Alessandro Nobili

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi request reprint Low folate and the risk of cognitive and functional deficits in the very old: the Monzino 80-plus study
    Mauro Tettamanti
    Laboratory of Geriatric Neuropsychiatry, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    J Am Coll Nutr 25:502-8. 2006
  2. pmc Association of mild anemia with cognitive, functional, mood and quality of life outcomes in the elderly: the "Health and Anemia" study
    Ugo Lucca
    Laboratory of Geriatric Neuropsychiatry, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    PLoS ONE 3:e1920. 2008
  3. ncbi request reprint The effect of a structured intervention on caregivers of patients with dementia and problem behaviors: a randomized controlled pilot study
    Alessandro Nobili
    Geriatric Neuropsychiatry Laboratory, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Alzheimer Dis Assoc Disord 18:75-82. 2004
  4. ncbi request reprint Use and misuse of antipsychotic drugs in patients with dementia in Alzheimer special care units
    Alessandro Nobili
    Laboratory of Quality Assessment of Geriatric Therapies and Services, Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, Milan 20156, Italy
    Int Clin Psychopharmacol 24:97-104. 2009
  5. doi request reprint Drug utilization and polypharmacy in an Italian elderly population: the EPIFARM-elderly project
    Alessandro Nobili
    Laboratory of Quality Assessment of Geriatric Therapies and Services, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Pharmacoepidemiol Drug Saf 20:488-96. 2011
  6. doi request reprint Polypharmacy, length of hospital stay, and in-hospital mortality among elderly patients in internal medicine wards. The REPOSI study
    Alessandro Nobili
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Mario Negri Institute for Pharmacological Research, via Giuseppe La Masa, 19, 20156 Milan, Italy
    Eur J Clin Pharmacol 67:507-19. 2011
  7. doi request reprint Potentially severe drug interactions in elderly outpatients: results of an observational study of an administrative prescription database
    A Nobili
    Laboratory of Quality Assessment of Geriatric Therapies and Services, and Drug Information Services for the Elderly, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Clin Pharm Ther 34:377-86. 2009
  8. doi request reprint Alzheimer special care units compared with traditional nursing home for dementia care: are there differences at admission and in clinical outcomes?
    Alessandro Nobili
    Laboratory of Quality Assessment of Geriatric Therapies and Services for the Elderly, Lombardy Region, Italy
    Alzheimer Dis Assoc Disord 22:352-61. 2008
  9. doi request reprint Association between clusters of diseases and polypharmacy in hospitalized elderly patients: results from the REPOSI study
    Alessandro Nobili
    Mario Negri Institute for Pharmacological Research, Milano, Italy
    Eur J Intern Med 22:597-602. 2011
  10. doi request reprint Antipsychotics prescription and cerebrovascular events in Italian older persons
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, IRCCS Istituto di Riceerche Farmacologiche Mario Negri, Milan, Italy
    J Clin Psychopharmacol 33:542-5. 2013

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Low folate and the risk of cognitive and functional deficits in the very old: the Monzino 80-plus study
    Mauro Tettamanti
    Laboratory of Geriatric Neuropsychiatry, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    J Am Coll Nutr 25:502-8. 2006
    ..To cross sectionally investigate the association of serum vitamin B(12) and folate concentrations with cognitive and functional ability in the very old in the general population...
  2. pmc Association of mild anemia with cognitive, functional, mood and quality of life outcomes in the elderly: the "Health and Anemia" study
    Ugo Lucca
    Laboratory of Geriatric Neuropsychiatry, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    PLoS ONE 3:e1920. 2008
    ..The objective of the present study was to cross-sectionally investigate the association of mild grade anemia with cognitive, functional, mood, and quality of life (QoL) variables in community-dwelling elderly persons...
  3. ncbi request reprint The effect of a structured intervention on caregivers of patients with dementia and problem behaviors: a randomized controlled pilot study
    Alessandro Nobili
    Geriatric Neuropsychiatry Laboratory, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Alzheimer Dis Assoc Disord 18:75-82. 2004
    ..The number of families lost to follow-up, the relatively short duration of the study, and the ceiling effect due to the severity of the clinical characteristics of patients probably all partly dilute the observed findings...
  4. ncbi request reprint Use and misuse of antipsychotic drugs in patients with dementia in Alzheimer special care units
    Alessandro Nobili
    Laboratory of Quality Assessment of Geriatric Therapies and Services, Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, Milan 20156, Italy
    Int Clin Psychopharmacol 24:97-104. 2009
    ..61-3.26). This study found high rate of use of antipsychotics in patients with dementia resident in Alzheimer special care units, frequent associations with other psychotropic medications and a strong correlation with BPSD...
  5. doi request reprint Drug utilization and polypharmacy in an Italian elderly population: the EPIFARM-elderly project
    Alessandro Nobili
    Laboratory of Quality Assessment of Geriatric Therapies and Services, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Pharmacoepidemiol Drug Saf 20:488-96. 2011
    ..To investigate the prescribing patterns and the prevalence of polypharmacy in community-dwelling elderly people, and to analyze the association of chronic medications and number of drug prescriptions with age and sex...
  6. doi request reprint Polypharmacy, length of hospital stay, and in-hospital mortality among elderly patients in internal medicine wards. The REPOSI study
    Alessandro Nobili
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Mario Negri Institute for Pharmacological Research, via Giuseppe La Masa, 19, 20156 Milan, Italy
    Eur J Clin Pharmacol 67:507-19. 2011
    ..We evaluated the prevalence and factors associated with polypharmacy and investigated the role of polypharmacy as a predictor of length of hospital stay and in-hospital mortality...
  7. doi request reprint Potentially severe drug interactions in elderly outpatients: results of an observational study of an administrative prescription database
    A Nobili
    Laboratory of Quality Assessment of Geriatric Therapies and Services, and Drug Information Services for the Elderly, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Clin Pharm Ther 34:377-86. 2009
    ..To estimate the prevalence of potentially severe drug-drug interactions (DDIs) and their relationship with age, sex and number of prescribed drugs...
  8. doi request reprint Alzheimer special care units compared with traditional nursing home for dementia care: are there differences at admission and in clinical outcomes?
    Alessandro Nobili
    Laboratory of Quality Assessment of Geriatric Therapies and Services for the Elderly, Lombardy Region, Italy
    Alzheimer Dis Assoc Disord 22:352-61. 2008
    ..Studies comparing Alzheimer Special Care Units (ASCUs) with traditional nursing homes (NHs) have reported conflicting results...
  9. doi request reprint Association between clusters of diseases and polypharmacy in hospitalized elderly patients: results from the REPOSI study
    Alessandro Nobili
    Mario Negri Institute for Pharmacological Research, Milano, Italy
    Eur J Intern Med 22:597-602. 2011
    ..We assessed which clusters of diseases are associated with polypharmacy in acute-care elderly in-patients...
  10. doi request reprint Antipsychotics prescription and cerebrovascular events in Italian older persons
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, IRCCS Istituto di Riceerche Farmacologiche Mario Negri, Milan, Italy
    J Clin Psychopharmacol 33:542-5. 2013
    ..92). In conclusion, only typical antipsychotics were associated with an increased odd of CVEs, but the association was duration dependent. Persons prescribed simultaneously with AChEI and antipsychotics may be at a lower risk of CVEs. ..
  11. doi request reprint Changes in trend of antipsychotics prescription in patients treated with cholinesterase inhibitors after warnings from Italian Medicines Agency. Results from the EPIFARM-Elderly Project
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur Neuropsychopharmacol 22:569-77. 2012
    ..Awaiting further studies to clarify their therapeutic role, physicians should prescribe antipsychotics very cautiously and only after careful risk-benefit assessment...
  12. doi request reprint Association of anticholinergic burden with cognitive and functional status in a cohort of hospitalized elderly: comparison of the anticholinergic cognitive burden scale and anticholinergic risk scale: results from the REPOSI study
    Luca Pasina
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Drug Information Service for the Elderly, Mario Negri Institute for Pharmacological Research, via Giuseppe La Masa, 19, 20156 Milan, Italy
    Drugs Aging 30:103-12. 2013
    ..Drugs with anticholinergic effects are associated with adverse events such as delirium and falls as well as cognitive decline and loss of independence...
  13. pmc Association of mild anemia with hospitalization and mortality in the elderly: the Health and Anemia population-based study
    Emma Riva
    Laboratory of Geriatric Neuropsychiatry, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Haematologica 94:22-8. 2009
    ..The aim of the present population-based study was to prospectively investigate the association of mild grade anemia with hospitalization and mortality...
  14. doi request reprint Geographical differences in the prevalence of chronic polypharmacy in older people: eleven years of the EPIFARM-Elderly Project
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, via Giuseppe La Masa, 19, 20156, Milan, Italy
    Eur J Clin Pharmacol 69:1477-83. 2013
    ..To compare the geographical differences in the prevalence of chronic polypharmacy in community-dwelling older people over 11 years...
  15. pmc Prevalence, incidence and types of mild anemia in the elderly: the "Health and Anemia" population-based study
    Mauro Tettamanti
    Laboratory of Geriatric Neuropsychiatry, Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Haematologica 95:1849-56. 2010
    ..The objectives of this study were to estimate the prevalence and incidence of mild grade anemia and to assess the frequency of anemia types in the elderly...
  16. doi request reprint Cholinesterase inhibitor use in Alzheimer's disease: the EPIFARM-Elderly Project
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Pharmacoepidemiol Drug Saf 20:497-505. 2011
    ....
  17. doi request reprint Risk factors for hospital readmission of elderly patients
    Carlotta Franchi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Intern Med 24:45-51. 2013
    ..The aim of this study was to identify which factors were associated with a risk of hospital readmission within 3 months after discharge of a sample of elderly patients admitted to internal medicine and geriatric wards...
  18. doi request reprint Drug-drug interactions in a cohort of hospitalized elderly patients
    Luca Pasina
    Laboratory for Quality Assessment of Geriatric Therapies and Services, Drug Information Service for the Elderly, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
    Pharmacoepidemiol Drug Saf 22:1054-60. 2013
    ....
  19. doi request reprint Antidepressants utilization among elderly in Lombardy from 2000 to 2007: dispensing trends and appropriateness
    Alberto Parabiaghi
    Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy
    Eur J Clin Pharmacol 67:1077-83. 2011
    ..To investigate the prevalence and incidence of antidepressant (AD) use in the elderly during an 8-year period and to evaluate AD treatment appropriateness...
  20. doi request reprint Trends in drug prescriptions to diabetic patients from 2000 to 2008 in Italy's Lombardy Region: a large population-based study
    Marta Baviera
    Laboratory of General Practice Research, Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Diabetes Res Clin Pract 93:123-30. 2011
    ..To analyze the prescribing patterns of antidiabetic and cardiovascular medications among diabetics in the most highly populated Italian Region, from 2000 to 2008...
  21. pmc A Population-based study of dementia in the oldest old: the Monzino 80-plus study
    Ugo Lucca
    Laboratory of Geriatric Neuropsychiatry, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    BMC Neurol 11:54. 2011
    ....
  22. doi request reprint How pre-marketing data can be used for predicting the weight of drug interactions in clinical practice
    Silvio Caccia
    Laboratory for Quality Assessment of Geriatric Therapies Services, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur J Intern Med 24:217-21. 2013
    ....
  23. doi request reprint Predicting the clinical relevance of drug interactions from pre-approval studies
    Silvio Caccia
    Laboratory of Drug Metabolism, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Drug Saf 32:1017-39. 2009
    ....
  24. doi request reprint Caregivers' perceptions of the therapeutic benefits of drug treatments for dementia
    Carlotta Franchi
    Laboratory for Quality Assessment of Geriatric Therapies and Services, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156, Milan, Italy
    Aging Clin Exp Res 25:677-83. 2013
    ..Only few studies deal with this topic in a small number of participants...
  25. pmc Critical appraisal of lurasidone in the management of schizophrenia
    Silvio Caccia
    Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
    Neuropsychiatr Dis Treat 8:155-68. 2012
    ..Ongoing trials in patients with bipolar disorder are being completed but, again, efficacy and safety have been investigated only in a few short-term clinical trials...
  26. pmc New atypical antipsychotics for schizophrenia: iloperidone
    Silvio Caccia
    Laboratory of Drug Metabolism, Mario Negri Institute for Pharmacological Research, 20156, Milan, Italy
    Drug Des Devel Ther 4:33-48. 2010
    ..Further comparative studies are needed to clarify the benefit/risk profile of iloperidone and its role in the treatment of schizophrenia...
  27. doi request reprint A critical review of the full economic evaluations of pharmacological treatments for colorectal cancer
    Livio Garattini
    CESAV, Centre for Health Economics, Mario Negri Institute for Pharmacological Research, 24020 Ranica BG, Italy
    J Med Econ 11:177-97. 2008
    ..This literature review makes a critical assessment of the methodology of the full economic evaluations (FEEs) conducted on colorectal cancer (CRC) pharmacological treatments...
  28. doi request reprint Utilization and costs of antiepileptic drugs in the elderly: still an unsolved issue
    Massimiliano Beghi
    Department of Clinical Psychiatry, University of Milano Bicocca, Milan, Italy
    Drugs Aging 26:157-68. 2009
    ..However, there are no cost-effectiveness studies in the elderly and further evidence is needed to confirm these assumptions...