Alberto Mantovani

Summary

Affiliation: Istituto Clinico Humanitas
Country: Italy

Publications

  1. doi The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance
    Paola Allavena
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Immunol Rev 222:155-61. 2008
  2. ncbi Tumor-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumor cell motility
    Graziella Solinas
    Department of Immunology and Inflammation, Clinical Institute Humanitas, Rozzano, Italy
    J Immunol 185:642-52. 2010
  3. pmc The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps
    Sebastien Jaillon
    Institut National de la Sante et de la Recherche Medicale, Equipe Avenir, Unité 564, University Hospital of Angers, University of Angers, Angers 49933, France
    J Exp Med 204:793-804. 2007
  4. ncbi La mala educación of tumor-associated macrophages: Diverse pathways and new players
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Cancer Cell 17:111-2. 2010
  5. doi Macrophages, innate immunity and cancer: balance, tolerance, and diversity
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Curr Opin Immunol 22:231-7. 2010
  6. doi The chemokine system in cancer biology and therapy
    Alberto Mantovani
    Department of Translational Medicine, University of Milan, I 20089 Rozzano, Milan, Italy
    Cytokine Growth Factor Rev 21:27-39. 2010
  7. ncbi Regulatory pathways in inflammation
    Alberto Mantovani
    Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Autoimmun Rev 7:8-11. 2007
  8. ncbi Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3
    Alberto Mantovani
    Istituto Clinico Humanitas, Via Manzoni 56, 20089, Milan, Rozzano, Italy
    J Clin Immunol 28:1-13. 2008
  9. doi The yin-yang of tumor-associated neutrophils
    Alberto Mantovani
    Istituto Clinico Humantas IRCCS and Department of Translational Medicine, University of Milan, Milan, Italy
    Cancer Cell 16:173-4. 2009
  10. doi Macrophage diversity and polarization in atherosclerosis: a question of balance
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Italy
    Arterioscler Thromb Vasc Biol 29:1419-23. 2009

Detail Information

Publications116 found, 100 shown here

  1. doi The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance
    Paola Allavena
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Immunol Rev 222:155-61. 2008
    ..Herein, the 'macrophage balance' is discussed in the context of the apparent paradox of tumor promotion by innate immunity-driven inflammation and the seemingly opposed tumor surveillance by adaptive immune responses...
  2. ncbi Tumor-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumor cell motility
    Graziella Solinas
    Department of Immunology and Inflammation, Clinical Institute Humanitas, Rozzano, Italy
    J Immunol 185:642-52. 2010
    ..In conclusion, MSF is a new molecule associated with the M2 polarization of M and expressed by TAMs. Its biological function may contribute to M-mediated promotion of cancer cell invasion and metastasis...
  3. pmc The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps
    Sebastien Jaillon
    Institut National de la Sante et de la Recherche Medicale, Equipe Avenir, Unité 564, University Hospital of Angers, University of Angers, Angers 49933, France
    J Exp Med 204:793-804. 2007
    ..Thus, neutrophils serve as a reservoir, ready for rapid release, of the long PTX3, a key component of humoral innate immunity with opsonic activity...
  4. ncbi La mala educación of tumor-associated macrophages: Diverse pathways and new players
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Cancer Cell 17:111-2. 2010
    ..Two reports published in this issue of Cancer Cell, Andreu et al. and Erez et al., shed new light on pathways and players involved in the orchestration of cancer-related inflammation...
  5. doi Macrophages, innate immunity and cancer: balance, tolerance, and diversity
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Curr Opin Immunol 22:231-7. 2010
    ..TAM can also express antitumor activity. Thus, in response to microenvironmental signals, TAM can exert dual influence on tumor growth and progression...
  6. doi The chemokine system in cancer biology and therapy
    Alberto Mantovani
    Department of Translational Medicine, University of Milan, I 20089 Rozzano, Milan, Italy
    Cytokine Growth Factor Rev 21:27-39. 2010
    ..Available information in preclinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies...
  7. ncbi Regulatory pathways in inflammation
    Alberto Mantovani
    Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Autoimmun Rev 7:8-11. 2007
    ....
  8. ncbi Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3
    Alberto Mantovani
    Istituto Clinico Humanitas, Via Manzoni 56, 20089, Milan, Rozzano, Italy
    J Clin Immunol 28:1-13. 2008
    ..Evidence suggests that PTX3 is a useful new serological marker, rapidly reflecting tissue inflammation and damage under diverse clinical conditions...
  9. doi The yin-yang of tumor-associated neutrophils
    Alberto Mantovani
    Istituto Clinico Humantas IRCCS and Department of Translational Medicine, University of Milan, Milan, Italy
    Cancer Cell 16:173-4. 2009
    ..A report in this issue of Cancer Cell now indicates that tumor-associated neutrophils in lung cancer can polarize to either "N1" or "N2" phenotype that inhibits or promotes cancer development, respectively...
  10. doi Macrophage diversity and polarization in atherosclerosis: a question of balance
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Italy
    Arterioscler Thromb Vasc Biol 29:1419-23. 2009
    ..Thus, a "macrophage balance" plays a major role in the pathogenesis of atherosclerotic plaques and affects evolution and complications of atherosclerosis...
  11. ncbi Linking inflammation reactions to cancer: novel targets for therapeutic strategies
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano Milan, Italy
    Adv Exp Med Biol 610:112-27. 2008
  12. ncbi Tuning inflammation and immunity by chemokine sequestration: decoys and more
    Alberto Mantovani
    Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy and Istituto di Patologia Generale, Universita degli Studi di Milano, Via Luigi Mangiagalli 31, 20133 Milan
    Nat Rev Immunol 6:907-18. 2006
    ..So, decoy receptors for chemokines represent a general strategy to tune, shape and temper innate and adaptive immunity...
  13. ncbi Inflammation and cancer: breast cancer as a prototype
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Breast 16:S27-33. 2007
    ..Here, we discuss evidence supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and a potential target of anti-cancer therapy...
  14. ncbi New vistas on macrophage differentiation and activation
    Alberto Mantovani
    Istituto Clinico Humanitas, Milan, Italy
    Eur J Immunol 37:14-6. 2007
    ....
  15. ncbi The long pentraxin PTX3 in vascular pathology
    Alberto Mantovani
    Research Laboratory in Immunology and Inflammation, Istituto Clinico Humanitas Via Manzoni, 56, 20089 Rozzano, Milan, Italy
    Vascul Pharmacol 45:326-30. 2006
    ....
  16. ncbi RalB signaling: a bridge between inflammation and cancer
    Alberto Mantovani
    Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano and University of Milan, Italy
    Cell 127:42-4. 2006
    ..In tumor cells the RalB/TBK1 pathway inhibits apoptosis and in nontumorigenic cells it stimulates an innate immune response...
  17. ncbi From phagocyte diversity and activation to probiotics: back to Metchnikoff
    Alberto Mantovani
    IRCCS Istituto Clinico Humanitas, Milan, Italy
    Eur J Immunol 38:3269-73. 2008
    ..Here, I give a personal view of some of these issues, including myeloid-derived suppressor cells, macrophage polarization and adaptive responses of mononuclear phagocytes...
  18. doi Molecular pathways and targets in cancer-related inflammation
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, Milan, Italy
    Ann Med 42:161-70. 2010
    ..Emerging evidence also suggests that cancer-related inflammation promotes genetic instability. Thus, cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies...
  19. ncbi Role of tumor-associated macrophages in tumor progression and invasion
    Alberto Mantovani
    Istituto Clinico Humanitas, 20089 Rozzano, Milan, Italy
    Cancer Metastasis Rev 25:315-22. 2006
    ..Here, we discuss evidence supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and a potential target of anti-cancer therapy...
  20. doi Cancer-related inflammation
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, Italy
    Nature 454:436-44. 2008
    ..The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment...
  21. ncbi p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance
    Alessandra Saccani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Cancer Res 66:11432-40. 2006
    ..Thus, p50 NF-kappaB overexpression accounts for the inability of TAM to mount an effective M1 antitumor response capable of inhibiting tumor growth...
  22. doi Divergent effects of hypoxia on dendritic cell functions
    Alessandra Mancino
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Milan, Italy
    Blood 112:3723-34. 2008
    ..Thus, hypoxia uncouples the promotion of inflammatory and tissue repair from sentinel functions in DCs, which we suggest is a safeguard mechanism against immune reactivity to damaged tissues...
  23. doi The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas
    Marco Locatelli
    Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    J Neuroimmunol 260:99-106. 2013
    ..In a multivariate logistic regression model, only the PTX3 score was significantly associated with the presence of a high-grade tumor. Thus, PTX3 may represent a new marker of cancer-related inflammation and glioma malignancy...
  24. doi The lymphatic system controls intestinal inflammation and inflammation-associated Colon Cancer through the chemokine decoy receptor D6
    Stefania Vetrano
    Division of Gastroenterology, Istituto Clinico Humanitas IRCCS, Milan, Italy
    Gut 59:197-206. 2010
    ....
  25. pmc Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6
    Virginia Maina
    Research Laboratory in Immunology and Inflammation, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    J Leukoc Biol 86:123-32. 2009
    ..The coordinated expression of PTX3 and TSG-6 may play a role in ECM remodeling at sites of inflammation...
  26. pmc Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6
    Yeny Martinez de la Torre
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Rozzano, 20089 Milan, Italy
    Proc Natl Acad Sci U S A 104:2319-24. 2007
    ..Thus, the promiscuous decoy receptor for inflammatory CC chemokines D6 plays a nonredundant role in the protection against fetal loss caused by systemic inflammation and antiphospholipid antibodies...
  27. ncbi Role of macrophage targeting in the antitumor activity of trabectedin
    Giovanni Germano
    Department Immunology and Inflammation, IRCCS Clinical and Research Institute Humanitas, 20089 Rozzano, Milan, Italy
    Cancer Cell 23:249-62. 2013
    ..This unexpected property may be exploited in different therapeutic strategies...
  28. pmc Cell-specific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells
    Andrea Doni
    Istituto Clinico Humanitas, Istituto Di Ricerca Cura a Caratte Re Scientifico, Department of Immunology and Inflammation, Rozzano, Milan, Italy
    J Biol Chem 283:29983-92. 2008
    ..The divergent effects of GC on PTX3 production probably reflect the different functions of this multifunctional molecule in innate immunity and in the construction of the extracellular matrix...
  29. ncbi Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Tumori 89:459-68. 2003
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumor growth and progression...
  30. doi Tumor associated macrophages and neutrophils in cancer
    Maria Rosaria Galdiero
    Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan 20089, Italy Division of Clinical Immunology and Allergy, University of Naples Federico II, Via Pansini 5, Naples 80131, Italy
    Immunobiology 218:1402-10. 2013
    ..Therefore, macrophages and neutrophils are both integrated in the regulation of the innate and adaptive immune responses in various inflammatory situations, including cancer. ..
  31. ncbi Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells
    Andrea Doni
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Immunol 33:2886-93. 2003
    ..These results suggest that DC of myelomonocytic origin are a major source of PTX3, a molecule which facilitates pathogen recognition and subsequent activation of innate and adaptive immunity...
  32. ncbi Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocyte-derived dendritic cells: selective upregulation by rapamycin
    Valeria Sordi
    Immunology of Diabetes Unit, San Raffaele Scientific Institute, Milan, Italy
    Transplantation 82:826-34. 2006
    ..The proper localization of DC in selected tissues is guided primarily by the coordinated expression of chemokine receptors (CKR). Here we show that immunosuppressive drugs have divergent effects on the modulation of CKR in maturing DC...
  33. pmc Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection
    Tania Véliz Rodriguez
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Infect Immun 80:100-9. 2012
    ..aeruginosa, in particular, by negatively regulating IL-1RI signaling, which plays a major role in the pathogenesis of this infectious disease...
  34. ncbi Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program
    Marcello Chieppa
    Department of Immunology, Istituto Mario Negri, Milan, Italy
    J Immunol 171:4552-60. 2003
    ....
  35. ncbi Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFN-gamma
    Andrea Doni
    Istituto Clinico Humanitas ICH, Via Manzoni, 56 20089 Rozzano, Milan, Italy
    J Leukoc Biol 79:797-802. 2006
    ..As PTX3 is also an extracellular matrix component, IL-10-enhanced PTX3 production may play a role in orchestration of tissue remodeling in chronic inflammation...
  36. ncbi Complement dependent amplification of the innate response to a cognate microbial ligand by the long pentraxin PTX3
    Alessia Cotena
    Istituto Clinico Humanitas, Rozzano Milan, Italy
    J Immunol 179:6311-7. 2007
    ..The results reported here demonstrate that PTX3 activates a complement-dependent humoral amplification loop of the innate response to a microbial ligand...
  37. doi Role of the chemokine scavenger receptor D6 in balancing inflammation and immune activation
    Elena M Borroni
    Laboratory of Leukocyte Biology, Department of Translational Medicine, University of Milan, IRCCS Istituto Clinico Humanitas, Italy
    Methods Enzymol 460:231-43. 2009
    ..Here we will discuss the expression and regulation of D6 during challenge with the pathogen, and its role in dampening inflammation in tissues and draining lymph nodes and in the organization of a protective immune response...
  38. doi Deficiency of the long pentraxin PTX3 promotes vascular inflammation and atherosclerosis
    Giuseppe Danilo Norata
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Circulation 120:699-708. 2009
    ....
  39. doi Macrophage polarization in tumour progression
    Antonio Sica
    Department of Inflammation and Immunology, Fondazione Humanitas per la Ricerca, 20089 Rozzano, Milan, Italy
    Semin Cancer Biol 18:349-55. 2008
    ..Here, we discuss recent findings suggesting that targeting tumour-associated macrophages (TAMs) polarization may represent a novel therapeutic strategy against cancer...
  40. ncbi The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility
    Barbara Bottazzi
    Istituto Clinico Humanitas, Rozzano, Milan, Italy
    J Leukoc Biol 79:909-12. 2006
    ..Thus, the prototypic long pentraxin PTX3 is a multifunctional, soluble pattern recognition receptor acting as a nonredundant component of the humoral arm of innate immunity and involved in matrix deposition and female fertility...
  41. doi Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology
    Oscar M Pello
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico, Rozzano, Milan, Italy
    Blood 119:411-21. 2012
    ..We conclude that c-MYC is a key player in alternative macrophage activation, and is therefore a potential therapeutic target in pathologies related to these cells, including tumors...
  42. doi Regulation of leukocyte recruitment by the long pentraxin PTX3
    Livija Deban
    Laboratory for Immunology and Inflammation, Instituto di Ricovero e Cura a Carattere Scientifico Istituto Clinico Humanitas, Rozzano, Italy
    Nat Immunol 11:328-34. 2010
    ....
  43. pmc Nonredundant role of CCRL2 in lung dendritic cell trafficking
    Karel Otero
    Istituto Clinico Humanitas, IRCCS, Rozzano, Italy
    Blood 116:2942-9. 2010
    ..These data show a nonredundant role of CCRL2 in lung DC trafficking and propose a role for this receptor in the control of excessive airway inflammatory responses...
  44. doi Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction
    Monica Salio
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circulation 117:1055-64. 2008
    ..It was therefore important to assess whether PTX3 plays a pathogenetic role in acute myocardial infarction...
  45. doi Evolution of the pentraxin family: the new entry PTX4
    Yeny Martinez de la Torre
    Laboratorio di Immunologia e Infiammazione, Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico, Rozzano
    J Immunol 184:5055-64. 2010
    ..Thus, PTX4 is a new unique member of the pentraxin superfamily, conserved in evolution...
  46. ncbi Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression
    Fernando O Martinez
    Istituto Clinico Humanitas, Rozzano, Italy
    J Immunol 177:7303-11. 2006
    ..Thus, transcriptome profiling reveals novel molecules and signatures associated with human monocyte-to-macrophage differentiation and polarized activation which may represent candidate targets in pathophysiology...
  47. ncbi Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13
    Patrick Perrier
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 172:7031-42. 2004
    ..This novel finding reveals that IL-10 sustains humoral immunity by inducing the production in APCs of the chemokine, CXCL13, which amplifies B cell recruitment and promotes lymphoid tissue neogenesis...
  48. doi The long pentraxin PTX3 as a prototypic humoral pattern recognition receptor: interplay with cellular innate immunity
    Barbara Bottazzi
    Istituto Clinico Humanitas, Rozzano, Italy
    Immunol Rev 227:9-18. 2009
    ..Here, we review the studies on PTX3 which emphasize the complexity and complementarity of the crosstalk between the cellular and humoral arms of innate immunity...
  49. pmc Recognition versus adaptive up-regulation and degradation of CC chemokines by the chemokine decoy receptor D6 are determined by their N-terminal sequence
    Benedetta Savino
    Department of Translational Medicine, University of Milan, 20089 Milan, Italy
    J Biol Chem 284:26207-15. 2009
    ..Sequence analysis indicated that a proline residue in position 2 of D6 ligands is dispensable for binding but crucial for D6 adaptive up-regulation and efficient degradation...
  50. ncbi A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation)
    Subhra K Biswas
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Blood 107:2112-22. 2006
    ..Thus, profiling of TAMs from a murine sarcoma revealed unexpected expression of IFN-inducible chemokines, associated with an M2 phenotype (IL-10high, IL-12low), and divergent regulation of the NF-kappaB versus the IRF-3/STAT1 pathway...
  51. ncbi Chemokine decoy receptors: new players in reproductive immunology
    Elena Monica Borroni
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Immunol Invest 37:483-97. 2008
    ....
  52. ncbi The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
    ....
  53. doi The long pentraxin 3 is a soluble and cell-associated component of the human semen
    Andrea Doni
    Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Int J Androl 32:255-64. 2009
    ..Moreover, PTX3 binds to spermatozoa, in particular with immotile cells, localizing in the neck and in the subacrosomial region. Finally, recombinant PTX3 did not interfere with sperm motility...
  54. ncbi Pentraxins in innate immunity and inflammation
    Cecilia Garlanda
    Istituto Clinico Humanitas, Via Manzoni, 56, 20089 Rozzano, Milan, Italy
    Novartis Found Symp 279:80-6; discussion 86-91, 216-9. 2006
    ..Thus, the prototypic long pentraxin PTX3 is a multifunctional soluble pattern recognition receptor at the crossroads between innate immunity, inflammation, matrix deposition and female fertility...
  55. doi Tumor-associated macrophages as a paradigm of macrophage plasticity, diversity, and polarization: lessons and open questions
    Alberto Mantovani
    Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    Arterioscler Thromb Vasc Biol 33:1478-83. 2013
    ..Preclinical and early clinical data suggest that macrophages may serve as tools for the development of innovative diagnostic and therapeutic strategies in cancer and chronic nonresolving inflammatory diseases...
  56. doi Macrophage plasticity and polarization in tissue repair and remodelling
    Alberto Mantovani
    Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, Milan, Italy
    J Pathol 229:176-85. 2013
    ..These properties of cells of the monocyte-macrophage lineage may represent a tool and a target for therapeutic exploitation...
  57. ncbi Role of CX3CR1/CX3CL1 axis in primary and secondary involvement of the nervous system by cancer
    Federica Marchesi
    Department of Immunology and Inflammation, IRCCS Humanitas Clinical Institute, Via Manzoni 56, 20089, Rozzano, Milan, Italy
    J Neuroimmunol 224:39-44. 2010
    ..This peculiar route of tumor spread is used also by other carcinomas (e.g. prostate, head and neck) and may represent a target for therapeutic intervention...
  58. doi PTX3 expression in the heart tissues of patients with myocardial infarction and infectious myocarditis
    Manuela Nebuloni
    Pathology Unit, L Sacco Department of Clinical Sciences, L Sacco Hospital, Universita degli Studi di Milano, Milan, Italy
    Cardiovasc Pathol 20:e27-35. 2011
    ..However, the actual localization and cellular sources of pentraxin 3 in ischemic and infectious cardiac pathology have not been carefully defined...
  59. doi Impact of the anti-inflammatory agent bindarit on the chemokinome: selective inhibition of the monocyte chemotactic proteins
    Massimiliano Mirolo
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Eur Cytokine Netw 19:119-22. 2008
    ..Here we report on the use of inhibition of synthesis as a potentially viable and selective approach to modify the chemokine system...
  60. doi TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization
    Cecilia Garlanda
    Istituto Clinico Humanitas, IRCCS, Department of Immunology and Inflammation, Rozzano, Milan, Italy
    Trends Immunol 30:439-46. 2009
    ..TIR8 also dampens TLR-mediated activation. The ability to dampen signaling from ILR family members and TLRs makes TIR8 a key regulator of inflammation, cancer-related inflammation, and autoimmunity...
  61. ncbi Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13
    Chris J Scotton
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 174:834-45. 2005
    ..The IL-13-induced modulation of genes related to IL-1 clearly highlights the tightly controlled and complex levels of regulation of the production and response to this potent proinflammatory cytokine...
  62. ncbi Generation and characterization of a mouse lymphatic endothelial cell line
    Marina Sironi
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Cell Tissue Res 325:91-100. 2006
    ..Whole genome transcriptional profiling identified a set of 150 known genes differentially expressed in MELC versus vascular endothelial cells. Thus, the MELC line may represent an invaluable source of lymphatic endothelium...
  63. ncbi Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family
    Cecilia Garlanda
    Istituto Clinico Humanitas IRCCS, Rozzano, Italy
    Cancer Res 67:6017-21. 2007
    ..Thus, these results are consistent with the hypothesis that TIR8, by negatively regulating intestinal inflammation, plays a nonredundant role in the control of the protumor activity of chronic inflammation in the gut...
  64. ncbi Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activation
    Livija Deban
    Laboratory for Immunology and Inflammation, Instituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, Rozzano, Italy
    J Immunol 181:8433-40. 2008
    ..Thus, our findings identify PTX3 as a unique FH ligand in that it can bind both of the two hot-spots of FH, namely SCR7 and SCR19-20 and indicate that PTX3 participates in the localization of functionally active FH...
  65. ncbi The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages
    Paola Allavena
    IRCCS Istituto Clinico Humanitas, Via Manzoni 56, Rozzano 20089, Milan, Italy
    Crit Rev Oncol Hematol 66:1-9. 2008
    ..In this review we will discuss the role of TAM in the inflammatory micro-environment of solid tumors and will try to identify potential target for future therapeutic approaches...
  66. doi The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma
    Federica Marchesi
    Department of Immunology and Inflammation, IRCCS Clinical Institute Humanitas, Rozzano, Milano, Italy
    Cancer Res 68:9060-9. 2008
    ..Thus, the CX3CR1-CX3CL1 axis could represent a valuable therapeutic target to prevent tumor perineural dissemination in pancreatic cancer...
  67. doi Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Hum Immunol 70:325-30. 2009
    ..As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer...
  68. doi Cancer-promoting tumor-associated macrophages: new vistas and open questions
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS and Dept Translational Medicine, University of Milan, Rozzano, Italy
    Eur J Immunol 41:2522-5. 2011
    ....
  69. doi Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation
    Raffaella Bonecchi
    Istituto Clinico Humanitas, Istituti di Ricovero e Cura a Carattere Scientifico IRCCS, Rozzano, Italy
    Blood 112:493-503. 2008
    ..D6 is not regulated at a transcriptional level in a variety of cellular contexts, thus ligand-dependent optimization of its scavenger performance represents a rapid and unique mechanism allowing D6 to control inflammation...
  70. doi Inactivation of junctional adhesion molecule-A enhances antitumoral immune response by promoting dendritic cell and T lymphocyte infiltration
    Masato Murakami
    FIRC Institute of Molecular Oncology, Milan, Italy
    Cancer Res 70:1759-65. 2010
    ..These findings support the idea that, in the Rip1Tag2 tumor model, abrogation of JAM-A reduces cancer development by increasing antitumor immune response...
  71. doi Cancer related inflammation: the macrophage connection
    Antonio Sica
    Fondazione Humanitas per Ricerca, 20089 Rozzano, Milan, Italy
    Cancer Lett 267:204-15. 2008
    ..This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches...
  72. doi Chemokine decoy receptors: structure-function and biological properties
    Raffaella Bonecchi
    Department of Translational Medicine, University of Milan, 20089 Rozzano, Milan, Italy
    Curr Top Microbiol Immunol 341:15-36. 2010
    ....
  73. ncbi Macrophage activation and polarization
    Fernando Oneissi Martinez
    Istituto Clinico Humanitas, I 20089 Rozzano, Italy
    Front Biosci 13:453-61. 2008
    ..Here we review the main functions of polarized macrophages and discuss the perspectives of this field...
  74. doi Chemokine receptors intracellular trafficking
    Elena M Borroni
    Department of Translational Medicine, University of Milan, I 20089 Rozzano, Milan, Italy
    Pharmacol Ther 127:1-8. 2010
    ....
  75. doi Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells
    Giuseppe Danilo Norata
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Arterioscler Thromb Vasc Biol 28:925-31. 2008
    ....
  76. doi Cytokines as a key component of cancer-related inflammation
    Giovanni Germano
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, Milan, Italy
    Cytokine 43:374-9. 2008
    ..Cytokines involved in cancer-related inflammation represent a target for innovative diagnostic and therapeutic strategies, and a future challenge for scientists and clinicians...
  77. doi Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells
    Giovanni Germano
    Department of Immunology and Inflammation, IRCCS Istituto Clinico Humanitas, Rozzano, Italy
    Cancer Res 70:2235-44. 2010
    ..In conclusion, trabectedin has dual effects in liposarcoma: in addition to direct growth inhibition, it affects the tumor microenvironment by reducing the production of key inflammatory mediators...
  78. ncbi Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
    Francesco Colotta
    Nerviano Medical Sciences, Nerviano, Milan, Italy
    Carcinogenesis 30:1073-81. 2009
    ..In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark...
  79. ncbi Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Vaccine 21:S43-7. 2003
    ..Evidence suggests that PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility...
  80. ncbi Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy
    Antonio Sica
    Istituto Clinico Humanitas, 20089 Rozzano, Milan, Italy
    Eur J Cancer 42:717-27. 2006
    ..Evidence is presented here supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and are a potential target for anti-cancer therapy...
  81. ncbi Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes
    Massimo Locati
    Istituto di Patologia Generale, Universita degli Studi di Milano, Milan, Italy
    J Immunol 168:3557-62. 2002
    ..Chemokine-induced chemokines production could represent a novel amplification loop of leukocyte recruitment, while a subset of chemokine-inducible transcripts could be involved in monocyte extravasation and tissue invasion...
  82. ncbi Tumor-associated macrophages: a molecular perspective
    Antonio Sica
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int Immunopharmacol 2:1045-54. 2002
    ..Emerging evidence starts to define the molecular basis for the peculiar functional phenotype of TAM and identifies possible therapeutic targets...
  83. ncbi The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells, and edits the cross-presentation of self, viral, and tumor antigens
    Paramita Baruah
    Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Institute, Milan, Italy
    Blood 107:151-8. 2006
    ..These data suggest that PTX3 acts as a third-party agent between microbial stimuli and dying cells, contributing to limit tissue damage under inflammatory conditions and the activation of autoreactive T cells...
  84. doi CD3+ cells at the invasive margin of deeply invading (pT3-T4) colorectal cancer and risk of post-surgical metastasis: a longitudinal study
    Luigi Laghi
    Laboratories of Molecular Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Lancet Oncol 10:877-84. 2009
    ..The aim of this study was to assess the relationship between the density of CD3+ TIL and the postsurgical occurrence of distant-organ metastases in a large series of patients with deeply invading and MSI-typed colorectal cancer...
  85. pmc Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
    Maria Grazia Borrello
    Departments of Experimental Oncology, Research Units 3 and 14, and Pathology, Istituto Nazionale Tumori, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 102:14825-30. 2005
    ..These results, demonstrating that the RET/PTC1 oncogene activates a proinflammatory program, provide a direct link between a transforming human oncogene, inflammation, and malignant behavior...
  86. doi Non-signaling chemokine receptors: mechanism of action and role in vivo
    Raffaella Bonecchi
    Istituto Clinico Humanitas, IRCCS Via Manzoni 113, I 20089 Rozzano, Milan, Italy
    J Neuroimmunol 198:14-9. 2008
    ..Here we review in vitro and in vivo evidences indicating that these 'silent' chemokine receptors represent a strategy to regulate innate and adaptive immunity...
  87. doi Pathways connecting inflammation and cancer
    Paola Allavena
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Curr Opin Genet Dev 18:3-10. 2008
    ..Thus, an intrinsic pathway of inflammation (driven in tumor cells), as well as an extrinsic pathway (in tumor-infiltrating leukocytes) have been described and both contribute to tumor progression...
  88. ncbi Targeting tumour-associated macrophages
    Antonio Sica
    Department of Immunology, Fondazione Humanitas per la Ricerca, 20089 Rozzano, Milan, Italy
    Expert Opin Ther Targets 11:1219-29. 2007
    ..This evidence strongly supports the idea that TAM are central orchestrators of the inflammatory networks expressed in the tumour microenvironment, and suggest these cells as possible targets of anticancer therapies...
  89. ncbi Pentraxins as a key component of innate immunity
    Barbara Bottazzi
    Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Curr Opin Immunol 18:10-5. 2006
    ..Evidence suggests that PTX3 acts as a non-redundant component of the humoral arm of innate immunity, downstream of, and complementary to, cellular recognition, as well as a tuner of inflammation...
  90. ncbi Regulation of the microsomal prostaglandin E synthase-1 in polarized mononuclear phagocytes and its constitutive expression in neutrophils
    Michela Mosca
    Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 82:320-6. 2007
    ..Neutrophils, the first cells to enter sites of inflammation, represent a ready-made, cellular source of mPGES-1...
  91. ncbi Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a negative regulator of IL-1/TLR signaling
    Cecilia Garlanda
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, 90134 Palermo, Italy
    J Immunol 179:3119-25. 2007
    ..Accordingly, blocking IL-1beta and TNF-alpha with a mix of anti-cytokine Abs, significantly prolonged survival of Tir8(-/-) mice. Thus, TIR8/SIGIRR plays a key role in damping inflammation and tissue damage in M. tuberculosis infection...
  92. doi Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization
    Antonio Inforzato
    Sigma Tau Research and Development, Via Pontina Km 30 400, Pomezia, Italy
    J Biol Chem 283:10147-61. 2008
    ..These findings indicate that protein oligomerization is essential for PTX3 activity within the cumulus matrix and implicate PTX3 tetramers as the functional molecular units required for cumulus matrix organization and stabilization...
  93. ncbi Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6
    Anna M Fra
    Section of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    J Immunol 170:2279-82. 2003
    ....
  94. ncbi Establishment of a high sensitivity plasma assay for human pentraxin3 as a marker for unstable angina pectoris
    Kenji Inoue
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1, Komaba, Meguro, Tokyo, 153 8904, Japan
    Arterioscler Thromb Vasc Biol 27:161-7. 2007
    ..To critically evaluate the role of PTX3 in UAP, a sensitive and precise measurement of PTX3 concentration is needed...
  95. ncbi The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells
    Benedetta Bussolati
    Cattedra di Nefrologia, Dipartimento di Medicina Interna, Università di Torino and Ospedale S Giovanni Battista, Torino, Italy
    J Immunol 170:1466-72. 2003
    ..The detection of this long pentraxin in the renal tissue of patients with glomerulonephritis suggests its potential role in the modulation of glomerular and tubular injury...
  96. ncbi Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
    Cecilia Garlanda
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Nature 420:182-6. 2002
    ..Thus, the long pentraxin Ptx3 is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents, in particular to the opportunistic fungal pathogen Aspergillus fumigatus...
  97. ncbi Long pentraxin PTX3 upregulates tissue factor expression in human endothelial cells: a novel link between vascular inflammation and clotting activation
    Emanuela Napoleone
    Antonio Taticchi Unit for Atherosclerosis and Thrombosis, Department of Vascular Medicine and Pharmacology, Istituto Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S Maria Imbaro, Italy
    Arterioscler Thromb Vasc Biol 22:782-7. 2002
    ..Our results suggest that PTX3, by increasing TF expression, potentially plays a role in thrombogenesis and ischemic vascular disease...
  98. ncbi Interferon-activated neutrophils store a TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) intracellular pool that is readily mobilizable following exposure to proinflammatory mediators
    Marco A Cassatella
    Division of General Pathology, Department of Pathology, University of Verona, Itlay
    J Leukoc Biol 79:123-32. 2006
    ....
  99. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression...
  100. ncbi Macrophage receptors implicated in the "adaptive" form of innate immunity
    D M E Bowdish
    Sir William Dunn School of Pathology, University of Oxford, 10 South Parks Road, Oxford OX1 3RE, UK
    Microbes Infect 9:1680-7. 2007
    ..This results in increased recognition of a broad spectrum of pathogens, enhancement of effector functions and altered regulation of the inflammatory response...
  101. ncbi Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Novartis Found Symp 256:137-45; discussion 146-8, 259-69. 2004
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression...