Nicola Nicolai

Summary

Affiliation: Istituto Nazionale Tumori
Country: Italy

Publications

  1. doi request reprint A Combination of Cisplatin and 5-Fluorouracil With a Taxane in Patients Who Underwent Lymph Node Dissection for Nodal Metastases From Squamous Cell Carcinoma of the Penis: Treatment Outcome and Survival Analyses in Neoadjuvant and Adjuvant Settings
    Nicola Nicolai
    Urology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    Clin Genitourin Cancer 14:323-30. 2016
  2. doi request reprint Clinical outcome in testicular sex cord stromal tumors: testis sparing vs. radical orchiectomy and management of advanced disease
    Nicola Nicolai
    Department of Surgery, Urology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy Testis Surgery Unit, Surgery Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy Electronic address
    Urology 85:402-6. 2015
  3. doi request reprint Concordance and prediction ability of original and reviewed vascular invasion and other prognostic parameters of clinical stage I nonseminomatous germ cell testicular tumors after retroperitoneal lymph node dissection
    Nicola Nicolai
    Testis Surgery Unit, Surgery Department, Istituto Nazionale dei Tumori, Milano, Italy
    J Urol 186:1298-302. 2011
  4. ncbi request reprint [Retroperitoneal surgery in the treatment of germ-cell tumors of the testis: retroperitoneal lymph node dissection (RPLND)]
    N Nicolai
    SC Chirurgia Urologica, Fondazione IRCCS Istituto Tumori, Milano
    Urologia 77:84-7. 2010
  5. doi request reprint Retroperitoneal lymph node dissection with no adjuvant chemotherapy in clinical stage I nonseminomatous germ cell tumours: long-term outcome and analysis of risk factors of recurrence
    Nicola Nicolai
    Surgery Department, Urology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Eur Urol 58:912-8. 2010
  6. doi request reprint [The treatment of early-stage germ cell tumors of the testis (GCTT)]
    Roberto Salvioni
    SC Chirurgia Urologica, Fondazione IRCCS Istituto Tumori di Milano, Italy
    Urologia 79:81-8. 2012
  7. doi request reprint Towards the definition of the best management and prognostic factors of teratoma with malignant transformation: a single-institution case series and new proposal
    Andrea Necchi
    Department of Medicine, Urology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    BJU Int 107:1088-94. 2011
  8. doi request reprint Long-term results of a combination of paclitaxel, cisplatin and gemcitabine for salvage therapy in male germ-cell tumours
    Nicola Nicolai
    Urology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    BJU Int 104:340-6. 2009
  9. doi request reprint Penile cancer
    Roberto Salvioni
    Department of Genitourinary Oncology, Urologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori of Milan, Milan, Italy
    Urol Oncol 27:677-85. 2009
  10. doi request reprint Persistent CD30 expression by embryonal carcinoma in the treatment time course: prognostic significance of a worthwhile target for personalized treatment
    Patrizia Giannatempo
    Department of Medical Oncology, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy
    J Urol 190:1919-24. 2013

Collaborators

Detail Information

Publications49

  1. doi request reprint A Combination of Cisplatin and 5-Fluorouracil With a Taxane in Patients Who Underwent Lymph Node Dissection for Nodal Metastases From Squamous Cell Carcinoma of the Penis: Treatment Outcome and Survival Analyses in Neoadjuvant and Adjuvant Settings
    Nicola Nicolai
    Urology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    Clin Genitourin Cancer 14:323-30. 2016
    ..The role of chemotherapy in nodal metastases from penile squamous cell carcinoma is not defined. We evaluated the efficacy of a combination of T-PF (a taxane, cisplatin, and 5-fluorouracil) in neoadjuvant and adjuvant settings...
  2. doi request reprint Clinical outcome in testicular sex cord stromal tumors: testis sparing vs. radical orchiectomy and management of advanced disease
    Nicola Nicolai
    Department of Surgery, Urology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy Testis Surgery Unit, Surgery Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy Electronic address
    Urology 85:402-6. 2015
    ..To assess the clinical outcome of testicular sex cord stromal tumors (TSCST) according to management and stage...
  3. doi request reprint Concordance and prediction ability of original and reviewed vascular invasion and other prognostic parameters of clinical stage I nonseminomatous germ cell testicular tumors after retroperitoneal lymph node dissection
    Nicola Nicolai
    Testis Surgery Unit, Surgery Department, Istituto Nazionale dei Tumori, Milano, Italy
    J Urol 186:1298-302. 2011
    ....
  4. ncbi request reprint [Retroperitoneal surgery in the treatment of germ-cell tumors of the testis: retroperitoneal lymph node dissection (RPLND)]
    N Nicolai
    SC Chirurgia Urologica, Fondazione IRCCS Istituto Tumori, Milano
    Urologia 77:84-7. 2010
    ....
  5. doi request reprint Retroperitoneal lymph node dissection with no adjuvant chemotherapy in clinical stage I nonseminomatous germ cell tumours: long-term outcome and analysis of risk factors of recurrence
    Nicola Nicolai
    Surgery Department, Urology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Eur Urol 58:912-8. 2010
    ..The best management for patients with clinical stage I (CS1) nonseminomatous germ cell tumours (NSGCT) is still under debate...
  6. doi request reprint [The treatment of early-stage germ cell tumors of the testis (GCTT)]
    Roberto Salvioni
    SC Chirurgia Urologica, Fondazione IRCCS Istituto Tumori di Milano, Italy
    Urologia 79:81-8. 2012
    ....
  7. doi request reprint Towards the definition of the best management and prognostic factors of teratoma with malignant transformation: a single-institution case series and new proposal
    Andrea Necchi
    Department of Medicine, Urology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    BJU Int 107:1088-94. 2011
    ..To investigate the optimal management and prognostic factors of patients with malignant transformation (MT) in germ-cell tumour (GCT) by re-evaluating Institutional series...
  8. doi request reprint Long-term results of a combination of paclitaxel, cisplatin and gemcitabine for salvage therapy in male germ-cell tumours
    Nicola Nicolai
    Urology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    BJU Int 104:340-6. 2009
    ....
  9. doi request reprint Penile cancer
    Roberto Salvioni
    Department of Genitourinary Oncology, Urologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori of Milan, Milan, Italy
    Urol Oncol 27:677-85. 2009
    ..Caution is advised in administering multimodal therapy that can have severe toxicity in elderly people...
  10. doi request reprint Persistent CD30 expression by embryonal carcinoma in the treatment time course: prognostic significance of a worthwhile target for personalized treatment
    Patrizia Giannatempo
    Department of Medical Oncology, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy
    J Urol 190:1919-24. 2013
    ..We evaluated persistent CD30 expression and its prognostic meaning in cases of post-chemotherapy residual disease...
  11. doi request reprint Etoposide, Methotrexate, and Dactinomycin Alternating With Cyclophosphamide and Vincristine (EMACO) for Male Patients With HCG-expressing, Chemoresistant Germ Cell Tumors
    Daniele Raggi
    Department of Medical Oncology Clinical Epidemiology and Trials Organization Unit Department of Surgery, Urology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
    Am J Clin Oncol 40:60-65. 2017
    ....
  12. doi request reprint Prognostic Factors of Adjuvant Taxane, Cisplatin, and 5-Fluorouracil Chemotherapy for Patients With Penile Squamous Cell Carcinoma After Regional Lymphadenectomy
    Andrea Necchi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    Clin Genitourin Cancer 14:518-523. 2016
    ..Little is known about the outcomes and prognostic factors of adjuvant chemotherapy for locally advanced penile squamous cell carcinoma after regional lymphadenectomy (LAD)...
  13. doi request reprint Immunohistochemistry to enhance prognostic allocation and guide decision-making of patients with advanced urothelial cancer receiving first-line chemotherapy
    Andrea Necchi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    Clin Genitourin Cancer 13:171-7.e1. 2015
    ..Knowledge of the expression of molecular drivers and potentially druggable targets might enhance prognostic classification of M UC...
  14. doi request reprint Long-term efficacy and safety outcomes of modified (simplified) MVAC (methotrexate/vinblastine/doxorubicin/cisplatin) as frontline therapy for unresectable or metastatic urothelial cancer
    Andrea Necchi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    Clin Genitourin Cancer 12:203-209.e1. 2014
    ..Modifying MVAC by reducing side effects may have the potential to improve efficacy...
  15. doi request reprint Postchemotherapy lymphadenectomy in patients with metastatic urothelial carcinoma: long-term efficacy and implications for trial design
    Andrea Necchi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    Clin Genitourin Cancer 13:80-86.e1. 2015
    ..The contribution of postchemotherapy pelvic (PLND) or retroperitoneal lymphadenectomy (RPLND) on survival in patients with advanced and metastatic UC is still unclear...
  16. doi request reprint Combination of paclitaxel, cisplatin, and gemcitabine (TPG) for multiple relapses or platinum-resistant germ cell tumors: long-term outcomes
    Andrea Necchi
    Department of Medical Oncology, Medical Oncology 2 Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    Clin Genitourin Cancer 12:63-69.e1. 2014
    ..We assessed the efficacy of a triple-combination chemotherapy in the salvage setting, beyond second-line regimens...
  17. doi request reprint The relationship between characteristics of inguinal lymph nodes and pelvic lymph node involvement in penile squamous cell carcinoma: a single institution experience
    Giovanni Lughezzani
    Department of Urology, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milano, Italy
    J Urol 191:977-82. 2014
    ..We determined predictors of pelvic lymph node metastases in patients with penile cancer...
  18. ncbi request reprint A simple model for predicting nodal metastasis in patients with clinical stage I nonseminomatous germ cell testicular tumors undergoing retroperitoneal lymph node dissection only
    Nicola Nicolai
    Urology Unit, Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    J Urol 171:172-6. 2004
    ..We built 2 models for distinguishing these risk categories...
  19. doi request reprint Interim (18)F-Fluorodeoxyglucose Positron Emission Tomography for Early Metabolic Assessment of Response to Cisplatin, Etoposide, and Bleomycin Chemotherapy for Metastatic Seminoma: Clinical Value and Future Directions
    Andrea Necchi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    Clin Genitourin Cancer 14:249-54. 2016
    ..In patients with metastatic seminoma, designing a risk-adapted strategy that may help personalize the burden of treatment and follow-up is required...
  20. doi request reprint Panitumumab Treatment for Advanced Penile Squamous Cell Carcinoma When Surgery and Chemotherapy Have Failed
    Andrea Necchi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    Clin Genitourin Cancer 14:231-6. 2016
    ..Patients with metastatic penile squamous cell carcinoma (SCC) have a poor prognosis and treatment options are needed when chemotherapy treatment fails. We present the final results of panitumumab treatment from our original series...
  21. doi request reprint Relationship between lymph node ratio and cancer-specific survival in a contemporary series of patients with penile cancer and lymph node metastases
    Giovanni Lughezzani
    Department of Urology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    BJU Int 116:727-33. 2015
    ..To evaluate the association between lymph node ratio (LNR) and cancer-specific survival (CSS) in a population of patients with penile cancer and lymph node metastases (LNM)...
  22. doi request reprint Prognostic reclassification of patients with intermediate-risk metastatic germ cell tumors: Implications for clinical practice, trial design, and molecular interrogation
    Daniele Raggi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Urol Oncol 33:332.e19-24. 2015
    ..We aimed to address the heterogeneity of this category by providing a proof of principle for reclassification attempt...
  23. doi request reprint Clinical Outcomes of Metastatic Poor Prognosis Germ Cell Tumors: Current Perspective From a Referral Center
    Andrea Necchi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    Clin Genitourin Cancer 13:385-391.e1. 2015
    ..We conducted a retrospective study to evaluate the outcome of patients referred to our tertiary cancer center...
  24. doi request reprint Predictors of health-related quality of life and adjustment to prostate cancer during active surveillance
    Lara Bellardita
    Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Eur Urol 64:30-6. 2013
    ..Although most patients report high levels of QoL, some men may be distressed by the idea of living with untreated cancer...
  25. doi request reprint Teratoma with somatic-type malignant components in germ cell tumors of the testis: a clinicopathologic analysis of 40 cases with outcome correlation
    Maurizio Colecchia
    Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Int J Surg Pathol 19:321-7. 2011
    ..A lower sensitivity to chemotherapy for a MSC when compared with typical GCT is reported. Surgical excision of the MSC is therefore an essential part of the management...
  26. doi request reprint Taxanes in combination with cisplatin and fluorouracil for advanced penile cancer: preliminary results
    Giorgio Pizzocaro
    Urologic Clinic 2nd, S Giuseppe Hospital, Milan University, Milan, Italy
    Eur Urol 55:546-51. 2009
    ..Chemotherapy is emerging in the management of advanced penile cancer...
  27. ncbi request reprint Laparoscopic Postchemotherapy Retroperitoneal Lymph-Node Dissection Can Be a Standard Option in Defined Nonseminomatous Germ Cell Tumor Patients
    Nicola Nicolai
    1 Testis Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    J Endourol 30:1112-1119. 2016
    ..Laparoscopic (L) PC-RPLND may improve tolerability profile. We evaluated viability, toxicity, and short to medium-term oncologic outcome of L-PC-RPLND following well-defined selection criteria...
  28. doi request reprint Treatment and Clinical Outcomes of Patients with Teratoma with Somatic-Type Malignant Transformation: An International Collaboration
    Patrizia Giannatempo
    Fondazione Istituti di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy
    J Urol 196:95-100. 2016
    ..We assessed prognostic factors, treatments and outcomes in patients with teratoma with malignant transformation, a rare occurrence among germ cell tumors...
  29. ncbi request reprint Clinical stage I nonseminomatous germ cell tumors of the testis in childhood and adolescence: an analysis of 31 cases
    Monica Terenziani
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    J Pediatr Hematol Oncol 24:454-8. 2002
    ..A conservative approach is the best option in children, while adolescent NSGCTT behaves like the adult disease and management must include similar treatment strategies...
  30. ncbi request reprint pT1 penile squamous cell carcinoma: a clinicopathologic study of 56 cases treated by CO2 laser therapy
    Maurizio Colecchia
    Dept of Pathology, Unit of Urology, Day Surgery, Foundation IRCCS National Institute of Tumors and Laboratory for Modeling and Scientific Computing MOX, Department of Mathematics, Milan Polytechnic, Milan, Italy
    Anal Quant Cytol Histol 31:153-60. 2009
    ..To evaluate the pathologic characteristics that are associated with outcomes in pT1 penile squamous cell carcinoma (SCC) treated with laser excision...
  31. doi request reprint Interim fluorine-18 fluorodeoxyglucose positron emission tomography for early metabolic assessment of therapeutic response to chemotherapy for metastatic transitional cell carcinoma
    Patrizia Giannatempo
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Clin Genitourin Cancer 12:433-9. 2014
    ..The prognostic impact of early metabolic response by fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) after 2 cycles of first-line chemotherapy is still unrecognized in metastatic transitional cell carcinoma (TCC)...
  32. doi request reprint Peniscopically controlled CO2 laser excision for conservative treatment of in situ and T1 penile carcinoma: report on 224 patients
    Gaetano Bandieramonte
    Department of Surgery, Day Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via G Venezian 1, Milan, Italy
    Eur Urol 54:875-82. 2008
    ..To evaluate the outcome of peniscopically controlled laser excision of early-stage penile carcinoma...
  33. doi request reprint Pazopanib in advanced and platinum-resistant urothelial cancer: an open-label, single group, phase 2 trial
    Andrea Necchi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Lancet Oncol 13:810-6. 2012
    ..We therefore investigated the activity and safety of pazopanib, a multitarget drug with antiangiogenic activity, in patients with urothelial cancer...
  34. doi request reprint Effect of Bleomycin Administration on the Development of Pulmonary Toxicity in Patients With Metastatic Germ Cell Tumors Receiving First-Line Chemotherapy: A Meta-Analysis of Randomized Studies
    Andrea Necchi
    Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy Electronic address
    Clin Genitourin Cancer . 2016
    ..Limited information is available about the effect of bleomycin administration on the development of pulmonary toxicity in metastatic germ cell tumors (GCT)...
  35. doi request reprint An open-label, single-arm, phase 2 study of the Aurora kinase A inhibitor alisertib in patients with advanced urothelial cancer
    Andrea Necchi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G Venezian 1, 20133, Milano, Italy
    Invest New Drugs 34:236-42. 2016
    ..Progress in developing effective salvage therapies for UC is warranted. Alisertib is an orally available, selective inhibitor of the aurora kinase A...
  36. doi request reprint The 6-year attendance of a multidisciplinary prostate cancer clinic in Italy: incidence of management changes
    Tiziana Magnani
    Prostate Cancer Programme, Scientific Director s Office Division of Radiation Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    BJU Int 110:998-1003. 2012
    ..The study is focused on the organisational aspects and adds a perspective from one of the major oncological centres of reference in Italy and in Europe...
  37. ncbi request reprint Thyroid as a target of metastases: a case of metastatic seminoma in a patient who died of a second cancer
    Franco Mattavelli
    Otorhinolaryngology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 95:91-3. 2009
    ..The thyroid is a rare site of metastases from any cancer, but any patient with a previous oncologic disease should inquire about a thyroid nodule...
  38. doi request reprint A Suggested Prognostic Reclassification of Intermediate and Poor-Risk Nonseminomatous Germ Cell Tumors
    Andrea Necchi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    Clin Genitourin Cancer . 2016
    ..We aimed to revisit the outcomes of intermediate and poor risk nonseminomatous GCTs (NSGCTs)...
  39. doi request reprint A prognostic model including pre- and postsurgical variables to enhance risk stratification of primary mediastinal nonseminomatous germ cell tumors: the 27-year experience of a referral center
    Andrea Necchi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    Clin Genitourin Cancer 13:87-93.e1. 2015
    ..Enhancing the risk stratification might result in tailoring a more personalized treatment strategy from the time of diagnosis...
  40. doi request reprint Predictors of CD34+ cell mobilization and collection in adult men with germ cell tumors: implications for the salvage treatment strategy
    Andrea Necchi
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Clin Genitourin Cancer 12:196-202.e1. 2014
    ..High-dose chemotherapy with tandem or triple carboplatin and etoposide course is currently the first curative choice for relapsing GCT. The collection of an adequate amount of hematopoietic (CD34(+)) stem cells is a priority...
  41. doi request reprint Low dose of ketoconazole in patients with prostate adenocarcinoma resistant to pharmacological castration
    Giuseppe Procopio
    Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori of Milan, Milan, Italy
    BJU Int 108:223-7. 2011
    ..To assess the efficacy of ketoconazole in patients with castration-resistant prostate cancer (CRPC)...
  42. ncbi request reprint Leydig cell tumor and hyperplasia: a review
    Maurizio Colecchia
    Department of Pathology, National Cancer Institute Foundation, Milan, Italy
    Anal Quant Cytol Histol 29:139-47. 2007
    ..Recent acquisitions on etiology and pathobiology of Leydig cell proliferations, unusual microscopic presentations and clinical and morphologic features predictive of malignancy are reported...
  43. doi request reprint The role of surgery in metastatic squamous cell carcinoma of the penis
    Nicola Nicolai
    Urology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Curr Opin Urol 26:596-601. 2016
    ..Prognosis of penile squamous cell cancer (PeSCC) depends on the involvement of the groin(s) as first step. We introduce the current available evidences that should rule the use of surgery in the management of PeSCC...
  44. pmc Experience with sorafenib in the treatment of advanced renal cell carcinoma
    Giuseppe Procopio
    Department of Medical Oncology, Fondazione IRCCS, Istituto Nazionale dei Tumori, Via G Venezian, Milan 1 20133, Italy
    Ther Adv Urol 4:303-13. 2012
    ....
  45. ncbi request reprint Andrological complications following retroperitoneal lymphnode dissection for testicular cancer: a narrative review
    Alessandro Crestani
    Urology Unit, Academic Medical Centre Hospital Santa Maria della Misericordia, Udine, Italy
    Minerva Urol Nefrol . 2016
    ....
  46. ncbi request reprint Laparoscopic adrenalectomy
    Nicola Nicolai
    Department of Intracavitary Surgery, Urology Unit, National Cancer Institute, Milan, Italy
    Tumori 89:556-9. 2003
    ..We investigated the following issues regarding laparoscopic adrenalectomy: techniques and advantages, indications in adrenal diseases, and the special case of pheochromocytoma...