Maura Massimino

Summary

Affiliation: Istituto Nazionale Tumori
Country: Italy

Publications

  1. doi Diffuse pontine gliomas in children: changing strategies, changing results? A mono-institutional 20-year experience
    Maura Massimino
    Pediatric Oncology Unit, Fondazione IRRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    J Neurooncol 87:355-61. 2008
  2. ncbi Results of nimotuzumab and vinorelbine, radiation and re-irradiation for diffuse pontine glioma in childhood
    Maura Massimino
    Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori INT, Via Venezian 1, 20133, Milano, Italy
    J Neurooncol 118:305-12. 2014
  3. pmc Case report: long-term survival of an infant syndromic patient affected by atypical teratoid-rhabdoid tumor
    Piergiorgio Modena
    Unit of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, 33081, Italy
    BMC Cancer 13:100. 2013
  4. doi Histological variants of medulloblastoma are the most powerful clinical prognostic indicators
    Maura Massimino
    Department of Pediatrics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Pediatr Blood Cancer 60:210-6. 2013
  5. doi Long-term results of combined preradiation chemotherapy and age-tailored radiotherapy doses for childhood medulloblastoma
    Maura Massimino
    Pediatric Oncology Unit, Fondazione IRCCS, Istituto Nazionale Tumori, Via Venezian, 1 20133, Milan, Italy
    J Neurooncol 108:163-71. 2012
  6. pmc Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts
    David W Ellison
    Dept, of Pathology, St, Jude Children s Research Hospital, Memphis, USA
    J Negat Results Biomed 10:7. 2011
  7. doi Second-look surgery for ependymoma: the Italian experience
    Maura Massimino
    Pediatric Unit, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico IRCCS Istituto Nazionale Tumori, Milano, Italy
    J Neurosurg Pediatr 8:246-50. 2011
  8. pmc Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma
    Maura Massimino
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    Neuro Oncol 7:41-8. 2005
  9. doi No salvage using high-dose chemotherapy plus/minus reirradiation for relapsing previously irradiated medulloblastoma
    Maura Massimino
    Division of Pediatrics, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 73:1358-63. 2009
  10. ncbi Conservative surgical approach for thyroid and lymph-node involvement in papillary thyroid carcinoma of childhood and adolescence
    Maura Massimino
    Unit of Pediatrics, Istituto Nazionale Tumori, Milan, Italy
    Pediatr Blood Cancer 46:307-13. 2006

Detail Information

Publications101 found, 100 shown here

  1. doi Diffuse pontine gliomas in children: changing strategies, changing results? A mono-institutional 20-year experience
    Maura Massimino
    Pediatric Oncology Unit, Fondazione IRRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    J Neurooncol 87:355-61. 2008
    ..Despite improved diagnostic, therapeutic, and supportive tools in pediatric neuro-oncology, little has been achieved for patients with diffuse pontine tumors...
  2. ncbi Results of nimotuzumab and vinorelbine, radiation and re-irradiation for diffuse pontine glioma in childhood
    Maura Massimino
    Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori INT, Via Venezian 1, 20133, Milano, Italy
    J Neurooncol 118:305-12. 2014
    ..One-year PFS and OS rates were 30 ± 10 % and 76 ± 9 %, respectively; 2-year OS was 27 ± 9 %; the median PFS and OS were 8.5 and 15 months, respectively. This strategy generated interesting results and warrants further investigation...
  3. pmc Case report: long-term survival of an infant syndromic patient affected by atypical teratoid-rhabdoid tumor
    Piergiorgio Modena
    Unit of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, 33081, Italy
    BMC Cancer 13:100. 2013
    ..A consistent fraction of cases carries de-novo SMARCB1/INI1 constitutional mutations in the setting of the "rhabdoid tumor predisposition syndrome" and the outcome is worst in infant syndromic ATRT patients...
  4. doi Histological variants of medulloblastoma are the most powerful clinical prognostic indicators
    Maura Massimino
    Department of Pediatrics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Pediatr Blood Cancer 60:210-6. 2013
    ..We centrally reviewed medulloblastoma cases from past 10 years reassessing their histology to ascertain its prognostic significance...
  5. doi Long-term results of combined preradiation chemotherapy and age-tailored radiotherapy doses for childhood medulloblastoma
    Maura Massimino
    Pediatric Oncology Unit, Fondazione IRCCS, Istituto Nazionale Tumori, Via Venezian, 1 20133, Milan, Italy
    J Neurooncol 108:163-71. 2012
    ....
  6. pmc Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts
    David W Ellison
    Dept, of Pathology, St, Jude Children s Research Hospital, Memphis, USA
    J Negat Results Biomed 10:7. 2011
    ....
  7. doi Second-look surgery for ependymoma: the Italian experience
    Maura Massimino
    Pediatric Unit, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico IRCCS Istituto Nazionale Tumori, Milano, Italy
    J Neurosurg Pediatr 8:246-50. 2011
    ..Second-look surgery for tumor remnants may be less harmful and enable complete removal. There is a potential, although still unclear, role for neoadjuvant chemotherapy in preparation for further surgery...
  8. pmc Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma
    Maura Massimino
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    Neuro Oncol 7:41-8. 2005
    ..Sequential and high-dose chemotherapy can be afforded in front-line therapy of childhood malignant glioma without excessive morbidity and rather encouraging results...
  9. doi No salvage using high-dose chemotherapy plus/minus reirradiation for relapsing previously irradiated medulloblastoma
    Maura Massimino
    Division of Pediatrics, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 73:1358-63. 2009
    ..Myeloablative regimens were frequently used for medulloblastoma relapsing after craniospinal irradiation (CSI): in 1997-2002, we used repeated surgery, standard-dose and myeloablative chemotherapy, and reirradiation...
  10. ncbi Conservative surgical approach for thyroid and lymph-node involvement in papillary thyroid carcinoma of childhood and adolescence
    Maura Massimino
    Unit of Pediatrics, Istituto Nazionale Tumori, Milan, Italy
    Pediatr Blood Cancer 46:307-13. 2006
    ..The aim of this study is to outline the possibility of a conservative approach (hemithyroidectomy plus selective neck dissection of clinically involved nodes, followed by TSH-suppressive therapy) in a selected group of patients...
  11. doi TSH suppression as a possible means of protection against hypothyroidism after irradiation for childhood Hodgkins lymphoma
    Maura Massimino
    Pediatrics Unit, Fondazione IRCCS, Istituto Nazionale Tumori, Milano, Italy
    Pediatr Blood Cancer 57:166-8. 2011
    ..009). TSH suppression could have a protective effect on thyroid function as shown in a small group of patients with HL...
  12. ncbi Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy
    Maura Massimino
    Neuro Oncology Functional Unit, Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 64:1031-7. 2006
    ..Supratentorial primitive neuroectodermal tumors (S-PNET) are rare and have a grim prognosis, frequently taking an aggressive course with local relapse and metastatic spread. We report the results of a mono-institutional therapeutic trial...
  13. doi Infant ependymoma in a 10-year AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) experience with omitted or deferred radiotherapy
    Maura Massimino
    Department of Pediatrics, Fondazione IRCCS, Istituto Nazionale Tumori, Milano, Italy
    Int J Radiat Oncol Biol Phys 80:807-14. 2011
    ..We treated 41 children under the age of 3 years with intracranial ependymoma between 1994 and 2003...
  14. ncbi Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor
    Maura Massimino
    Department of Pediatrics, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 69:404-10. 2007
    ..Hence, our study was launched in 1998 to evaluate the protective effect of TSH suppression during CSI for medulloblastoma/primitive neuroectodermal tumor...
  15. doi Nimotuzumab for pediatric diffuse intrinsic pontine gliomas
    Maura Massimino
    Pediatric Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian, 1 20133 Milano, Italy
    Expert Opin Biol Ther 11:247-56. 2011
    ..So far, no improvement has been achieved with the addition of single/poly-chemotherapy regimens. An urgent need is to advance in this field, from both the biological and the clinical points of view...
  16. ncbi Use of high-dose chemotherapy in front-line therapy of childhood malignant glioma
    Maura Massimino
    Pediatric Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy
    Expert Rev Anticancer Ther 6:709-17. 2006
    ..New protocols under evaluation include new agents with specific biological targets, multiple cycles of high-dose chemotherapy, and vaccination, as an immunotherapeutic approach...
  17. ncbi Transitory, spontaneously recovering, peripheral facial nerve palsy after vinorelbine administration
    M Massimino
    Neuro Oncology Functional Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, I 20133, Milan, Italy
    Neurol Sci 27:110-3. 2006
    ..We describe possible neurological and oncological implications of this unusual side effect, until now not reported in any other series dealing with vinorelbine as adjuvant treatment...
  18. ncbi Unusual primary secreting germ cell tumor of the spine. Case report
    Maura Massimino
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan Italy
    J Neurosurg Spine 5:65-7. 2006
    ..The occurrence of this rare tumor located primarily in the spine warrants attention in pathological studies of spinal tumors in young patients...
  19. doi A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma
    Maura Massimino
    Division of Paediatrics, Fond IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133, Milan, Italy
    J Neurooncol 100:65-71. 2010
    ..023), with three-year PFS and OS rates of 70 and 100%, respectively. Lower doses of cisplatin/etoposide are still effective in progressive low-grade glioma, with less acute and persistent morbidity...
  20. ncbi Hyperfractionated radiotherapy and chemotherapy for childhood ependymoma: final results of the first prospective AIEOP (Associazione Italiana di Ematologia-Oncologia Pediatrica) study
    Maura Massimino
    Department of Pediatric Oncology, Istituto Nazionale Tumori, Milano, Italy
    Int J Radiat Oncol Biol Phys 58:1336-45. 2004
    ..A postsurgical "stage-based" protocol for ependymoma was designed...
  21. doi Is there a role for myeloablative chemotherapy with autologous hematopoietic cell rescue in the management of childhood high-grade astrocytomas?
    Maura Massimino
    Pediatric Neuro Oncology at Pediatrics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Pediatr Blood Cancer 54:641-3. 2010
    ..It is, however, still doubtful if better responses translate into improved outcome and which patients can have a true beneficial from this treatment strategy...
  22. ncbi Thyroid iatrogenic sequelae after the treatment of pediatric cancer
    M Massimino
    Department of Pediatrics, IRCCS Foundation, National Cancer Institute, Milan, Italy
    Q J Nucl Med Mol Imaging 53:526-35. 2009
    ....
  23. ncbi Salvage treatment for childhood ependymoma after surgery only: Pitfalls of omitting "at once" adjuvant treatment
    Maura Massimino
    Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 65:1440-5. 2006
    ..To discuss the results obtained by giving adjuvant treatment for childhood ependymoma (EPD) at relapse after complete surgery only...
  24. ncbi Radiation-induced thyroid changes: a retrospective and a prospective view
    Maura Massimino
    Department of Medical Oncology, Paediatrics Unit, Istituto Nazionale Tumori, Via Venezian, 1, Milan 20133, Italy
    Eur J Cancer 45:2546-51. 2009
    ..Increasing numbers of children are being cured of cancers by treatments that include radiation also involving the thyroid bed: these children warrant an early diagnosis and treatment of any radiation-related thyroid changes...
  25. doi Hyperfractionated accelerated radiotherapy in the Milan strategy for metastatic medulloblastoma
    Lorenza Gandola
    Radiotherapy Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milano, Italy
    J Clin Oncol 27:566-71. 2009
    ..With a view to improving the prognosis for patients with metastatic medulloblastoma, we tested the efficacy and toxicity of a hyperfractionated accelerated radiotherapy (HART) regimen delivered after intensive sequential chemotherapy...
  26. doi Evolving of therapeutic strategies for CNS-PNET
    Maura Massimino
    Department of Pediatrics, Fond IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Pediatr Blood Cancer 60:2031-5. 2013
    ..Efforts were subsequently made to improve the prognosis and to de-escalate the treatment for selected patient groups...
  27. ncbi Survival of adults treated for medulloblastoma using paediatric protocols
    Filippo Spreafico
    Paediatric Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Eur J Cancer 41:1304-10. 2005
    ....
  28. ncbi Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumors
    Filippo Spreafico
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 70:1011-9. 2008
    ..Brain necrosis or other subacute iatrogenic reactions has been recognized as a potential complication of radiotherapy (RT), although the possible synergistic effects of high-dose chemotherapy and RT might have been underestimated...
  29. ncbi Papillary thyroid carcinoma of childhood and adolescence: a 30-year experience at the Istituto Nazionale Tumori in Milan
    Paola Collini
    Department of Anatomical Pathology, Istituto Nazionale Tumori, Milan, Italy
    Pediatr Blood Cancer 46:300-6. 2006
    ..The aim of this study was to verify this assumption in a single-institution series spanning a 30-year period with a very long follow-up...
  30. ncbi Evolving treatment strategies for parameningeal rhabdomyosarcoma: the experience of the Istituto Nazionale Tumori of Milan
    Cristina Meazza
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milano MI, Italy
    Head Neck 27:49-57. 2005
    ..Ninety pediatric patients with parameningeal rhabdomyosarcoma (PM-RMS) were treated between 1970 and 2002 at the Istituto Nazionale Tumori, Milan...
  31. ncbi Adult-type soft tissue sarcomas in pediatric-age patients: experience at the Istituto Nazionale Tumori in Milan
    Andrea Ferrari
    Pediatric Oncology Unit, Department of Pathology, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milano, Italy
    J Clin Oncol 23:4021-30. 2005
    ..We report on a large group of 182 patients younger than 18 years old treated at a single institution over a 25-year period...
  32. ncbi Intensive, very short-term chemotherapy for advanced Burkitt's lymphoma in children
    Filippo Spreafico
    Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 20:2783-8. 2002
    ..To improve the 63% event-free survival (EFS) achieved before 1986 in Murphy's stage III to IV Burkitt's lymphoma (BL), both chemotherapy and supportive care were intensified...
  33. doi Comparison of the prognostic value of assessing tumor diameter versus tumor volume at diagnosis or in response to initial chemotherapy in rhabdomyosarcoma
    Andrea Ferrari
    Pediatric Oncology Unit, Division of Medical Statistics and Biometry, Radiology and Radiotherapy Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 28:1322-8. 2010
    ....
  34. ncbi Clinical experience with psychological aspects in pediatric patients amputated for malignancies
    Carlo Alfredo Clerici
    Pediatric Oncology Unit, Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 90:399-404. 2004
    ..Studies addressing the psychological aspects of limb amputation in childhood cancer are still relatively limited, and the results have sometimes been contradictory...
  35. ncbi [Adolescents with cancer: the "Youth Project" at the Istituto Nazionale Tumori in Milan]
    Andrea Ferrari
    Struttura Complessa di Oncologia Pediatrica, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
    Recenti Prog Med 104:10-6. 2013
    ..The paper also describes the activity of the Adolescent Commission established by the Italian Pediatric Hematology Oncology (AIEOP)...
  36. doi The Youth Project at the Istituto Nazionale Tumori in Milan
    Andrea Ferrari
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Tumori 98:399-407. 2012
    ..The location of the pediatric unit within a cancer referral center and the cooperation with divisions dedicated to adults have played an important role in the project's creation...
  37. ncbi Assistance to parents who have lost their child with cancer
    Carlo Alfredo Clerici
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    Tumori 92:306-10. 2006
    ..To assess the psychological needs of parents after the death of their child from cancer...
  38. ncbi Rhabdomyosarcoma of the head and neck region: experience at the pediatric unit of the Istituto Nazionale Tumori, Milan
    Cristina Meazza
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan
    J Otolaryngol 35:53-9. 2006
    ..This study aims to describe the clinical features and outcome of pediatric patients with head and neck rhabdomyosarcoma (RMS), which can be divided into parameningeal, orbital, or nonorbital, nonparameningeal...
  39. doi Soft tissue sarcomas of childhood and adolescence: the prognostic role of tumor size in relation to patient body size
    Andrea Ferrari
    Pediatric Oncology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milano, Italy
    J Clin Oncol 27:371-6. 2009
    ....
  40. ncbi Clinical stage I nonseminomatous germ cell tumors of the testis in childhood and adolescence: an analysis of 31 cases
    Monica Terenziani
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    J Pediatr Hematol Oncol 24:454-8. 2002
    ..A conservative approach is the best option in children, while adolescent NSGCTT behaves like the adult disease and management must include similar treatment strategies...
  41. ncbi Etoposide, cisplatin, epirubicin chemotherapy in the treatment of pediatric liver tumors
    Michela Casanova
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Via Venezian, 1 20133 Milano, Italy
    Pediatr Hematol Oncol 22:189-98. 2005
    ..EPE chemotherapy seems to be effective in the treatment of childhood malignant liver tumors. Etoposide could be suggested as part of intensive multidrug regimens for HCC and high-risk HB...
  42. ncbi Neuroblastoma in patients over 12 years old: a 20-year experience at the Istituto Nazionale Tumori of Milan
    Marta Giorgia Podda
    Department of Paediatric Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 96:684-9. 2010
    ..As neuroblastoma is rare in adolescents and exceedingly rare in adults, few series are reported in the literature. In the present study, we analyzed the outcomes and clinical characteristics of a mono-institutional series...
  43. ncbi Adult Wilms' tumor: A monoinstitutional experience and a review of the literature
    Monica Terenziani
    Unità di Oncologia Pediatrica, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 101:289-93. 2004
    ..The authors reviewed their institutional experience regarding adult patients with Wilms' tumor (WT) to assess their clinical characteristics and compliance with respect to children's treatment guidelines...
  44. ncbi High response rate and manageable toxicity with an intensive, short-term chemotherapy programme for Burkitt's lymphoma in adults
    Massimo Di Nicola
    Cristina Gandini Bone Marrow Transplantation Unit, Istituto Nazionale Tumori, Milan, Italy
    Br J Haematol 126:815-20. 2004
    ..Responding patients achieving less than complete response (CR) after completion of the initial induction phase, were promptly shifted to a high-dose, stem cell supported sequential chemotherapy schema (R-HDS)...
  45. ncbi High response rate to cisplatin/etoposide regimen in childhood low-grade glioma
    Maura Massimino
    Pediatric Oncology, Radiodiagnostic E and Radiotherapy Unit, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 20:4209-16. 2002
    ..The aim of this study was to avoid radiotherapy and to induce an objective response in children with low-grade glioma (LGG) using a simple chemotherapy regimen based on cisplatin and etoposide...
  46. ncbi Mirror therapy for phantom limb pain in an adolescent cancer survivor
    Carlo Alfredo Clerici
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Tumori 98:e27-30. 2012
    ..Here we discuss the advantages of an unconventional rehabilitation technique, the recently reported mirror therapy, whose positive effects might be due, according to some researchers, to neuronal plasticity mechanisms...
  47. ncbi Immunomodulation in a treatment program including pre- and post-operative interleukin-2 and chemotherapy for childhood osteosarcoma
    Roberto Luksch
    Department of Medical Oncology, Pediatric Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 89:263-8. 2003
    ..An additional aim was to assess whether any correlation between the immune modifications and the clinical outcome could be found...
  48. ncbi Papillary carcinoma of the thyroid gland of childhood and adolescence: Morphologic subtypes, biologic behavior and prognosis: a clinicopathologic study of 42 sporadic cases treated at a single institution during a 30-year period
    Paola Collini
    Department of Anatomic Pathology, Istituto Nazionale Tumori, Milan, Italy
    Am J Surg Pathol 30:1420-6. 2006
    ..At variance with adults, presence of the tall cell morphology did not carry a worst prognostic significance...
  49. doi End of life in children with cancer: experience at the pediatric oncology department of the istituto nazionale tumori in Milan
    Silvia Beretta
    Struttura Complessa di Oncologia Pediatrica, Istituto Nazionale Tumori, Milano, Italy
    Pediatr Blood Cancer 54:88-91. 2010
    ..Coping with end-stage pediatric cancer patients and the related bereavement is a challenge for all the caregivers involved...
  50. ncbi Prolonged 14-day continuous infusion of high-dose ifosfamide with an external portable pump: feasibility and efficacy in refractory pediatric sarcoma
    Cristina Meazza
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milano MI, Italy
    Pediatr Blood Cancer 55:617-20. 2010
    ..Ifosfamide is currently used to treat pediatric sarcomas and increasing its dosage may be associated with a better response rate. Prolonged continuous infusion seems an attractive administration modality...
  51. doi Adaptive functioning in children in the first six months after surgery for brain tumours
    Chiara Vago
    Developmental Neurology Unit, Carlo Besta National Neurological Institute, Milan, Italy
    Disabil Rehabil 33:953-60. 2011
    ..To examine the adaptive functioning of children who underwent surgery for brain tumours with a view to analyse the related acute impairments and to describe their short-term outcome...
  52. ncbi Endodermal sinus tumor of the vagina
    Monica Terenziani
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milano, Italy
    Pediatr Blood Cancer 48:577-8. 2007
    ..Both patients remained alive and disease-free, without having had surgical procedures except for biopsies. Platinum-based chemotherapy is able to achieve complete remissions and should be considered for vaginal endodermal sinus tumors...
  53. ncbi Thyroid carcinoma after treatment for malignancies in childhood and adolescence: from diagnosis through follow-up
    Marta Giorgia Podda
    Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133, Milan, Italy
    Med Oncol 31:121. 2014
    ..Our data confirm a good prognosis for secondary thyroid cancer, prompting us to encourage a minimalist approach to the treatment of these particular patients wherever possible...
  54. ncbi Five questions for assessing psychological problems in pediatric patients cured of neoplastic disease
    Carlo Alfredo Clerici
    Istituto Nazionale Tumori, Milan, Italy
    Pediatr Hematol Oncol 21:481-7. 2004
    ..Experience drawn from pediatric oncology might suggest an approach based on a physician-patient relationship that could provide the means for identifying patients' psychological needs and problems...
  55. ncbi Vinorelbine in previously treated advanced childhood sarcomas: evidence of activity in rhabdomyosarcoma
    Michela Casanova
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    Cancer 94:3263-8. 2002
    ..Vinca alkaloids have proved active against a number of pediatric malignancies. The aim of this study was to assess the feasibility and effectiveness of using vinorelbine in previously treated pediatric patients with advanced sarcomas...
  56. ncbi Psychological assessment of women on an early breast screening program after radiotherapy to the chest wall for childhood cancer
    Carlo Alfredo Clerici
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 94:568-73. 2008
    ..This study investigates the psychological status in a population of female patients who received chest irradiation for a childhood cancer and were screened for second primary breast cancer...
  57. doi Psychological referral and consultation for adolescents and young adults with cancer treated at pediatric oncology unit
    Carlo Alfredo Clerici
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Pediatr Blood Cancer 51:105-9. 2008
    ....
  58. doi Occurrence of breast cancer after chest wall irradiation for pediatric cancer, as detected by a multimodal screening program
    Monica Terenziani
    Pediatric Oncology Unit, Radiology Department, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Int J Radiat Oncol Biol Phys 85:35-9. 2013
    ..To assess the occurrence of breast cancer (BC) after exposure to ionizing radiation for pediatric cancer, by means of a multimodal screening program...
  59. doi At least we can send some flowers
    Carlo Alfredo Clerici
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via G Venezian 1, Milan, Italy
    Tumori 98:146e-148e. 2012
    ..If patients die, their families and the care-providing staff need help to cope with the loss...
  60. ncbi Adult-type soft tissue sarcomas in paediatric age: a nomogram-based prognostic comparison with adult sarcoma
    Andrea Ferrari
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Eur J Cancer 43:2691-7. 2007
    ..The study compares the outcome of paediatric patients with adult-type soft tissue sarcomas with that reported for adults, taking into account the effect of established prognostic factors...
  61. doi Radiation-induced glioblastoma in a medulloblastoma patient: a case report with molecular features
    Marco Gessi
    Division of Neuropathology, Intituto Nazionale Neurologico C Besta, Milano, Italy
    Neuropathology 28:633-9. 2008
    ..Moreover RIGs seem to be a heterogeneous group of tumors that may resemble either primary or secondary GBM...
  62. ncbi Symptom interval in pediatric patients with solid tumors: adolescents are at greater risk of late diagnosis
    Laura Veneroni
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Pediatr Blood Cancer 60:605-10. 2013
    ....
  63. doi Intracranial ependymoma: factors affecting outcome
    Maura Massimino
    Division of Pediatric Oncology, Istituto Nazionale dei Tumori, Milan, Italy
    Future Oncol 5:207-16. 2009
    ..For high-risk patients, with residual tumor, an interesting, although experimental, approach could be chemotherapy followed by secondary surgery and postoperative conformal irradiation...
  64. doi Childhood medulloblastoma
    Maura Massimino
    Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Crit Rev Oncol Hematol 79:65-83. 2011
    ....
  65. ncbi Pharmacokinetics of temozolomide given three times a day in pediatric and adult patients
    Anna Riccardi
    Division of Pediatric Oncology, Department of Pediatrics, Catholic University, Largo A Gemelli, 8, 00168 Rome, Italy
    Cancer Chemother Pharmacol 52:459-64. 2003
    ....
  66. doi [Psychopharmacology and psychotherapy in pediatric oncology. Update and perspectives of integration]
    Carlo Alfredo Clerici
    SC Pediatria, Fondazione IRCCS Istituto Nazionale Tumori, Milano
    Recenti Prog Med 102:314-20. 2011
    ..The specific issues relating to the psychopathological diagnosis in the course of organic disease are discussed and aspects of behavior determined by biological mechanisms directly related to the disease and care...
  67. ncbi Use of ICF to describe functioning and disability in children with brain tumours
    Daniela Ajovalasit
    Neurology, Public Health, Disability Unit Scientific Directorate, Neurological Institute Carlo Besta IRCCS Foundation, Milan, Italy
    Disabil Rehabil 31:S100-7. 2009
    ..To underline the importance of Environmental Factors for reducing Disability and to demonstrate the complex condition of life, especially in terms of social inclusion and participation for children and adolescents affected by brain tumour...
  68. ncbi Emerging treatments and gene expression profiling in high-risk medulloblastoma
    Iacopo Sardi
    Department of Pediatrics, Onco hematology and Neuro surgery Units, University of Florence Medical School, A Meyer Children s Hospital, Florence, Italy
    Paediatr Drugs 9:81-96. 2007
    ....
  69. doi Prognostic determinants in epithelioid sarcoma
    Patrizia Gasparini
    Unit of Molecular Cytogenetics, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Eur J Cancer 47:287-95. 2011
    ....
  70. doi Pediatric brain tumors: mutations of two dioxygenases (hABH2 and hABH3) that directly repair alkylation damage
    Valentina Cetica
    Onco Hematology Unit, Department of Pediatrics, Florence Medical School, A Meyer Children s Hospital, Viale Pieraccini 24, 50139, Florence, Italy
    J Neurooncol 94:195-201. 2009
    ..This is the first study of hABH2 and hABH3 in pediatric brain tumors; further molecular investigations of their mutations and expression may help determine their role in response to chemotherapy...
  71. pmc A female survivor of childhood medulloblastoma presenting with growth-hormone-induced edema and inflammatory lesions: a case report
    Veronica Biassoni
    Department of Pediatric Oncology, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy
    J Med Case Reports 3:17. 2009
    ..There are few reports, however, on the "in-vivo" induction of edema and symptomatic inflammatory lesions during replacement therapy...
  72. ncbi Psychological support in children and adolescents with cancer when amputation is required
    Andrea Ferrari
    Pediatric Oncology Unit, Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy
    Med Pediatr Oncol 38:261-5. 2002
  73. ncbi Treatment of sporadic nonmedullary thyroid carcinomas in pediatric age
    Paola Collini
    Istituto Nazionale Tumori, Anatomic Pathology C Unit, Via Venezian, 1, Milan, Italy
    Expert Rev Anticancer Ther 7:23-30. 2007
    ....
  74. ncbi Peculiar features and tailored management of adult cancers occurring in pediatric age
    Andrea Ferrari
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Expert Rev Anticancer Ther 10:1837-51. 2010
    ..This article describes a few such tumors and points to the need for forms of international cooperation with a view to gaining a better understanding of these particular conditions and improving patient management...
  75. doi Clinical and molecular description of a Wilms tumor in a patient with tuberous sclerosis complex
    Filippo Spreafico
    Pediatric Oncology Unit, Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Am J Med Genet A 155:1419-24. 2011
    ..To the best of our knowledge, this is the second report of a patient with tuberous sclerosis who developed a WT, and it represents the first case in which a detailed clinical and molecular description is provided...
  76. ncbi Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics
    Piergiorgio Modena
    Unit of Molecular Cytogenetics, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    J Clin Oncol 24:5223-33. 2006
    ..To delineate clinically relevant molecular signatures of intracranial ependymoma...
  77. ncbi Verdi and death
    Maura Massimino
    Pediatric Oncology Unit, Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy
    Med Pediatr Oncol 38:260. 2002
  78. ncbi In vivo T-cell immune response against anaplastic lymphoma kinase in patients with anaplastic large cell lymphomas
    Lorena Passoni
    Oncogenic Fusion Protein Unit, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    Haematologica 91:48-55. 2006
    ..One of the promising ALK-targeted therapeutic options is cancer vaccination. In this study, we investigate whether ALK is a tumor-associated antigen suitable for immune interventions...
  79. ncbi Prognostic value of clinicopathologic characteristics including neuroectodermal differentiation in osseous Ewing's sarcoma family of tumors in children
    R Luksch
    Divisione di Oncologia Pediatrica, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan
    Tumori 85:101-7. 1999
    ....
  80. pmc Stage 4 neuroblastoma: sequential hemi-body irradiation or high-dose chemotherapy plus autologous haemopoietic stem cell transplantation to consolidate primary treatment
    R Luksch
    Unità di Pediatria, Istituto Nazionale Tumori di Milano, Via Venezian, 1 20133 Milan, Italy
    Br J Cancer 92:1984-8. 2005
    ..The high-dose chemotherapy adopted in the second program enabled a proportion of patients to obtain long-term survival but, since the clinical results remain unsatisfactory, new treatment strategies are warranted...
  81. ncbi Undifferentiated nasopharyngeal carcinoma in children and adolescents: comparison between staging systems
    M Casanova
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milano, Italy
    Ann Oncol 12:1157-62. 2001
    ..We investigated the clinical implications of the new system by comparing it with the 4th edition in a cohort of pediatric undifferentiated nasopharyngeal carcinoma (UNPC)...
  82. ncbi Prognostic significance of p80 and visceral involvement in childhood CD30 anaplastic large cell lymphoma (ALCL)
    M Massimino
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Via G Venezian, I 20133 Milan, Italy
    Med Pediatr Oncol 37:97-102. 2001
    ....
  83. ncbi Effects of recombinant human granulocyte-macrophage colony-stimulating factor in an intensive treatment program for children with Ewing's sarcoma
    R Luksch
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milan, Italy
    Haematologica 86:753-60. 2001
    ....
  84. ncbi Intravascular lymphomatosis (IL) in a child mimicking a posterior fossa tumor
    M Massimino
    Unit of Pediatrics, Istituto Nazionale Tumori, Milan, Italy
    J Neurooncol 51:47-50. 2001
    ..She remained alive in continuous complete remission at 21 months after diagnosis. The case here reported is unique for age, tumor presentation, and, so far, favourable outcome, in spite of the delayed histological diagnosis...
  85. ncbi Management of medulloblastoma and ependymoma in infants: a single-institution long-term retrospective report
    M Massimino
    Division of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    Childs Nerv Syst 16:15-20. 2000
    ..In 4 of 6 evaluable children school performance was satisfactory. One child in whom the entire CNS was irradiated developed glioblastoma multiforme 120 months after the first diagnosis of medulloblastoma...
  86. ncbi Childhood liposarcoma: a single-institutional twenty-year experience
    A Ferrari
    Division of Pediatric Oncology, Istituto Nazionale Tumori, Milano, Italy
    Pediatr Hematol Oncol 16:415-21. 1999
    ..The high proportion of resectable tumors accounts for the excellent survival of the patients in this study. The role of both adjuvant chemotherapy and radiotherapy is uncertain and awaits multicentric cooperative prospective studies...
  87. ncbi Cytogenetic and molecular characterization of T-cell acute lymphoblastic leukemia as a second tumor after anaplastic large-cell lymphoma in a boy
    D Perotti
    Division of Pediatric Oncology, Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milan, Italy
    Haematologica 84:554-7. 1999
    ..The different T-cell receptor rearrangement evidenced in the two tumors indicates that this second malignancy most likely emerged de novo, but was plausibly related to the previous radiation and chemotherapy...
  88. doi Cognition before and after chemotherapy alone in children with chiasmatic-hypothalamic tumors
    Daria Riva
    Developmental Neurology Division, Fondazione IRCCS Istituto Nazionale Neurologico C Besta, Via Celoria, 1120133, Milan, Italy
    J Neurooncol 92:49-56. 2009
    ..The multifactorial origin of such cognitive impairments is discussed. This type of study needs to be repeated in larger, but nonetheless carefully selected groups of patients...
  89. ncbi Childhood malignant ovarian germ cell tumors: a monoinstitutional experience
    M Terenziani
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, 20133, Italy
    Gynecol Oncol 81:436-40. 2001
    ..CONCLUSIONS: MOGCT are highly chemosensitive and curable, with preservation of reproductive function. The management of recurrent disease remains an open issue...
  90. ncbi Lymphomas of the bone: a pathological and clinical study of 54 cases
    Umberto Gianelli
    Departement of Medicine, Surgery and Dental Sciences, AO S Paolo HSP, Milan, Italy
    Int J Surg Pathol 10:257-66. 2002
    ..This study details the clinical and pathological characteristics of bone lymphomas. Our immunohistochemical and molecular data suggest that most of them are "de novo" DLBCL and support their follicle center origin...
  91. ncbi A case of pediatric tumefactive demyelinating lesion misdiagnosed and treated as glioblastoma
    Daria Riva
    Department of Developmental Neurology, Istituto Nazionale Neurologico C Besta, Milano, Italy
    J Child Neurol 23:944-7. 2008
    ..This article reports a 10-year-old girl who underwent surgery for a left parietal lesion misinterpreted as a glioblastoma which subsequently proved to be a case of giant plaque...
  92. ncbi Case report: Pseudomonas aeruginosa-related intervertebral discitis in a young boy with medulloblastoma
    E Mazza
    Department of Pediatric, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    J Neurooncol 68:245-8. 2004
    ..In this case surgicopathological assessment is crucial and mandatory...
  93. ncbi A case of relapsing glioblastoma multiforme responding to vinorelbine
    V Biassoni
    Department of Pediatric, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133, Milan, Italy
    J Neurooncol 80:195-201. 2006
    ....
  94. doi Rectal burkitt lymphoma in childhood
    Francesca Favini
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Istituti Clinici di Perfezionamento, Milano, Italy
    J Pediatr Hematol Oncol 30:176-8. 2008
    ..The role of surgery for this tumor is limited nowadays, except for surgical emergencies, biopsies, and second-look surgery in selected cases...
  95. ncbi Intrathecal methotrexate affects cognitive function in children with medulloblastoma
    D Riva
    Developmental Neurology Unit, Istituto Nazionale Neurologico C Besta, Milano, Italy
    Neurology 59:48-53. 2002
    ..Cognitive impairment occurs after malignant brain tumor treatment in children, following brain radiotherapy and systemic and intrathecal chemotherapy...
  96. ncbi Serum and cerebrospinal fluid human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) in intracranial germ cell tumors
    E Seregni
    RIA Laboratory, Nuclear Medicine Division, Istituto Nazionale per la Studio e la Cura dei Tumori, Milan, Italy
    Int J Biol Markers 17:112-8. 2002
    ..We conclude that these two markers, and mostly betahCG, may be useful in the diagnosis and monitoring of the response to therapy of patients with intracranial germ cell tumors...
  97. ncbi Treatment with oral etoposide for childhood recurrent ependymomas
    Alessandro Sandri
    Pediatric Oncology Department, University of Turin, Torino, Italy
    J Pediatr Hematol Oncol 27:486-90. 2005
    ..7%. These results emphasize that oral etoposide is an attractive option for childhood recurrent ependymomas in terms of administration, tolerability, and neuroradiologic response...
  98. ncbi Metastatic ependymoma: a multi-institutional retrospective analysis of prognostic factors
    Stergios Zacharoulis
    Department of Pediatrics, The Royal Marsden Hospital, Sutton, Surrey, UK
    Pediatr Blood Cancer 50:231-5. 2008
    ..Metastatic ependymoma is exceedingly rare at diagnosis with variable prognosis reported in the literature. The purpose of this study was to identify prognostic factors in children with metastatic ependymoma...
  99. ncbi New concepts in the treatment of brain tumors in very young children
    Maria Luisa Garre'
    Neuro Oncology Unit, Hemato Oncology Department, Giannina Gaslini Children s Research Hospital IGG, Largo G Gaslini 5, 16148 Genova, Italy
    Expert Rev Neurother 6:489-500. 2006
    ....
  100. ncbi Brain tumors in children and adolescents: cognitive and psychological disorders at different ages
    Geraldina Poggi
    IRCCS Eugenio Medea, Via Don Luigi Monza 23842, Bosisio Parini LC, Italy
    Psychooncology 14:386-95. 2005
    ..These findings are relevant as they point out the long-term outcome of brain tumor survivors. Hence, the recommendation to diversify psychological interventions and rehabilitation plans according to the patients' age...
  101. doi Antidepressants in pediatric oncology
    Carlo Alfredo Clerici
    Pediatr Blood Cancer 50:1290-1; author reply 1291-2. 2008