S Pichini

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. ncbi request reprint Quantification of arecoline (areca nut alkaloid) in neonatal biological matrices by high-performance liquid chromatography/electrospray quadrupole mass spectrometry
    Simona Pichini
    Drug Research and Control Department, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    Rapid Commun Mass Spectrom 17:1958-64. 2003
  2. ncbi request reprint In utero exposure to smoking and newborn neurobehavior: how to assess neonatal withdrawal syndrome?
    Simona Pichini
    Drug Research and Evaluation Department, Istituto Superiore di Sanita, Rome, Italy
    Ther Drug Monit 28:288-90. 2006
  3. ncbi request reprint Quantification of the plant-derived hallucinogen Salvinorin A in conventional and non-conventional biological fluids by gas chromatography/mass spectrometry after Salvia divinorum smoking
    Simona Pichini
    Drug Research and Evaluation Department, Istituto Superiore di Sanità Rome, Italy
    Rapid Commun Mass Spectrom 19:1649-56. 2005
  4. ncbi request reprint HAIRVEQ: an external quality control scheme for drugs of abuse analysis in hair
    S Pichini
    Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    Forensic Sci Int 145:109-15. 2004
  5. ncbi request reprint Application of a validated high-performance liquid chromatography-mass spectrometry assay to the analysis of m- and p-hydroxybenzoylecgonine in meconium
    S Pichini
    Drug Research and Evaluation Department, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 820:151-6. 2005
  6. ncbi request reprint Development and validation of a liquid chromatography-mass spectrometry assay for the determination of opiates and cocaine in meconium
    S Pichini
    Clinical Biochemistry Department, Istituto Superiore di Sanita, 00161 Rome, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 794:281-92. 2003
  7. ncbi request reprint Effects of repeated doses of MDMA ("ecstasy") on cell-mediated immune response in humans
    R Pacifici
    Clinical Biochemistry Department, , Roma, Italy
    Life Sci 69:2931-41. 2001
  8. doi request reprint Pharmacokinetics of methylphenidate in oral fluid and sweat of a pediatric subject
    E Marchei
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Forensic Sci Int 196:59-63. 2010
  9. ncbi request reprint Pharmacokinetics and cytokine production in heroin and morphine-treated mice
    R Pacifici
    Clinical Biochemistry Department, Istituto Superiore di Sanita, V le Regina Elena 299, 00161, Rome, Italy
    Int J Immunopharmacol 22:603-14. 2000
  10. ncbi request reprint Assessment of exposure to opiates and cocaine during pregnancy in a Mediterranean city: preliminary results of the "Meconium Project"
    Simona Pichini
    Drug Research and Evaluation Department, Istituto Superiore di Sanita, Rome, Italy
    Forensic Sci Int 153:59-65. 2005

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Quantification of arecoline (areca nut alkaloid) in neonatal biological matrices by high-performance liquid chromatography/electrospray quadrupole mass spectrometry
    Simona Pichini
    Drug Research and Control Department, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    Rapid Commun Mass Spectrom 17:1958-64. 2003
    ..Two newborns from Asian mothers who declared areca nut consumption presented arecoline in meconium with concentrations in the range 0.006-0.008 micro g/g; also the urine from one neonate tested positive for the drug...
  2. ncbi request reprint In utero exposure to smoking and newborn neurobehavior: how to assess neonatal withdrawal syndrome?
    Simona Pichini
    Drug Research and Evaluation Department, Istituto Superiore di Sanita, Rome, Italy
    Ther Drug Monit 28:288-90. 2006
    ..The neonatal withdrawal syndrome is characterized by irritability, tremors, and sleep disturbances, most typically observed in newborns of heavy smoking mothers...
  3. ncbi request reprint Quantification of the plant-derived hallucinogen Salvinorin A in conventional and non-conventional biological fluids by gas chromatography/mass spectrometry after Salvia divinorum smoking
    Simona Pichini
    Drug Research and Evaluation Department, Istituto Superiore di Sanità Rome, Italy
    Rapid Commun Mass Spectrom 19:1649-56. 2005
    ..divinorum in human biological fluids as a biomarker of plant consumption. Salvinorin A was detected in urine (2.4 and 10.9 ng/mL) and saliva (11.1 and 25.0 ng/mL), but not in sweat patches from consumers...
  4. ncbi request reprint HAIRVEQ: an external quality control scheme for drugs of abuse analysis in hair
    S Pichini
    Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    Forensic Sci Int 145:109-15. 2004
    ....
  5. ncbi request reprint Application of a validated high-performance liquid chromatography-mass spectrometry assay to the analysis of m- and p-hydroxybenzoylecgonine in meconium
    S Pichini
    Drug Research and Evaluation Department, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 820:151-6. 2005
    ..A positivity of range of concentrations varied between 0.007 and 0.338 microg/g, confirming the importance of these two hydroxylated derivatives to monitor fetal exposure to cocaine...
  6. ncbi request reprint Development and validation of a liquid chromatography-mass spectrometry assay for the determination of opiates and cocaine in meconium
    S Pichini
    Clinical Biochemistry Department, Istituto Superiore di Sanita, 00161 Rome, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 794:281-92. 2003
    ..The method was validated in the range 0.005-1.00 microg/g using 1 g of meconium per assay and applied to analysis of meconium in newborns to assess fetal exposure to opiates and cocaine...
  7. ncbi request reprint Effects of repeated doses of MDMA ("ecstasy") on cell-mediated immune response in humans
    R Pacifici
    Clinical Biochemistry Department, , Roma, Italy
    Life Sci 69:2931-41. 2001
    ....
  8. doi request reprint Pharmacokinetics of methylphenidate in oral fluid and sweat of a pediatric subject
    E Marchei
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Forensic Sci Int 196:59-63. 2010
    ..Moreover, MPH measurement in sweat patches can be used for noninvasive monitoring of MPH consumption and misuse in situations where detection of recent abuse is of interest...
  9. ncbi request reprint Pharmacokinetics and cytokine production in heroin and morphine-treated mice
    R Pacifici
    Clinical Biochemistry Department, Istituto Superiore di Sanita, V le Regina Elena 299, 00161, Rome, Italy
    Int J Immunopharmacol 22:603-14. 2000
    ..Deficient or excess expression of these key mediators may predispose the host to aberrant defence mechanisms...
  10. ncbi request reprint Assessment of exposure to opiates and cocaine during pregnancy in a Mediterranean city: preliminary results of the "Meconium Project"
    Simona Pichini
    Drug Research and Evaluation Department, Istituto Superiore di Sanita, Rome, Italy
    Forensic Sci Int 153:59-65. 2005
    ..Of the four newborns exposed to arecoline, one showed a low birth weight, low intrauterine growth, hyporeflexia and hypotonia...
  11. ncbi request reprint Development and validation of a liquid chromatography-mass spectrometry assay for hair analysis of methylphenidate
    E Marchei
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    Forensic Sci Int 176:42-6. 2008
    ..This fact could be either attributed to sebum or sweat shunt with the most proximal hair segment or drug degradation by cosmetic treatments in more distal segments...
  12. doi request reprint Assessment of exposure to environmental tobacco smoke in young adolescents following implementation of smoke-free policy in Italy
    M Pellegrini
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Forensic Sci Int 196:97-100. 2010
    ....
  13. doi request reprint On-site screening and GC-MS analysis of cocaine and heroin metabolites in body-packers urine
    E Marchei
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    J Pharm Biomed Anal 48:383-7. 2008
    ....
  14. ncbi request reprint A rapid and simple procedure for the determination of ephedrine alkaloids in dietary supplements by gas chromatography-mass spectrometry
    Emilia Marchei
    Drug Control and Evaluation Department, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    J Pharm Biomed Anal 41:1633-41. 2006
    ..The method was applied to analysis of various dietary supplements containing Ma-huang (Ephedra Sinica) and Sida Cordifolia plant extracts promoted for aiding weight control and boosting sports performance and energy...
  15. ncbi request reprint Immunological consequences of zidovudine treatment in control and morphine or methadone treated mice
    R Pacifici
    Clinical Biochemistry Department, Istituto Superiore di Sanita, Rome, Italy
    Immunopharmacol Immunotoxicol 14:355-81. 1992
    ..Furthermore, there is no indication of additive or synergistic toxic effects of AZT, morphine and methadone on the immune functions above that seen with each of these drugs when tested alone...
  16. ncbi request reprint Ethylglucuronide and ethylsulfate in meconium to assess gestational ethanol exposure: preliminary results in two Mediterranean cohorts
    Simona Pichini
    1Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Roma, Italy
    Can J Clin Pharmacol 16:e370-5. 2009
    ..Among the minor nonoxidative products of ethanol metabolism, there are ethyl glucuronide (EtG) and ethyl sulfate (EtS)...
  17. pmc A helpline telephone service for tobacco related issues: the Italian experience
    Enrica Pizzi
    Therapeutic Research and Medicines Evaluation Department, Italian Epidemiological Observatory on Tobacco, Alcohol and Drugs of Abuse, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Int J Environ Res Public Health 6:900-14. 2009
    ..The Helpline is centrally operated through the Istituto Superiore di Sanità and it has served over 17.000 tobacco users and others...
  18. doi request reprint Pharmacokinetics and therapeutic drug monitoring of psychotropic drugs in pediatrics
    Simona Pichini
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, V le Regina Elena 299, Rome 00161, Italy
    Ther Drug Monit 31:283-318. 2009
    ..Several examples will be provided where the use of alternative matrices, such as saliva, is proposed to minimize inconvenience and patient discomfort...
  19. doi request reprint Liquid chromatography-tandem mass spectrometry for fatty acid ethyl esters in meconium: assessment of prenatal exposure to alcohol in two European cohorts
    Simona Pichini
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Pharm Biomed Anal 48:927-33. 2008
    ..6 and 86.7% for the different analytes. The validated method was applied to analysis of meconium in newborns of two European cities. The two cohorts presented with different prevalence of gestational ethanol consumption during pregnancy...
  20. ncbi request reprint Development and validation of a gas chromatography-mass spectrometry assay for opiates and cocaine in human teeth
    Manuela Pellegrini
    Drug Research and Control Department, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    J Pharm Biomed Anal 40:662-8. 2006
    ..6 to 81.7 ng/g and cocaethylene present in only one sample at 10 ng/g value. Teeth can be a promising non-invasive biological matrix in biomedical analysis for both clinical and forensic purposes...
  21. pmc National survey of the smoking cessation services in Italy
    Alessandra Di Pucchio
    Therapeutic Research and Medicines Evaluation Department, Italian Epidemiological Observatory on Tobacco, Alcohol and Drugs of Abuse, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Int J Environ Res Public Health 6:915-26. 2009
    ..This study shows the importance of maintaining a national coordination among different SCS supporting their activity and encouraging the start up of additional services throughout the country...
  22. doi request reprint Effect of physical fitness and endurance exercise on indirect biomarkers of growth hormone and insulin misuse: Immunoassay-based measurement in urine samples
    Simona Pichini
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    J Pharm Biomed Anal 53:1003-10. 2010
    ..The variations observed in different biomarkers should be taken in consideration in the hypothesis of setting reference concentration ranges for doping detection...
  23. doi request reprint Liquid chromatography-atmospheric pressure ionization electrospray mass spectrometry determination of "hallucinogenic designer drugs" in urine of consumers
    Simona Pichini
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Pharm Biomed Anal 47:335-42. 2008
    ..4 and 95.6% for the different analytes. Higher analytes concentrations in hydrolyzed samples showed the presence of conjugated compounds in urine...
  24. ncbi request reprint Development and validation of a high-performance liquid chromatography-mass spectrometry assay for methylxanthines and taurine in dietary supplements
    Emilia Marchei
    Drug Research and Evaluation Department, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    J Pharm Biomed Anal 37:499-507. 2005
    ..Conversely, herbal powders, tablets and capsules mainly contained mg amounts of caffeine per gram of product with the other two methylxanthines in the range of ten to hundred microg/g...
  25. ncbi request reprint A rapid and simple procedure for the determination of cannabinoids in hemp food products by gas chromatography-mass spectrometry
    Manuela Pellegrini
    Drug Research and Control Department, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    J Pharm Biomed Anal 36:939-46. 2005
    ..Products possibly originating from drug-type cannabis plants were found in the majority of analyzed specimens...
  26. ncbi request reprint Immunosuppression and oxidative stress induced by acute and chronic exposure to cocaine in rat
    Roberta Pacifici
    Clinical Biochemistry Department, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    Int Immunopharmacol 3:581-92. 2003
    ..Cocaine N-oxidative metabolism may be an indirect contributor, via oxidative stress...
  27. ncbi request reprint Combined immunomodulating properties of 3,4-methylenedioxymethamphetamine (MDMA) and cannabis in humans
    Roberta Pacifici
    Dipartimento del Farmaco, Istituto Superiore di Sanita, Rome, Italy
    Addiction 102:931-6. 2007
    ..Participants Polydrug consumers of 3,4-methylenedioxymethamphetamine (MDMA) and cannabis (n = 37) compared to cannabis users only (n = 23) and control group (n = 34)...
  28. doi request reprint Liquid chromatography-electrospray ionization mass spectrometry determination of methylphenidate and ritalinic acid in conventional and non-conventional biological matrices
    Emilia Marchei
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, 00161 Rome, Italy
    J Pharm Biomed Anal 49:434-9. 2009
    ..9-90.3% for MPH and 36.3-92.4% for RA in the different biological matrices. This method was applied to therapeutic monitoring of MHP and RA in conventional and non-conventional biological matrices from individuals in drug treatment...
  29. ncbi request reprint Liquid chromatography/electrospray ionization tandem mass spectrometry assay for determination of nicotine and metabolites, caffeine and arecoline in breast milk
    Manuela Pellegrini
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Rapid Commun Mass Spectrom 21:2693-703. 2007
    ..This LC/MS/MS assay provides adequate sensitivity and performance characteristics for the simultaneous quantification of biomarkers of three of the drugs most commonly used worldwide (tobacco, caffeine and areca nut)...
  30. ncbi request reprint Cell-mediated immune response in MDMA users after repeated dose administration: studies in controlled versus noncontrolled settings
    R Pacifici
    Clinical Biochemistry Department, Istituto Superiore di Sanita, Rome, Italy
    Ann N Y Acad Sci 965:421-33. 2002
    ..These permanent alterations in immunologic homeostasis may result in impairment of general health and subsequent increased susceptibility to infection and immune-related disorders...
  31. doi request reprint High-performance liquid chromatography-diode array and electrospray-mass spectrometry analysis of non-allowed substances in cosmetic products for preventing hair loss and other hormone-dependent skin diseases
    Daniela De Orsi
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    J Pharm Biomed Anal 48:641-8. 2008
    ....
  32. ncbi request reprint Quantification of Delta9-tetrahydrocannabinol and its major metabolites in meconium by gas chromatographic-mass spectrometric assay: assay validation and preliminary results of the "meconium project"
    Emilia Marchei
    Drug Research and Evaluation Department, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    Ther Drug Monit 28:700-6. 2006
    ..Within positive samples, THC-COOH and THC-OH (range: 33.7 to 182.1 and 20.7 to 493.3 microg/g, respectively) were both present in the majority of cases with only 1 specimen with THC-OH as the most abundant metabolite and 2 with THC only...
  33. ncbi request reprint On-site testing of 3,4-methylenedioxymethamphetamine (ecstasy) in saliva with Drugwipe and Drugread: a controlled study in recreational users
    Simona Pichini
    Clinical Biochemistry Department, Istituto Superiore di Sanita, 00161 Rome, Italy
    Clin Chem 48:174-6. 2002
  34. ncbi request reprint A rapid and simple procedure for the determination of synephrine in dietary supplements by gas chromatography-mass spectrometry
    Emilia Marchei
    Drug Control and Evaluation Department, Istituto Superiore di Sanita, V le Regina Elena 299, 00161, Rome, Italy
    J Pharm Biomed Anal 41:1468-72. 2006
    ..Amount of synephrine present in such products ranged from 3.1 microg/mg solid product to 480.2 microg/mL liquid product...
  35. ncbi request reprint Usefulness of sweat testing for the detection of methylphenidate after fast- and extended-release drug administration: a pilot study
    Emilia Marchei
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Ther Drug Monit 32:508-11. 2010
    ..RA was not detected in either of the sweat patches probably because of its acidic properties. Measuring MPH in sweat patches can be a viable alternative to urine testing for noninvasive monitoring of use and misuse of the drug...
  36. doi request reprint Nonnucleoside reverse transcriptase inhibitor concentrations during treatment interruptions and the emergence of resistance: a substudy of the ISS-PART Trial
    Maria Pirillo
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    AIDS Res Hum Retroviruses 26:541-5. 2010
    ....
  37. ncbi request reprint Paroxetine inhibits acute effects of 3,4-methylenedioxymethamphetamine on the immune system in humans
    Roberta Pacifici
    Istituto Superiore di Sanita, Rome, Italy
    J Pharmacol Exp Ther 309:285-92. 2004
    ....
  38. doi request reprint High performance liquid chromatography-diode array and electrospray-mass spectrometry analysis of vardenafil, sildenafil, tadalafil, testosterone and local anesthetics in cosmetic creams sold on the Internet web sites
    Daniela De Orsi
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, V le Regina Elena 299, 00161, Rome, Italy
    J Pharm Biomed Anal 50:362-9. 2009
    ..This method was successfully applied to the analysis of substances under investigations present in cosmetic creams, freely sold on the Internet web-sites...
  39. doi request reprint Correlation between methylphenidate and ritalinic acid concentrations in oral fluid and plasma
    Emilia Marchei
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Clin Chem 56:585-92. 2010
    ..We studied the excretion profile of methylphenidate (MPH) and its metabolite ritalinic acid (RA) in oral fluid and plasma, the oral fluid-to-plasma (OF/P) drug ratio, and the variations of oral fluid pH after drug administration...
  40. doi request reprint Assessment of foetal exposure to cigarette smoke after recent implementations of smoke-free policy in Italy
    Mario Franchini
    Department of Obstetrics and Gynaecology, S M Annunziata Hospital, Florence, Italy
    Acta Paediatr 97:546-50. 2008
    ....
  41. ncbi request reprint Modulation of the immune system in cannabis users
    Roberta Pacifici
    JAMA 289:1929-31. 2003
  42. ncbi request reprint Prevalence of gestational exposure to cannabis in a Mediterranean city by meconium analysis
    Jaime Lozano
    Unitat de Recerca Infància i Entorn URIE, Paediatric Service, Hospital del Mar, and Departament de Pediatria, Ginecologia i Obstetrica, i Medicina Preventiva, Universitat Autonoma, Barcelona, Spain
    Acta Paediatr 96:1734-7. 2007
    ..To investigate the prevalence of in utero exposure to cannabis in a cohort of 974 mother-infants dyads from Barcelona (Spain)...
  43. doi request reprint Alarming prevalence of fetal alcohol exposure in a Mediterranean city
    Oscar Garcia-Algar
    Unitat de Recerca Infància i Entorn URIE, Paediatric Service, Hospital del Mar, and Departament de Pediatria, Ginecologia i Obstetricia, i Medicina Preventiva, Universitat Autonoma Barcelona, Spain
    Ther Drug Monit 30:249-54. 2008
    ..This study, which highlights a 45% ethanol consumption during pregnancy in a low socioeconomic status cohort, may serve as an eye opener for Europeans that gestational alcohol exposure is not endemic only in areas outside of Europe...
  44. ncbi request reprint Stability studies of principal illicit drugs in oral fluid: preparation of reference materials for external quality assessment schemes
    Montserrat Ventura
    Unitat de Recerca en Farmacologia, Institut Municipal d Investigacio Medica, Spain
    Ther Drug Monit 29:662-5. 2007
    ....
  45. ncbi request reprint Neonatal withdrawal syndrome after chronic maternal drinking of mate
    Itziar Martin
    Neonatology Unit, Service of Pediatrics, Hospital Universitari del Mar, Barcelona, Spain
    Ther Drug Monit 29:127-9. 2007
    ..The mother was strongly advised to initiate a considerable, progressive, constant reduction of mate consumption to a maximum of 2 cups a day for the duration of breastfeeding...
  46. ncbi request reprint Usefulness of sweat testing for the detection of MDMA after a single-dose administration
    Simona Pichini
    Istituto Superiore di Sanita, Roma, Italy
    J Anal Toxicol 27:294-303. 2003
    ..However, few false-negative results (18%) appeared in the first 6 h after administration. Both sweat patch testing and the onsite sweat strip test may find useful application for noninvasive monitoring of MDMA abuse in sweat...
  47. ncbi request reprint Confirmation of gestational exposure to alprazolam by analysis of biological matrices in a newborn with neonatal sepsis
    Oscar Garcia-Algar
    Servicio de Pediatria, Hospital Universitari del Mar, Barcelona, Spain
    Clin Toxicol (Phila) 45:295-8. 2007
    ..Different biological matrices are suitable for drug testing in newborns presenting with an acute withdrawal syndrome...
  48. ncbi request reprint Determination of arecoline (areca nut alkaloid) and nicotine in hair by high-performance liquid chromatography/electrospray quadrupole mass spectrometry
    Emilia Marchei
    Rapid Commun Mass Spectrom 19:3416-8. 2005
  49. ncbi request reprint TDM grand rounds: neonatal nicotine withdrawal syndrome in an infant prenatally and postnatally exposed to heavy cigarette smoke
    Federica Vagnarelli
    Paediatric Service and Neonatal Intensive Care Unit, Ospedale Santa Maria delle Croci, Ravenna, Italy
    Ther Drug Monit 28:585-8. 2006
    ..The breast-fed newborn continued to have 3 to 4 crises of spontaneous tremors and alternant muscular rigidity per day for a month. More studies are needed to establish neonatal nicotine withdrawal...
  50. ncbi request reprint Neonatal urinary cotinine correlates with behavioral alterations in newborns prenatally exposed to tobacco smoke
    Giuseppina Mansi
    Department of Pediatrics, Division of Neonatology, University Federico II, 80010 Naples, Italy
    Pediatr Res 61:257-61. 2007
    ..364). Neonatal behavior can be significantly altered in a dose-dependent manner even after modest prenatal exposure to tobacco smoke...
  51. ncbi request reprint 3,4-methylenedioxymethamphetamine (MDMA) intoxication in an infant chronically exposed to cocaine
    Oscar Garcia-Algar
    Paediatric Service, Hospital del Mar, Barcelona, Spain
    Ther Drug Monit 27:409-11. 2005
    ..Periodic clinical and laboratory follow-ups were requested to check eventual long-term effects of exposure to illicit drugs and discontinuation of the child from exposure to dangerous environments...
  52. ncbi request reprint Effects of maternal smoking during pregnancy on newborn neurobehavior: neonatal nicotine withdrawal syndrome
    Oscar Garcia-Algar
    Pediatrics 113:623-4; author reply 623-4. 2004
  53. ncbi request reprint A simple and reliable procedure for the determination of psychoactive drugs in oral fluid by gas chromatography-mass spectrometry
    Mitona Pujadas
    Grup de Recerca Clínica en Farmacologia Humana i Neurociencies, Unitat de Farmacologia, Institut Municipal d Investigacio Medica, Dr Aiguader 88, 08003 Barcelona, Spain
    J Pharm Biomed Anal 44:594-601. 2007
    ..2 ng/ml oral fluid for the different analytes. The developed analytical methodology was applied to investigate the presence of psychoactive drugs in oral fluid from injured individuals attending the emergency room (MACIUS project)...
  54. ncbi request reprint Assessment of chronic exposure to MDMA in a group of consumers by segmental hair analysis
    Simona Pichini
    Istituto Superiore di Sanita, Roma, Italy
    Ther Drug Monit 28:106-9. 2006
    ..Doubling the monthly consumption increases hair MDMA by around 1 ng/mg hair up to a level of 4 consumed tablets a month. It does not seem possible to draw definitive conclusions from higher concentrations in hair samples...
  55. ncbi request reprint Evaluation of immunoassays for the measurement of erythropoietin (EPO) as an indirect biomarker of recombinant human EPO misuse in sport
    Rosario Abellan
    Unitat de Recerca en Farmacologia, Institut Municipal d Investigacio Medica, c Doctor Aiguader 80, 08003 Barcelona, Spain
    J Pharm Biomed Anal 35:1169-77. 2004
    ..Better inter-laboratory results were obtained with the CHEM assay and, hence, it is considered the recommended assay for anti-doping control analysis...
  56. ncbi request reprint Contribution of cytochrome P450 2D6 to 3,4-methylenedioxymethamphetamine disposition in humans: use of paroxetine as a metabolic inhibitor probe
    Mireia Segura
    Pharmacology Research Unit, Barcelona, Spain
    Clin Pharmacokinet 44:649-60. 2005
    ..This study was aimed at assessing the contribution of CYP2D6 to MDMA disposition in vivo using paroxetine as a metabolic probe inhibitor. Paroxetine, a CYP2D6 inhibitor, was repeatedly administered before MDMA administration...
  57. ncbi request reprint Clinical pharmacokinetics of amfetamine and related substances: monitoring in conventional and non-conventional matrices
    Rafael de la Torre
    Pharmacology Unit, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Clin Pharmacokinet 43:157-85. 2004
    ..Because of the physicochemical properties of amfetamine-type stimulants, this group of drugs is one of the most suitable for drug testing in non-conventional matrices...
  58. ncbi request reprint Usefulness of sweat testing for the detection of cannabis smoke
    Rafael de la Torre
    Clin Chem 50:1961-2. 2004
  59. ncbi request reprint [Acute poisoning and chronic exposure to cocaine in a child]
    Oscar Garcia-Algar
    Med Clin (Barc) 125:436-7. 2005
  60. ncbi request reprint Assessment of chronic exposure to cigarette smoke and its change during pregnancy by segmental analysis of maternal hair nicotine
    Simona Pichini
    Clinical Biochemistry Dept Istituto Superiore di Sanità, Roma, Italy
    J Expo Anal Environ Epidemiol 13:144-51. 2003
    ..Finally, chronic exposure to cigarette smoke during pregnancy, assessed by maternal hair nicotine, correlated negatively with anthropometric parameters of newborns...
  61. ncbi request reprint Areca-nut abuse and neonatal withdrawal syndrome
    María Angeles López-Vilchez
    Neonatology Unit, Service of Pediatrics, Hospital Universitari del Mar, Barcelona, Spain
    Pediatrics 117:e129-31. 2006
    ..Here we present a case of neonatal withdrawal syndrome in an infant born to a woman who was a chronic areca-nut user. Arecoline, the principal neuroactive alkaloid in areca nuts, was found in the mother's placenta...
  62. ncbi request reprint Quantitative determination of paroxetine and its 4-hydroxy-3-methoxy metabolite in plasma by high-performance liquid chromatography/electrospray ion trap mass spectrometry: application to pharmacokinetic studies
    Mireia Segura
    Institut Municipal d Investigacio Medica IMIM, Barcelona, Spain
    Rapid Commun Mass Spectrom 17:1455-61. 2003
    ..After the 20-mg dose, the mean peak plasma concentration was 8.60 microg/L for paroxetine and 92.40 microg/L for HM paroxetine showing a tenfold ratio between the metabolite and the parent drug along the entire time-concentration curve...
  63. ncbi request reprint Fetal exposure to cocaine and infections during the first 18 months of life in infants from a Mediterranean city
    Oscar Garcia-Algar
    Pediatric Service, Unitat de Recerca Infancia i Entorn, Hospital Universitari del Mar, Universitat Autonoma, Barcelona, Spain
    Acta Paediatr 96:762-3. 2007
    ..The incidence of infections during the first 18 months of life was investigated in 36 infants prenatally exposed to cocaine and in 72 non-exposed controls from Barcelona, Spain...
  64. ncbi request reprint Disposition of gamma-hydroxybutyric acid in conventional and nonconventional biologic fluids after single drug administration: issues in methodology and drug monitoring
    Sergio Abanades
    Pharmacology Research Unit, Human Pharmacology and Clinical Neurosciences Research Group, Institut Municipal d Investigacio Medica, Barcelona, Spain
    Ther Drug Monit 29:64-70. 2007
    ..5 hours after drug administration and lasting for 2 hours. Oral fluid and sweat appeared not to be suitable biologic matrices for monitoring GHB consumption. GHB-mediated subjective effects are related to GHB plasma concentrations...
  65. ncbi request reprint Sources and concentrations of indoor nitrogen dioxide in Barcelona, Spain
    Oscar Garcia-Algar
    Pediatric Service, Hospital del Mar, Barcelona, Spain
    J Air Waste Manag Assoc 53:1312-7. 2003
    ..The absence of central heating was also associated with higher NO2 concentrations. Finally, each ppb increase in outdoor NO2 was associated with a 1% increase in indoor concentrations...
  66. ncbi request reprint Development and validation of a gas chromatography-mass spectrometry assay for hair analysis of amphetamine, methamphetamine and methylenedioxy derivatives
    Mitona Pujadas
    Institut Municipal d Investigacio Medica, Doctor Aiguader 80, E 08003 Barcelona, Spain
    J Chromatogr B Analyt Technol Biomed Life Sci 798:249-55. 2003
    ..Otherwise, further studies are needed to validate methodology developed in case of amphetamine consumption...
  67. pmc A longitudinal study of environmental tobacco smoke exposure in children: parental self reports versus age dependent biomarkers
    Carme Puig
    Environmental and Pediatric Research Unit URIE, Pediatric Department, Hospital del Mar, Barcelona, Spain
    BMC Public Health 8:47. 2008
    ..Our aim is to assess changes between ETS exposure at the end of pregnancy and at 4 years of age determined by the parents' self-report and measurement of cotinine in age related biological matrices...
  68. ncbi request reprint Nicotine concentrations in deciduous teeth and cumulative exposure to tobacco smoke during childhood
    Oscar Garcia-Algar
    JAMA 290:196-7. 2003
  69. doi request reprint Ultrasensitive detection of nicotine and cotinine in teeth by high-performance liquid chromatography/tandem mass spectrometry
    Emilia Marchei
    Rapid Commun Mass Spectrom 22:2609-12. 2008
  70. ncbi request reprint A simple and reliable method for the determination of nicotine and cotinine in teeth by gas chromatography/mass spectrometry
    Jose Antonio Pascual
    Rapid Commun Mass Spectrom 17:2853-5. 2003
  71. ncbi request reprint [Neonatal effects of smoking habit during pregnancy and sociodemographic determinants in Barcelona, Spain]
    Simona Pichini
    Departamento de Bioquímica Clínica Istituto Superiore di Sanità Roma Italia
    Med Clin (Barc) 118:53-6. 2002
    ..The aim of this study was the to investigate the correlation between smoking during pregnancy and the neonatal characteristics and sociodemographic determinants of smoking habit during pregnancy...