Luca Pasina

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. doi request reprint A Multicomponent Intervention to Optimize Psychotropic Drug Prescription in Elderly Nursing Home Residents: An Italian Multicenter, Prospective, Pilot Study
    Luca Pasina
    Pharmacotherapy and Appropriateness of Drugs Prescription Unit, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, via Giuseppe La Masa, 19, 20156, Milan, Italy
    Drugs Aging 33:143-9. 2016
  2. doi request reprint Inappropriate prescription of allopurinol and febuxostat and risk of adverse events in the elderly: results from the REPOSI registry
    L Pasina
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Drug Information Service for the Elderly, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, via Giuseppe La Masa, 19, 20156, Milan, Italy
    Eur J Clin Pharmacol 70:1495-503. 2014
  3. pmc Critical appraisal of lurasidone in the management of schizophrenia
    Silvio Caccia
    Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
    Neuropsychiatr Dis Treat 8:155-68. 2012
  4. doi request reprint Medication non-adherence among elderly patients newly discharged and receiving polypharmacy
    L Pasina
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Drug Information Service for the Elderly, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156, Milan, Italy
    Drugs Aging 31:283-9. 2014
  5. doi request reprint Association of anticholinergic burden with cognitive and functional status in a cohort of hospitalized elderly: comparison of the anticholinergic cognitive burden scale and anticholinergic risk scale: results from the REPOSI study
    Luca Pasina
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Drug Information Service for the Elderly, Mario Negri Institute for Pharmacological Research, via Giuseppe La Masa, 19, 20156 Milan, Italy
    Drugs Aging 30:103-12. 2013
  6. doi request reprint Prevalence and appropriateness of drug prescriptions for peptic ulcer and gastro-esophageal reflux disease in a cohort of hospitalized elderly
    L Pasina
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Intern Med 22:205-10. 2011
  7. pmc A Population-based study of dementia in the oldest old: the Monzino 80-plus study
    Ugo Lucca
    Laboratory of Geriatric Neuropsychiatry, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    BMC Neurol 11:54. 2011
  8. doi request reprint Association between clusters of diseases and polypharmacy in hospitalized elderly patients: results from the REPOSI study
    Alessandro Nobili
    Mario Negri Institute for Pharmacological Research, Milano, Italy
    Eur J Intern Med 22:597-602. 2011
  9. doi request reprint Drug-drug interactions in a cohort of hospitalized elderly patients
    Luca Pasina
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Drug Information Service for the Elderly, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
    Pharmacoepidemiol Drug Saf 22:1054-60. 2013
  10. doi request reprint Polypharmacy, length of hospital stay, and in-hospital mortality among elderly patients in internal medicine wards. The REPOSI study
    Alessandro Nobili
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Mario Negri Institute for Pharmacological Research, via Giuseppe La Masa, 19, 20156 Milan, Italy
    Eur J Clin Pharmacol 67:507-19. 2011

Detail Information

Publications29

  1. doi request reprint A Multicomponent Intervention to Optimize Psychotropic Drug Prescription in Elderly Nursing Home Residents: An Italian Multicenter, Prospective, Pilot Study
    Luca Pasina
    Pharmacotherapy and Appropriateness of Drugs Prescription Unit, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, via Giuseppe La Masa, 19, 20156, Milan, Italy
    Drugs Aging 33:143-9. 2016
    ..Prescription for short periods of time only are usually recommended to avoid the risk of adverse drug reactions and potentially severe drug-drug interactions (DDIs)...
  2. doi request reprint Inappropriate prescription of allopurinol and febuxostat and risk of adverse events in the elderly: results from the REPOSI registry
    L Pasina
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Drug Information Service for the Elderly, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, via Giuseppe La Masa, 19, 20156, Milan, Italy
    Eur J Clin Pharmacol 70:1495-503. 2014
    ....
  3. pmc Critical appraisal of lurasidone in the management of schizophrenia
    Silvio Caccia
    Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
    Neuropsychiatr Dis Treat 8:155-68. 2012
    ..Ongoing trials in patients with bipolar disorder are being completed but, again, efficacy and safety have been investigated only in a few short-term clinical trials...
  4. doi request reprint Medication non-adherence among elderly patients newly discharged and receiving polypharmacy
    L Pasina
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Drug Information Service for the Elderly, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156, Milan, Italy
    Drugs Aging 31:283-9. 2014
    ..Little is known about medication adherence among older adults living at home and requiring complex medication regimens...
  5. doi request reprint Association of anticholinergic burden with cognitive and functional status in a cohort of hospitalized elderly: comparison of the anticholinergic cognitive burden scale and anticholinergic risk scale: results from the REPOSI study
    Luca Pasina
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Drug Information Service for the Elderly, Mario Negri Institute for Pharmacological Research, via Giuseppe La Masa, 19, 20156 Milan, Italy
    Drugs Aging 30:103-12. 2013
    ..Drugs with anticholinergic effects are associated with adverse events such as delirium and falls as well as cognitive decline and loss of independence...
  6. doi request reprint Prevalence and appropriateness of drug prescriptions for peptic ulcer and gastro-esophageal reflux disease in a cohort of hospitalized elderly
    L Pasina
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Intern Med 22:205-10. 2011
    ..Inappropriate prescription is of particular concern among elderly patients, who have often multiple comorbidities and need many drugs...
  7. pmc A Population-based study of dementia in the oldest old: the Monzino 80-plus study
    Ugo Lucca
    Laboratory of Geriatric Neuropsychiatry, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    BMC Neurol 11:54. 2011
    ....
  8. doi request reprint Association between clusters of diseases and polypharmacy in hospitalized elderly patients: results from the REPOSI study
    Alessandro Nobili
    Mario Negri Institute for Pharmacological Research, Milano, Italy
    Eur J Intern Med 22:597-602. 2011
    ..We assessed which clusters of diseases are associated with polypharmacy in acute-care elderly in-patients...
  9. doi request reprint Drug-drug interactions in a cohort of hospitalized elderly patients
    Luca Pasina
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Drug Information Service for the Elderly, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
    Pharmacoepidemiol Drug Saf 22:1054-60. 2013
    ....
  10. doi request reprint Polypharmacy, length of hospital stay, and in-hospital mortality among elderly patients in internal medicine wards. The REPOSI study
    Alessandro Nobili
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Mario Negri Institute for Pharmacological Research, via Giuseppe La Masa, 19, 20156 Milan, Italy
    Eur J Clin Pharmacol 67:507-19. 2011
    ..We evaluated the prevalence and factors associated with polypharmacy and investigated the role of polypharmacy as a predictor of length of hospital stay and in-hospital mortality...
  11. doi request reprint Changes in trend of antipsychotics prescription in patients treated with cholinesterase inhibitors after warnings from Italian Medicines Agency. Results from the EPIFARM-Elderly Project
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur Neuropsychopharmacol 22:569-77. 2012
    ..Awaiting further studies to clarify their therapeutic role, physicians should prescribe antipsychotics very cautiously and only after careful risk-benefit assessment...
  12. doi request reprint Antipsychotics prescription and cerebrovascular events in Italian older persons
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, IRCCS Istituto di Riceerche Farmacologiche Mario Negri, Milan, Italy
    J Clin Psychopharmacol 33:542-5. 2013
    ..92). In conclusion, only typical antipsychotics were associated with an increased odd of CVEs, but the association was duration dependent. Persons prescribed simultaneously with AChEI and antipsychotics may be at a lower risk of CVEs. ..
  13. doi request reprint Cholinesterase inhibitor use in Alzheimer's disease: the EPIFARM-Elderly Project
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Pharmacoepidemiol Drug Saf 20:497-505. 2011
    ....
  14. doi request reprint Risk factors for hospital readmission of elderly patients
    Carlotta Franchi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Intern Med 24:45-51. 2013
    ..The aim of this study was to identify which factors were associated with a risk of hospital readmission within 3 months after discharge of a sample of elderly patients admitted to internal medicine and geriatric wards...
  15. doi request reprint Geographical differences in the prevalence of chronic polypharmacy in older people: eleven years of the EPIFARM-Elderly Project
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, via Giuseppe La Masa, 19, 20156, Milan, Italy
    Eur J Clin Pharmacol 69:1477-83. 2013
    ..To compare the geographical differences in the prevalence of chronic polypharmacy in community-dwelling older people over 11 years...
  16. doi request reprint Gender difference in drug use in hospitalized elderly patients
    Paola Santalucia
    Scientific Direction, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Neuroscience, IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy Electronic address
    Eur J Intern Med 26:483-90. 2015
    ..The aims of this study were to evaluate whether or not there are gender differences in drug use at hospital admission and prescription at discharge and to evaluate the effect of hospitalization on medication patterns in the elderly...
  17. doi request reprint Changes in clinical outcomes for community-dwelling older people exposed to incident chronic polypharmacy: a comparison between 2001 and 2009
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Pharmacoepidemiol Drug Saf 25:204-11. 2016
    ....
  18. doi request reprint The drug prescription network: a system-level view of drug co-prescription in community-dwelling elderly people
    Gianfranco Bazzoni
    1 Department of Molecular Biochemistry and Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Rejuvenation Res 18:153-61. 2015
    ..g., its emergence as a heavily co-prescribed hub) in comparison with other drugs. ..
  19. doi request reprint Gout, allopurinol intake and clinical outcomes in the hospitalized multimorbid elderly
    Carlotta Franchi
    Department of Neuroscience, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy Electronic address
    Eur J Intern Med 25:847-52. 2014
    ....
  20. doi request reprint Adherence to antibiotic treatment guidelines and outcomes in the hospitalized elderly with different types of pneumonia
    Raffaella Rossio
    Department of Pathophysiology and Transplantation, IRCCS Ca Granda Maggiore Policlinico Hospital Foundation, Milan, Italy
    Eur J Intern Med 26:330-7. 2015
    ....
  21. doi request reprint Comparison of Health Care Resource Utilization by Immigrants Versus Native Elderly People
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, via Giuseppe La Masa, 19, 20156, Milan, Italy
    J Immigr Minor Health 18:1-7. 2016
    ..99, 95 % CI 0.99-1.04). A lower rate of health care resource utilization was observed in elderly immigrants who had been living in the host region for as many as 10 years. ..
  22. doi request reprint Electrocardiographic monitoring for new prescriptions of quetiapine co-prescribed with acetylcholinesterase inhibitors or memantine from 2005 to 2009. A population study on community-dwelling older people in Italy
    Claudio Bilotta
    Geriatric Medicine Outpatient Service, Department of Urban Outpatient Services, Istituti Clinici di Perfezionamento Hospital, viale Andrea Doria 52, 20124, Milan, Italy
    Eur J Clin Pharmacol 70:1487-94. 2014
    ....
  23. ncbi request reprint Use and misuse of antipsychotic drugs in patients with dementia in Alzheimer special care units
    Alessandro Nobili
    Laboratory of Quality Assessment of Geriatric Therapies and Services, Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, Milan 20156, Italy
    Int Clin Psychopharmacol 24:97-104. 2009
    ..61-3.26). This study found high rate of use of antipsychotics in patients with dementia resident in Alzheimer special care units, frequent associations with other psychotropic medications and a strong correlation with BPSD...
  24. doi request reprint Changes in drug prescribing to Italian community-dwelling elderly people: the EPIFARM-Elderly Project 2000-2010
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, via Giuseppe La Masa, 19, 20156, Milan, Italy
    Eur J Clin Pharmacol 70:437-43. 2014
    ..To investigate the changes in the last decade (2000-2010) in drug prescribing among community-dwelling elderly people aged 65-94 years, in relation to age and sex...
  25. doi request reprint Drug utilization and polypharmacy in an Italian elderly population: the EPIFARM-elderly project
    Alessandro Nobili
    Laboratory of Quality Assessment of Geriatric Therapies and Services, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Pharmacoepidemiol Drug Saf 20:488-96. 2011
    ..To investigate the prescribing patterns and the prevalence of polypharmacy in community-dwelling elderly people, and to analyze the association of chronic medications and number of drug prescriptions with age and sex...
  26. doi request reprint How pre-marketing data can be used for predicting the weight of drug interactions in clinical practice
    Silvio Caccia
    Laboratory for Quality Assessment of Geriatric Therapies Services, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur J Intern Med 24:217-21. 2013
    ....
  27. doi request reprint Predicting the clinical relevance of drug interactions from pre-approval studies
    Silvio Caccia
    Laboratory of Drug Metabolism, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Drug Saf 32:1017-39. 2009
    ....
  28. doi request reprint Prevalence of dementia in the oldest old: the Monzino 80-plus population based study
    Ugo Lucca
    Department of Neuroscience, Laboratory of Geriatric Neuropsychiatry, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy Electronic address
    Alzheimers Dement 11:258-70.e3. 2015
    ..The objective is to estimate the prevalence of dementia and levels of dementia severity in a very large population of oldest old and to investigate the relation between age and dementia prevalence in the extreme ages...
  29. pmc New atypical antipsychotics for schizophrenia: iloperidone
    Silvio Caccia
    Laboratory of Drug Metabolism, Mario Negri Institute for Pharmacological Research, 20156, Milan, Italy
    Drug Des Devel Ther 4:33-48. 2010
    ..Further comparative studies are needed to clarify the benefit/risk profile of iloperidone and its role in the treatment of schizophrenia...