Serge Masson

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi High-sensitivity cardiac troponin T for detection of subtle abnormalities of cardiac phenotype in a general population of elderly individuals
    S Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Intern Med 273:306-17. 2013
  2. ncbi Serial measurement of cardiac troponin T using a highly sensitive assay in patients with chronic heart failure: data from 2 large randomized clinical trials
    Serge Masson
    Department of Cardiovascular Research, Istituto Mario Negri, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Circulation 125:280-8. 2012
  3. ncbi Prevalence and prognostic value of elevated urinary albumin excretion in patients with chronic heart failure: data from the GISSI-Heart Failure trial
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circ Heart Fail 3:65-72. 2010
  4. doi The predictive value of stable precursor fragments of vasoactive peptides in patients with chronic heart failure: data from the GISSI-heart failure (GISSI-HF) trial
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan, Italy
    Eur J Heart Fail 12:338-47. 2010
  5. doi An update on cardiac troponins as circulating biomarkers in heart failure
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156, Milan, Italy
    Curr Heart Fail Rep 7:15-21. 2010
  6. doi Adiponectin in chronic heart failure: influence of diabetes and genetic variants
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur J Clin Invest 41:1330-8. 2011
  7. ncbi Clinical, neurohormonal, and inflammatory markers and overall prognostic role of chronic obstructive pulmonary disease in patients with heart failure: data from the Val-HeFT heart failure trial
    Lidia Staszewsky
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Card Fail 13:797-804. 2007
  8. ncbi Direct comparison of B-type natriuretic peptide (BNP) and amino-terminal proBNP in a large population of patients with chronic and symptomatic heart failure: the Valsartan Heart Failure (Val-HeFT) data
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Clin Chem 52:1528-38. 2006
  9. ncbi Cardiovascular oxidative stress is reduced by an ACE inhibitor in a rat model of streptozotocin-induced diabetes
    Fabio Fiordaliso
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Life Sci 79:121-9. 2006
  10. ncbi Incremental prognostic value of changes in B-type natriuretic peptide in heart failure
    Roberto Latini
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Am J Med 119:70.e23-30. 2006

Detail Information

Publications39

  1. ncbi High-sensitivity cardiac troponin T for detection of subtle abnormalities of cardiac phenotype in a general population of elderly individuals
    S Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Intern Med 273:306-17. 2013
    ..To investigate the association between circulating cardiac biomarkers and minor abnormalities in cardiac phenotype [left ventricular (LV) mass and midwall fractional shortening (MFS)] in elderly individuals in a general population sample...
  2. ncbi Serial measurement of cardiac troponin T using a highly sensitive assay in patients with chronic heart failure: data from 2 large randomized clinical trials
    Serge Masson
    Department of Cardiovascular Research, Istituto Mario Negri, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Circulation 125:280-8. 2012
    ..We determined the association between changes over time in hs-cTnT and outcome in patients with chronic HF...
  3. ncbi Prevalence and prognostic value of elevated urinary albumin excretion in patients with chronic heart failure: data from the GISSI-Heart Failure trial
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circ Heart Fail 3:65-72. 2010
    ..There is, however, only limited information on the prevalence and prognostic role of urinary albumin excretion in patients with established chronic heart failure...
  4. doi The predictive value of stable precursor fragments of vasoactive peptides in patients with chronic heart failure: data from the GISSI-heart failure (GISSI-HF) trial
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan, Italy
    Eur J Heart Fail 12:338-47. 2010
    ..We measured the plasma concentrations of four stable precursor fragments of neurohormonal systems in patients with chronic HF and evaluated their relationship with outcome...
  5. doi An update on cardiac troponins as circulating biomarkers in heart failure
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156, Milan, Italy
    Curr Heart Fail Rep 7:15-21. 2010
    ..In the absence of further experimental evidences, the pathophysiologic basis for the elevation of circulating cardiac troponins in patients with stable chronic heart failure remains speculative...
  6. doi Adiponectin in chronic heart failure: influence of diabetes and genetic variants
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur J Clin Invest 41:1330-8. 2011
    ..We also assessed the influence of these confounders on the prognostic value of adiponectin...
  7. ncbi Clinical, neurohormonal, and inflammatory markers and overall prognostic role of chronic obstructive pulmonary disease in patients with heart failure: data from the Val-HeFT heart failure trial
    Lidia Staszewsky
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Card Fail 13:797-804. 2007
    ..Because little information is available about the population of patients with both syndromes, we assessed the characteristics and the independent contribution of COPD to outcomes in patients with stable chronic heart failure...
  8. ncbi Direct comparison of B-type natriuretic peptide (BNP) and amino-terminal proBNP in a large population of patients with chronic and symptomatic heart failure: the Valsartan Heart Failure (Val-HeFT) data
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Clin Chem 52:1528-38. 2006
    ..This work aimed to provide a direct comparison of the prognostic value of BNP and NT-proBNP in patients with chronic and stable HF...
  9. ncbi Cardiovascular oxidative stress is reduced by an ACE inhibitor in a rat model of streptozotocin-induced diabetes
    Fabio Fiordaliso
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Life Sci 79:121-9. 2006
    ..The absence of an additive effect, suggests a common mechanism of action, through the reduction of oxidative stress...
  10. ncbi Incremental prognostic value of changes in B-type natriuretic peptide in heart failure
    Roberto Latini
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Am J Med 119:70.e23-30. 2006
    ..We hypothesized that B-type natriuretic peptide changes during treatment of heart failure may provide independent information on disease progression and outcome in patients enrolled in the Val-HeFT trial...
  11. ncbi Effect of beta-adrenergic and renin-angiotensin system blockade on myocyte apoptosis and oxidative stress in diabetic hypertensive rats
    Fabio Fiordaliso
    Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Life Sci 81:951-9. 2007
    ..In conclusion, hypertensive rat is no more susceptible than its normotensive control to acute apoptosis induced by diabetes. Oxidative stress might be considered the common trigger for cardiac myocyte apoptosis in both conditions...
  12. ncbi The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT
    Roberto Latini
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur Heart J 25:292-9. 2004
    ..Mainly because of small sample size, the predictive value of different NH has never been compared, while taking into account demographic, clinical and echocardiographic markers of risk in HF...
  13. doi Left atrial remodeling and response to valsartan in the prevention of recurrent atrial fibrillation: the GISSI-AF echocardiographic substudy
    Lidia Staszewsky
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circ Cardiovasc Imaging 4:721-8. 2011
    ..Angiotensin receptor blockers were proposed for reversing LA remodeling. We evaluated the effect of valsartan on LA remodeling in patients with a recent episode of AF and the effect of LA size on AF recurrence (AFr)...
  14. ncbi Neurohormonal modulation in heart failure of ischemic etiology: correlates with left ventricular remodeling
    Roberto Latini
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Curr Heart Fail Rep 3:157-63. 2006
    ..Whether knowledge of biomarkers' concentration can improve the clinical outcome of patients with HF by helping in guiding and monitoring their therapy treatment is a stimulating working hypothesis still to be verified...
  15. ncbi The prognostic value of big endothelin-1 in more than 2,300 patients with heart failure enrolled in the Valsartan Heart Failure Trial (Val-HeFT)
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Card Fail 12:375-80. 2006
    ..Here, we examined its prognostic value in a large population of patients with chronic heart failure...
  16. doi Elevated plasma renin activity predicts adverse outcome in chronic heart failure, independently of pharmacologic therapy: data from the Valsartan Heart Failure Trial (Val-HeFT)
    Serge Masson
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Card Fail 16:964-70. 2010
    ..We evaluated the association between PRA and outcome in patients with chronic HF treated with ACEi and beta-blockers...
  17. doi Predictors of mortality in 6975 patients with chronic heart failure in the Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico-Heart Failure trial: proposal for a nomogram
    Simona Barlera
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circ Heart Fail 6:31-9. 2013
    ..We developed a prognostic model to assess the risk of all-cause mortality in patients with chronic heart failure...
  18. ncbi Effects of valsartan on circulating brain natriuretic peptide and norepinephrine in symptomatic chronic heart failure: the Valsartan Heart Failure Trial (Val-HeFT)
    Roberto Latini
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circulation 106:2454-8. 2002
    ..The long-term effects of angiotensin receptor blockers on BNP and NE in heart failure patients are not known...
  19. doi Prognostic value of changes in N-terminal pro-brain natriuretic peptide in Val-HeFT (Valsartan Heart Failure Trial)
    Serge Masson
    Department of Cardiovascular Reearch, Istituto Mario Negri, Milan, Italy
    J Am Coll Cardiol 52:997-1003. 2008
    ..This study sought to evaluate the association between changes over time of N-terminal pro-brain natriuretic peptide (NT-proBNP) expressed in different ways and outcome in patients with stable and chronic heart failure (HF)...
  20. ncbi Valsartan for the treatment of heart failure
    Roberto Latini
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche, Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Expert Opin Pharmacother 5:181-93. 2004
    ....
  21. ncbi Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure
    Roberto Latini
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circulation 116:1242-9. 2007
    ..We assessed the prognostic value of circulating cardiac troponin T in patients with stable chronic HF with a traditional (cTnT) and a new precommercial highly sensitive assay (hsTnT)...
  22. ncbi Antioxidant treatment attenuates hyperglycemia-induced cardiomyocyte death in rats
    Fabio Fiordaliso
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    J Mol Cell Cardiol 37:959-68. 2004
    ..NAC effectively protects from hyperglycemia-induced myocyte cell death and compensatory hypertrophy through direct scavenging of ROS and replenishment of the intracellular glutathione content...
  23. ncbi Significance of measurable cardiac troponin by high-sensitivity assays in patients with chronic stable heart failure
    Roberto Latini
    Department of Cardiovascular Research, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Coron Artery Dis 24:716-9. 2013
    ....
  24. ncbi Pentraxin-3 in chronic heart failure: the CORONA and GISSI-HF trials
    Roberto Latini
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Eur J Heart Fail 14:992-9. 2012
    ..Since the role of inflammation in the progression of chronic heart failure (HF) is debated, we investigated the prognostic value of PTX3 and the effect of a statin in two large populations of patients with HF...
  25. ncbi Role of brain natriuretic peptide in the diagnosis and management of heart failure: current concepts
    Roberto Latini
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Card Fail 8:288-99. 2002
    ..Brain natriuretic peptide (BNP), a member of the natriuretic peptide family, has recently emerged as an important neurohormone in the pathophysiology of heart failure...
  26. ncbi Eplerenone, a selective aldosterone blocker, improves diastolic function in aged rats with small-to-moderate myocardial infarction
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Card Fail 10:433-41. 2004
    ..05). Eplerenone normalized echocardiographic and hemodynamic evidences of diastolic dysfunction, as well as myocardial interstitial collagen and aortic fibrosis (all parameters statistically different from untreated MI)...
  27. doi Amino-terminal pro-B-type natriuretic peptides and prognosis in chronic heart failure
    Serge Masson
    Department of Cardiovascular Research, Laboratory of Cardiovascular Clinical Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Am J Cardiol 101:56-60. 2008
    ..Thus, serial assessment of NT-proBNP is valuable for prognostication in chronic HF in outpatients, and, as such, a measurement at each patient visit or the following of changes in clinical stability is recommended...
  28. ncbi Appraisal of the role of angiotensin II and aldosterone in ventricular myocyte apoptosis in adult normotensive rat
    Noeleen De Angelis
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri Milan, Italy
    J Mol Cell Cardiol 34:1655-65. 2002
    ....
  29. ncbi In vivo cardioprotection by N-acetylcysteine and isosorbide 5-mononitrate in a rat model of ischemia-reperfusion
    Laura Calvillo
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milano
    Cardiovasc Drugs Ther 17:199-208. 2003
    ..We evaluated the effect of N-acetylcysteine (NAC, infused i.v.), isosorbide 5-mononitrate (IS5MN, by gavage), or their combination on cardiac injury in an in vivo rat model of 30-min ischemia followed by 24 hours or 7 days of reperfusion...
  30. doi Plasma n-3 polyunsaturated fatty acids in chronic heart failure in the GISSI-Heart Failure Trial: relation with fish intake, circulating biomarkers, and mortality
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Am Heart J 165:208-15.e4. 2013
    ..Circulating levels of n-3 PUFA, an objective estimation of exposure, have never been measured in a large cohort of patients with HF...
  31. ncbi Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension
    Vanessa Zambelli
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano MI, Italy
    Eur J Pharmacol 667:287-91. 2011
    ..Aminaftone may represent a novel treatment strategy of pulmonary hypertension...
  32. ncbi Predicting atrial fibrillation recurrence with circulating inflammatory markers in patients in sinus rhythm at high risk for atrial fibrillation: data from the GISSI atrial fibrillation trial
    Serge Masson
    Department of Cardiovascular Research, Istituto Mario Negri, Via Giuseppe La Masa 19, Milan, Italy
    Heart 96:1909-14. 2010
    ..Inflammation may play a significant role in the pathogenesis of atrial fibrillation (AF)...
  33. ncbi Levels of circulating pro-angiogenic cells predict cardiovascular outcomes in patients with chronic heart failure
    Giovanna Balconi
    Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milano, Italy
    J Card Fail 15:747-55. 2009
    ..A low level of PACs is associated with worse outcome in patients with coronary heart disease. However, little is known about PACs in heart failure (HF)...
  34. ncbi Comparative measurement of N-terminal pro-brain natriuretic peptide and brain natriuretic peptide in ambulatory patients with heart failure
    Serge Masson
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Clin Chem Lab Med 40:761-3. 2002
    ..16 pM, ratio 24) and NT-proBNP (1306 vs. 57 pM, ratio 23). We conclude that N-terminal proBNP, as assayed in the present study, correlates equally to BNP with clinical variables in patients with heart failure...
  35. ncbi Hydroxytyrosol attenuates peripheral neuropathy in streptozotocin-induced diabetes in rats
    Giuseppe Ristagno
    Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy
    J Agric Food Chem 60:5859-65. 2012
    ..05). The present study provides evidence of the therapeutic potential of the natural substance hydroxytyrosol in the early stage of diabetic neuropathy. ..
  36. ncbi Myocardial infarction: animal models
    Stefano Chimenti
    Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Methods Mol Med 98:217-26. 2004
    ..Moreover, this model allows testing of the protective effects of anti-inflammatory drugs in experimental myocardial infarction...
  37. ncbi Biomarkers of myocyte injury in heart failure
    Roberto Latini
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Heart Fail Clin 5:529-36. 2009
    ..The advent of a new generation of high-sensitivity immunoassays for cardiac troponins offers challenges for scientists and clinicians and will likely change the understanding and interpretation of cardiac injury...
  38. doi Early kynurenine pathway activation following cardiac arrest in rats, pigs, and humans
    Giuseppe Ristagno
    Department of Cardiovascular Research, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy Electronic address
    Resuscitation 84:1604-10. 2013
    ..In the present study, TRP and KP metabolites concentrations were measured in plasma from rats, pigs and humans after cardiac arrest (CA) in order to assess KP activation and its potential role in post-resuscitation outcome...
  39. doi Natriuretic peptides in acute chest pain and acute coronary syndrome: from pathophysiology to clinical and prognostic applications
    Nadia Aspromonte
    Cardiovascular Department, San Filippo Neri Hospital, Rome, Italy
    Coron Artery Dis 24:33-9. 2013
    ..Plasma levels of natriuretic peptides (NPs) appear to have an important prognostic value in many clinical settings including coronary artery disease and provide additional information about cardiovascular risk...