M Muzio

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. pmc Micrococci and peptidoglycan activate TLR2-->MyD88-->IRAK-->TRAF-->NIK-->IKK-->NF-kappaB signal transduction pathway that induces transcription of interleukin-8
    Q Wang
    Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 46408, USA
    Infect Immun 69:2270-6. 2001
  2. ncbi Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes
    M Muzio
    Department of Immunology, Mario Negri Institute, Milano, Italy
    J Leukoc Biol 67:450-6. 2000
  3. pmc The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, I 20157 Milan, Italy
    J Exp Med 187:2097-101. 1998
  4. ncbi Toll-like receptor family and signalling pathway
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Via Eritrea 62, Milano, I 20157, Italy
    Biochem Soc Trans 28:563-6. 2000
  5. ncbi Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Milan, Italy
    J Immunol 164:5998-6004. 2000
  6. ncbi Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4
    F Colotta
    Centro Daniela e Catullo Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Science 261:472-5. 1993
  7. pmc The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor
    F Re
    Istituto di Ricerche Farmacologiche Mario Negri, Centro Daniela e Catullo Borgomainerio, Milano, Italy
    J Exp Med 179:739-43. 1994
  8. ncbi Bacterial lipopolysaccharide causes rapid shedding, followed by inhibition of mRNA expression, of the IL-1 type II receptor, with concomitant up-regulation of the type I receptor and induction of incompletely spliced transcripts
    G Penton-Rol
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 162:2931-8. 1999
  9. ncbi Toll-like receptors (TLRs) signalling and expression pattern
    M Muzio
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Endotoxin Res 7:297-300. 2001
  10. ncbi Macrophage control of inflammation: negative pathways of regulation of inflammatory cytokines
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Novartis Found Symp 234:120-31; discussion 131-5. 2001

Collaborators

Detail Information

Publications18

  1. pmc Micrococci and peptidoglycan activate TLR2-->MyD88-->IRAK-->TRAF-->NIK-->IKK-->NF-kappaB signal transduction pathway that induces transcription of interleukin-8
    Q Wang
    Northwest Center for Medical Education, Indiana University School of Medicine, Gary, Indiana 46408, USA
    Infect Immun 69:2270-6. 2001
    ..These data indicate that micrococci and PGN induce TLR2-dependent activation of the gene for IL-8 and that this activation requires MyD88, IRAK, NIK, IKK, and NF-kappaB and may also utilize TRAF6 and, to a lesser extent, TRAF2...
  2. ncbi Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes
    M Muzio
    Department of Immunology, Mario Negri Institute, Milano, Italy
    J Leukoc Biol 67:450-6. 2000
    ..Alternately, the expression of a TLR in a single cell type may indicate a specific role for this molecule in a restricted setting...
  3. pmc The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, I 20157 Milan, Italy
    J Exp Med 187:2097-101. 1998
    ..Conversely, a dominant negative version of TRAF6 failed to block hToll-induced activation of stress-activated protein kinase/c-Jun NH2-terminal kinases, thus suggesting an early divergence of the two pathways...
  4. ncbi Toll-like receptor family and signalling pathway
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Via Eritrea 62, Milano, I 20157, Italy
    Biochem Soc Trans 28:563-6. 2000
    ..Alternatively, the expression of a TLR in a single cell type may indicate a specific role for this molecule in a restricted setting...
  5. ncbi Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Milan, Italy
    J Immunol 164:5998-6004. 2000
    ..These data suggest that TLR can be classified based on expression pattern as ubiquitous (TLR1), restricted (TLR2, TLR4, and TLR5 in myelomonocytic cells), and specific (TLR3 in DC) molecules...
  6. ncbi Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4
    F Colotta
    Centro Daniela e Catullo Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Science 261:472-5. 1993
    ..The existence of multiple pathways of regulation emphasizes the need for tight control of IL-1 action...
  7. pmc The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor
    F Re
    Istituto di Ricerche Farmacologiche Mario Negri, Centro Daniela e Catullo Borgomainerio, Milano, Italy
    J Exp Med 179:739-43. 1994
    ..The induction by Dex of the type II receptor, a decoy molecule for IL-1, may contribute to the immunosuppressive and antiinflammatory activities of Dex...
  8. ncbi Bacterial lipopolysaccharide causes rapid shedding, followed by inhibition of mRNA expression, of the IL-1 type II receptor, with concomitant up-regulation of the type I receptor and induction of incompletely spliced transcripts
    G Penton-Rol
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 162:2931-8. 1999
    ..This early event, followed by prolonged inhibition of IL-1RII expression and up-regulation of IL-1RI, may render monocytes more responsive to IL-1 at sites of inflammation...
  9. ncbi Toll-like receptors (TLRs) signalling and expression pattern
    M Muzio
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Endotoxin Res 7:297-300. 2001
    ..Differential expression and regulation as well as distinct, though overlapping, ligand recognition patterns may underlie the existence of a such a large, seemingly redundant, TLR family...
  10. ncbi Macrophage control of inflammation: negative pathways of regulation of inflammatory cytokines
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Novartis Found Symp 234:120-31; discussion 131-5. 2001
    ..These mediators offer new paradigms to understand diverse pathologies, and provide tools and targets for the development of novel therapeutic strategies...
  11. ncbi Regulation of inhibitory pathways of the interleukin-1 system
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Ann N Y Acad Sci 840:338-51. 1998
    ..The structural and functional features of this molecule as well as initial evidence of involvement in human pathology will be discussed...
  12. doi The functional in vitro response to CD40 ligation reflects a different clinical outcome in patients with chronic lymphocytic leukemia
    C Scielzo
    Laboratory of Lymphoid Malignancies, Division of Molecular Oncology, Istituto Scientifico San Raffaele, Milan, Italy
    Leukemia 25:1760-7. 2011
    ..This indicates that the functional differences observed in vitro may reflect a different leukemic potential in vivo likely responsible for a distinct clinical course...
  13. doi An overview of chronic lymphocytic leukaemia biology
    M T S Bertilaccio
    Laboratory of Lymphoid Malignancies, Division of Molecular Oncology, Istituto Scientifico San Raffaele, Milan, Italy
    Best Pract Res Clin Haematol 23:21-32. 2010
    ..In this context, mouse models are helpful tools in understanding disease mechanisms and in evaluating the efficacy of novel therapeutic agents...
  14. pmc Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist
    M Muzio
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Exp Med 182:623-8. 1995
    ..We propose to refer to this new form of icIL-1ra as icIL-1ra type II...
  15. ncbi IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    M Muzio
    University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA
    Science 278:1612-5. 1997
    ..Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation...
  16. ncbi IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein
    L E Jensen
    Department of Pharmacology, Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 164:5277-86. 2000
    ..This suggests that sIL-1RAcP may act as an inhibitor of IL-1 by directly interacting with IL-1RI to abolish its capacity to transduce signal...
  17. ncbi FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens
    M Muzio
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 272:2952-6. 1997
    ..Furthermore, CrmA, a pox virus-encoded serpin that inhibits Fas and tumor necrosis factor-induced cell death attenuates the ability of FLICE to activate downstream caspases...
  18. ncbi FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex
    M Muzio
    University of Michigan Medical School Department of Pathology, Ann Arbor, Michigan 48109, USA
    Cell 85:817-27. 1996
    ..Taken together, this is unique biochemical evidence to link a death receptor physically to the proapoptotic proteases of the ICE/CED-3 family...