J Hepatol 43:958-64. 2005
  6. ncbi request reprint Molecular epidemiology of a hepatitis C virus outbreak in a hemodialysis unit in Italy
    Enea Spada
    Istituto Superiore di Sanita, National Centre of Epidemiology, Surveillance and Health Promotion, Clinical Epidemiology Unit, Rome, Italy
    J Med Virol 80:261-7. 2008
  7. doi request reprint Acute hepatitis B 14 years after the implementation of universal vaccination in Italy: areas of improvement and emerging challenges
    Alfonso Mele
    National Centre of Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanita, Rome, Italy
    Clin Infect Dis 46:868-75. 2008
  8. doi request reprint Impact of viral selected mutations on T cell mediated immunity in chronically evolving and self limiting acute HCV infection
    Silvia Guglietta
    Department of Cellular and Developmental Biology, Sapienza University of Rome, Rome, Italy
    Virology 386:398-406. 2009
  9. ncbi request reprint Rare HVR1-HCV genotype 1b variants in patients with B non Hodgkin's lymphoma. Comparison with viral sequences detected in cases of lymphoproliferative disorders and B cell compartmentalisation
    Stefano Dettori
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Disease, Istituto Superiore di Sanita, Rome
    New Microbiol 30:265-70. 2007
  10. doi request reprint Estimating the incidence, prevalence and clinical burden of hepatitis C over time in Italy
    Andrea Mariano
    Reparto di Epidemiologia Clinica e Linee Guida, Istituto Superiore di Sanita, Rome, Italy
    Scand J Infect Dis 41:689-99. 2009

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infection
    Silvia Guglietta
    Department of Cellular and Developmental Biology University of Rome La Sapienza, Rome, Italy
    Eur J Immunol 35:2627-37. 2005
    ..These results support the view that acute-phase CD8+ T cell responses exert a biologically relevant pressure on HCV replication and that viruses escaping this host response could have a significant survival advantage...
  2. ncbi request reprint Changing epidemiology of parenterally transmitted viral hepatitis: results from the hepatitis surveillance system in Italy
    E Spada
    Clinical Epidemiology Unit, Laboratory of Epidemiology e Biostatistics, Istituto Superiore di Sanita, Rome, Italy
    Dig Liver Dis 33:778-84. 2001
    ..In 1991, compulsory hepatitis B virus vaccination and screening for anti-hepatitis C virus of blood banks were introduced in Italy...
  3. pmc Use of the minimum spanning tree model for molecular epidemiological investigation of a nosocomial outbreak of hepatitis C virus infection
    Enea Spada
    Istituto Superiore di Sanita, National Center of Epidemiology, Surveillance, and Health Promotion, Clinical Epidemiology Unit, via Regina Elena 299, 00161 Rome, Italy
    J Clin Microbiol 42:4230-6. 2004
    ..In conclusion, the MST model, supported by an exhaustive clinical-epidemiological investigation, appears to be a useful tool in tracing the history of transmission in outbreaks of HCV infection...
  4. pmc Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance
    E Spada
    Istituto Superiore di Sanita, National Center of Epidemiology, Surveillance and Health Promotion, Clinical Epidemiology Unit, Viale Regina Elena 299, 00161 Rome, Italy
    Gut 53:1673-81. 2004
    ..The aim of this study was to identify early prognostic markers of disease resolution by performing a comprehensive analysis of viral and host factors during the natural course of acute HCV infection...
  5. ncbi request reprint An outbreak of hepatitis A virus infection with a high case-fatality rate among injecting drug users
    Enea Spada
    Istituto Superiore di Sanita, National Center of Epidemiology, Surveillance and Health Promotion, Clinical Epidemiology Unit, Viale Regina Elena 299, 00161 Rome, Italy
    J Hepatol 43:958-64. 2005
    ..We attempted a thorough evaluation of the outbreak, including epidemiological, clinical and virological analyses...
  6. ncbi request reprint Molecular epidemiology of a hepatitis C virus outbreak in a hemodialysis unit in Italy
    Enea Spada
    Istituto Superiore di Sanita, National Centre of Epidemiology, Surveillance and Health Promotion, Clinical Epidemiology Unit, Rome, Italy
    J Med Virol 80:261-7. 2008
    ..The outbreak was probably due to breaks of infection control procedures although a related-machine transmission cannot be excluded in one of the cases...
  7. doi request reprint Acute hepatitis B 14 years after the implementation of universal vaccination in Italy: areas of improvement and emerging challenges
    Alfonso Mele
    National Centre of Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanita, Rome, Italy
    Clin Infect Dis 46:868-75. 2008
    ..In 1991, vaccination of infants and adolescents became mandatory. We report the impact of universal vaccination 14 years after its beginning...
  8. doi request reprint Impact of viral selected mutations on T cell mediated immunity in chronically evolving and self limiting acute HCV infection
    Silvia Guglietta
    Department of Cellular and Developmental Biology, Sapienza University of Rome, Rome, Italy
    Virology 386:398-406. 2009
    ....
  9. ncbi request reprint Rare HVR1-HCV genotype 1b variants in patients with B non Hodgkin's lymphoma. Comparison with viral sequences detected in cases of lymphoproliferative disorders and B cell compartmentalisation
    Stefano Dettori
    Viral Hepatitis Unit, Department of Infectious, Parasitic and Immune Mediated Disease, Istituto Superiore di Sanita, Rome
    New Microbiol 30:265-70. 2007
    ..In conclusion, the HCV predominants circulating in B-NHL cases seem to be associated with clonal selection of rare variants...
  10. doi request reprint Estimating the incidence, prevalence and clinical burden of hepatitis C over time in Italy
    Andrea Mariano
    Reparto di Epidemiologia Clinica e Linee Guida, Istituto Superiore di Sanita, Rome, Italy
    Scand J Infect Dis 41:689-99. 2009
    ..This is due to differences in the age-specific prevalence, most of HCV-positive Italians currently being >65 y of age...
  11. doi request reprint Evaluation of the compliance with the protocol for preventing perinatal hepatitis B infection in Italy
    Enea Spada
    National Centre of Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanita, Rome, Italy
    J Infect 62:165-71. 2011
    ..To evaluate the compliance with the protocol for preventing perinatal hepatitis B infection in Italy, including HBsAg screening of pregnant women and immunization of newborns to infected mothers...
  12. ncbi request reprint Acute hepatitis delta virus infection in Italy: incidence and risk factors after the introduction of the universal anti-hepatitis B vaccination campaign
    Alfonso Mele
    National Centre of Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanita, Rome, 00162, Italy
    Clin Infect Dis 44:e17-24. 2007
    ..Updates on the incidence of and risk factors for acute hepatitis delta virus infection in Italy, as well as in other countries, are lacking, and the impact of the mandatory anti-hepatitis B vaccination has not been evaluated...
  13. doi request reprint Risk factors for and incidence of acute hepatitis C after the achievement of blood supply safety in Italy: results from the national surveillance system
    Enea Spada
    Istituto Superiore di Sanita, National Centre of Epidemiology, Surveillance and Health Promotion, Rome, Italy
    J Med Virol 85:433-40. 2013
    ..Effective prevention programs for intravenous drug users and strict adherence to universal precautions in healthcare settings are needed...
  14. pmc Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection
    Debora Franceschini
    Dipartimento di Medicina Interna e Specialita Mediche, Sapienza Universita di Roma, Rome, Italy
    PLoS Pathog 8:e1002759. 2012
    ....
  15. pmc Early impairment of hepatitis C virus specific T cell proliferation during acute infection leads to failure of viral clearance
    A Folgori
    Istituto di Ricerche di Biologia Molecolare P Angeletti, Via Pontina Km 30 600, 00040, Pomezia, Rome, Italy
    Gut 55:1012-9. 2006
    ..The aim of this study was to verify if and when such immune dysfunction is established by measuring the breadth, magnitude, function, and duration of CMI in a large cohort of subjects during the natural course of acute HCV infection...
  16. pmc Role of IL28B Gene Polymorphism and Cell-Mediated Immunity in Spontaneous Resolution of Acute Hepatitis C
    Enea Spada
    National Centre of Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanita, Rome
    Clin Infect Dis 57:803-11. 2013
    ..Self-limiting AHC was independently associated with CC genotype. The correlation between IL28B.rs12979860 genotypes and CMI is suggestive of a possible important role of CMI in favoring hepatitis C virus clearance in CC patients. ..
  17. ncbi request reprint High prevalence of hepatitis B virus infection in B-cell non-Hodgkin's lymphoma
    Fabrizio Marcucci
    Istituto Superiore di Sanita, Rome, Italy
    Haematologica 91:554-7. 2006
    ..75-7.66). HBV/HCV co-infection was found in four cases, but in no controls. The finding of a positive association between HBV infection and B-NHL raises the possibility that HBV may play an etiologic role in the induction of B-NHL...
  18. doi request reprint Acute hepatitis A in Italy: incidence, risk factors and preventive measures
    M E Tosti
    National Centre of Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanita, Rome, Italy
    J Viral Hepat 15:26-32. 2008
    ....
  19. ncbi request reprint Case fatality rate of acute viral hepatitis in Italy: 1995-2000. An update
    E Bianco
    Laboratory of Epidemiology and Biostatistics, Istituto Superiore di Sanita, Rome, Italy
    Dig Liver Dis 35:404-8. 2003
    ..Fulminant hepatic failure is the most serious complication of viral hepatitis. Although this event occurs rarely, it may be fatal...
  20. ncbi request reprint Risk of parenterally transmitted hepatitis following exposure to surgery or other invasive procedures: results from the hepatitis surveillance system in Italy
    A Mele
    Laboratory of Epidemiology, , Rome, Italy
    J Hepatol 35:284-9. 2001
    ..Since a large proportion of the adult general population is exposed to these procedures and an effective HCV vaccine is not yet available, non-immunological means of controlling iatrogenic modes of transmission are extremely important...
  21. doi request reprint Immune complexed (IC) hepatitis C virus (HCV) in chronically and acutely HCV-infected patients
    E Riva
    Department of Biomedical Research, University Campus Bio Medico, Via E Longoni n 47, 00185, Rome, Italy
    Med Microbiol Immunol 198:13-8. 2009
    ..Collectively, these findings strengthen the possibility that IC virus could play a critical role in the pathogenesis of HCV infection...
  22. doi request reprint Influence of specific CD4+ T cells and antibodies on evolution of hypervariable region 1 during acute HCV infection
    Cristiano Scotta
    Department of Cellular and Developmental Biology, La Sapienza University of Rome, Italy
    J Hepatol 48:216-28. 2008
    ..However, these studies have not been performed examining the relationship between HVR1 evolution and the development of specific immunity to autologous HVR1 sequences...
  23. ncbi request reprint Incidence of parenterally transmitted acute viral hepatitis among healthcare workers in Italy
    Maria Elena Tosti
    National Centre of Epidemiology Surveillance and Health Promotion, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Infect Control Hosp Epidemiol 28:629-32. 2007