Antonio Sica

Summary

Affiliation: Istituto Clinico Humanitas
Country: Italy

Publications

  1. ncbi request reprint Targeting tumour-associated macrophages
    Antonio Sica
    Department of Immunology, Fondazione Humanitas per la Ricerca, 20089 Rozzano, Milan, Italy
    Expert Opin Ther Targets 11:1219-29. 2007
  2. ncbi request reprint Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy
    Antonio Sica
    Istituto Clinico Humanitas, 20089 Rozzano, Milan, Italy
    Eur J Cancer 42:717-27. 2006
  3. doi request reprint Hypoxia: a double-edged sword of immunity
    Antonio Sica
    Istituto Clinico Humanitas, IRCCS, Italy via Manzoni, Rozzano, Milan, Italy
    J Mol Med (Berl) 89:657-65. 2011
  4. doi request reprint Macrophage polarization in tumour progression
    Antonio Sica
    Department of Inflammation and Immunology, Fondazione Humanitas per la Ricerca, 20089 Rozzano, Milan, Italy
    Semin Cancer Biol 18:349-55. 2008
  5. doi request reprint The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance
    Paola Allavena
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Immunol Rev 222:155-61. 2008
  6. ncbi request reprint p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance
    Alessandra Saccani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Cancer Res 66:11432-40. 2006
  7. doi request reprint Divergent effects of hypoxia on dendritic cell functions
    Alessandra Mancino
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Milan, Italy
    Blood 112:3723-34. 2008
  8. ncbi request reprint Tumor promotion by tumor-associated macrophages
    Chiara Porta
    Fondazione Humanitas per la Ricerca, Istituto Clinico Humanitas, 20089 Milan, Italy
    Adv Exp Med Biol 604:67-86. 2007
  9. doi request reprint Macrophage plasticity and polarization in tissue repair and remodelling
    Alberto Mantovani
    Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, Milan, Italy
    J Pathol 229:176-85. 2013
  10. ncbi request reprint The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages
    Paola Allavena
    IRCCS Istituto Clinico Humanitas, Via Manzoni 56, Rozzano 20089, Milan, Italy
    Crit Rev Oncol Hematol 66:1-9. 2008

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Targeting tumour-associated macrophages
    Antonio Sica
    Department of Immunology, Fondazione Humanitas per la Ricerca, 20089 Rozzano, Milan, Italy
    Expert Opin Ther Targets 11:1219-29. 2007
    ..This evidence strongly supports the idea that TAM are central orchestrators of the inflammatory networks expressed in the tumour microenvironment, and suggest these cells as possible targets of anticancer therapies...
  2. ncbi request reprint Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy
    Antonio Sica
    Istituto Clinico Humanitas, 20089 Rozzano, Milan, Italy
    Eur J Cancer 42:717-27. 2006
    ..Evidence is presented here supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and are a potential target for anti-cancer therapy...
  3. doi request reprint Hypoxia: a double-edged sword of immunity
    Antonio Sica
    Istituto Clinico Humanitas, IRCCS, Italy via Manzoni, Rozzano, Milan, Italy
    J Mol Med (Berl) 89:657-65. 2011
    ..Selective inhibition of hypoxic signaling pathways in myeloid versus lymphoid cells may open new therapeutic opportunities in diseases characterized by low oxygen tension...
  4. doi request reprint Macrophage polarization in tumour progression
    Antonio Sica
    Department of Inflammation and Immunology, Fondazione Humanitas per la Ricerca, 20089 Rozzano, Milan, Italy
    Semin Cancer Biol 18:349-55. 2008
    ..Here, we discuss recent findings suggesting that targeting tumour-associated macrophages (TAMs) polarization may represent a novel therapeutic strategy against cancer...
  5. doi request reprint The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance
    Paola Allavena
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Immunol Rev 222:155-61. 2008
    ..Herein, the 'macrophage balance' is discussed in the context of the apparent paradox of tumor promotion by innate immunity-driven inflammation and the seemingly opposed tumor surveillance by adaptive immune responses...
  6. ncbi request reprint p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance
    Alessandra Saccani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Cancer Res 66:11432-40. 2006
    ..Thus, p50 NF-kappaB overexpression accounts for the inability of TAM to mount an effective M1 antitumor response capable of inhibiting tumor growth...
  7. doi request reprint Divergent effects of hypoxia on dendritic cell functions
    Alessandra Mancino
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Milan, Italy
    Blood 112:3723-34. 2008
    ..Thus, hypoxia uncouples the promotion of inflammatory and tissue repair from sentinel functions in DCs, which we suggest is a safeguard mechanism against immune reactivity to damaged tissues...
  8. ncbi request reprint Tumor promotion by tumor-associated macrophages
    Chiara Porta
    Fondazione Humanitas per la Ricerca, Istituto Clinico Humanitas, 20089 Milan, Italy
    Adv Exp Med Biol 604:67-86. 2007
    ..Therapeutic targeting of cancer promoting inflammatory reactions is in its infancy, and its development is crucially dependent on defining the underlying cellular and molecular mechanisms in relevant systems...
  9. doi request reprint Macrophage plasticity and polarization in tissue repair and remodelling
    Alberto Mantovani
    Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, Milan, Italy
    J Pathol 229:176-85. 2013
    ..These properties of cells of the monocyte-macrophage lineage may represent a tool and a target for therapeutic exploitation...
  10. ncbi request reprint The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages
    Paola Allavena
    IRCCS Istituto Clinico Humanitas, Via Manzoni 56, Rozzano 20089, Milan, Italy
    Crit Rev Oncol Hematol 66:1-9. 2008
    ..In this review we will discuss the role of TAM in the inflammatory micro-environment of solid tumors and will try to identify potential target for future therapeutic approaches...
  11. doi request reprint Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Hum Immunol 70:325-30. 2009
    ..As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer...
  12. pmc The p50 subunit of NF-κB orchestrates dendritic cell lifespan and activation of adaptive immunity
    Paola Larghi
    Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    PLoS ONE 7:e45279. 2012
    ....
  13. pmc Angiostatin anti-angiogenesis requires IL-12: the innate immune system as a key target
    Adriana Albini
    Polo Scientifico e Tecnologico, IRCCS Multimedica, Milan, Italy
    J Transl Med 7:5. 2009
    ..Here we present evidence that IL-12, a principal TH1 cytokine with potent anti-angiogenic activity, is the mediator of angiostatin's activity...
  14. pmc Cell-specific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells
    Andrea Doni
    Istituto Clinico Humanitas, Istituto Di Ricerca Cura a Caratte Re Scientifico, Department of Immunology and Inflammation, Rozzano, Milan, Italy
    J Biol Chem 283:29983-92. 2008
    ..The divergent effects of GC on PTX3 production probably reflect the different functions of this multifunctional molecule in innate immunity and in the construction of the extracellular matrix...
  15. ncbi request reprint Role of tumor-associated macrophages in tumor progression and invasion
    Alberto Mantovani
    Istituto Clinico Humanitas, 20089 Rozzano, Milan, Italy
    Cancer Metastasis Rev 25:315-22. 2006
    ..Here, we discuss evidence supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and a potential target of anti-cancer therapy...
  16. doi request reprint Cancer related inflammation: the macrophage connection
    Antonio Sica
    Fondazione Humanitas per Ricerca, 20089 Rozzano, Milan, Italy
    Cancer Lett 267:204-15. 2008
    ..This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches...
  17. doi request reprint Macrophages, innate immunity and cancer: balance, tolerance, and diversity
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Curr Opin Immunol 22:231-7. 2010
    ..TAM can also express antitumor activity. Thus, in response to microenvironmental signals, TAM can exert dual influence on tumor growth and progression...
  18. ncbi request reprint Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Tumori 89:459-68. 2003
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumor growth and progression...
  19. ncbi request reprint Inflammation and cancer: breast cancer as a prototype
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Breast 16:S27-33. 2007
    ..Here, we discuss evidence supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and a potential target of anti-cancer therapy...
  20. doi request reprint Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
    Francesco Colotta
    Nerviano Medical Sciences, Nerviano, Milan, Italy
    Carcinogenesis 30:1073-81. 2009
    ..In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark...
  21. doi request reprint A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships
    Ferdinando Pucci
    Angiogenesis and Tumor Targeting Research Unit, San Raffaele Institute, Olgettina 58, Milan, Italy
    Blood 114:901-14. 2009
    ....
  22. pmc Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB
    Chiara Porta
    Fondazione Humanitas per la Ricerca, 20089 Rozzano, Italy
    Proc Natl Acad Sci U S A 106:14978-83. 2009
    ..Thus, NF-kappaB p50 is a key component in the orchestration of M2-driven inflammatory reactions...
  23. ncbi request reprint Macrophage activation and polarization
    Fernando Oneissi Martinez
    Istituto Clinico Humanitas, I 20089 Rozzano, Italy
    Front Biosci 13:453-61. 2008
    ..Here we review the main functions of polarized macrophages and discuss the perspectives of this field...
  24. doi request reprint Pathways connecting inflammation and cancer
    Paola Allavena
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Curr Opin Genet Dev 18:3-10. 2008
    ..Thus, an intrinsic pathway of inflammation (driven in tumor cells), as well as an extrinsic pathway (in tumor-infiltrating leukocytes) have been described and both contribute to tumor progression...
  25. doi request reprint Cancer-related inflammation
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, Italy
    Nature 454:436-44. 2008
    ..The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment...
  26. pmc Macrophage plasticity and polarization: in vivo veritas
    Antonio Sica
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    J Clin Invest 122:787-95. 2012
    ..The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for macrophage-centered diagnostic and therapeutic strategies...
  27. ncbi request reprint New vistas on macrophage differentiation and activation
    Alberto Mantovani
    Istituto Clinico Humanitas, Milan, Italy
    Eur J Immunol 37:14-6. 2007
    ....
  28. ncbi request reprint Tumor-associated macrophages: a molecular perspective
    Antonio Sica
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int Immunopharmacol 2:1045-54. 2002
    ..Emerging evidence starts to define the molecular basis for the peculiar functional phenotype of TAM and identifies possible therapeutic targets...
  29. ncbi request reprint Macrophage polarization comes of age
    Alberto Mantovani
    Istituto Clinico Humanitas, and Institute of General Pathology, University of Milan, Milan, Italy
    Immunity 23:344-6. 2005
    ..Genetic approaches have begun to shed new light on mechanisms underlying macrophage polarization and on the actual in vivo significance of polarized M2 cells ( [this issue of Immunity])...
  30. ncbi request reprint A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation)
    Subhra K Biswas
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Blood 107:2112-22. 2006
    ..Thus, profiling of TAMs from a murine sarcoma revealed unexpected expression of IFN-inducible chemokines, associated with an M2 phenotype (IL-10high, IL-12low), and divergent regulation of the NF-kappaB versus the IRF-3/STAT1 pathway...
  31. ncbi request reprint Tolerance in intestinal inflammation and cancer
    Marisa Vulcano
    Laboratory of Gastroenterology and Immunopathology, Division of Gastroenterology, Instituto Clinico Humanitas, Milan, Italy
    Curr Drug Targets 9:404-12. 2008
    ..Nevertheless, antigen uptake and presentation seems to be a crucial factor in this issue. In this review, we will discuss the key role of immune intestinal cells in the development of mucosal immunity, tolerance and disease...
  32. doi request reprint Cellular and molecular pathways linking inflammation and cancer
    Chiara Porta
    DiSCAFF, University of Piemonte Orientale A Avogadro, Novara, Italy
    Immunobiology 214:761-77. 2009
    ..Recent advances in the understanding of the cellular and molecular pathways involved in cancer-related inflammation as well as their potential relevance as diagnostic, prognostic and therapeutic targets are herein discussed...
  33. ncbi request reprint Linking inflammation reactions to cancer: novel targets for therapeutic strategies
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano Milan, Italy
    Adv Exp Med Biol 610:112-27. 2008
  34. pmc Altered macrophage differentiation and immune dysfunction in tumor development
    Antonio Sica
    Istituto Clinico Humanitas, Instituto di Ricovero e Cura a Carattere Scientifico IRCCS, Rozzano, Italy
    J Clin Invest 117:1155-66. 2007
    ....
  35. doi request reprint Inactivation of junctional adhesion molecule-A enhances antitumoral immune response by promoting dendritic cell and T lymphocyte infiltration
    Masato Murakami
    FIRC Institute of Molecular Oncology, Milan, Italy
    Cancer Res 70:1759-65. 2010
    ..These findings support the idea that, in the Rip1Tag2 tumor model, abrogation of JAM-A reduces cancer development by increasing antitumor immune response...
  36. ncbi request reprint Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation
    Lorenzo Piemonti
    Laboratory of Experimental Surgery, Surgical Department, S Raffaele Scientific Institute, Via Olgettina, Milan, Italy University of Milano Bicocca, Milan, Italy
    Diabetes 51:55-65. 2002
    ....
  37. ncbi request reprint Expression of CD4 on human peripheral blood neutrophils
    Priscilla Biswas
    Laboratory of Clinical Immunology, San Raffaele Scientific Institute, Milan, Italy
    Blood 101:4452-6. 2003
    ..Owing to their abundance in peripheral blood, CD4+ neutrophils may influence significantly the biodistribution of HIV delivering it to sites of inflammation or to additional tissue reservoirs...
  38. ncbi request reprint Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression...
  39. ncbi request reprint Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms
    Subhra K Biswas
    Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology and Research, Singapore
    J Immunol 180:2011-7. 2008
    ..In this review, we discuss the evidence for this plasticity of macrophage functions, the specific signaling mechanisms that may be regulating it, and the new targets for anticancer therapies highlighted by these findings...
  40. ncbi request reprint Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Novartis Found Symp 256:137-45; discussion 146-8, 259-69. 2004
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression...
  41. ncbi request reprint Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy
    Semin Cancer Biol 14:155-60. 2004
    ..Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression...
  42. ncbi request reprint Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression
    Alberto Mantovani
    Instituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Eur J Cancer 40:1660-7. 2004
    ..As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression...
  43. ncbi request reprint The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
    ....
  44. ncbi request reprint Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia ind
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, 900 Veteran Avenue, Los Angeles, California 90095, USA
    J Biol Chem 280:22473-81. 2005
    ..Thus, a combination of low oxygen tension and overexpression of EGFR within the primary tumor of NSCLC may provide the microenvironmental signals necessary to upregulate CXCR4 expression and promote metastasis...
  45. ncbi request reprint Glutathione protects mice from lethal sepsis by limiting inflammation and potentiating host defense
    Pia Villa
    Mario Negri Institute for Pharmacological Research and National Research Council, Cellular and Molecular Pharmacology Center, Via Eritrea 62, 20157 Milan, Italy
    J Infect Dis 185:1115-20. 2002
    ..Thus, migration of neutrophils to a site of infection and to a distant site is differently regulated, and optimal GSH levels are important for an efficient response to sepsis...