U Pastorino

Summary

Affiliation: Istituto Nazionale Tumori
Country: Italy

Publications

  1. ncbi request reprint Thoracopleuropneumonectomy with riblike reconstruction for recurrent thoracic sarcomas
    Ugo Pastorino
    Thoracic Surgery Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Ann Surg Oncol 21:1610-5. 2014
  2. pmc Testing of human papillomavirus in lung cancer and non-tumor lung tissue
    Antonella Galvan
    Department of Predictive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Via Amadeo 42, Milan 20133, Italy
    BMC Cancer 12:512. 2012
  3. doi request reprint Current status of lung cancer screening
    Ugo Pastorino
    Division of Thoracic Surgery, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    Thorac Surg Clin 23:129-40. 2013
  4. doi request reprint Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial
    Ugo Pastorino
    Unit of Thoracic Surgery, Foundation IRCCS National Cancer Institute of Milan, Via Venezian 1, Milan, Italy
    Eur J Cancer Prev 21:308-15. 2012
  5. ncbi request reprint Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results
    Ugo Pastorino
    Division of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
    Lancet 362:593-7. 2003
  6. ncbi request reprint Fluorodeoxyglucose positron emission tomography improves preoperative staging of resectable lung metastasis
    U Pastorino
    Department of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
    J Thorac Cardiovasc Surg 126:1906-10. 2003
  7. ncbi request reprint Long-term survival after salvage surgery for invasive thymoma with intracardiac extension
    Ugo Pastorino
    Division of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 94:772-6. 2008
  8. doi request reprint Prolonged remission of disseminated atypical adenomatous hyperplasia under gefitinib
    Ugo Pastorino
    Department of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
    J Thorac Oncol 4:266-7. 2009
  9. ncbi request reprint Lung cancer stage is an independent risk factor for surgical mortality
    Ugo Pastorino
    Istituto Nazionale Tumori, Milan, Italy
    Tumori 94:362-9. 2008
  10. doi request reprint Fluorodeoxyglucose uptake measured by positron emission tomography and standardized uptake value predicts long-term survival of CT screening detected lung cancer in heavy smokers
    Ugo Pastorino
    Division of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
    J Thorac Oncol 4:1352-6. 2009

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Thoracopleuropneumonectomy with riblike reconstruction for recurrent thoracic sarcomas
    Ugo Pastorino
    Thoracic Surgery Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Ann Surg Oncol 21:1610-5. 2014
    ....
  2. pmc Testing of human papillomavirus in lung cancer and non-tumor lung tissue
    Antonella Galvan
    Department of Predictive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Via Amadeo 42, Milan 20133, Italy
    BMC Cancer 12:512. 2012
    ..Risk factors for lung cancer, such as cigarette smoking, environmental pollution, asbestos, and genetic determinants, are well-known, whereas involvement of the human papillomavirus (HPV) is still unclear...
  3. doi request reprint Current status of lung cancer screening
    Ugo Pastorino
    Division of Thoracic Surgery, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    Thorac Surg Clin 23:129-40. 2013
    ..Trials in Europe have different study designs and an observational arm. Strategies to reduce lung cancer mortality should combine early detection with primary prevention and innovative biologic approaches...
  4. doi request reprint Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial
    Ugo Pastorino
    Unit of Thoracic Surgery, Foundation IRCCS National Cancer Institute of Milan, Via Venezian 1, Milan, Italy
    Eur J Cancer Prev 21:308-15. 2012
    ..There was no evidence of a protective effect of annual or biennial LDCT screening. Furthermore, a meta-analysis of the four published randomized trials showed similar overall mortality in the LDCT arms compared with the control arm...
  5. ncbi request reprint Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results
    Ugo Pastorino
    Division of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
    Lancet 362:593-7. 2003
    ..We investigated the efficacy of repeated yearly spiral CT and selective use of positron emission tomography (PET) in a large cohort of high-risk volunteers...
  6. ncbi request reprint Fluorodeoxyglucose positron emission tomography improves preoperative staging of resectable lung metastasis
    U Pastorino
    Department of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
    J Thorac Cardiovasc Surg 126:1906-10. 2003
    ..This study evaluated the role of PET in the preoperative assessment of resectable lung metastases...
  7. ncbi request reprint Long-term survival after salvage surgery for invasive thymoma with intracardiac extension
    Ugo Pastorino
    Division of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 94:772-6. 2008
    ..The patient is disease free 8.5 years after radical thymectomy and subsequent resection of 2 second primary lung adenocarcinomas...
  8. doi request reprint Prolonged remission of disseminated atypical adenomatous hyperplasia under gefitinib
    Ugo Pastorino
    Department of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
    J Thorac Oncol 4:266-7. 2009
    ..We describe an interesting case of disseminated AAH showing a sustained remission under Gefitinib therapy...
  9. ncbi request reprint Lung cancer stage is an independent risk factor for surgical mortality
    Ugo Pastorino
    Istituto Nazionale Tumori, Milan, Italy
    Tumori 94:362-9. 2008
    ..To study surgical mortality and evaluate major risk factors, with specific focus on the role of pathological stage in patients undergoing lung cancer resection...
  10. doi request reprint Fluorodeoxyglucose uptake measured by positron emission tomography and standardized uptake value predicts long-term survival of CT screening detected lung cancer in heavy smokers
    Ugo Pastorino
    Division of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
    J Thorac Oncol 4:1352-6. 2009
    ..Purpose of this study is to clarify whether standardized uptake value (SUV) can predict clinical outcome of computed tomography (CT) screening detected lung cancer...
  11. ncbi request reprint Early detection of lung cancer
    Ugo Pastorino
    Division of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
    Respiration 73:5-13. 2006
    ....
  12. pmc Lung cancer screening
    U Pastorino
    Division of Thoracic Surgery, Istituto Nazionale Tumori, Via Venezian 1, 20133, Milan, Italy
    Br J Cancer 102:1681-6. 2010
    ..Numerous ongoing large-scale randomised trials are under way in high-risk individuals with different study designs. The initial results should be available within the next 2 years...
  13. pmc Fluoro-deoxi-glucose uptake and angiogenesis are independent biological features in lung metastases
    G Veronesi
    Department of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Br J Cancer 86:1391-5. 2002
    ..Glucose uptake and angiogenesis appear to be independent biological features in lung metastasis. This observation may have implications for future antiangiogenic therapies...
  14. ncbi request reprint Low morbidity of bronchoplastic procedures after chemotherapy for lung cancer
    G Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Lung Cancer 36:91-7. 2002
    ..To evaluate if induction chemotherapy, with or without irradiation, represents an additional risk factor for early and late morbidity and perioperative mortality in bronchoplastic procedures for lung cancers...
  15. ncbi request reprint AZGP1 mRNA levels in normal human lung tissue correlate with lung cancer disease status
    F S Falvella
    Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Oncogene 27:1650-6. 2008
    ..These results support the hypothesis that differences in the gene-expression levels of the normal tissue may be predictive of genetic predisposition to lung cancer in humans...
  16. ncbi request reprint Association between cigarette smoking and FHIT gene alterations in lung cancer
    G Sozzi
    Division of Experimental Oncology A, Instituto Nazionale Tumori, Milan, Italy
    Cancer Res 57:2121-3. 1997
    ..0001), whereas no difference in loss of heterozygosity rate was observed at D10S197 locus. These findings suggest that FHIT is a candidate molecular target of carcinogens contained in tobacco smoke...
  17. ncbi request reprint Quantification of free circulating DNA as a diagnostic marker in lung cancer
    Gabriella Sozzi
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 21:3902-8. 2003
    ..This study was designed to assess the sensitivity and specificity of a quantitative molecular assay of circulating DNA to identify patients with lung cancer and monitor their disease...
  18. ncbi request reprint Results of conservative surgery for stage I lung cancer
    U Pastorino
    Department of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
    Tumori 76:38-43. 1990
    ....
  19. ncbi request reprint Combined tracheal sleeve and superior vena cava resections for non-small cell lung cancer
    L Spaggiari
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Ann Thorac Surg 70:1172-5. 2000
    ..However, more effective induction therapy may potentially expand the benefit of locally extended resections...
  20. ncbi request reprint Incident lung cancer survival. Long-term follow-up of a population-based study in Italy
    U Pastorino
    Department of Thoracic Surgery (OCT, National Cancer Institute, Milan, Italy
    Tumori 76:199-204. 1990
    ....
  21. ncbi request reprint Preoperative chemotherapy is essential for conservative surgery of Askin tumors
    G Veronesi
    Thoracic Surgery Division, European Institute of Oncology, Milan, Italy
    J Thorac Cardiovasc Surg 125:428-9. 2003
  22. ncbi request reprint p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas?
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    J Pathol 198:100-9. 2002
    ..Although p63 is likely to be involved in the development of pulmonary squamous cell carcinoma, it does not carry any prognostic implication for NSCLC patients...
  23. ncbi request reprint Double prosthetic replacement of pulmonary artery and superior vena cava and sleeve lobectomy for lung cancer
    P Solli
    Division of Thoracic Surgery, European Institute of Oncology IEO, Via Ripamonti 435, 20141, Milan, Italy
    Eur J Cardiothorac Surg 20:1045-8. 2001
    ....
  24. doi request reprint FGFR4 Gly388Arg polymorphism may affect the clinical stage of patients with lung cancer by modulating the transcriptional profile of normal lung
    Felicia S Falvella
    Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy
    Int J Cancer 124:2880-5. 2009
    ....
  25. ncbi request reprint Cervico-thoracic tumors resection through transmanubrial osteomuscular sparing approach
    L Spaggiari
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Eur J Cardiothorac Surg 16:564-7. 1999
    ..Sparing the main osteo-muscular structures, it respects shoulder mobility of the scapular girdle, thus avoiding deformities due to clavicle resection...
  26. ncbi request reprint BHLHB3: a candidate tumor suppressor in lung cancer
    F S Falvella
    Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Oncogene 27:3761-4. 2008
    ..These results point to the potential role of the BHLHB3 protein as a tumor suppressor for lung cancer...
  27. ncbi request reprint Cardiac dislocation after extended pneumonectomy with pericardioplasty
    G Veronesi
    Thoracic Surgery Division, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Eur J Cardiothorac Surg 19:89-91. 2001
    ..In the case of major pericardial excision resulting in extensive mobilisation of the SVC a complete reconstruction of pericardium and mediastinal pleura is recommended in order to prevent cardiac dislocation...
  28. ncbi request reprint Transmanubrial approach with antero-lateral thoracotomy for apical chest tumor
    L Spaggiari
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Ann Thorac Surg 68:590-3. 1999
    ....
  29. ncbi request reprint Results of superior vena cava resection for lung cancer. Analysis of prognostic factors
    Lorenzo Spaggiari
    Department of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Lung Cancer 44:339-46. 2004
    ..The benefits of superior vena cava (SVC) resection for lung cancer remain controversial. Data obtained in four international centers were analyzed in order to identify prognostic factors and thus guide in future patient selection...
  30. pmc Lung metastases from melanoma: when is surgical treatment warranted?
    F Leo
    Department of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, Milan, 20141, Italy
    Br J Cancer 83:569-72. 2000
    ..The prognostic grouping system proposed by the International Registry of Lung Metastases provides a simple and effective method for improving the selection of surgical candidates...
  31. ncbi request reprint Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities
    G Sozzi
    Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy
    Cancer Res 57:5207-12. 1997
    ..In addition, absence of Fhit protein in some precancerous dysplastic lesions suggested that FHIT inactivation may occur at an early phase of lung carcinogenesis...
  32. ncbi request reprint Double transmanubrial approach and sternotomy for resection of a giant thymic carcinoid tumor
    L Spaggiari
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Ann Thorac Surg 72:629-31. 2001
    ..We report the use of a "double" transmanubrial approach for the resection of a giant mediastinal mass requiring bilateral vascular dissection and superior vena cava system resection and replacement...
  33. ncbi request reprint Lung resection as salvage treatment for metastatic osteosarcoma
    U Pastorino
    Division of Thoracic Surgery, Istituto Nazionale Tumori, Milan
    Tumori 74:201-6. 1988
    ..These data support the concept of pulmonary metastasectomy as effective salvage therapy for metastatic osteosarcomas whose distant spread is confined in the lungs...
  34. ncbi request reprint Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk
    Felicia S Falvella
    Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy
    Clin Cancer Res 15:1837-42. 2009
    ....
  35. ncbi request reprint Common polymorphisms in D12S1034 flanking genes RASSF8 and BHLHB3 are not associated with lung adenocarcinoma risk
    F Stefania Falvella
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milan, Italy
    Lung Cancer 56:1-7. 2007
    ..Our results suggest that BHLHB3 variants may affect lung ADCA prognosis...
  36. ncbi request reprint Association of the PDCD5 locus with lung cancer risk and prognosis in smokers
    Monica Spinola
    Department of Experimental Oncology and Laboratories, Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 24:1672-8. 2006
    ..Whole-genome scan association analysis was carried out to identify genetic variants predictive of lung cancer risk in smokers and to confirm the identified variants in an independent sample...
  37. ncbi request reprint Superior vena cava resection with prosthetic replacement for non-small cell lung cancer: long-term results of a multicentric study
    Lorenzo Spaggiari
    Department of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, Milan, Italy
    Eur J Cardiothorac Surg 21:1080-6. 2002
    ..To establish a historical benchmark for this extended surgery, we have updated and reviewed data from four international centers...
  38. ncbi request reprint Adipose tissue displays trophic properties on normal lung cellular components without promoting cancer cells growth
    F Andriani
    Tumor Genomics Unit, Department of Experimental Oncology Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    J Cell Physiol 228:1166-73. 2013
    ..These preclinical findings provide preliminary evidence on the potential efficacy of AFT to accelerate lung tissue repair without undesired tumor promoting effects on putative residual cancer cells...
  39. ncbi request reprint Detection of microsatellite alterations in plasma DNA of non-small cell lung cancer patients: a prospect for early diagnosis
    G Sozzi
    Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy
    Clin Cancer Res 5:2689-92. 1999
    ..These findings highlight new prospects for early tumor detection by noninvasive screening procedures based on the analysis of genetic changes in plasma...
  40. doi request reprint Lung function predicts lung cancer risk in smokers: a tool for targeting screening programmes
    E Calabro
    Division of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Eur Respir J 35:146-51. 2010
    ..Test screening for lung cancer using airflow obstruction with FEV(1) <90% is a strategy worth future consideration...
  41. doi request reprint Plasma DNA quantification in lung cancer computed tomography screening: five-year results of a prospective study
    Gabriella Sozzi
    Department of Experimental Oncology, Molecular Cytogenetics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Am J Respir Crit Care Med 179:69-74. 2009
    ..Free circulating plasma DNA has emerged as a potential biomarker for early lung cancer detection. In a previous case-control study we have shown that high levels of plasma DNA are a strong risk factor for lung cancer...
  42. doi request reprint Genome-wide association study in discordant sibships identifies multiple inherited susceptibility alleles linked to lung cancer
    Antonella Galvan
    Fondazione IRCCS, Istituto Nazionale Tumori, 20133 Milan, Italy
    Carcinogenesis 31:462-5. 2010
    ....
  43. doi request reprint Pulmonary nodules: volume repeatability at multidetector CT lung cancer screening
    Alfonso Marchiano
    Department of Diagnostic Imaging and Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy
    Radiology 251:919-25. 2009
    ..To assess in vivo volumetric repeatability of an automated software algorithm in pulmonary nodules detected during a lung cancer screening trial...
  44. doi request reprint Anterior diaphragmatic plication in mediastinal surgery: the "reefing the mainsail" technique
    Francesco Leo
    Thoracic Surgery Department, Istituto Nazionale dei Tumori, Milan, Italy
    Ann Thorac Surg 90:2065-7. 2010
    ....
  45. doi request reprint Sunitinib malate and figitumumab in solitary fibrous tumor: patterns and molecular bases of tumor response
    Silvia Stacchiotti
    Adult Sarcoma Medical Oncology Unit, Department of Cancer Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy
    Mol Cancer Ther 9:1286-97. 2010
    ..SM has antitumor activity in SFT, possibly through a PDGFRB-mediated mechanism, but treatments with IGFIR/insulin receptor and possibly epidermal growth factor receptor inhibitors are worth testing...
  46. doi request reprint Superior vena cava resection in thoracic malignancies: does prosthetic replacement pose a higher risk?
    Francesco Leo
    Thoracic Surgery Department, Istituto Nazionale dei Tumori, Via Venezian 1, 20100 Milan, Italy
    Eur J Cardiothorac Surg 37:764-9. 2010
    ..This study tested the hypothesis that PTFE replacement may interfere with perioperative outcome...
  47. ncbi request reprint Effects of prolonged storage of whole plasma or isolated plasma DNA on the results of circulating DNA quantification assays
    Gabriella Sozzi
    Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    J Natl Cancer Inst 97:1848-50. 2005
    ..These data provide valuable information for the rational planning of retrospective studies of banked series of biological samples, particularly if collected over a long period of time, as can occur in large clinical trials...
  48. ncbi request reprint Methylation profile in tumor and sputum samples of lung cancer patients detected by spiral computed tomography: a nested case-control study
    Rosalia Cirincione
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Cancer 118:1248-53. 2006
    ....
  49. ncbi request reprint Detecting lung cancer in plasma with the use of multiple genetic markers
    Francesca Andriani
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Cancer 108:91-6. 2004
    ..2%) of stage I patients whose tumors had an alteration. These results provide the proof of principle that plasma DNA alterations are tumor-specific in most cases and support blood testing as a noninvasive strategy for early detection...
  50. ncbi request reprint Double, metachronous thyroid metastases of colon cancer
    Franco Mattavelli
    Otorhinolaryngology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 92:249-51. 2006
  51. ncbi request reprint Lack of telomerase activity in lung carcinoids is dependent on human telomerase reverse transcriptase transcription and alternative splicing and is associated with long telomeres
    Nadia Zaffaroni
    Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori and Department of Thoracic Surgery, Istituto Clinico Humanitas, Milan, Italy
    Clin Cancer Res 11:2832-9. 2005
    ..Knowledge of the mechanisms by which telomerase is differentially regulated in neuroendocrine lung tumors is important for a better understanding of the pathogenesis of these malignancies...
  52. ncbi request reprint Analysis of potential receptor tyrosine kinase targets in intimal and mural sarcomas
    E Tamborini
    Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Miano, Via G Venezian 1, 20133 Milan, Italy
    J Pathol 212:227-35. 2007
    ..In predictive terms, the evidence of gene amplification/high polysomy of several RTKs, together with PDGFRA, PDGFRB and EGFR expression and phosphorylation, suggests that these tumours may be sensitive to RTK-inhibiting treatments...
  53. ncbi request reprint Pleurectomy in primary pneumothorax: is extensive pleurectomy necessary?
    F Leo
    Department of Thoracic Surgery, European Institute of Oncology, Milano, Italy
    J Cardiovasc Surg (Torino) 41:633-6. 2000
    ..The aim of the study was to evaluate the results of parietal pleurectomy in patients with primary spontaneous pneumothorax comparing extensive pleurectomy performed by thoracotomy versus more limited pleurectomy performed by VATS...
  54. ncbi request reprint Lung cancer chemoprevention with retinol palmitate. Preliminary data from a randomized trial on stage Ia non small-cell lung cancer
    U Pastorino
    Department of Chest Surgery, National Cancer Institute, Milan, Italy
    Acta Oncol 27:773-82. 1988
    ..A longer follow-up is necessary to establish whether a significant proportion of early recurrences could be prevented, or only delayed, by vitamin A administration...
  55. ncbi request reprint Life-threatening giant mediastinal goiter: a surgical challenge
    G Veronesi
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    J Cardiovasc Surg (Torino) 42:429-30. 2001
    ..The dimension of the lesions, the mediastinal anatomy alterations and the severe intraoperative haemorrhage represented major technical difficulties during surgical resection...
  56. ncbi request reprint Detection of overexpressed and phosphorylated wild-type kit receptor in surgical specimens of small cell lung cancer
    Elena Tamborini
    Experimental Molecular Pathology, Department of Pathology, Istituto Nazionale per lo Studio e al Cura dei Tumori, Milan, Italy
    Clin Cancer Res 10:8214-9. 2004
    ....
  57. ncbi request reprint Intrathoracic myoplasty for prosthesis infection after superior vena cava replacement for lung cancer
    Lorenzo Spaggiari
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Ann Thorac Surg 74:1231-3. 2002
    ..We report a case in which an intrathoracic muscle flap transposition was used to cure tracheal fistula associated with prosthesis infection without the explant of the vascular graft...
  58. ncbi request reprint Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene
    Monica Spinola
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milan, Italy
    Cancer Lett 251:311-6. 2007
    ....
  59. ncbi request reprint Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival
    Monica Spinola
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Milan, Italy
    Lung Cancer 55:271-7. 2007
    ..These results suggest that polymorphisms in the MYCL1 LD region affect lung cancer survival but that the functional element(s) may show population-specific patterns...
  60. ncbi request reprint Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer
    Monica Spinola
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milan, Italy
    Oncogene 24:5502-9. 2005
    ..Our findings raise the possibility of TRIT1 as a candidate lung tumor suppressor...
  61. ncbi request reprint Functional FGFR4 Gly388Arg polymorphism predicts prognosis in lung adenocarcinoma patients
    Monica Spinola
    Department of Experimental Oncology, Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milan, Italy
    J Clin Oncol 23:7307-11. 2005
    ..The purpose of this study was to investigate the involvement of the FGFR4 polymorphism in lung tumorigenesis...
  62. ncbi request reprint Identification of RASSF8 as a candidate lung tumor suppressor gene
    F S Falvella
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Milan, Italy
    Oncogene 25:3934-8. 2006
    ..These results raise the possibility protein encoded by RASSF8 is a novel tumor suppressor for lung cancer...
  63. doi request reprint Elevated levels of the acute-phase serum amyloid are associated with heightened lung cancer risk
    Mattia Cremona
    Department of Experimental Oncology and Laboratory, National Cancer Institute, Milan, Italy
    Cancer 116:1326-35. 2010
    ..The authors investigated whether early stage lung cancer could be identified by proteomic analyses of plasma...
  64. ncbi request reprint Extended resections for lung cancer: indications and results
    Ugo Pastorino
    Thoracic Surgery Division, European Institute of Oncology, Milan, Italy
    Surg Oncol 11:207-16. 2002
  65. ncbi request reprint Anomalous segmental vein for right upper lobe: an unusual anatomical variation
    Lorenzo Spaggiari
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Ann Thorac Surg 74:267. 2002
  66. doi request reprint A polygenic model with common variants may predict lung adenocarcinoma risk in humans
    Antonella Galvan
    Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy
    Int J Cancer 123:2327-30. 2008
    ..3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population...
  67. ncbi request reprint History of the surgical management of pulmonary metastases and development of the International Registry
    Ugo Pastorino
    Division of Thoracic Surgery, Istituto Europeo di Oncologia, Via Ripamonti 435, Milan, Italy 20141
    Semin Thorac Cardiovasc Surg 14:18-28. 2002
    ....
  68. ncbi request reprint A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients
    Giacomo Manenti
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Milan, Italy
    Carcinogenesis 27:1386-90. 2006
    ..3; 95% CI 1.4-3.7; P = 0.001]. These findings suggest that the LRMP V141L polymorphism can predict survival in lung ADCA and that the role of LRMP and CASC1 in human lung cancer risk may differ from that in mice...
  69. doi request reprint Promoter polymorphisms and transcript levels of nicotinic receptor CHRNA5
    Felicia S Falvella
    Department of Predictive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Via G Venezian 1, Milan, Italy
    J Natl Cancer Inst 102:1366-70. 2010
    ....
  70. doi request reprint Postoperative exacerbation of chronic obstructive pulmonary disease. Does it exist?
    Francesco Leo
    Thoracic Surgery Department, European Institute of Oncology, Milan, Italy
    Eur J Cardiothorac Surg 33:424-9. 2008
    ..This study was designed to verify if definition of acute COPD exacerbation is applicable to patients who underwent pulmonary surgery, and if it has any impact on postoperative morbidity and mortality...
  71. ncbi request reprint Impact of limited pulmonary function on the management of resectable lung cancer
    Piergiorgio Solli
    Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Lung Cancer 41:71-9. 2003
    ..Purpose of this study was to investigate the frequency of LPF in lung cancer and its impact of on surgical eligibility and postoperative outcome...
  72. ncbi request reprint Respiratory function changes after chemotherapy: an additional risk for postoperative respiratory complications?
    Francesco Leo
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Ann Thorac Surg 77:260-5; discussion 265. 2004
    ....
  73. ncbi request reprint Preoperative chemotherapy in non-small-cell lung cancer: nothing new in N2 disease
    Tommaso De Pas
    J Clin Oncol 20:2603-4; author reply 2605. 2002
  74. doi request reprint Computed tomography screening for lung cancer in a high-risk population: update on current status
    Patrizia Russo
    J Natl Cancer Inst 100:1043-4. 2008
  75. ncbi request reprint Independent value of fascin immunoreactivity for predicting lymph node metastases in typical and atypical pulmonary carcinoids
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Via G Ripamonti, 435, I 20141 Milan, Italy
    Lung Cancer 42:203-13. 2003
    ..Targeting the fascin pathway could be a novel therapeutic strategy of pulmonary carcinoids...
  76. ncbi request reprint Computed tomography screening and lung cancer outcomes
    Peter B Bach
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    JAMA 297:953-61. 2007
    ..Randomized controlled trials assessing CT screening are currently under way...
  77. ncbi request reprint Patients with known or suspected lung cancer: evaluation of clinical management changes due to 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) study
    Gino Pepe
    Division of Nuclear Medicine, Institute H S Raffaele, University of Milan, Via Olgettina 60, 20132 Milan, Italy
    Nucl Med Commun 26:831-7. 2005
    ..To determine prospectively from the referring physician's point of view the impact of F-fluorodeoxyglucose positron emission tomography (F-FDG PET) results on the management decisions in patients with known or suspected lung cancer...
  78. ncbi request reprint Benchmarking lung cancer mortality rates in current and former smokers
    Peter B Bach
    Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 221, New York, NY 10021, USA
    Chest 126:1742-9. 2004
    ..The model is intended for use in analyzing a population of subjects who are undergoing lung cancer screening or receiving lung cancer chemoprevention, to determine whether the intervention has altered lung cancer mortality...
  79. ncbi request reprint Lung cancers detected by screening with spiral computed tomography have a malignant phenotype when analyzed by cDNA microarray
    Fabrizio Bianchi
    Cancer Research UK Tumor Pathology Group, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, United Kingdom
    Clin Cancer Res 10:6023-8. 2004
    ..Spiral computed tomography (CT) can detect lung cancer at an early stage, but the malignant potential is unknown. The question is, as follows: do these small lesions have the same lethal potential as do symptomatic tumors?..
  80. ncbi request reprint IGG practice guidelines on germ cell tumor in adult male patients
    Ugo De Giorgi
    Oncologia Medica, Centro Oncologico Ospedale V Fazzi, Lecce, Italy
    Tumori 94:96-109. 2008
    ..The Italian Germ cell cancer Group (IGG) has developed the following clinical recommendations, which identify the current standards in diagnosis and treatment of germ cell tumors in adult males...
  81. ncbi request reprint Microvessel density as a prognostic factor in non-small-cell lung carcinoma: a meta-analysis of individual patient data
    Marialena Trivella
    Cancer Research UK NHS Centre for Statistics in Medicine, Oxford, UK
    Lancet Oncol 8:488-99. 2007
    ..We aimed to collect individual patient data to assess microvessel-density counts (ie, a measure of angiogenesis) as a prognostic factor in non-small-cell lung carcinoma...
  82. ncbi request reprint Pleomorphic carcinomas of the lung show a selective distribution of gene products involved in cell differentiation, cell cycle control, tumor growth, and tumor cell motility: a clinicopathologic and immunohistochemical study of 31 cases
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Institute of European Oncology and University of Milan School of Medicine, Italy
    Am J Surg Pathol 27:1203-15. 2003
    ....
  83. ncbi request reprint Results of lung metastasectomy from breast cancer: prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases
    Godehard Friedel
    Department of Thoracic Surgery, Klink Schillerhoehe, Solitudestrasse 18, D 70839 Gerlingen, Germany
    Eur J Cardiothorac Surg 22:335-44. 2002
    ..Although the prognosis after resection of isolated metastases to the lung is much better than after chemotherapy most oncologists and gynecologists disapprove of lung metastasectomy...
  84. ncbi request reprint Retrospective study of resection of pulmonary metastases in patients with advanced colorectal cancer: the development of a preoperative chemotherapy strategy
    Francesca Negri
    Department of Medicine, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, U K
    Clin Colorectal Cancer 4:101-6. 2004
    ..Moreover, preoperative chemotherapy produced a high response rate, with no patients experiencing disease progression before surgery...
  85. ncbi request reprint Surgery in small-cell lung carcinoma. Where is the rationale?
    Francesco Leo
    Thoracic Surgery Service, Nice University Hospital, Nice, France
    Semin Surg Oncol 21:176-81. 2003
    ..Surgery in stage II and III must be planned on a multidisciplinary basis, in the context of controlled clinical trials...
  86. ncbi request reprint Chemoprevention of lung cancer: soon daily practice?
    Nico van Zandwijk
    Head Dept Thoracic Oncology, Netherlands Cancer Institute, Amsterdam
    Expert Rev Anticancer Ther 3:91-8. 2003
    ..After more than 20 years of worldwide research, the prospects for effective lung cancer treatment are better than ever...
  87. ncbi request reprint Primary human alveolar type II epithelial cell chemokine release: effects of cigarette smoke and neutrophil elastase
    Ian R Witherden
    Lung Cell Biology, National Heart and Lung Institute, Imperial College of Science, London, United Kingdom
    Am J Respir Cell Mol Biol 30:500-9. 2004
    ..We hypothesize that reduced ATII cell-derived chemokine levels compromise alveolar repair, contributing to cigarette smoke-induced alveolar damage and emphysema...