Research Topics
| Claudia MuratoriSummaryAffiliation: Istituto Superiore di Sanit Country: Italy Publications
| Collaborators |
Detail Information
Publications
Generation and characterization of a stable cell population releasing fluorescent HIV-1-based Virus Like Particles in an inducible wayClaudia Muratori
National AIDS Center, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
BMC Biotechnol 6:52. 2006..We sought to overcome such a limitation by using a cell line releasing HIV-1 particles in an inducible way, and by exploiting the ability of a HIV-1 Nef mutant to be incorporated in virions at quite high levels...
DC contact with HIV-1-infected cells leads to high levels of Env-mediated virion endocytosis coupled with enhanced HIV-1 Ag presentationClaudia Muratori
Division of Pathogenesis of Retroviruses, National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
Eur J Immunol 39:404-16. 2009..Our results provide a better understanding of the mechanisms underlying the induction of the anti-HIV adaptive immune response...
Virological consequences of early events following cell-cell contact between human immunodeficiency virus type 1-infected and uninfected CD4+ cellsEliana Ruggiero
Division of Pathogenesis of Retroviruses, National AIDS Center, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
J Virol 82:7773-89. 2008..In sum, the HIV-1 transmission following contact between an HIV-1-infected and an uninfected CD4(+) cell can occur through different mechanisms, leading to distinguishable virological outcomes...
Human immunodeficiency virus type 1 (HIV-1) protease inhibitors block cell-to-cell HIV-1 endocytosis in dendritic cellsClaudia Muratori
Division of Pathogenesis of Retroviruses, National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
J Gen Virol 90:2777-87. 2009..Our results contribute to a better delineation of the mechanisms underlying HIV-1 trans-infection activity in DCs, whilst having implications for the development of new anti-HIV microbicide strategies...
Astrocytes contacting HIV-1-infected macrophages increase the release of CCL2 in response to the HIV-1-dependent enhancement of membrane-associated TNFα in macrophagesClaudia Muratori
National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
Glia 58:1893-904. 2010..These observations could mirror a mechanism of recruitment of leukocytes through the BBB, likely contributing to the increase in both viral load and inflammation in central nervous system of HIV-infected patients...
Lentivirus-based virus-like particles as a new protein delivery toolClaudia Muratori
Division of Pathogenesis of Retroviruses, National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
Methods Mol Biol 614:111-24. 2010..Besides having potential utility in the field of basic virology, these VLPs represent a useful reference model for recovering alternative retro- or lentiviral based VLPs for the cell delivery of polypeptides/proteins of interest...
Inducible expression of the deltaNGFr/F12Nef fusion protein as a new tool for anti-human immunodeficiency virus type 1 gene therapyClaudia Muratori
Laboratory of Virology, Istituto Superiore di Sanit, 00161 Rome, Italy
Hum Gene Ther 13:1751-66. 2002..Thus, the HIV-1-targetable expression of the deltaNGFr/F12Nef fusion protein represents a novel and powerful tool for an effective anti-HIV-1 gene therapy strategy...
Macrophages transmit human immunodeficiency virus type 1 products to CD4-negative cells: involvement of matrix metalloproteinase 9Claudia Muratori
Division of Pathogenesis of Retroviruses, National AIDS Center, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
J Virol 81:9078-87. 2007..The macrophage-driven transfer of HIV-1 products to diverse CD4-negative cell types may have a significant role in AIDS pathogenesis...
Anti-tumor CD8+ T cell immunity elicited by HIV-1-based virus-like particles incorporating HPV-16 E7 proteinPaola Di Bonito
Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
Virology 395:45-55. 2009..These results make Nef(mut) VLPs a promising candidate for new vaccine strategies focused on the induction of CD8(+) T cell immunity...
