Giovanni Maga

Summary

Affiliation: Istituto di Genetica Molecolare
Country: Italy

Publications

  1. Brai A, Fazi R, Tintori C, Zamperini C, Bugli F, Sanguinetti M, et al. Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents. Proc Natl Acad Sci U S A. 2016;113:5388-93 pubmed publisher
    ..Pharmacokinetics and toxicity studies in rats confirmed a good safety profile and bioavailability of 16d. Thus, DDX3 is here validated as a valuable therapeutic target. ..
  2. Bavagnoli L, Cucuzza S, Campanini G, Rovida F, Paolucci S, Baldanti F, et al. The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA. Nucleic Acids Res. 2015;43:9405-17 pubmed publisher
    ..These results point to a previously undetected role of the last C-ter 20 aa for the catalytic activity of PA-X and support distinct roles for these proteins in the viral life cycle. ..
  3. Mentegari E, Kissova M, Bavagnoli L, Maga G, Crespan E. DNA Polymerases ? and ?: The Double-Edged Swords of DNA Repair. Genes (Basel). 2016;7: pubmed publisher
    ..This review summarizes the most recent results on the ambivalent properties of these enzymes in limiting or promoting genetic instability in mammalian cells, as well as their potential use as targets for anticancer chemotherapy. ..
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    Maga G, Villani G, Ramadan K, Shevelev I, Tanguy Le Gac N, Blanco L, et al. Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. J Biol Chem. 2002;277:48434-40 pubmed
    ..Our results suggest that the complex between PCNA and pol lambda may play an important role in the bypass of abasic sites in human cells. ..
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    Maga G, Blanca G, Shevelev I, Frouin I, Ramadan K, Spadari S, et al. The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1. FASEB J. 2004;18:1743-5 pubmed
    ..Given the high rate of frameshift mutations induced by pol lambda and its ability to bypass abasic sites, accurate regulation of pol lambda activity by PCNA and p21 concerted action might be important for preventing genetic instability. ..
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    Maga G, Ramadan K, Locatelli G, Shevelev I, Spadari S, Hubscher U. DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A. J Biol Chem. 2005;280:1971-81 pubmed
  7. Maga G, Shevelev I, Villani G, Spadari S, Hubscher U. Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda. Nucleic Acids Res. 2006;34:1405-15 pubmed
    ..Possible physiological implications of these findings for the in vivo fidelity of pol lambda are discussed. ..
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    Maga G, Villani G, Crespan E, Wimmer U, Ferrari E, Bertocci B, et al. 8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. Nature. 2007;447:606-8 pubmed
  9. Maga G, Crespan E, Wimmer U, van Loon B, Amoroso A, Mondello C, et al. Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair. Proc Natl Acad Sci U S A. 2008;105:20689-94 pubmed publisher

More Information

Publications12

  1. Maga G, van Loon B, Crespan E, Villani G, Hubscher U. The block of DNA polymerase delta strand displacement activity by an abasic site can be rescued by the concerted action of DNA polymerase beta and Flap endonuclease 1. J Biol Chem. 2009;284:14267-75 pubmed publisher
    ..Our data identify a previously unnoticed deleterious effect of the AP site lesion on normal cell metabolism and suggest the existence of a novel repair pathway that might be important in preventing replication fork stalling. ..
  2. Kissova M, Maga G, Crespan E. The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: Implications for drug design. Bioorg Med Chem. 2016;24:4555-4562 pubmed publisher
    ..Our results revealed the different mechanisms of action of these two enzymes and may open a new avenue for the future design of specific Kit inhibitors. ..
  3. Garbelli A, Riva V, Crespan E, Maga G. How to win the HIV-1 drug resistance hurdle race: running faster or jumping higher?. Biochem J. 2017;474:1559-1577 pubmed publisher