G Matarese

Summary

Affiliation: Istituto di Endocrinologia e Oncologia Sperimentale
Country: Italy

Publications

  1. ncbi Balancing susceptibility to infection and autoimmunity: a role for leptin?
    Giuseppe Matarese
    Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via S Pansini 5, 80131, Napoli, Italy
    Trends Immunol 23:182-7. 2002
  2. ncbi Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation
    Mehdi Fazeli
    Division of Clinical Sciences North, University of Sheffield, Sheffield S5 7AU, UK
    J Immunol Methods 312:190-200. 2006
  3. ncbi Leptin and the immune system: how nutritional status influences the immune response
    G Matarese
    Laboratorio di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via S Pansini, 5 80131 Napoli, Italy
    Eur Cytokine Netw 11:7-14. 2000
  4. ncbi Leptin as a novel therapeutic target for immune intervention
    G Matarese
    Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via S Pansini, 5 80131 Napoli, Italy
    Curr Drug Targets Inflamm Allergy 1:13-22. 2002
  5. ncbi The intricate interface between immune system and metabolism
    Giuseppe Matarese
    Institute of Endocrinology Oncology Research, c o Department of Biology and Molecular Cellular Pathology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Trends Immunol 25:193-200. 2004
  6. pmc Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells
    Giuseppe Matarese
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 102:5150-5. 2005
  7. ncbi Leptin in autoimmunity: many questions, some answers
    G Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy
    Tissue Antigens 70:87-95. 2007
  8. ncbi Leptin and adipocytokines: bridging the gap between immunity and atherosclerosis
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli 80131, Italy
    Curr Pharm Des 13:3676-80. 2007
  9. doi Regulatory CD4 T cells: sensing the environment
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Italy
    Trends Immunol 29:12-7. 2008
  10. doi Leptin as a metabolic link to multiple sclerosis
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Via S Pansini 5, 80131 Napoli, Italy
    Nat Rev Neurol 6:455-61. 2010

Collaborators

Detail Information

Publications47

  1. ncbi Balancing susceptibility to infection and autoimmunity: a role for leptin?
    Giuseppe Matarese
    Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via S Pansini 5, 80131, Napoli, Italy
    Trends Immunol 23:182-7. 2002
    ....
  2. ncbi Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation
    Mehdi Fazeli
    Division of Clinical Sciences North, University of Sheffield, Sheffield S5 7AU, UK
    J Immunol Methods 312:190-200. 2006
    ..In conclusion, this study has identified a mAb to the human leptin receptor which inhibits leptin signalling and acts as a leptin antagonist in vitro...
  3. ncbi Leptin and the immune system: how nutritional status influences the immune response
    G Matarese
    Laboratorio di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via S Pansini, 5 80131 Napoli, Italy
    Eur Cytokine Netw 11:7-14. 2000
    ..According to this view, leptin might represent an important target for immune intervention in a variety of pathophysiological conditions...
  4. ncbi Leptin as a novel therapeutic target for immune intervention
    G Matarese
    Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via S Pansini, 5 80131 Napoli, Italy
    Curr Drug Targets Inflamm Allergy 1:13-22. 2002
    ..This review focuses on the potential therapeutic utilities for agents that manipulate the leptin-adipocyte axis and discusses novel strategies for an immune intervention in pathologic conditions...
  5. ncbi The intricate interface between immune system and metabolism
    Giuseppe Matarese
    Institute of Endocrinology Oncology Research, c o Department of Biology and Molecular Cellular Pathology, Federico II University of Naples, Via S Pansini 5, 80131 Naples, Italy
    Trends Immunol 25:193-200. 2004
    ....
  6. pmc Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells
    Giuseppe Matarese
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 102:5150-5. 2005
    ..These findings show an inverse relationship between leptin secretion and the frequency of T(Regs) in RRMS and may have implications for the pathogenesis of and therapy for multiple sclerosis...
  7. ncbi Leptin in autoimmunity: many questions, some answers
    G Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy
    Tissue Antigens 70:87-95. 2007
    ....
  8. ncbi Leptin and adipocytokines: bridging the gap between immunity and atherosclerosis
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli 80131, Italy
    Curr Pharm Des 13:3676-80. 2007
    ....
  9. doi Regulatory CD4 T cells: sensing the environment
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Italy
    Trends Immunol 29:12-7. 2008
    ....
  10. doi Leptin as a metabolic link to multiple sclerosis
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Via S Pansini 5, 80131 Napoli, Italy
    Nat Rev Neurol 6:455-61. 2010
    ..We also consider the translational implications of these new findings for improved management of MS...
  11. doi The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis?
    Giuseppe Matarese
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Via S Pansini 5, 80131, Napoli, Italy
    J Leukoc Biol 84:893-9. 2008
    ....
  12. doi Regulatory T cells in obesity: the leptin connection
    Giuseppe Matarese
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Napoli, Italy
    Trends Mol Med 16:247-56. 2010
    ..Here, we provide an update on recent findings relating Treg cells to obesity and discuss how the intricate network of interactions among leptin, Treg cells and adipose tissue might provide new strategies for therapeutic interventions...
  13. ncbi Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis
    G Matarese
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita degli Studi di Napoli Federico II, Italy
    J Clin Endocrinol Metab 85:2483-7. 2000
    ..These data suggest that the proinflammatory and neoangiogenic actions of leptin may contribute to the pathogenesis of endometriosis...
  14. ncbi Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease?
    Giuseppe Matarese
    Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli, Italy
    Trends Mol Med 9:223-8. 2003
    ..In this review, we focus on the multiple processes underlying the complex pathogenesis of endometriosis, with particular emphasis on the role played by the immune system with the induction of autoimmunity...
  15. ncbi Requirement for leptin in the induction and progression of autoimmune encephalomyelitis
    G Matarese
    Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli, Italy
    J Immunol 166:5909-16. 2001
    ..Our findings suggest that leptin is required for the induction and maintenance of an effective proinflammatory immune response in the CNS...
  16. ncbi Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males
    G Matarese
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, , Italy
    Eur J Immunol 31:1324-32. 2001
    ..Our findings indicate that leptin administration to susceptible females resulted in a more severe disease, and that reduced leptin levels in male SJL mice may contribute to the gender-related differences in the induction phase of EAE...
  17. ncbi The peritoneal fluid concentration of leptin is increased in women with peritoneal but not ovarian endometriosis
    G De Placido
    Dipartimento di Ginecologia e Ostetricia, Medicina della Riproduzione ed Endoscopia Ginecologica, Universita degli Studi di Napoli 'Federico II, Via Pansini 5, 80131, Napoli, Italy
    Hum Reprod 16:1251-4. 2001
    ..The data suggest that leptin may play a role in the development of peritoneal endometriosis, and that different biochemical phenomena might be involved in the pathogenesis of the ovarian form of the disease...
  18. pmc The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients
    D Montanaro
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, , Napoli, Italy
    Clin Exp Immunol 123:288-93. 2001
    ..Consequently, it appears that peptide 84-98, considered as a relevant autoantigen, is not implicated in the pathogenesis of MS in our population from southern Italy...
  19. ncbi Association of pelvic endometriosis with alopecia universalis, autoimmune thyroiditis and multiple sclerosis
    C Alviggi
    Department of Gynecological, Obstetric, and Urological Sciences and Medicine of Reproduction, Institute of Experimental Endocrinology and Oncology, National Research Council IEOS CNR, Napoli, Italy
    J Endocrinol Invest 29:182-9. 2006
    ....
  20. ncbi Modulation of CD45 tyrosine phosphatase activity by antigen
    F Lago Paz
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, , Naples, Italy
    Eur J Immunol 31:777-82. 2001
    ..Since the recruitment of CD4 is an initial step in the activation process, the inhibition of this pool of CD45 molecules would be crucial to prevent dephosphorylation of relevant substrates which promote the activation process...
  21. pmc Defective dendritic cell maturation in a child with nucleotide excision repair deficiency and CD4 lymphopenia
    L Racioppi
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, , Italy
    Clin Exp Immunol 126:511-8. 2001
    ..Overall, the results of our study suggest that a defective TFIIH complex might result in alterations in T cells and DC functions leading to a severe immunodeficiency...
  22. ncbi Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy
    G Matarese
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche and Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Roma, Italy
    Clin Endocrinol (Oxf) 57:643-6. 2002
    ....
  23. pmc Leptin in intestinal inflammation: good and bad gut feelings
    G Matarese
    Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli, Italy
    Gut 53:921-2. 2004
    ..Leptin has a the potent effect on T cell mediated intestinal autoimmunity and may have a role in the development of such diseases...
  24. ncbi The Yin and Yang of CD4(+) regulatory T cells in autoimmunity and cancer
    M Galgani
    Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Italy
    Curr Med Chem 16:4626-31. 2009
    ..Tregs play a key role in the mechanisms of immune tolerance and actively suppress pro-inflammatory responses, thus providing a beneficial action in autoimmunity and detrimental effects in cancer...
  25. ncbi Leptin in immunology
    Giuseppe Matarese
    Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia Sperimenttale, Consiglio Nazionale delle Ricerche, Naples, Italy
    J Immunol 174:3137-42. 2005
    ..We review herein recent advances on the role of leptin in the pathophysiology of immune responses...
  26. ncbi Immune phenotype and serum leptin in children with obesity-related liver disease
    Raffaele Iorio
    Department of Pediatrics, University of Naples Federico II, 80131 Naples, Italy
    J Clin Endocrinol Metab 91:341-4. 2006
    ..Little is known about pathogenesis of obesity-related liver disease in childhood. Data on the relationship among leptin, immunological parameters, and liver disease in obese children are lacking...
  27. pmc Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis
    Veronica De Rosa
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Naples, Italy
    J Clin Invest 116:447-55. 2006
    ..Taken together, our data provide what we believe is a new molecular basis for leptin antagonism in EAE and envision novel strategies of leptin-based molecular targeting in the disease...
  28. ncbi A key role of leptin in the control of regulatory T cell proliferation
    Veronica De Rosa
    Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, 80131 Napoli, Italy
    Immunity 26:241-55. 2007
    ..Together with the finding of enhanced proliferation of T(reg) cells observed in leptin- and ObR-deficient mice, these results suggest a potential for therapeutic interventions in immune and autoimmune diseases...
  29. ncbi Leptin accelerates autoimmune diabetes in female NOD mice
    Giuseppe Matarese
    Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli, Italy
    Diabetes 51:1356-61. 2002
    ..These findings indicate that leptin can favor proinflammatory cell responses and directly influence development of autoimmune disease mediated by Th1 responses...
  30. pmc Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses
    Veronica Sanna
    Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche IEOS CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Napoli, Italy
    J Clin Invest 111:241-50. 2003
    ..Given that leptin appears to regulate EAE susceptibility, inflammatory anorexia, and pathogenic T-cell immune function, we postulate that it may offer a potential target in the treatment of multiple sclerosis...
  31. ncbi Exon 6 and 2 peroxisome proliferator-activated receptor-gamma polymorphisms in polycystic ovary syndrome
    Francesco Orio
    Department of Molecular and Clinical Endocrinology and Oncology, University Federico II, 80131 Naples, Italy
    J Clin Endocrinol Metab 88:5887-92. 2003
    ....
  32. doi Divergent immunomodulatory effects of recombinant and urinary-derived FSH, LH, and hCG on human CD4+ T cells
    Fortunata Carbone
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy
    J Reprod Immunol 85:172-9. 2010
    ....
  33. ncbi High serum leptin in patients with chronic graft-versus-host disease after hematopoietic stem cell transplantation
    Libose Tauchmanovà
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Naples, Italy
    Transplantation 78:1376-83. 2004
    ..Increased serum leptin has been described after various organ transplants, with a mechanism that is still unclear...
  34. ncbi Leptin: the prototypic adipocytokine and its role in NAFLD
    Claudio Procaccini
    Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale, delle Ricerche IEOS CNR, Via S Pansini, 5 80131 Naples, Italy
    Curr Pharm Des 16:1902-12. 2010
    ....
  35. doi Cellular and molecular crosstalk between leptin receptor and estrogen receptor-{alpha} in breast cancer: molecular basis for a novel therapeutic setting
    Roberta Fusco
    Dipartimento di Biologia Strutturale e Funzionale, Universita di Napoli Federico II, Naples, Italy
    Endocr Relat Cancer 17:373-82. 2010
    ..In conclusion, this study suggests a crosstalk between LepR and ERalpha, and could envisage novel therapeutic settings aimed at targeting the LepR in breast cancers...
  36. ncbi The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis
    Giovanni Frisullo
    Istituto di Neurologia, Dipartimento di Neuroscienze, Universita Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168 Roma, Italy
    J Neuroimmunol 192:174-83. 2007
    ..Our data suggest that ObR may be involved in the development of clinical relapses in RRMS patients and suggest a rationale for potential targeting of the leptin axis during MS...
  37. ncbi Leptin-based immune intervention: current status and future directions
    Antonio La Cava
    Department of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32 59, Los Angeles, CA 90095 1670, USA
    Curr Opin Investig Drugs 4:1327-32. 2003
    ..This review presents current preclinical evidence and potential applications for leptin-based immune approaches aimed at improving therapy for chronic and autoimmune conditions...
  38. pmc Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor
    I Sadaf Farooqi
    Cambridge Institute for Medical Research, University Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 356:237-47. 2007
    ..A single family has been described in which obesity results from a mutation in the leptin-receptor gene (LEPR), but the prevalence of such mutations in severe, early-onset obesity has not been systematically examined...
  39. pmc Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
    I Sadaf Farooqi
    University Department of Medicine, Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Invest 110:1093-103. 2002
    ..The subcutaneous administration of recombinant human leptin has major and sustained beneficial effects on the multiple phenotypic abnormalities associated with congenital human leptin deficiency...
  40. ncbi The weight of leptin in immunity
    Antonio La Cava
    Autoimmunity and Tolerance Laboratory, Department of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32 59, Los Angeles, California 90095 1670, USA
    Nat Rev Immunol 4:371-9. 2004
    ..Here, we review the advances and controversy for a role of leptin in the pathophysiology of immune responses...
  41. ncbi Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines
    Graham M Lord
    Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    J Leukoc Biol 72:330-8. 2002
    ..However, despite this inhibition of proliferation, the production of proinflammatory cytokines is significantly enhanced by leptin. The findings demonstrated here show further complexity in the actions of leptin on the immune system...
  42. ncbi Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis
    Anna Maria Malfitano
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, via Ponte Don Melillo 84084 Fisciano Salerno, Italy
    J Neuroimmunol 171:110-9. 2006
    ..Our findings have relevance for the use of arvanil and related compounds as a novel immunotherapeutic approach in the treatment of multiple sclerosis...
  43. ncbi A key regulatory role for histamine in experimental autoimmune encephalomyelitis: disease exacerbation in histidine decarboxylase-deficient mice
    Silvia Musio
    Immunology and Muscular Pathology Unit, National Neurological Institute C Besta, Milan, Italy
    J Immunol 176:17-26. 2006
    ..Understanding which receptor(s) for histamine is/are involved in regulating autoimmunity against the CNS might help in the development of new strategies of treatment for EAE and multiple sclerosis...
  44. pmc Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans
    Jean L Chan
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:8481-6. 2006
    ..Studies involving more severe and/or chronic leptin deficiency are needed to precisely define the lower limit of normal leptin levels for each of leptin's physiologic targets...
  45. ncbi Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice
    Elizabeth Papathanassoglou
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 176:7745-52. 2006
    ..Taken together, our data further support the notion that nutritional status acting via leptin-dependent mechanisms may alter the nature and vigor of the immune response...
  46. ncbi Unraveling the multiple roles of leptin in inflammation and autoimmunity
    Antonio La Cava
    Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
    J Mol Med (Berl) 82:4-11. 2004
    ..This review focuses on the multiple roles of leptin in chronic inflammation and autoimmunity and suggests new possible therapeutic implications for leptin modulators...
  47. ncbi From cannabis to endocannabinoids in multiple sclerosis: a paradigm of central nervous system autoimmune diseases
    Anna Maria Malfitano
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano SA, Italy
    Curr Drug Targets CNS Neurol Disord 4:667-75. 2005
    ....