S Salvati

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. ncbi Diet, lipids and brain development
    S Salvati
    Neurochemistry Section, Laboratory of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanita, Rome, Italy
    Dev Neurosci 22:481-7. 2000
  2. ncbi Eicosapentaenoic acid stimulates the expression of myelin proteins in rat brain
    Serafina Salvati
    Department of Food, Nutrition and Health, Istituto Superiore di Sanita, Rome, Italy
    J Neurosci Res 86:776-84. 2008
  3. ncbi Polyunsaturated fatty acids and neurological diseases
    S Salvati
    Department of Food, Nutrition and Health, Istituto Superiore di Sanita, Rome, Italy
    Mini Rev Med Chem 6:1201-11. 2006
  4. ncbi Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells
    Serafina Salvati
    Department of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanita, V le Regina Elena, Roma 299 00161, Italy
    Neurochem Int 44:331-8. 2004
  5. ncbi Micronutrient-enriched rapeseed oils improve the brain oxidant/antioxidant system in rats fed a high-fat diet
    Serafina Salvati
    Department of Public Veterinary Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy
    J Agric Food Chem 59:4483-8. 2011
  6. ncbi Dietary prenatal lipids affect myelin gene expression in postnatal undernourished rats
    Serafina Salvati
    Neurochemistry Section, Istituto Superiore di Sanita, Rome, Italy
    Nutr Neurosci 5:243-50. 2002
  7. ncbi Effect of micronutrient-enriched sunflower oils on plasma lipid profile and antioxidant status in high-fat-fed rats
    R Di Benedetto
    Department of Public Veterinary Health and Food Safety, Istituto Superiore di Sanita, Rome, Italy
    J Agric Food Chem 58:5328-33. 2010
  8. ncbi Effect of arachidonic, eicosapentaenoic and docosahexaenoic acids on the oxidative status of C6 glioma cells
    Fabiana Leonardi
    Food Science, Nutrition and Health Department, Intituto Superiore di Sanit, Rome, Italy
    Free Radic Res 39:865-74. 2005
  9. ncbi Th 1 cytokine production by peripheral blood mononuclear cells in X-linked adrenoleukodystrophy
    - Di Biase A
    Department of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    J Neurol Sci 182:161-5. 2001
  10. ncbi Sexual dimorphic evolution of metabolic programming in non-genetic non-alimentary mild metabolic syndrome model in mice depends on feed-back mechanisms integrity for pro-opiomelanocortin-derived endogenous substances
    Stefano Loizzo
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, via Regina Elena 299, 00161 Roma, Italy
    Peptides 31:1598-605. 2010

Collaborators

  • D Pietraforte
  • Mirella Nardini
  • Laura Ricceri
  • R Masella
  • S Spampinato
  • A Capasso
  • Giuseppe Seghieri
  • Ciriaco Carru
  • A Zinellu
  • Carla Fiorentini
  • Antonella Di Biase
  • Rita Di Benedetto
  • Lucilla Attorri
  • Fabiana Leonardi
  • Massimo Sanchez
  • R Di Benedetto
  • Stefano Loizzo
  • A Di Biase
  • Michela Alessandra Denti
  • Francesco Natali
  • Giorgia Montagna
  • - Di Biase A
  • C Avellino
  • M Cappa
  • Stefano Vella
  • Irene Guarino
  • Giovanni V Frajese
  • Flavia Franconi
  • Gabriella Galietta
  • Alberto Loizzo
  • Rafael Ramirez Morales
  • A Eusepi
  • F Chiarotti
  • Vincent Agrapart
  • L Attorri
  • Andrea Fortuna
  • Gabriele Campana
  • Stefania Carta
  • Paolo Renzi
  • Giovanni Ghirlanda
  • Giulia David
  • Gabriele V Gnoni
  • Francesca Pellizzari Tregno
  • Luisa Siculella
  • Diego Colabianchi
  • Roberto Cotrufo
  • Natalia Cannelli
  • Carlo Piantadosi
  • Marco Cappa
  • Mariarosa A B Melone
  • Filippo M Santorelli
  • Clarice Patrono
  • Lucilla Attori
  • Sara Travaglione
  • N Merendino
  • F Sforza
  • R Vari

Detail Information

Publications18

  1. ncbi Diet, lipids and brain development
    S Salvati
    Neurochemistry Section, Laboratory of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanita, Rome, Italy
    Dev Neurosci 22:481-7. 2000
    ..Thus, the use of particular lipids in human nutrition must be carefully screened for possible effects on brain development...
  2. ncbi Eicosapentaenoic acid stimulates the expression of myelin proteins in rat brain
    Serafina Salvati
    Department of Food, Nutrition and Health, Istituto Superiore di Sanita, Rome, Italy
    J Neurosci Res 86:776-84. 2008
    ..These results corroborate the clinical studies of the n-3 PUFA beneficial effects on several demyelinating diseases...
  3. ncbi Polyunsaturated fatty acids and neurological diseases
    S Salvati
    Department of Food, Nutrition and Health, Istituto Superiore di Sanita, Rome, Italy
    Mini Rev Med Chem 6:1201-11. 2006
    ..Furthermore, it reports the evidence pointing to potential mechanisms of omega-3 fatty acids in development of neurological disorders and efficacy of their supplementation in terms of symptom management...
  4. ncbi Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells
    Serafina Salvati
    Department of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanita, V le Regina Elena, Roma 299 00161, Italy
    Neurochem Int 44:331-8. 2004
    ..PLP promoter activity was inhibited by pre-treatment with H89 (protein kinase A (PKA) inhibitor), but not with PD98059 (MAPK inhibitor), suggesting that EPA stimulates the expression of PLP via cAMP-mediated pathways...
  5. ncbi Micronutrient-enriched rapeseed oils improve the brain oxidant/antioxidant system in rats fed a high-fat diet
    Serafina Salvati
    Department of Public Veterinary Health and Food Safety, Istituto Superiore di Sanità, Rome, Italy
    J Agric Food Chem 59:4483-8. 2011
    ..These results indicate that a regular intake of optimized rapeseed oils can prevent oxidative stress, providing evidence that optimized rapeseed oils could be a functional food with potentially important neuroprotective properties...
  6. ncbi Dietary prenatal lipids affect myelin gene expression in postnatal undernourished rats
    Serafina Salvati
    Neurochemistry Section, Istituto Superiore di Sanita, Rome, Italy
    Nutr Neurosci 5:243-50. 2002
    ..These data suggest that the high lipid content of the prenatal diet independently from its fatty acid composition affects the myelin gene expression decreasing myelin susceptibility to postnatal undernutrition...
  7. ncbi Effect of micronutrient-enriched sunflower oils on plasma lipid profile and antioxidant status in high-fat-fed rats
    R Di Benedetto
    Department of Public Veterinary Health and Food Safety, Istituto Superiore di Sanita, Rome, Italy
    J Agric Food Chem 58:5328-33. 2010
    ..These results suggest that a regular intake of optimized sunflower oils can help to improve lipid status and reduce lipid peroxidation in plasma...
  8. ncbi Effect of arachidonic, eicosapentaenoic and docosahexaenoic acids on the oxidative status of C6 glioma cells
    Fabiana Leonardi
    Food Science, Nutrition and Health Department, Intituto Superiore di Sanit, Rome, Italy
    Free Radic Res 39:865-74. 2005
    ..No significant changes were observed in the ARA group with respect to untreated cells. These data show that EPA and DHA induce alterations in the oxidative status that could affect the glial function...
  9. ncbi Th 1 cytokine production by peripheral blood mononuclear cells in X-linked adrenoleukodystrophy
    - Di Biase A
    Department of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    J Neurol Sci 182:161-5. 2001
    ..This characteristic profile of cytokine production could be related to the biochemical defect and could have a role in central nervous system (CNS) pathogenesis...
  10. ncbi Sexual dimorphic evolution of metabolic programming in non-genetic non-alimentary mild metabolic syndrome model in mice depends on feed-back mechanisms integrity for pro-opiomelanocortin-derived endogenous substances
    Stefano Loizzo
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, via Regina Elena 299, 00161 Roma, Italy
    Peptides 31:1598-605. 2010
    ..The role of sex hormones is still to be elucidated...
  11. ncbi Docosahexaenoic acid supplementation induces dose and time dependent oxidative changes in C6 glioma cells
    Fabiana Leonardi
    Department of Food Science, Nutrition and Health, Istituto Superiore di Sanita, V Ie Regina Elena, Roma, Italy
    Free Radic Res 41:748-56. 2007
    ..Therefore, the final effect of DHA on cellular redox status is dependent on dose and time supplementation...
  12. ncbi Effects of L-mono methyl-arginine, N-acetyl-cysteine and diphenyleniodonium on free radical release in C6 glial cells enriched in hexacosenoic acid
    Antonella Di Biase
    Food Science, Nutrition and Health Division, Instituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Neurochem Res 30:215-23. 2005
    ..Since this signalling is related to neurotoxic effect, our data substantiate the role of the free radicals in X-linked adrenoleukodystrophy pathogenesis, as HA cells have been used as an in vitro model for this disease...
  13. ncbi Free radical release in C6 glial cells enriched in hexacosanoic acid: implication for X-linked adrenoleukodystrophy pathogenesis
    Antonella Di Biase
    Department of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Neurochem Int 44:215-21. 2004
    ..This hypothesis suggests that the cerebral damage in ALD could be due to intracellular signalling activated by interaction of exogenous factors with the particular membrane fatty acid composition...
  14. ncbi RNAi-mediated silencing of ABCD3 gene expression in rat C6 glial cells: a model system to study PMP70 function
    Rita Di Benedetto
    Department of Food Science, Nutrition and Health, Istituto Superiore di Sanita, Rome, Italy
    Neurochem Int 52:1106-13. 2008
    ..Considered as a whole, our results indicate that the abcd3kd cell line is a valuable tool to further study the function of PMP70 and eventually its role in X-linked adrenoleukodystrophy...
  15. ncbi Susceptibility to oxidation of plasma low-density lipoprotein in X-linked adrenoleukodystrophy: effects of simvastatin treatment
    A Di Biase
    Department of Metabolism and Pathological Biochemistry, Istituto Superiore di Sanita, Rome, Italy
    Mol Genet Metab 71:651-5. 2000
    ..Simvastatin therapy, an HMG-CoA reductase inhibitor, seems to be a protective pharmacological agent against the higher oxidizability of LDL in plasma from ALD patients...
  16. ncbi PMP70 knock-down generates oxidative stress and pro-inflammatory cytokine production in C6 glial cells
    Rita Di Benedetto
    Department of Food Science, Nutrition and Health, Istituto Superiore di Sanita, Rome, Italy
    Neurochem Int 54:37-42. 2009
    ..The scenery induced by the knock-down of PMP70 in C6 cells recall the oxidative and inflammatory status observed in human X-ALD and thus reinforce the idea that PMP70 could affect the clinical course of the disease...
  17. ncbi Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells
    Francesco Natali
    Laboratory of Biochemistry and Molecular Biology, Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy
    J Lipid Res 48:1966-75. 2007
    ..The downregulation of ACC and HMGCR activities and expression by oleic acid could contribute to the reduced lipogenesis and cholesterologenesis...
  18. ncbi Identification of seven novel mutations in ABCD1 by a DHPLC-based assay in Italian patients with X-linked adrenoleukodystrophy
    Giorgia Montagna
    Molecular Medicine and Endocrinology, IRCCS Bambino Gesù Children s Hospital, Rome
    Hum Mutat 25:222. 2005
    ..Ser514Arg changes, respectively). Adding new variants to the repertoire of ABCD1 mutations in X-ALD, our data provide an efficient, cost-effective, and reliable DHPLC detection protocol for mutation screening of X-ALD families...