Anna Rita Migliaccio

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. ncbi request reprint In vivo expansion of purified hematopoietic stem cells transplanted in nonablated W/Wv mice
    A R Migliaccio
    Lindsay F Kimball Research Laboratory, New York Blood Center, NY, USA
    Exp Hematol 27:1655-66. 1999
  2. ncbi request reprint Role of thrombopoietin in mast cell differentiation
    Anna Rita Migliaccio
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann N Y Acad Sci 1106:152-74. 2007
  3. ncbi request reprint Role of GATA-1 in normal and neoplastic hemopoiesis
    Anna Rita Migliaccio
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann N Y Acad Sci 1044:142-58. 2005
  4. pmc Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease
    Anna Rita Migliaccio
    Departments of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Exp Hematol 36:158-71. 2008
  5. ncbi request reprint A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-beta1 in the development of myelofibrosis
    Alessandro M Vannucchi
    Clinical Biochemistry, Istituto Superiore Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Blood 105:3493-501. 2005
  6. ncbi request reprint Robust levels of long-term multilineage reconstitution in the absence of stem cell self-replication in W/Wv mice transplanted with purified stem cells
    Anna Rita Migliaccio
    Laboratorio di Biochimica Clinica, Istituto Superiore di Sanita, 00161 Rome, Italy
    J Hematother Stem Cell Res 12:409-24. 2003
  7. ncbi request reprint Cell therapy: filling the gap between basic science and clinical trials October 15-17, 2001, Rome, Italy
    Anna Rita Migliaccio
    Laboratorio Biochimica Clinica, Istituto Superiore Sanita, Rome, Italy
    Stem Cells 21:348-56. 2003
  8. pmc The return of Romeo. Scientists' international mobility and the future of research in Europe
    Anna Rita Migliaccio
    Istituto Superiore di Sanità in Rome, Italy
    EMBO Rep 7:1067-71. 2006
  9. pmc GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant
    Anna Rita Migliaccio
    Department of Biomorphology, University G D Annunzio, 66100 Chieti, Italy
    J Exp Med 197:281-96. 2003
  10. doi request reprint Under HEMA conditions, self-replication of human erythroblasts is limited by autophagic death
    Giovanni Migliaccio
    Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    Blood Cells Mol Dis 47:182-97. 2011

Collaborators

Detail Information

Publications45

  1. ncbi request reprint In vivo expansion of purified hematopoietic stem cells transplanted in nonablated W/Wv mice
    A R Migliaccio
    Lindsay F Kimball Research Laboratory, New York Blood Center, NY, USA
    Exp Hematol 27:1655-66. 1999
    ..5 years earlier with 250-500 C57BL Rho-dull cells. We conclude that murine HSC have extensive amplification capacity in nonmyeloablated animals...
  2. ncbi request reprint Role of thrombopoietin in mast cell differentiation
    Anna Rita Migliaccio
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann N Y Acad Sci 1106:152-74. 2007
    ..Some of the possible implications of this newly described biological activity of thrombopoietin will be discussed...
  3. ncbi request reprint Role of GATA-1 in normal and neoplastic hemopoiesis
    Anna Rita Migliaccio
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Ann N Y Acad Sci 1044:142-58. 2005
    ..We review our current understanding of the role of GATA-1 in normal and neoplastic hematopoiesis as emerging from these genetic approaches...
  4. pmc Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease
    Anna Rita Migliaccio
    Departments of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Exp Hematol 36:158-71. 2008
    ....
  5. ncbi request reprint A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-beta1 in the development of myelofibrosis
    Alessandro M Vannucchi
    Clinical Biochemistry, Istituto Superiore Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Blood 105:3493-501. 2005
    ..These data indicate that the TPO(high) and GATA-1(low) alterations are linked in an upstream-downstream relationship along a pathobiologic pathway leading to development of myelofibrosis in mice and, possibly, of IM in humans...
  6. ncbi request reprint Robust levels of long-term multilineage reconstitution in the absence of stem cell self-replication in W/Wv mice transplanted with purified stem cells
    Anna Rita Migliaccio
    Laboratorio di Biochimica Clinica, Istituto Superiore di Sanita, 00161 Rome, Italy
    J Hematother Stem Cell Res 12:409-24. 2003
    ..1neg in that few pMRC are included among Sca-1+ cells and that MRC and pMRC are two distinct and separable cell populations...
  7. ncbi request reprint Cell therapy: filling the gap between basic science and clinical trials October 15-17, 2001, Rome, Italy
    Anna Rita Migliaccio
    Laboratorio Biochimica Clinica, Istituto Superiore Sanita, Rome, Italy
    Stem Cells 21:348-56. 2003
    ....
  8. pmc The return of Romeo. Scientists' international mobility and the future of research in Europe
    Anna Rita Migliaccio
    Istituto Superiore di Sanità in Rome, Italy
    EMBO Rep 7:1067-71. 2006
  9. pmc GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant
    Anna Rita Migliaccio
    Department of Biomorphology, University G D Annunzio, 66100 Chieti, Italy
    J Exp Med 197:281-96. 2003
    ..These abnormalities, which were mirrored by impaired mast differentiation in vitro, were reversed by retroviral-mediated expression of GATA-1 cDNA. These data indicate an essential role for GATA-1 in mast cell differentiation...
  10. doi request reprint Under HEMA conditions, self-replication of human erythroblasts is limited by autophagic death
    Giovanni Migliaccio
    Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    Blood Cells Mol Dis 47:182-97. 2011
    ....
  11. pmc Increased differentiation of dermal mast cells in mice lacking the Mpl gene
    Barbara Ghinassi
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Stem Cells Dev 18:1081-92. 2009
    ..These results suggest that not only does ligation of thrombopoietin with the Mpl receptor exert an effect at the mast cell restricted progenitor cell level, but also plays an unexpected yet important role in mast cell maturation...
  12. ncbi request reprint Variegation of the phenotype induced by the Gata1low mutation in mice of different genetic backgrounds
    Fabrizio Martelli
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Blood 106:4102-13. 2005
    ..We propose that the variegation in myelofibrosis expressed by Gata1low mutants of different strains might represent a model to study the variability of the clinical picture of the human disease...
  13. ncbi request reprint Differential amplification of murine bipotent megakaryocytic/erythroid progenitor and precursor cells during recovery from acute and chronic erythroid stress
    Massimo Sanchez
    Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Stem Cells 24:337-48. 2006
    ..A model describing the relationship between MEP, PEM, and common myeloid progenitor cells is presented...
  14. pmc The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor
    Barbara Ghinassi
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Blood 109:1460-71. 2007
    ..These results confirm the crucial role played by Gata1 in hematopoietic commitment and identify, as a new target for the Gata1 action, the restriction point at which common myeloid progenitors become either MEPs or MCPs...
  15. pmc Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation
    Anna Rita Migliaccio
    Department of Hematology Oncology and Molecular Medicine, Instituto Superiore Sanità, Rome, Italy
    Blood 114:2107-20. 2009
    ..By analyzing the mechanism that rescues hematopoiesis in mice carrying this mutation, we provide evidence that extramedullary microenvironments sustain maturation of stem cells that would be otherwise incapable of maturing in the marrow...
  16. pmc The dominant negative β isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells expanded from polycythemia vera patients
    Lilian Varricchio
    The Tisch Cancer Institute and Myeloproliferative Disease Research Consortium, Mount Sinai School of Medicine, New York, NY, USA
    Blood 118:425-36. 2011
    ..These data indicate that GRβ expression and the presence of A3669G likely contribute to development of erythrocytosis in PV and provide a potential target for identification of novel therapeutic agents...
  17. pmc CXCR4-independent rescue of the myeloproliferative defect of the Gata1low myelofibrosis mouse model by Aplidin
    Maria Verrucci
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    J Cell Physiol 225:490-9. 2010
    ..These results indicate that Aplidin effectively alters the natural history of myelofibrosis in Gata1(low) mice and suggest this drug as candidate for clinical evaluation in PMF...
  18. ncbi request reprint Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1(low) mice
    Lucia Centurione
    Department of Biomorphology, University G D Annunzio, Chieti, Italy
    Blood 104:3573-80. 2004
    ..We suggest that such an increased and pathologic neutrophil emperipolesis may represent one of the mechanisms leading to myelofibrosis by releasing fibrogenic MK cytokines and neutrophil proteases in the microenvironment...
  19. ncbi request reprint Isolation of TPO-dependent subclones from the multipotent 32D cell line
    Giovanni Amabile
    Department of Cell Biology and Neurosciences, Istituto Superiore Sanita, Rome
    Blood Cells Mol Dis 35:241-52. 2005
    ..7 in both cases). In conclusion, the 32D TPO subclones described here are among the few pure Mk cell lines isolated so far and, for their unique properties, may prove themselves as a useful model to study Mk differentiation...
  20. pmc Dynamic regulation of Gata1 expression during the maturation of conventional dendritic cells
    Gergely T Kozma
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Exp Hematol 38:489-503.e1. 2010
    ..To identify the regulatory sequences driving Gata1 expression in conventional dendritic cells (cDC)...
  21. pmc Thrombopoietin inhibits murine mast cell differentiation
    Fabrizio Martelli
    Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Stem Cells 26:912-9. 2008
    ....
  22. ncbi request reprint Molecular profiling of CD34+ cells in idiopathic myelofibrosis identifies a set of disease-associated genes and reveals the clinical significance of Wilms' tumor gene 1 (WT1)
    Paola Guglielmelli
    Department of Hematology, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy
    Stem Cells 25:165-73. 2007
    ....
  23. ncbi request reprint Protein kinase Calpha is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the (A)gamma globin-promoter in cellular models of hemoglobin switching
    Angela Di Baldassarre
    Department of Biomorphology, University of Chieti Pescara, Chieti, Italy
    J Cell Biochem 101:411-24. 2007
    ..These results suggest that different PKC isoforms may exert ontogenetic-specific functions in erythropoiesis and that modulation of PKCalpha might affect the activity of (A)gamma-promoter-driven reporters...
  24. ncbi request reprint Interleukin-3 and erythropoietin cooperate in the regulation of the expression of erythroid-specific transcription factors during erythroid differentiation
    Barbara Ghinassi
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Exp Hematol 35:735-47. 2007
    ..To characterize how interleukin-3 and erythropoietin regulate cell fate by modulating the expression of lineage-specific transcription factors...
  25. pmc Removal of the spleen in mice alters the cytokine expression profile of the marrow micro-environment and increases bone formation
    Fabrizio Martelli
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    Ann N Y Acad Sci 1176:77-86. 2009
    ..These results confirm the role of megakaryocytes as regulator of bone formation in mice and suggest that a cross-talk between the spleen and marrow may regulate the total numbers of hemopoietic niches present in an animal...
  26. pmc Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis
    Alessandro M Vannucchi
    Department of Hematology, University of Florence, Florence, Italy
    Am J Pathol 167:849-58. 2005
    ..We conclude that megakaryocytes from IM patients have reduced GATA-1 content, possibly contributing to disease pathogenesis as in the GATA-1(low) mice and also representing a novel IM-associated marker...
  27. ncbi request reprint Ex vivo amplification of T cells from human cord blood
    Anna Rita Migliaccio
    Laboratory of Clinical Biochemistry, Istituto Superiore di Sanita, Rome, Italy
    Pathol Biol (Paris) 53:151-8. 2005
    ..These ex vivo generated T cells resemble precursors for the lymphoid lineage present in adult bone marrow in terms of active transcription of RAG-2 and pTalpha...
  28. doi request reprint Compensated variability in the expression of globin-related genes in erythroblasts generated ex vivo from different donors
    Lilian Varricchio
    Istituto Superiore Sanita, Rome, Italy
    Transfusion 50:672-84. 2010
    ..Expression of balanced levels of globin mRNA is essential for normal red blood cell function and survival but it is unknown whether the expression of the globin genes in ex vivo expanded cells is balanced...
  29. ncbi request reprint Reflections on the European Union Eurythron Network Meeting "Molecular Control of Erythropoiesis," September 22-23, 2005, Istituto Superiore di Sanità, Rome, Italy
    Anna Rita Migliaccio
    Instituto Superore di Sanità, Rome, Italy
    Stem Cells 24:2478-82. 2006
    ....
  30. pmc Ex-vivo expansion of red blood cells: how real for transfusion in humans?
    Anna Rita Migliaccio
    The Tisch Cancer Institute and Myeloproliferative Disease Research Consortium MPD RC, Mount Sinai School of Medicine, New York, NY 10029, USA
    Blood Rev 26:81-95. 2012
    ..It is conceived that by the time these studies will be completed, technical barriers to mass cell production will have been eliminated making transfusion with ex-vivo generated red cells a reality...
  31. ncbi request reprint 5-azacytidine reactivates the erythroid differentiation potential of the myeloid-restricted murine cell line 32D Ro
    Marta Baiocchi
    Department of Hematology, Instituto Superiore Sanità, Rome, Italy
    Exp Cell Res 285:258-67. 2003
    ....
  32. pmc Concise review: stem cell-derived erythrocytes as upcoming players in blood transfusion
    Ann Zeuner
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Stem Cells 30:1587-96. 2012
    ..New technologies for ex vivo erythroid cell generation will hopefully provide alternative transfusion products to meet present and future clinical requirements...
  33. ncbi request reprint Expression of signal transduction proteins during the differentiation of primary human erythroblasts
    Viviana Di Giacomo
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore Sanita, Rome, Italy
    J Cell Physiol 202:831-8. 2005
    ....
  34. ncbi request reprint Spontaneous switch from Agamma- to beta-globin promoter activity in a stable transfected dual reporter vector
    Giovanni Migliaccio
    Gene and Cell Therapy, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Blood Cells Mol Dis 34:174-80. 2005
    ....
  35. pmc Characterization of the TGF-β1 signaling abnormalities in the Gata1low mouse model of myelofibrosis
    Maria Zingariello
    Department of Medicine, Campus Biomedico, and
    Blood 121:3345-63. 2013
    ..These data identify altered expression signatures of TGF-β1 signaling that may be responsible for MF in Gata1(low) mice and may represent additional targets for therapeutic intervention in PMF...
  36. pmc Phenotypic definition of the progenitor cells with erythroid differentiation potential present in human adult blood
    Valentina Tirelli
    Cell Biology and Neuroscience, Superior Health Institute, 00161 Rome, Italy
    Stem Cells Int 2011:602483. 2011
    ....
  37. ncbi request reprint In vitro mass production of human erythroid cells from the blood of normal donors and of thalassemic patients
    Giovanni Migliaccio
    Laboratory of Biochimica Clinica, Istituto Superiore Sanita, Rome, Italy
    Blood Cells Mol Dis 28:169-80. 2002
    ..Because of the high number of erythroid cells that are generated from modest volumes of blood, this method will prove useful in donor-specific studies of erythroid differentiation...
  38. pmc The potential of stem cells as an in vitro source of red blood cells for transfusion
    Anna Rita Migliaccio
    Tisch Cancer Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Stem Cell 10:115-9. 2012
    ..In this article, we summarize recent progress in producing RBCs from various cell sources, and discuss the hurdles that remain for translation into the clinical arena...
  39. ncbi request reprint Pericyte coverage of abnormal blood vessels in myelofibrotic bone marrows
    Eva Zetterberg
    Division of Hematology and Center for Inflammation and Hematology Research, Department of Medicine, The Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
    Haematologica 92:597-604. 2007
    ..Since pericyte abnormalities are described on solid tumor vessels we studied whether vessel morphology and pericyte coverage in bone marrow samples from patients with myelofibrosis differed from that in samples from controls...
  40. ncbi request reprint Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia
    Antonello Mai
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Universita degli Studi di Roma La Sapienza, Roma, Italy
    Mol Pharmacol 72:1111-23. 2007
    ..The low toxicity exerted by compounds 9 and 24 in all of the assays investigated suggests that these new HDAC inhibitors should be considered for personalized therapy of selected patients with beta(0) thalassemia...
  41. ncbi request reprint Impaired GATA-1 expression and myelofibrosis in an animal model
    Alessandro M Vannucchi
    UF di Ematologia, Az Osp Careggi, University of Florence, 50134 Florence, Italy
    Pathol Biol (Paris) 52:275-9. 2004
    ....
  42. ncbi request reprint Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1(low) mice)
    Alessandro Maria Vannucchi
    Department of Ematologia, University of Florence, Italy
    Blood 100:1123-32. 2002
    ..In conclusion, impaired GATA-1 expression may contribute to the development of myelofibrosis, and the GATA-1(low) mutants may represent a suitable animal model for the human disease that may shed light on its pathogenesis...
  43. ncbi request reprint Placental/umbilical cord blood for unrelated-donor bone marrow reconstitution: relevance of nucleated red blood cells
    Cladd E Stevens
    Wolf Szmuness Laboratory of Epidemiology, the F H Allen Laboratory of Immunogenetics, and the Laboratory of Hematopoietic Progenitors of the New York Blood Center, New York, NY 10021, USA
    Blood 100:2662-4. 2002
    ..The correlation between the number of NRBCs and the number of hematopoietic progenitor cells probably reflects the involvement of early stem cells in erythroid responses...
  44. ncbi request reprint Pathogenesis of myelofibrosis with myeloid metaplasia: lessons from mouse models of the disease
    Alessandro M Vannucchi
    Hematology Unit, University of Florence, AOC, Italy
    Semin Oncol 32:365-72. 2005
    ....
  45. pmc Histone deacetylase inhibitors and hemoglobin F induction in beta-thalassemia
    Anna Rita Migliaccio
    Division of Hematology Oncology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Int J Biochem Cell Biol 40:2341-7. 2008
    ....