A Mantovani

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157, Milan, Italy
    Trends Immunol 22:328-36. 2001
  2. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
  3. ncbi Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Vaccine 21:S43-7. 2003
  4. ncbi Tuning of innate immunity and polarized responses by decoy receptors
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Faculty of Medicine, University of Milan, Milan, Italy
    Int Arch Allergy Immunol 132:109-15. 2003
  5. ncbi Extracellular and intracellular decoys in the tuning of inflammatory cytokines and Toll-like receptors: the new entry TIR8/SIGIRR
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 75:738-42. 2004
  6. ncbi Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Tumori 89:459-68. 2003
  7. ncbi Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy
    Semin Cancer Biol 14:155-60. 2004
  8. ncbi Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression
    Alberto Mantovani
    Instituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Eur J Cancer 40:1660-7. 2004
  9. ncbi Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells
    A Vecchi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 66:489-94. 1999
  10. pmc Selective induction of phospholipase D1 in pathogen-activated human monocytes
    M Locati
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    Biochem J 358:119-25. 2001

Collaborators

Detail Information

Publications150 found, 100 shown here

  1. ncbi Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157, Milan, Italy
    Trends Immunol 22:328-36. 2001
    ..Moreover, silent nonsignaling receptors could act as decoys for chemokines. Therefore, the use of decoy receptors is a general strategy to regulate the action of primary pro-inflammatory cytokines and chemokines...
  2. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression...
  3. ncbi Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Vaccine 21:S43-7. 2003
    ..Evidence suggests that PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility...
  4. ncbi Tuning of innate immunity and polarized responses by decoy receptors
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Faculty of Medicine, University of Milan, Milan, Italy
    Int Arch Allergy Immunol 132:109-15. 2003
    ..Decoy receptors represent a strategy to tune inflammatory and polarized adaptive responses...
  5. ncbi Extracellular and intracellular decoys in the tuning of inflammatory cytokines and Toll-like receptors: the new entry TIR8/SIGIRR
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 75:738-42. 2004
    ..Thus, extracellular and intracellular decoys tune the activation of members of the IL-1/TLR receptor family...
  6. ncbi Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Tumori 89:459-68. 2003
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumor growth and progression...
  7. ncbi Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy
    Semin Cancer Biol 14:155-60. 2004
    ..Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression...
  8. ncbi Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression
    Alberto Mantovani
    Instituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Eur J Cancer 40:1660-7. 2004
    ..As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression...
  9. ncbi Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells
    A Vecchi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 66:489-94. 1999
    ..This study shows that selective responsiveness of mature and immature DC to inducible vs. constitutively produced chemokines can contribute to the regulated trafficking of DC...
  10. pmc Selective induction of phospholipase D1 in pathogen-activated human monocytes
    M Locati
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    Biochem J 358:119-25. 2001
    ..Therefore PLD1 might have a relevant role in immune responses against pathogens and in chronic inflammation...
  11. pmc Molecules and structures involved in the adhesion of natural killer cells to vascular endothelium
    P Allavena
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Exp Med 173:439-48. 1991
    ....
  12. pmc Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses
    P Fraticelli
    Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Clin Invest 107:1173-81. 2001
    ..These results indicate that regulated expression of FKN in ECs participates in an amplification circuit of polarized type I responses...
  13. ncbi Molecules involved in the adhesion and cytotoxicity of activated monocytes on endothelial cells
    N Jonjic
    Instituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 148:2080-3. 1992
    ..Thus, in the ensemble of adhesion molecules available for interaction between endothelium and activated monocytes, the hierarchy of their importance may vary for different functions...
  14. ncbi Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4
    F Colotta
    Centro Daniela e Catullo Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Science 261:472-5. 1993
    ..The existence of multiple pathways of regulation emphasizes the need for tight control of IL-1 action...
  15. ncbi Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 161:1083-6. 1998
    ..Conversely, the slower acquisition of responsiveness to ELC/MIP-3beta may guide subsequent localization of DC in lymphoid organs...
  16. ncbi Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo
    S Saccani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Centro Daniela e Catullo Borgomainerio, 20157 Milano, Italy
    Cytokine 10:773-80. 1998
    ..Therefore, members of IL-1R family are independently and divergently regulated in mononuclear phagocytes exposed to the prototypic pro-inflammatory signal LPS in vitro and in vivo...
  17. ncbi Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells
    D D'Ambrosio
    Roche Milano Ricerche, Milan, Italy
    J Immunol 161:5111-5. 1998
    ....
  18. ncbi Heterogeneity in human melanoma cell adhesion to cytokine activated endothelial cells correlates with VLA-4 expression
    I Martin-Padura
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Cancer Res 51:2239-41. 1991
    ..These data demonstrate intratumor heterogeneity in the expression of VLA-4 and that this can represent a crucial determinant of tumor cell interaction with EC during secondary spread...
  19. ncbi Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Milan, Italy
    J Immunol 164:5998-6004. 2000
    ..These data suggest that TLR can be classified based on expression pattern as ubiquitous (TLR1), restricted (TLR2, TLR4, and TLR5 in myelomonocytic cells), and specific (TLR3 in DC) molecules...
  20. ncbi Human monocyte-derived and CD34+ cell-derived dendritic cells express functional receptors for platelet activating factor
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    FEBS Lett 418:98-100. 1997
    ..Since DC are highly motile cells, protein chemoattractants as well as bioactive phospholipids are likely to contribute to tissue localization of DC, in vivo...
  21. ncbi The role of chemokines in the regulation of dendritic cell trafficking
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 66:1-9. 1999
    ..A better understanding of the molecular basis of DC trafficking may provide molecular and conceptual tools to direct and modulate DC traffic as a strategy to up-regulate and orient specific immunity...
  22. ncbi Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma
    A Sica
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 164:733-8. 2000
    ....
  23. ncbi Interferon-gamma inhibits expression of the long pentraxin PTX3 in human monocytes
    N Polentarutti
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 28:496-501. 1998
    ..PTX3 protein secretion by activated monocytes is also suppressed by exposure to IFN-gamma. Altogether, these data identify a negative pathway of regulation mediated by IFN-gamma, which may occur under inflammatory conditions...
  24. ncbi Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes
    R Bonecchi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 164:3862-9. 2000
    ..Therefore, IL-8 and related chemokines may contribute to the accumulation and positioning of mononuclear phagocytes in Th2-dominated responses...
  25. ncbi Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component
    B Bottazzi
    From the Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    J Biol Chem 272:32817-23. 1997
    ....
  26. ncbi MCP-1 and CCR2 in HIV infection: regulation of agonist and receptor expression
    S Sozzani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 62:30-3. 1997
    ..High levels of MCP-1 may underlie monocyte recruitment and tissue damage in CMV encephalitis and may represent a rapid and useful tool in the diagnostic armamentarium for neurological disorders associated with HIV...
  27. ncbi Heterogeneous susceptibility of human melanoma clones to monocyte cytotoxicity: role of ICAM-1 defined by antibody blocking and gene transfer
    N Jonjic
    Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
    Eur J Immunol 22:2255-60. 1992
    ....
  28. ncbi Macrophage control of inflammation: negative pathways of regulation of inflammatory cytokines
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Novartis Found Symp 234:120-31; discussion 131-5. 2001
    ..These mediators offer new paradigms to understand diverse pathologies, and provide tools and targets for the development of novel therapeutic strategies...
  29. ncbi Monocytes from Wiskott-Aldrich patients differentiate in functional mature dendritic cells with a defect in CD83 expression
    P Allavena
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 31:3413-21. 2001
    ....
  30. ncbi Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages
    A Sica
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 164:762-7. 2000
    ..Blocking IL-10, as well as other immunosuppressive cytokines present in the tumor microenvironment, such as TGF-beta, may complement therapeutic strategies aimed at activating type I antitumor immune responses...
  31. ncbi Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 159:1993-2000. 1997
    ..Chemokines may play a role in the trafficking of DC under resting or stimulated conditions. Chemokine receptors expressed in DC are likely to underlie HIV infection of this cell type...
  32. ncbi Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells
    N Polentarutti
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur Cytokine Netw 8:271-4. 1997
    ..In contrast, IL-4, IL-13 and IL-10 either did not affect or they amplified MCP-3 induction in EC. EC-produced MCP-3 may be important in the regulation of extravasation of receptor-expressing cells, including NK cells and eosinophils...
  33. ncbi Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program
    Marcello Chieppa
    Department of Immunology, Istituto Mario Negri, Milan, Italy
    J Immunol 171:4552-60. 2003
    ....
  34. ncbi Bacterial lipopolysaccharide causes rapid shedding, followed by inhibition of mRNA expression, of the IL-1 type II receptor, with concomitant up-regulation of the type I receptor and induction of incompletely spliced transcripts
    G Penton-Rol
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 162:2931-8. 1999
    ..This early event, followed by prolonged inhibition of IL-1RII expression and up-regulation of IL-1RI, may render monocytes more responsive to IL-1 at sites of inflammation...
  35. ncbi Regulation of the chemokine system at the level of chemokine receptor expression and signaling activity
    M Locati
    Istituto di Patologia Generale, University of Milan, Milano, Italy
    Immunobiology 204:536-42. 2001
    ..Receptor signaling activity represents a further potential level of regulation of the system. Finally, chemokines can also influence the microenvironment by modulating gene expression in target cells...
  36. pmc Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
    R Bonecchi
    Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    J Exp Med 187:129-34. 1998
    ..It may also determine different susceptibility of Th1s and Th2s to human immunodeficiency virus strains using different fusion coreceptors...
  37. ncbi Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo
    M Vulcano
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 31:812-22. 2001
    ..Processing of MDC to MDC(3-69) and shorter forms which do not recognize CCR4 is likely to represent a feedback mechanism of negative regulation...
  38. ncbi The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses
    E M Borroni
    Istituto Clinico Humanitas, Via Manzoni 56, I 20089 Rozzano, Milan, Italy
    Biochem Soc Trans 34:1014-7. 2006
    ....
  39. pmc Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family
    Cecilia Garlanda
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 101:3522-6. 2004
    ..Thus, TIR8 represents a negative pathway of regulation of the IL-1 receptor/TLR system, expressed in epithelial cells and DC, crucial for tuning inflammation in the gastrointestinal tract...
  40. pmc Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle-sized T antigen: implications for the pathogenesis of opportunistic vascular tumors
    C Garlanda
    Istituto Mario Negri, Milan, Italy
    Proc Natl Acad Sci U S A 91:7291-5. 1994
    ....
  41. ncbi A new monoclonal antibody (5D3-F7) which recognizes human monocyte-chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells
    G Peri
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol Methods 174:249-57. 1994
    ..The 5D3-F7 mAb provides a novel, highly specific reagent with which to investigate the in vitro and in vivo production and role of MCP-1...
  42. ncbi A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants
    Q G Dong
    Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    Arterioscler Thromb Vasc Biol 17:1599-604. 1997
    ..The general strategy outlined here is simple, effective, and flexible, allowing the inclusion of further positive or negative selection steps...
  43. pmc Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment
    P Allavena
    Department of Immunology and Inflammation, IRCCS Humanitas Clinical Institute Department of Translational Medicine, University of Milan, Milan, Rozzano, Italy
    Clin Exp Immunol 167:195-205. 2012
    ....
  44. doi Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    G Solinas
    Department of Immunology and Inflammation, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    J Leukoc Biol 86:1065-73. 2009
    ..Thus, together with other myeloid-related cells present at the tumor site (Tie2 macrophages and MDSCs), TAM represent an attractive target of novel biological therapies of tumors...
  45. ncbi Role of leukocyte function-associated antigen-1 and very late antigen-4 in the adhesion and transmigration of c-myc-transfected B-lymphoblastoid cell lines across vascular endothelium
    C Paganin
    Immunology Laboratory, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int J Clin Lab Res 24:29-32. 1994
    ..This may be relevant in the localization and malignant behavior of B-cell lymphomas carrying an activated c-myc oncogene...
  46. pmc Expression of a long pentraxin, PTX3, by monocytes exposed to the mycobacterial cell wall component lipoarabinomannan
    V Vouret-Craviari
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Infect Immun 65:1345-50. 1997
    ..The significance of PTX3 in the immunobiology of mycobacterial infection and its relevance in relation to clinical involvement remain to be determined...
  47. ncbi Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients
    B Muller
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Crit Care Med 29:1404-7. 2001
    ..Compared with the short pentraxin C-reactive protein, PTX3 may be a more direct indicator of tissue involvement by inflammatory and infectious processes...
  48. ncbi Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells
    Andrea Doni
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Immunol 33:2886-93. 2003
    ..These results suggest that DC of myelomonocytic origin are a major source of PTX3, a molecule which facilitates pathogen recognition and subsequent activation of innate and adaptive immunity...
  49. doi Divergent effects of hypoxia on dendritic cell functions
    Alessandra Mancino
    Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Milan, Italy
    Blood 112:3723-34. 2008
    ..Thus, hypoxia uncouples the promotion of inflammatory and tissue repair from sentinel functions in DCs, which we suggest is a safeguard mechanism against immune reactivity to damaged tissues...
  50. doi The chemokine system in cancer biology and therapy
    Alberto Mantovani
    Department of Translational Medicine, University of Milan, I 20089 Rozzano, Milan, Italy
    Cytokine Growth Factor Rev 21:27-39. 2010
    ..Available information in preclinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies...
  51. ncbi The long pentraxin PTX3 in vascular pathology
    Alberto Mantovani
    Research Laboratory in Immunology and Inflammation, Istituto Clinico Humanitas Via Manzoni, 56, 20089 Rozzano, Milan, Italy
    Vascul Pharmacol 45:326-30. 2006
    ....
  52. doi The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance
    Paola Allavena
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Immunol Rev 222:155-61. 2008
    ..Herein, the 'macrophage balance' is discussed in the context of the apparent paradox of tumor promotion by innate immunity-driven inflammation and the seemingly opposed tumor surveillance by adaptive immune responses...
  53. pmc Cell-specific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells
    Andrea Doni
    Istituto Clinico Humanitas, Istituto Di Ricerca Cura a Caratte Re Scientifico, Department of Immunology and Inflammation, Rozzano, Milan, Italy
    J Biol Chem 283:29983-92. 2008
    ..The divergent effects of GC on PTX3 production probably reflect the different functions of this multifunctional molecule in innate immunity and in the construction of the extracellular matrix...
  54. ncbi Chemokine receptors: interaction with HIV-1 and viral-encoded chemokines
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Pharm Acta Helv 74:305-12. 2000
    ..This biological activity could represent a strategy developed by the virus to subvert immunity impairing the generation of an effective anti-viral immune response...
  55. pmc The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor
    F Re
    Istituto di Ricerche Farmacologiche Mario Negri, Centro Daniela e Catullo Borgomainerio, Milano, Italy
    J Exp Med 179:739-43. 1994
    ..The induction by Dex of the type II receptor, a decoy molecule for IL-1, may contribute to the immunosuppressive and antiinflammatory activities of Dex...
  56. ncbi The chemokine system: tuning and shaping by regulation of receptor expression and coupling in polarized responses
    M Locati
    Centro di Eccellenza IDET, Institute of General Pathology, University of Milan, Milan, Italy
    Allergy 57:972-82. 2002
  57. ncbi Toll-like receptor family and signalling pathway
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Via Eritrea 62, Milano, I 20157, Italy
    Biochem Soc Trans 28:563-6. 2000
    ..Alternatively, the expression of a TLR in a single cell type may indicate a specific role for this molecule in a restricted setting...
  58. ncbi Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration
    T Ravizza
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Neuroscience 105:43-53. 2001
    ..Our results provide evidence that pentraxin 3 is synthesized in brain after seizures and may exert a protective role in seizure-induced neurodegeneration...
  59. ncbi Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3
    Alberto Mantovani
    Istituto Clinico Humanitas, Via Manzoni 56, 20089, Milan, Rozzano, Italy
    J Clin Immunol 28:1-13. 2008
    ..Evidence suggests that PTX3 is a useful new serological marker, rapidly reflecting tissue inflammation and damage under diverse clinical conditions...
  60. doi Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction
    Monica Salio
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circulation 117:1055-64. 2008
    ..It was therefore important to assess whether PTX3 plays a pathogenetic role in acute myocardial infarction...
  61. pmc Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6
    Virginia Maina
    Research Laboratory in Immunology and Inflammation, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    J Leukoc Biol 86:123-32. 2009
    ..The coordinated expression of PTX3 and TSG-6 may play a role in ECM remodeling at sites of inflammation...
  62. ncbi Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
    Cecilia Garlanda
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Nature 420:182-6. 2002
    ..Thus, the long pentraxin Ptx3 is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents, in particular to the opportunistic fungal pathogen Aspergillus fumigatus...
  63. doi Cytokines as a key component of cancer-related inflammation
    Giovanni Germano
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, Milan, Italy
    Cytokine 43:374-9. 2008
    ..Cytokines involved in cancer-related inflammation represent a target for innovative diagnostic and therapeutic strategies, and a future challenge for scientists and clinicians...
  64. ncbi The long pentraxin PTX3 as a link among innate immunity, inflammation, and female fertility
    Barbara Bottazzi
    Istituto Clinico Humanitas, Rozzano, Milan, Italy
    J Leukoc Biol 79:909-12. 2006
    ..Thus, the prototypic long pentraxin PTX3 is a multifunctional, soluble pattern recognition receptor acting as a nonredundant component of the humoral arm of innate immunity and involved in matrix deposition and female fertility...
  65. ncbi A novel mechanism of colon carcinoma cell adhesion to the endothelium triggered by beta 1 integrin chain
    I Martin-Padura
    Laboratory of Vascular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Biol Chem 269:6124-32. 1994
    ....
  66. ncbi IL-1 inducible genes in human umbilical vein endothelial cells
    M Introna
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur Heart J 14:78-81. 1993
    ..PTX3 may represent a novel marker of inflammatory reactions, particularly those involving the vessel wall...
  67. doi Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer
    S Danese
    Inflammatory Bowel Disease Unit, Division of Gastroenterology, Milan, Italy
    Oncogene 29:3313-23. 2010
    ..Dissection of molecular pathways involved in colitis-associated cancer may offer opportunities for innovative therapeutic strategies...
  68. pmc The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, I 20157 Milan, Italy
    J Exp Med 187:2097-101. 1998
    ..Conversely, a dominant negative version of TRAF6 failed to block hToll-induced activation of stress-activated protein kinase/c-Jun NH2-terminal kinases, thus suggesting an early divergence of the two pathways...
  69. ncbi Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
    M Romano
    Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    Immunity 6:315-25. 1997
    ..Hence, in vivo and in vitro evidence supports the concept that the IL-6 system plays an unexpected positive role in local inflammatory reactions by amplifying leukocyte recruitment...
  70. ncbi Toll-like receptors (TLRs) signalling and expression pattern
    M Muzio
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Endotoxin Res 7:297-300. 2001
    ..Differential expression and regulation as well as distinct, though overlapping, ligand recognition patterns may underlie the existence of a such a large, seemingly redundant, TLR family...
  71. ncbi Molecular pathways linking inflammation and cancer
    A Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Curr Mol Med 10:369-73. 2010
    ..Cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies...
  72. doi Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Hum Immunol 70:325-30. 2009
    ..As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer...
  73. ncbi p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance
    Alessandra Saccani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Cancer Res 66:11432-40. 2006
    ..Thus, p50 NF-kappaB overexpression accounts for the inability of TAM to mount an effective M1 antitumor response capable of inhibiting tumor growth...
  74. doi Macrophage polarization in tumour progression
    Antonio Sica
    Department of Inflammation and Immunology, Fondazione Humanitas per la Ricerca, 20089 Rozzano, Milan, Italy
    Semin Cancer Biol 18:349-55. 2008
    ..Here, we discuss recent findings suggesting that targeting tumour-associated macrophages (TAMs) polarization may represent a novel therapeutic strategy against cancer...
  75. ncbi The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages
    Paola Allavena
    IRCCS Istituto Clinico Humanitas, Via Manzoni 56, Rozzano 20089, Milan, Italy
    Crit Rev Oncol Hematol 66:1-9. 2008
    ..In this review we will discuss the role of TAM in the inflammatory micro-environment of solid tumors and will try to identify potential target for future therapeutic approaches...
  76. ncbi The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
    ....
  77. ncbi Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Novartis Found Symp 256:137-45; discussion 146-8, 259-69. 2004
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression...
  78. ncbi PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation
    F Fazzini
    Istituto Scientifico H San Raffaele and Università, Milan, Italy
    Arthritis Rheum 44:2841-50. 2001
    ..To verify whether the prototypical long pentraxin PTX3 represents an indicator of the activity of small-vessel vasculitis...
  79. ncbi Migratory response of human natural killer cells to lymphotactin
    B Giancarlo
    Department of Immunology and Cell Biology, Mario Negri Institute, Milano, Italy
    Eur J Immunol 26:3238-41. 1996
    ..Finally, in contrast to other cytokines (IL-2 and IL-12) which in addition to chemotaxis augment NK cell adhesion to endothelial cells in vitro, Lptn did not affect the adhesiveness of NK cells to vascular endothelium...
  80. ncbi PTX3, A prototypical long pentraxin, is an early indicator of acute myocardial infarction in humans
    G Peri
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circulation 102:636-41. 2000
    ..The possibility that PTX3 is altered in patients with acute myocardial infarction (AMI) has not yet been tested...
  81. ncbi Early activation signals in endothelial cells. Stimulation by cytokines
    M Introna
    Dipartimento di Immunologia e Biologia Cellulare, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Arterioscler Thromb Vasc Biol 17:423-8. 1997
    ..Only a few molecular pathways have been characterized so far, and key issues in endothelial biology, such as endothelial specificity of gene expression and heterogeneity of different endothelial populations, remain largely unexplored...
  82. ncbi Macrophage infiltration and growth of sarcoma clones expressing different amounts of monocyte chemotactic protein/JE
    S Walter
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int J Cancer 49:431-5. 1991
    ..These results are consistent with the hypothesis that TDCF, identified as MCP/JE, is one important determinant of macrophage infiltration in tumors...
  83. ncbi Role of tumor-associated macrophages in tumor progression and invasion
    Alberto Mantovani
    Istituto Clinico Humanitas, 20089 Rozzano, Milan, Italy
    Cancer Metastasis Rev 25:315-22. 2006
    ..Here, we discuss evidence supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and a potential target of anti-cancer therapy...
  84. doi The Toll-IL-1R member Tir8/SIGIRR negatively regulates adaptive immunity against kidney grafts
    Marina Noris
    Transplant Research Center Chiara Cucchi De Alessandri and Gilberto Crespi, Mario Negri Institute for Pharmacological Research, Via Camozzi 3, 24020 Ranica, Bergamo, Italy
    J Immunol 183:4249-60. 2009
    ..Thus, TIR8 acts locally as a key regulator of allogeneic immune response in the kidney. Tir8 expression and/or signaling in donor tissue are envisaged as a novel target for control of innate immunity and amelioration of graft survival...
  85. doi Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells
    Giuseppe Danilo Norata
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Arterioscler Thromb Vasc Biol 28:925-31. 2008
    ....
  86. doi The lymphatic system controls intestinal inflammation and inflammation-associated Colon Cancer through the chemokine decoy receptor D6
    Stefania Vetrano
    Division of Gastroenterology, Istituto Clinico Humanitas IRCCS, Milan, Italy
    Gut 59:197-206. 2010
    ....
  87. ncbi Pentraxins in innate immunity and inflammation
    Cecilia Garlanda
    Istituto Clinico Humanitas, Via Manzoni, 56, 20089 Rozzano, Milan, Italy
    Novartis Found Symp 279:80-6; discussion 86-91, 216-9. 2006
    ..Thus, the prototypic long pentraxin PTX3 is a multifunctional soluble pattern recognition receptor at the crossroads between innate immunity, inflammation, matrix deposition and female fertility...
  88. ncbi Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy
    Antonio Sica
    Istituto Clinico Humanitas, 20089 Rozzano, Milan, Italy
    Eur J Cancer 42:717-27. 2006
    ..Evidence is presented here supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and are a potential target for anti-cancer therapy...
  89. ncbi The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells, and edits the cross-presentation of self, viral, and tumor antigens
    Paramita Baruah
    Cancer Immunotherapy and Gene Therapy Program, H San Raffaele Institute, Milan, Italy
    Blood 107:151-8. 2006
    ..These data suggest that PTX3 acts as a third-party agent between microbial stimuli and dying cells, contributing to limit tissue damage under inflammatory conditions and the activation of autoreactive T cells...
  90. doi Chemokine decoy receptors: structure-function and biological properties
    Raffaella Bonecchi
    Department of Translational Medicine, University of Milan, 20089 Rozzano, Milan, Italy
    Curr Top Microbiol Immunol 341:15-36. 2010
    ....
  91. ncbi Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFN-gamma
    Andrea Doni
    Istituto Clinico Humanitas ICH, Via Manzoni, 56 20089 Rozzano, Milan, Italy
    J Leukoc Biol 79:797-802. 2006
    ..As PTX3 is also an extracellular matrix component, IL-10-enhanced PTX3 production may play a role in orchestration of tissue remodeling in chronic inflammation...
  92. doi Molecular pathways and targets in cancer-related inflammation
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, Milan, Italy
    Ann Med 42:161-70. 2010
    ..Emerging evidence also suggests that cancer-related inflammation promotes genetic instability. Thus, cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies...
  93. ncbi Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction
    Roberto Latini
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Circulation 110:2349-54. 2004
    ..The aim of this study was to assess the prognostic value of PTX3 in MI compared with the best-known and clinically relevant biological markers...
  94. ncbi Tumor-associated macrophages: a molecular perspective
    Antonio Sica
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int Immunopharmacol 2:1045-54. 2002
    ..Emerging evidence starts to define the molecular basis for the peculiar functional phenotype of TAM and identifies possible therapeutic targets...
  95. ncbi Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility
    Cecilia Garlanda
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Annu Rev Immunol 23:337-66. 2005
    ..Thus, the prototypic long pentraxin PTX3 is a multifunctional soluble pattern recognition receptor at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility...
  96. doi Deficiency of the long pentraxin PTX3 promotes vascular inflammation and atherosclerosis
    Giuseppe Danilo Norata
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Circulation 120:699-708. 2009
    ....
  97. doi TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization
    Cecilia Garlanda
    Istituto Clinico Humanitas, IRCCS, Department of Immunology and Inflammation, Rozzano, Milan, Italy
    Trends Immunol 30:439-46. 2009
    ..TIR8 also dampens TLR-mediated activation. The ability to dampen signaling from ILR family members and TLRs makes TIR8 a key regulator of inflammation, cancer-related inflammation, and autoimmunity...
  98. doi Cancer related inflammation: the macrophage connection
    Antonio Sica
    Fondazione Humanitas per Ricerca, 20089 Rozzano, Milan, Italy
    Cancer Lett 267:204-15. 2008
    ..This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches...
  99. ncbi The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1
    F Colotta
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Immunol Today 15:562-6. 1994
    ..Here, Francesco Colotta and colleagues review the properties of these receptors and summarize evidence indicating that the type II receptor acts as a regulated decoy target for IL-1...
  100. ncbi Regulatory pathways in inflammation
    Alberto Mantovani
    Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Autoimmun Rev 7:8-11. 2007
    ....
  101. doi Chemokine receptors intracellular trafficking
    Elena M Borroni
    Department of Translational Medicine, University of Milan, I 20089 Rozzano, Milan, Italy
    Pharmacol Ther 127:1-8. 2010
    ....