A Mantovani

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi request reprint The chemokine system: redundancy for robust outputs
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62 20157 Milan Italy
    Immunol Today 20:254-7. 1999
  2. ncbi request reprint Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites
    M Introna
    Istituto di Recerche Farmacologiche Mario Negri, Milano, Italy
    Blood 87:1862-72. 1996
  3. pmc Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells
    C A Power
    Geneva Biomedical Research Institute, GlaxoWellcome Research and Development, Geneva, Switzerland
    J Exp Med 186:825-35. 1997
  4. ncbi request reprint Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19
    P Scapini
    Department of Pathology, Section of General Pathology, University of Verona, Verona, Italy
    Eur J Immunol 31:1981-8. 2001
  5. ncbi request reprint The chemokine system: tuning and shaping by regulation of receptor expression and coupling in polarized responses
    M Locati
    Centro di Eccellenza IDET, Institute of General Pathology, University of Milan, Milan, Italy
    Allergy 57:972-82. 2002
  6. ncbi request reprint Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction
    P Proost
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Biol Chem 274:3988-93. 1999
  7. ncbi request reprint Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo
    M Vulcano
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 31:812-22. 2001
  8. pmc The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, I 20157 Milan, Italy
    J Exp Med 187:2097-101. 1998
  9. ncbi request reprint Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo
    S Saccani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Centro Daniela e Catullo Borgomainerio, 20157 Milano, Italy
    Cytokine 10:773-80. 1998
  10. ncbi request reprint Toll-like receptor family and signalling pathway
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Via Eritrea 62, Milano, I 20157, Italy
    Biochem Soc Trans 28:563-6. 2000

Collaborators

Detail Information

Publications44

  1. ncbi request reprint The chemokine system: redundancy for robust outputs
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62 20157 Milan Italy
    Immunol Today 20:254-7. 1999
    ..Here, Alberto Mantovani argues that such robustness provides a conceptual framework to understand these intriguing aspects of the chemokine system...
  2. ncbi request reprint Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites
    M Introna
    Istituto di Recerche Farmacologiche Mario Negri, Milano, Italy
    Blood 87:1862-72. 1996
    ..Thus, mptx3 shows a distinct pattern of in vivo expression indicative of a significant role in cardiovascular and inflammatory pathology...
  3. pmc Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells
    C A Power
    Geneva Biomedical Research Institute, GlaxoWellcome Research and Development, Geneva, Switzerland
    J Exp Med 186:825-35. 1997
    ....
  4. ncbi request reprint Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19
    P Scapini
    Department of Pathology, Section of General Pathology, University of Verona, Verona, Italy
    Eur J Immunol 31:1981-8. 2001
    ....
  5. ncbi request reprint The chemokine system: tuning and shaping by regulation of receptor expression and coupling in polarized responses
    M Locati
    Centro di Eccellenza IDET, Institute of General Pathology, University of Milan, Milan, Italy
    Allergy 57:972-82. 2002
  6. ncbi request reprint Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction
    P Proost
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Biol Chem 274:3988-93. 1999
    ....
  7. ncbi request reprint Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo
    M Vulcano
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 31:812-22. 2001
    ..Processing of MDC to MDC(3-69) and shorter forms which do not recognize CCR4 is likely to represent a feedback mechanism of negative regulation...
  8. pmc The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, I 20157 Milan, Italy
    J Exp Med 187:2097-101. 1998
    ..Conversely, a dominant negative version of TRAF6 failed to block hToll-induced activation of stress-activated protein kinase/c-Jun NH2-terminal kinases, thus suggesting an early divergence of the two pathways...
  9. ncbi request reprint Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo
    S Saccani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Centro Daniela e Catullo Borgomainerio, 20157 Milano, Italy
    Cytokine 10:773-80. 1998
    ..Therefore, members of IL-1R family are independently and divergently regulated in mononuclear phagocytes exposed to the prototypic pro-inflammatory signal LPS in vitro and in vivo...
  10. ncbi request reprint Toll-like receptor family and signalling pathway
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Via Eritrea 62, Milano, I 20157, Italy
    Biochem Soc Trans 28:563-6. 2000
    ..Alternatively, the expression of a TLR in a single cell type may indicate a specific role for this molecule in a restricted setting...
  11. ncbi request reprint Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Milan, Italy
    J Immunol 164:5998-6004. 2000
    ..These data suggest that TLR can be classified based on expression pattern as ubiquitous (TLR1), restricted (TLR2, TLR4, and TLR5 in myelomonocytic cells), and specific (TLR3 in DC) molecules...
  12. ncbi request reprint Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma
    A Sica
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 164:733-8. 2000
    ....
  13. ncbi request reprint MCP-1 and CCR2 in HIV infection: regulation of agonist and receptor expression
    S Sozzani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 62:30-3. 1997
    ..High levels of MCP-1 may underlie monocyte recruitment and tissue damage in CMV encephalitis and may represent a rapid and useful tool in the diagnostic armamentarium for neurological disorders associated with HIV...
  14. pmc Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells
    R Godiska
    ICOS Corporation, Bothell, Washington 98021, USA
    J Exp Med 185:1595-604. 1997
    ..Unlike most other CC chemokines, MDC is encoded on human chromosome 16. MDC is thus a unique member of the CC chemokine family that may play a fundamental role in the function of dendritic cells, natural killer cells, and monocytes...
  15. ncbi request reprint Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes
    V V Alles
    Laboratory of Immunology, Istituto di Ricerche Farmacologiche, Mario Negri, Milano, Italy
    Blood 84:3483-93. 1994
    ..Thus, PTX3, unlike the classical pentraxins CRP and SAP, is expressed and released by cells of the monocyte-macrophage lineage exposed to inflammatory signals...
  16. pmc Selective induction of phospholipase D1 in pathogen-activated human monocytes
    M Locati
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    Biochem J 358:119-25. 2001
    ..Therefore PLD1 might have a relevant role in immune responses against pathogens and in chronic inflammation...
  17. ncbi request reprint IL-2-regulated expression of the monocyte chemotactic protein-1 receptor (CCR2) in human NK cells: characterization of a predominant 3.4-kilobase transcript containing CCR2B and CCR2A sequences
    N Polentarutti
    Institute of Pharmacologic Research, Mario Negri, Milano, Italy
    J Immunol 158:2689-94. 1997
    ..The predominant long transcript is polyadenylated and present in the cytoplasm. The augmented migratory capacity of IL-2 activated vs resting NK cells was associated with increased CCR2 transcript levels...
  18. ncbi request reprint PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages
    S N Diniz
    Ludwig Institute for Cancer Research, Sao Paulo, Brazil
    J Leukoc Biol 75:649-56. 2004
    ..Our results provide evidence for a role of PTX3 as an important component of the innate-immune response and as part of the host mechanisms that control fungal recognition and phagocytosis...
  19. ncbi request reprint Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells
    M Lech
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    Kidney Int 72:182-92. 2007
    ..TIR8/SIGIRR does not suppress TLR signaling in tubular epithelial cells, which supports their role as sensors of microbial infection in the kidney...
  20. ncbi request reprint The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses
    E M Borroni
    Istituto Clinico Humanitas, Via Manzoni 56, I 20089 Rozzano, Milan, Italy
    Biochem Soc Trans 34:1014-7. 2006
    ....
  21. ncbi request reprint The presence of functional mannose receptor on macrophages at the maternal-fetal interface
    G Laskarin
    Department of Physiology and Immunology, School of Medicine, University of Rijeka, B Branchetta 20 1, 51000 Rijeka, Croatia
    Hum Reprod 20:1057-66. 2005
    ..The mannose receptor (MR) is involved in the initiation of the immune response and regulation of homeostasis during inflammation and tissue remodeling...
  22. ncbi request reprint Scleroderma fibroblasts constitutively express the long pentraxin PTX3
    M M Luchetti
    Istituto di Clinica Medica Generale, Ematologia ed Immunologia Clinica, Univer sità Politecnica delle Marche, Ancona, Italy
    Clin Exp Rheumatol 22:S66-72. 2004
    ..Unlike the classical pentraxins, PTX3 is expressed in response to IL-1beta and TNF-alpha but not to IL-6. The present study was designed to investigate the expression of PTX3 in normal and scleroderma fibroblasts...
  23. ncbi request reprint Macrophage control of inflammation: negative pathways of regulation of inflammatory cytokines
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Novartis Found Symp 234:120-31; discussion 131-5. 2001
    ..These mediators offer new paradigms to understand diverse pathologies, and provide tools and targets for the development of novel therapeutic strategies...
  24. pmc Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses
    P Fraticelli
    Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Clin Invest 107:1173-81. 2001
    ..These results indicate that regulated expression of FKN in ECs participates in an amplification circuit of polarized type I responses...
  25. ncbi request reprint Regulation of the chemokine system at the level of chemokine receptor expression and signaling activity
    M Locati
    Istituto di Patologia Generale, University of Milan, Milano, Italy
    Immunobiology 204:536-42. 2001
    ..Receptor signaling activity represents a further potential level of regulation of the system. Finally, chemokines can also influence the microenvironment by modulating gene expression in target cells...
  26. ncbi request reprint Chemoattractants MDC and TARC are secreted by malignant B-cell precursors following CD40 ligation and support the migration of leukemia-specific T cells
    P Ghia
    Department of Adult Oncology and Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Blood 98:533-40. 2001
    ..Blood. 2001;98:533-540)..
  27. ncbi request reprint IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein
    L E Jensen
    Department of Pharmacology, Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 164:5277-86. 2000
    ..This suggests that sIL-1RAcP may act as an inhibitor of IL-1 by directly interacting with IL-1RI to abolish its capacity to transduce signal...
  28. ncbi request reprint Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes
    R Bonecchi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 164:3862-9. 2000
    ..Therefore, IL-8 and related chemokines may contribute to the accumulation and positioning of mononuclear phagocytes in Th2-dominated responses...
  29. ncbi request reprint Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
    E Hirsch
    Department of Genetics, Biology and Biochemistry, University of Torino, Turin, Italy
    Science 287:1049-53. 2000
    ..These results demonstrate that PI3Kgamma is a crucial signaling molecule required for macrophage accumulation in inflammation...
  30. ncbi request reprint Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4
    F Colotta
    Centro Daniela e Catullo Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Science 261:472-5. 1993
    ..The existence of multiple pathways of regulation emphasizes the need for tight control of IL-1 action...
  31. ncbi request reprint Reactive oxygen intermediates cause rapid release of the interleukin-1 decoy receptor from human myelomonocytic cells
    P Sambo
    Istituto de Ricerche Farmacologiche Mario Negri, Milano, Italy
    Blood 87:1682-6. 1996
    ..Release of the IL-1 type II decoy R might represent one mechanism by which ROI antagonize and limit the proinflammatory effects of IL-1...
  32. ncbi request reprint Production and identification of natural monocyte chemotactic protein from virally infected murine fibroblasts. Relationship with the product of the mouse competence (JE) gene
    J Van Damme
    Rega Institute, University of Leuven, Belgium
    Eur J Biochem 199:223-9. 1991
    ..In all probability the 7-8-kDa MCP form represents the natural product of the mouse gene JE. Murine MCP can thus be classified in the novel family of small inducible inflammatory proteins...
  33. ncbi request reprint Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells
    L Meda
    Institute of General Pathology, University of Verona, Verona, Italy
    J Immunol 157:1213-8. 1996
    ..Taken together, our findings uncover another novel biologic action of Abeta(25-35) and might help in better understanding the mechanisms underlying mononuclear phagocyte recruitment and activation into amyloid deposits...
  34. ncbi request reprint Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes
    F Colotta
    Department of Immunology and Microbiology, Pharmacia Research Center, Nerviano, Italy
    J Immunol 156:2534-41. 1996
    ..The results show that, on exposure to diverse molecules with anti-inflammatory properties, mononuclear phagocytes express and release copious amounts of a novel version of the soluble IL-1 decoy RII...
  35. ncbi request reprint Migratory response of human natural killer cells to lymphotactin
    B Giancarlo
    Department of Immunology and Cell Biology, Mario Negri Institute, Milano, Italy
    Eur J Immunol 26:3238-41. 1996
    ..Finally, in contrast to other cytokines (IL-2 and IL-12) which in addition to chemotaxis augment NK cell adhesion to endothelial cells in vitro, Lptn did not affect the adhesiveness of NK cells to vascular endothelium...
  36. ncbi request reprint Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
    M Romano
    Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    Immunity 6:315-25. 1997
    ..Hence, in vivo and in vitro evidence supports the concept that the IL-6 system plays an unexpected positive role in local inflammatory reactions by amplifying leukocyte recruitment...
  37. pmc Expression of a long pentraxin, PTX3, by monocytes exposed to the mycobacterial cell wall component lipoarabinomannan
    V Vouret-Craviari
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Infect Immun 65:1345-50. 1997
    ..The significance of PTX3 in the immunobiology of mycobacterial infection and its relevance in relation to clinical involvement remain to be determined...
  38. ncbi request reprint Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells
    N Polentarutti
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur Cytokine Netw 8:271-4. 1997
    ..In contrast, IL-4, IL-13 and IL-10 either did not affect or they amplified MCP-3 induction in EC. EC-produced MCP-3 may be important in the regulation of extravasation of receptor-expressing cells, including NK cells and eosinophils...
  39. pmc Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
    R Bonecchi
    Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    J Exp Med 187:129-34. 1998
    ..It may also determine different susceptibility of Th1s and Th2s to human immunodeficiency virus strains using different fusion coreceptors...
  40. ncbi request reprint Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor
    G Bernardini
    Regina Elena Cancer Institute, Department of Experimental Medicine and Pathology, University of Rome, La Sapienza, Italy
    Eur J Immunol 28:582-8. 1998
    ..The pattern of CCR8 mRNA expression and the functional effects exerted by its ligand suggest that the triggering of this receptor may regulate multiple functions including activation, migration and proliferation of lymphoid cells...
  41. ncbi request reprint Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor
    S Struyf
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Belgium
    J Immunol 161:2672-5. 1998
    ..These findings suggest that MDC recognizes another, yet unidentified, receptor. We conclude that minimal NH2-terminal truncation of MDC differentially affects its various immunologic functions...
  42. ncbi request reprint Interferon-gamma inhibits expression of the long pentraxin PTX3 in human monocytes
    N Polentarutti
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 28:496-501. 1998
    ..PTX3 protein secretion by activated monocytes is also suppressed by exposure to IFN-gamma. Altogether, these data identify a negative pathway of regulation mediated by IFN-gamma, which may occur under inflammatory conditions...
  43. ncbi request reprint Human immunodeficiency virus replication induces monocyte chemotactic protein-1 in human macrophages and U937 promonocytic cells
    M Mengozzi
    AIDS Immunopathogenesis Unit, DIBIT, San Raffaele Scientific Institute, Milano, Italy
    Blood 93:1851-7. 1999
    ..HIV replication-dependent expression of MCP-1 in MP may be of particular relevance for the pathogenesis of HIV infection in nonlymphoid organs such as the brain...
  44. pmc The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor
    F Re
    Istituto di Ricerche Farmacologiche Mario Negri, Centro Daniela e Catullo Borgomainerio, Milano, Italy
    J Exp Med 179:739-43. 1994
    ..The induction by Dex of the type II receptor, a decoy molecule for IL-1, may contribute to the immunosuppressive and antiinflammatory activities of Dex...