Carmela Santangelo

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. doi request reprint CCAAT/enhancer-binding protein-β participates in oxidized LDL-enhanced proliferation in 3T3-L1 cells
    Carmela Santangelo
    Department of Veterinary Public Health and Food Safety, Italian National Institute of Health, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Biochimie 93:1510-9. 2011
  2. ncbi request reprint Polyphenols, intracellular signalling and inflammation
    Carmela Santangelo
    Centro Nazionale per la Qualita degli Alimenti e per i Rischi Alimentari, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann Ist Super Sanita 43:394-405. 2007
  3. ncbi request reprint Hepatocyte growth factor protects rat RINm5F cell line against free fatty acid-induced apoptosis by counteracting oxidative stress
    Carmela Santangelo
    National Centre for Food Quality and Risk Assessment, Section of Nutrition, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Mol Endocrinol 38:147-58. 2007
  4. doi request reprint Oxidised LDL up-regulate CD36 expression by the Nrf2 pathway in 3T3-L1 preadipocytes
    Massimo D'Archivio
    National Centre for Food Quality and Risk Assessment, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    FEBS Lett 582:2291-8. 2008
  5. doi request reprint Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages
    Rosaria Varì
    Department of Veterinary Public Health and Food Safety, Italian National Institute of Health, Rome, Italy
    J Nutr Biochem 22:409-17. 2011
  6. pmc Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases
    Beatrice Scazzocchio
    Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanita, Rome, Italy
    J Lipid Res 50:832-45. 2009
  7. ncbi request reprint Tyrosol, the major extra virgin olive oil compound, restored intracellular antioxidant defences in spite of its weak antioxidative effectiveness
    Roberta Di Benedetto
    National Centre for Food Quality and Risk Assessment, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Nutr Metab Cardiovasc Dis 17:535-45. 2007
  8. ncbi request reprint Apoptosis in cancer and atherosclerosis: polyphenol activities
    Claudio Giovannini
    Centro Nazionale per la Qualita degli Alimenti e per i Rischi Alimentari, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann Ist Super Sanita 43:406-16. 2007
  9. pmc Cyanidin-3-O-β-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARγ activity in human omental adipocytes
    Beatrice Scazzocchio
    Department of Veterinary Public Health and Food Safety, National Institute of Health, Rome, Italy
    Diabetes 60:2234-44. 2011
  10. doi request reprint Predominant role of obesity/insulin resistance in oxidative stress development
    Massimo D'Archivio
    Department of Veterinary Public Health and Food Safety, Italian National Institute of Health, Rome, Italy
    Eur J Clin Invest 42:70-8. 2012

Collaborators

Detail Information

Publications20

  1. doi request reprint CCAAT/enhancer-binding protein-β participates in oxidized LDL-enhanced proliferation in 3T3-L1 cells
    Carmela Santangelo
    Department of Veterinary Public Health and Food Safety, Italian National Institute of Health, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Biochimie 93:1510-9. 2011
    ..These findings show that the altered expression pattern of C/EBPβ is involved in the increase in the number of proliferating cells induced by oxLDL, in hormone-stimulated 3T3-L1 cells...
  2. ncbi request reprint Polyphenols, intracellular signalling and inflammation
    Carmela Santangelo
    Centro Nazionale per la Qualita degli Alimenti e per i Rischi Alimentari, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann Ist Super Sanita 43:394-405. 2007
    ..A clear understanding of the molecular mechanisms of action of phenolic compounds is crucial in the valuation of these potent molecules as potential prophylactic and therapeutic agents...
  3. ncbi request reprint Hepatocyte growth factor protects rat RINm5F cell line against free fatty acid-induced apoptosis by counteracting oxidative stress
    Carmela Santangelo
    National Centre for Food Quality and Risk Assessment, Section of Nutrition, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Mol Endocrinol 38:147-58. 2007
    ..In conclusion, in rat insulin-producing RINm5F cells, HGF exerts its prosurvival effect by counteracting the increased intracellular oxidative stress and, consequently, by inhibiting apoptosis induced by chronic exposure to FFAs...
  4. doi request reprint Oxidised LDL up-regulate CD36 expression by the Nrf2 pathway in 3T3-L1 preadipocytes
    Massimo D'Archivio
    National Centre for Food Quality and Risk Assessment, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    FEBS Lett 582:2291-8. 2008
    ..Besides strengthening the hypothesis that oxLDL can contribute to the onset of insulin-resistance, data herein presented highlight the significance of oxLDL-induced CD36 overexpression within the cellular defence response...
  5. doi request reprint Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages
    Rosaria Varì
    Department of Veterinary Public Health and Food Safety, Italian National Institute of Health, Rome, Italy
    J Nutr Biochem 22:409-17. 2011
    ..This knowledge could contribute to novel diet-based approaches aimed at counteracting oxidative injury by reinforcing endogenous defences...
  6. pmc Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases
    Beatrice Scazzocchio
    Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanita, Rome, Italy
    J Lipid Res 50:832-45. 2009
    ..This suggests that oxLDL might participate in the development of insulin resistance...
  7. ncbi request reprint Tyrosol, the major extra virgin olive oil compound, restored intracellular antioxidant defences in spite of its weak antioxidative effectiveness
    Roberta Di Benedetto
    National Centre for Food Quality and Risk Assessment, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Nutr Metab Cardiovasc Dis 17:535-45. 2007
    ..This study compared the protective effects of tyrosol and hydroxytyrosol, two biophenols greatly different in antioxidant power, on J774 A.1-mediated oxidation of LDL...
  8. ncbi request reprint Apoptosis in cancer and atherosclerosis: polyphenol activities
    Claudio Giovannini
    Centro Nazionale per la Qualita degli Alimenti e per i Rischi Alimentari, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann Ist Super Sanita 43:406-16. 2007
    ....
  9. pmc Cyanidin-3-O-β-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARγ activity in human omental adipocytes
    Beatrice Scazzocchio
    Department of Veterinary Public Health and Food Safety, National Institute of Health, Rome, Italy
    Diabetes 60:2234-44. 2011
    ..This study aimed at investigating whether cyanidin-3-O-β-glucoside (C3G) and its metabolite protocatechuic acid (PCA) might have a role in glucose transport activation in human omental adipocytes and 3T3-L1 cells...
  10. doi request reprint Predominant role of obesity/insulin resistance in oxidative stress development
    Massimo D'Archivio
    Department of Veterinary Public Health and Food Safety, Italian National Institute of Health, Rome, Italy
    Eur J Clin Invest 42:70-8. 2012
    ..This study aimed at investigating the individual role played by obesity, insulin resistance and type 2 diabetes in the occurrence of fasting and postprandial oxidative stress...
  11. ncbi request reprint Oxidised LDL modulate adipogenesis in 3T3-L1 preadipocytes by affecting the balance between cell proliferation and differentiation
    Roberta Masella
    National Centre for Food Quality and Risk Assessment, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    FEBS Lett 580:2421-9. 2006
    ..These results point to oxLDL as a modulator of adipose tissue mass and as possible link between obesity and its clinical complications...
  12. pmc Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention
    Carmela Santangelo
    National Centre for Food Quality and Risk Assessment, , Viale Regina Elena 299, 00161 Rome Italy
    Int J Mol Sci 9:213-28. 2008
    ....
  13. pmc Molecular epidemiological and antibiotic susceptibility characterization of Brucella isolates from humans in Sicily, Italy
    Cinzia Marianelli
    Dipartimento di Sanità Alimentare ed Animale, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Clin Microbiol 45:2923-8. 2007
    ..This study represents the first epidemiological data from molecular typing of Brucella strains circulating in Italy and, in particular, in eastern Sicily...
  14. ncbi request reprint Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokines
    Carmela Santangelo
    National Center for Food Quality and Risk Assessment, Istituto Superiore di Sanita, Rome, Italy
    Eur J Endocrinol 152:485-9. 2005
    ....
  15. ncbi request reprint [Polyphenols and endogenous antioxidant defences: effects on glutathione and glutathione related enzymes]
    Claudio Giovannini
    Centro Nazionale per la Qualita degli Alimenti e per i Rischi Alimentari, Istituto Superiore di Sanita, Roma
    Ann Ist Super Sanita 42:336-47. 2006
    ..The latest studies strongly suggest that dietary polyphenols can stimulate antioxidant enzyme transcription through ARE...
  16. ncbi request reprint Effects of monounsaturated vs. saturated fat on postprandial lipemia and adipose tissue lipases in type 2 diabetes
    Angela A Rivellese
    Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Clin Nutr 27:133-41. 2008
    ..The effects of different dietary fatty acids on postprandial lipid metabolism in type 2 diabetic patients are still debated...
  17. ncbi request reprint Defective lymphocyte caspase-3 expression in type 1 diabetes mellitus
    Francesco Vendrame
    Department of Clinical Sciences Endocrinology, University La Sapienza, Rome, Italy
    Eur J Endocrinol 152:119-25. 2005
    ....
  18. ncbi request reprint The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets
    Lorella Marselli
    Dipartimento di Endocrinologia e Metabolismo, Sezione Metabolismo, Universita di Pisa, Via Paradisa 2, Ospedale Cisanello, 56100 Pisa, Italy
    Eur J Endocrinol 151:207-14. 2004
    ..We hypothesized that PBRs can have a role in human islet physiopathology, and evaluated the effects of prolonged exposure to two specific PBR ligands, PK11195 and Ro5-4864 on the function and survival of isolated human islets...
  19. ncbi request reprint Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
    Roberto Lupi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Diabetes 51:1437-42. 2002
    ..The cytostatic action is likely to be due to the FFA-induced reduction of intraislet glucose metabolism, and the proapoptotic effects are mostly caspase mediated, partially dependent on ceramide pathway, and possibly Bcl-2 regulated...
  20. ncbi request reprint Upregulation of mitochondrial peripheral benzodiazepine receptor expression by cytokine-induced damage of human pancreatic islets
    M Letizia Trincavelli
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonnanno 6, 56126 Pisa, Italy
    J Cell Biochem 84:636-44. 2002
    ..These results suggest a possible role of peripheral benzodiazepine receptors in the organism response to tissue damage associated with inflammatory mediator production...