Andrea Savarino

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. pmc A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model
    Iart Luca Shytaj
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, Rome, Italy
    PLoS Pathog 8:e1002774. 2012
  2. pmc A candidate anti-HIV reservoir compound, auranofin, exerts a selective 'anti-memory' effect by exploiting the baseline oxidative status of lymphocytes
    B Chirullo
    Istituto Superiore di Sanita, Viale Regina Elena, 299, Rome, Italy
    Cell Death Dis 4:e944. 2013
  3. pmc A cure for AIDS: a matter of timing?
    Iart Luca Shytaj
    Istituto Superiore di Sanita, Viale Regina Elena, 299, Rome 00161, Italy
    Retrovirology 10:145. 2013
  4. pmc Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?
    Andrea Savarino
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, Rome 299 00161, Italy
    Retrovirology 9:75. 2012
  5. pmc "Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence
    Andrea Savarino
    Dept of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161, Rome, Italy
    Retrovirology 6:52. 2009
  6. pmc Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS
    Andrea Savarino
    Dept of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161, Rome, Italy
    Retrovirology 4:79. 2007
  7. pmc Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy
    Mark G Lewis
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161, Rome, Italy
    Retrovirology 7:21. 2010
  8. ncbi request reprint Response of feline immunodeficiency virus (FIV) to tipranavir may provide new clues for development of broad-based inhibitors of retroviral proteases acting on drug-resistant HIV-1
    Sandro Norelli
    Department of Infectious, Parasitic and Immune mediate Diseases, Istituto Superiore di Sanita, Viale Regina Elena, Rome, Italy
    Curr HIV Res 6:306-17. 2008
  9. ncbi request reprint Role of lymphocyte multidrug resistance protein 1 in HIV infection: expression, function, and consequences of inhibition
    Mothanje Barbara Lucia
    Department of Infectious Diseases, Catholic University, Rome, Italy
    J Acquir Immune Defic Syndr 40:257-66. 2005
  10. pmc Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS
    Iart Luca Shytaj
    Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161, Rome, Italy
    Retrovirology 10:71. 2013

Collaborators

Detail Information

Publications23

  1. pmc A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model
    Iart Luca Shytaj
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, Rome, Italy
    PLoS Pathog 8:e1002774. 2012
    ....
  2. pmc A candidate anti-HIV reservoir compound, auranofin, exerts a selective 'anti-memory' effect by exploiting the baseline oxidative status of lymphocytes
    B Chirullo
    Istituto Superiore di Sanita, Viale Regina Elena, 299, Rome, Italy
    Cell Death Dis 4:e944. 2013
    ..In conclusion, our results demonstrate that AF selectively targets the T(CM)/T(TM) lymphocyte subsets, which encompass the HIV reservoir, by affecting redox-sensitive cell death pathways...
  3. pmc A cure for AIDS: a matter of timing?
    Iart Luca Shytaj
    Istituto Superiore di Sanita, Viale Regina Elena, 299, Rome 00161, Italy
    Retrovirology 10:145. 2013
    ..A synthetic interpretation of these results could be pivotal in order to develop an effective and widely available cure. ..
  4. pmc Therapeutic imprinting of the immune system: towards a remission of AIDS in primates?
    Andrea Savarino
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, Rome 299 00161, Italy
    Retrovirology 9:75. 2012
    ....
  5. pmc "Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence
    Andrea Savarino
    Dept of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161, Rome, Italy
    Retrovirology 6:52. 2009
    ....
  6. pmc Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS
    Andrea Savarino
    Dept of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161, Rome, Italy
    Retrovirology 4:79. 2007
    ..Integrase strand transfer inhibitors (INSTIs) are emerging as a promising new drug class for HIV-1 treatment, and we evaluated the possibility of inhibiting FIV replication using INSTIs...
  7. pmc Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy
    Mark G Lewis
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161, Rome, Italy
    Retrovirology 7:21. 2010
    ....
  8. ncbi request reprint Response of feline immunodeficiency virus (FIV) to tipranavir may provide new clues for development of broad-based inhibitors of retroviral proteases acting on drug-resistant HIV-1
    Sandro Norelli
    Department of Infectious, Parasitic and Immune mediate Diseases, Istituto Superiore di Sanita, Viale Regina Elena, Rome, Italy
    Curr HIV Res 6:306-17. 2008
    ....
  9. ncbi request reprint Role of lymphocyte multidrug resistance protein 1 in HIV infection: expression, function, and consequences of inhibition
    Mothanje Barbara Lucia
    Department of Infectious Diseases, Catholic University, Rome, Italy
    J Acquir Immune Defic Syndr 40:257-66. 2005
    ..Our results are consistent with a model wherein HIV replication is favored by the MRP1-related oxidative stress and inhibition of MRP1 may contribute to the antiviral activity of PIs...
  10. pmc Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS
    Iart Luca Shytaj
    Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161, Rome, Italy
    Retrovirology 10:71. 2013
    ..Moreover, auranofin could synergize with a fully suppressive ART protocol and induce a drug-free post-therapy containment of viremia...
  11. pmc Different pH requirements are associated with divergent inhibitory effects of chloroquine on human and avian influenza A viruses
    Livia Di Trani
    Dept of Food and Animal Health, Istituto Superiore di Sanita, Rome, Italy
    Virol J 4:39. 2007
    ..Overall, the present study highlights the critical importance of a host cell factor such as intravesicular pH in determining the anti-influenza activity of chloroquine and other lysosomotropic agents...
  12. ncbi request reprint Anti-HIV effects of chloroquine: inhibition of viral particle glycosylation and synergism with protease inhibitors
    Andrea Savarino
    Department of Infectious Diseases, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Acquir Immune Defic Syndr 35:223-32. 2004
    ..We tested the effects of chloroquine (CQ) on glycosylation of HIV particles and in combination with protease inhibitors (PIs) on HIV replication and on P-glycoprotein (P-gp)/multidrug resistance protein-1 (MRP1)...
  13. ncbi request reprint A historical sketch of the discovery and development of HIV-1 integrase inhibitors
    Andrea Savarino
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanità Viale Regina Elena, 299 00161 Rome, Italy
    Expert Opin Investig Drugs 15:1507-22. 2006
    ..This review reconstructs (in the general context of the history of AIDS research) the principal steps that led to the integrase inhibitors currently in clinical trials, and discusses possible future directions...
  14. ncbi request reprint Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and beta-hemoglobinopathies
    Dante Rotili
    Pasteur Institute, Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, p le A Moro, 5, 00185, Rome, Italy
    Curr Top Med Chem 9:272-91. 2009
    ....
  15. pmc In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate
    Andrea Savarino
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Retrovirology 4:21. 2007
    ..However, mapping of the DNA and INSTI binding sites within the IN catalytic core domain (CCD) has been uncertain...
  16. doi request reprint Characterization of the serological response to phospholipase D protein of Chlamydophila pneumoniae in patients with acute coronary syndromes
    Fabiola Mancini
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Microbes Infect 11:367-73. 2009
    ..pneumoniae infection. The CpPLD protein and its P5 peptide could be plausible antigens for the diagnosis of C. pneumoniae chronic infections in ACS patients...
  17. ncbi request reprint Effects of chloroquine on viral infections: an old drug against today's diseases?
    Andrea Savarino
    Department of Infectious Diseases, Universita Cattolica del Sacro Cuore, Rome, Italy
    Lancet Infect Dis 3:722-7. 2003
    ....
  18. ncbi request reprint New insights into the antiviral effects of chloroquine
    Andrea Savarino
    Lancet Infect Dis 6:67-9. 2006
  19. ncbi request reprint Expanding the frontiers of existing antiviral drugs: possible effects of HIV-1 protease inhibitors against SARS and avian influenza
    Andrea Savarino
    Laboratory of Viral Immunology, Department of Infectious Diseases, Universita Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, I 00168 Rome, Italy
    J Clin Virol 34:170-8. 2005
    ..Although this evidence is still far from being definitive, the results so far obtained suggest that PIs should be seriously taken into consideration for further testing as potential therapeutic agents for SARS and avian influenza...
  20. ncbi request reprint On the use of chloroquine for chikungunya
    Andrea Savarino
    Lancet Infect Dis 7:633. 2007
  21. ncbi request reprint Risks and benefits of chloroquine use in anticancer strategies
    Andrea Savarino
    Lancet Oncol 7:792-3. 2006
  22. ncbi request reprint Role of FAS in HIV infection
    Umberto Dianzani
    Interdisciplinary Research Center of Autoimmune Diseases, Department of Medical Sciences, A Avogadro University of Eastern Piedmont, Novara, Italy
    Curr HIV Res 1:405-17. 2003
    ....
  23. ncbi request reprint Human CD38 interferes with HIV-1 fusion through a sequence homologous to the V3 loop of the viral envelope glycoprotein gp120
    Andrea Savarino
    Laboratory of Immunology, Interdisciplinary Research Center of Autoimmune Diseases, Department of Medical Science, University of Eastern Piedmont, Novara, Italy
    FASEB J 17:461-3. 2003
    ..Conversely, a deletion in the V3-like region abrogated the anti-HIV-1 activity of CD38 and its lateral association with CD4. These findings may provide new insights into the early events of HIV-1 fusion and strategies to intervene...