G Laviola

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. pmc Immunization with DAT fragments is associated with long-term striatal impairment, hyperactivity and reduced cognitive flexibility in mice
    Walter Adriani
    Dept Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Behav Brain Funct 8:54. 2012
  2. pmc Delay aversion but preference for large and rare rewards in two choice tasks: implications for the measurement of self-control parameters
    Walter Adriani
    Behavioural Neuroscience Section, Dept, Cell Biology and Neurosciences, Istituto Superiore di Sanita, Roma, Italy
    BMC Neurosci 7:52. 2006
  3. ncbi request reprint Beneficial effects of enriched environment on adolescent rats from stressed pregnancies
    Giovanni Laviola
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena, 299, I 00161 Roma, Italy
    Eur J Neurosci 20:1655-64. 2004
  4. ncbi request reprint D-amphetamine-related reinforcing effects are reduced in mice exposed prenatally to estrogenic endocrine disruptors
    Giovanni Laviola
    Section of Behavioral Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena, 299 I 00161 Roma, Italy
    Brain Res Bull 65:235-40. 2005
  5. ncbi request reprint [Psychobiological determinants of risk behavior in adolescence]
    Giovanni Laviola
    Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Roma
    Ann Ist Super Sanita 38:279-87. 2002
  6. ncbi request reprint Social withdrawal, neophobia, and stereotyped behavior in developing rats exposed to neonatal asphyxia
    G Laviola
    Section of Behavioral Pathophysiology, Lab Fisiopatologia OS, Dipartimento Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Psychopharmacology (Berl) 175:196-205. 2004
  7. ncbi request reprint Peculiar response of adolescent mice to acute and chronic stress and to amphetamine: evidence of sex differences
    Giovanni Laviola
    Section of Behavioral Pathophysiology, Lab Fisiopatologia O S, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 130:117-25. 2002
  8. ncbi request reprint Paradoxical effects of prenatal acetylcholinesterase blockade on neuro-behavioral development and drug-induced stereotypies in reeler mutant mice
    Giovanni Laviola
    Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Psychopharmacology (Berl) 187:331-44. 2006
  9. ncbi request reprint Striatal dopamine sensitization to D-amphetamine in periadolescent but not in adult rats
    G Laviola
    Section of Behavioural Pathophysiology, Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    Pharmacol Biochem Behav 68:115-24. 2001
  10. ncbi request reprint Psychobiological risk factors for vulnerability to psychostimulants in human adolescents and animal models
    G Laviola
    Section of Behavioural Pathophysiology, Labor F O S, Istituto Superiore di Sanita, Rome, Italy
    Neurosci Biobehav Rev 23:993-1010. 1999

Detail Information

Publications70

  1. pmc Immunization with DAT fragments is associated with long-term striatal impairment, hyperactivity and reduced cognitive flexibility in mice
    Walter Adriani
    Dept Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Behav Brain Funct 8:54. 2012
    ..Here, we assessed the interplay between DAT auto-immunity and behavioural / neurochemical phenotype...
  2. pmc Delay aversion but preference for large and rare rewards in two choice tasks: implications for the measurement of self-control parameters
    Walter Adriani
    Behavioural Neuroscience Section, Dept, Cell Biology and Neurosciences, Istituto Superiore di Sanita, Roma, Italy
    BMC Neurosci 7:52. 2006
    ..It has been suggested that PD protocols also measure impulsivity, however, a clear dissociation has been reported between delay and probability discounting...
  3. ncbi request reprint Beneficial effects of enriched environment on adolescent rats from stressed pregnancies
    Giovanni Laviola
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena, 299, I 00161 Roma, Italy
    Eur J Neurosci 20:1655-64. 2004
    ..This is a first indication that an environmental intervention, such as enriched housing, during adolescence can beneficially affect basal immune parameters and rats response to both early stress and drug-induced immunosuppression...
  4. ncbi request reprint D-amphetamine-related reinforcing effects are reduced in mice exposed prenatally to estrogenic endocrine disruptors
    Giovanni Laviola
    Section of Behavioral Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena, 299 I 00161 Roma, Italy
    Brain Res Bull 65:235-40. 2005
    ..These data confirm that exposure to weak environmental estrogens in the period of brain sexual differentiation can influence adult behavior...
  5. ncbi request reprint [Psychobiological determinants of risk behavior in adolescence]
    Giovanni Laviola
    Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Roma
    Ann Ist Super Sanita 38:279-87. 2002
    ..AIDS and car accident)...
  6. ncbi request reprint Social withdrawal, neophobia, and stereotyped behavior in developing rats exposed to neonatal asphyxia
    G Laviola
    Section of Behavioral Pathophysiology, Lab Fisiopatologia OS, Dipartimento Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Psychopharmacology (Berl) 175:196-205. 2004
    ..In conclusion, these findings suggest an increased risk of developing social withdrawal, neophobia and behavioral stereotypies (common symptoms found in schizophrenia and autism) as a consequence of neonatal asphyxia in preterm humans...
  7. ncbi request reprint Peculiar response of adolescent mice to acute and chronic stress and to amphetamine: evidence of sex differences
    Giovanni Laviola
    Section of Behavioral Pathophysiology, Lab Fisiopatologia O S, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 130:117-25. 2002
    ....
  8. ncbi request reprint Paradoxical effects of prenatal acetylcholinesterase blockade on neuro-behavioral development and drug-induced stereotypies in reeler mutant mice
    Giovanni Laviola
    Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Psychopharmacology (Berl) 187:331-44. 2006
    ..Chlorpyrifos, a potent and reversible acetylcholinesterase blocker used as a pesticide, and the "reeler" mouse, lacking the extracellular-matrix protein Reelin, were used...
  9. ncbi request reprint Striatal dopamine sensitization to D-amphetamine in periadolescent but not in adult rats
    G Laviola
    Section of Behavioural Pathophysiology, Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    Pharmacol Biochem Behav 68:115-24. 2001
    ..Thus, a neurobiological substrate for an age-related increased vulnerability towards the addictive risks of these drugs is suggested...
  10. ncbi request reprint Psychobiological risk factors for vulnerability to psychostimulants in human adolescents and animal models
    G Laviola
    Section of Behavioural Pathophysiology, Labor F O S, Istituto Superiore di Sanita, Rome, Italy
    Neurosci Biobehav Rev 23:993-1010. 1999
    ..A deeper understanding of psychostimulant effects during adolescence on the complex interaction between genetic, neurobiologic, psychosocial, and environmental factors will lead to earlier and more effective prevention and treatment...
  11. ncbi request reprint Risk-taking behavior in adolescent mice: psychobiological determinants and early epigenetic influence
    Giovanni Laviola
    Section of Behavioral Pathophysiology, Lab Fisiopatologia O S, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Roma, Italy
    Neurosci Biobehav Rev 27:19-31. 2003
    ..Actually, this model is able to show behavioral features that resemble those found in human adolescents, including vulnerability to the consumption of psychoactive drugs...
  12. ncbi request reprint Elevated novelty seeking and peculiar d-amphetamine sensitization in periadolescent mice compared with adult mice
    W Adriani
    Behavioral Pathophysiology Section, , Rome, Italy
    Behav Neurosci 112:1152-66. 1998
    ..This appears to be a useful model to study psychobiological risk factors involved in vulnerability to addiction during human adolescence...
  13. ncbi request reprint Neurobehavioural disorders in the infant reeler mouse model: interaction of genetic vulnerability and consequences of maternal separation
    Elisa Ognibene
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Behav Brain Res 177:142-9. 2007
    ....
  14. ncbi request reprint Peculiar vulnerability to nicotine oral self-administration in mice during early adolescence
    Walter Adriani
    Behavioural Pathophysiology Section, Lab F O S, Istituto Superiore di Sanita, Viale Regina Elena 299, Roma, Italy
    Neuropsychopharmacology 27:212-24. 2002
    ..The present animal model might be useful to investigate psychobiological determinants involved in early tobacco smoking in human adolescents..
  15. ncbi request reprint Impulsivity-anxiety-related behavior and profiles of morphine-induced analgesia in heterozygous reeler mice
    Elisa Ognibene
    Behavioral Neuroscience Section, Dept Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, Italy
    Brain Res 1131:173-80. 2007
    ..The HZ genotype can thus represent a useful animal model for the study of behavioral disorders consequent to reduced neural plasticity...
  16. doi request reprint Increased impulsive behavior and risk proneness following lentivirus-mediated dopamine transporter over-expression in rats' nucleus accumbens
    W Adriani
    Behavioral Neuroscience Section, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Roma, Italy
    Neuroscience 159:47-58. 2009
    ..Thus, a reduced dopaminergic tone following altered accumbal DAT function may subserve a sensation-seeker phenotype and the vulnerability to impulse-control disorders...
  17. ncbi request reprint Elevated levels of impulsivity and reduced place conditioning with d-amphetamine: two behavioral features of adolescence in mice
    Walter Adriani
    Section of Behavioural Pathophysiology, Laboratorio Fisiopatologia O S, Istituto Superiore di Sanita, Rome, Italy
    Behav Neurosci 117:695-703. 2003
    ..Hence, 2 main features of adolescence were elevated impulsivity and restlessness, and low (or absent) rewarding efficacy of amphetamine...
  18. ncbi request reprint delta-Opioid modulation of social interactions in juvenile mice weaned at different ages
    M L Terranova
    Section of Behavioural Pathophysiology, Labor FOS, , Viale Regina Elena 299, Rome I-00161, Italy
    Physiol Behav 73:393-400. 2001
    ....
  19. doi request reprint Home cage testing of delay discounting in rats
    S Koot
    Istituto Superiore di Sanita, Rome, Italy
    Behav Res Methods 41:1169-76. 2009
    ..Current research is focusing on further validation of this and similar protocols...
  20. doi request reprint Autoantibodies against opioid or glutamate receptors are associated with changes in morphine reward and physical dependence in mice
    Francesca Capone
    Section of Behavioral Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    Psychopharmacology (Berl) 197:535-48. 2008
    ..This study characterized the role of aAbs to these receptors in behavioral modulations recruited during opioid tolerance and sensitization...
  21. ncbi request reprint 1H MRS-detectable metabolic brain changes and reduced impulsive behavior in adult rats exposed to methylphenidate during adolescence
    W Adriani
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Roma, Italy
    Neurotoxicol Teratol 29:116-25. 2007
    ..In summary, MPH exposure during adolescence produced enduring MRS-detectable biochemical modifications in brain reward-related circuits, which may account for increased self-control capacity of adult rats...
  22. pmc Altered profiles of spontaneous novelty seeking, impulsive behavior, and response to D-amphetamine in rats perinatally exposed to bisphenol A
    Walter Adriani
    Section of Behavioral Pathophysiology, Laboratorio Fisiopatologia O S, Istituto Superiore di Sanita, Roma, Italy
    Environ Health Perspect 111:395-401. 2003
    ..This may be a cause for concern for public health, confirming that exposure to a weak environmental estrogen in the period of sexual differentiation of the brain can influence adult behavior...
  23. ncbi request reprint Methylphenidate administration to adolescent rats determines plastic changes on reward-related behavior and striatal gene expression
    Walter Adriani
    Department of Cell Biology and Neurosciences, Behavioral Neuroscience Section, Istituto Superiore di Sanita, Roma, Italy
    Neuropsychopharmacology 31:1946-56. 2006
    ..These modifications might in turn trigger enduring changes responsible for the adult neurobehavioral profile, that is, altered processing of incentive values and a modified flexibility/habit balance...
  24. ncbi request reprint Environmental enrichment during adolescence reverses the effects of prenatal stress on play behaviour and HPA axis reactivity in rats
    Sara Morley-Fletcher
    Section of Behavioural Pathophysiology, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena, 299, I 00161 Roma, Italy
    Eur J Neurosci 18:3367-74. 2003
    ..Moreover, they confirm that PS may well represent a suitable animal model for the design and testing of new therapeutic strategies for behavioural disorders produced by early insults...
  25. ncbi request reprint Spontaneous novelty seeking and amphetamine-induced conditioning and sensitization in adult mice: evidence of dissociation as a function of age at weaning
    Walter Adriani
    Section of Behavioural Pathophysiology, Lab Fisiopatologia O S, Istituto Superiore di Sanita, Viale Regina Elena 299, Roma, Italy
    Neuropsychopharmacology 27:225-36. 2002
    ..These results appear relevant to the issue of early experiences as possible risk factors for a number of psychiatric disorders in humans, including the abuse of drugs...
  26. ncbi request reprint Response to novelty, social and self-control behaviors, in rats exposed to neonatal anoxia: modulatory effects of an enriched environment
    Walter Adriani
    Section of Behavioural Neuroscience, Department Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Psychopharmacology (Berl) 184:155-65. 2006
    ..Beneficial effects of stimulation by an enriched environment during the still-plastic window of adolescence are suggested in these animals...
  27. doi request reprint Compromised decision-making and increased gambling proneness following dietary serotonin depletion in rats
    S Koot
    Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Roma, Italy
    Neuropharmacology 62:1640-50. 2012
    ..The data are discussed in terms of changes within forebrain loops involved in cognitive and motivational/affective processes...
  28. ncbi request reprint Sub-neurotoxic neonatal anoxia induces subtle behavioural changes and specific abnormalities in brain group-I metabotropic glutamate receptors in rats
    P Casolini
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Faculty of Medicine, Rome, Italy
    J Neurochem 95:137-45. 2005
    ....
  29. doi request reprint Early postnatal behavioral changes in the Mecp2-308 truncation mouse model of Rett syndrome
    B De Filippis
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, Italy
    Genes Brain Behav 9:213-23. 2010
    ..This analysis has provided evidence of precocious behavioral markers of RTT and has identified an early developmental window of opportunities on which potential therapies could be investigated...
  30. ncbi request reprint Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats
    Walter Adriani
    INSERM U 588, Institut Francois Magendie, Domaine de Carreire, rue C Saint Saëns, Bordeaux Cedex, 33077, France
    Psychopharmacology (Berl) 184:382-90. 2006
    ..Exposure to nicotine during periadolescence, but not similar exposure in the postadolescent period, increases nicotine self-administration in rats, but underlying mechanisms remain poorly understood...
  31. ncbi request reprint Long-term effects of neonatal basal forebrain cholinergic lesions on radial maze learning and impulsivity in rats
    Maria L Scattoni
    Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Behav Pharmacol 17:517-24. 2006
    ..This animal model may thus be useful to investigate some cognitive deficits and other secondary symptoms seen in Alzheimer's disease...
  32. doi request reprint The effect of early maternal separation on brain derived neurotrophic factor and monoamine levels in adult heterozygous reeler mice
    Elisa Ognibene
    Section of Behavioral Neuroscience, Dept Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 32:1269-76. 2008
    ..The modulatory effects of a chronic treatment with the atypical antipsychotic olanzapine (OLZ, 1.5 mg/kg for 40 days) were also investigated...
  33. doi request reprint Cognitive impulsivity in animal models: role of response time and reinforcing rate in delay intolerance with two-choice operant tasks
    Walter Adriani
    Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Neuropharmacology 58:694-701. 2010
    ..Conversely, a drug-enhanced capacity to cope with delay may involve an internal ability to adjust expectancy about such a reinforcing rate...
  34. doi request reprint Abnormal behavioral and neurotrophic development in the younger sibling receiving less maternal care in a communal nursing paradigm in rats
    Simone Macri
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Psychoneuroendocrinology 35:392-402. 2010
    ..This is the first indication that adverse environments, not requiring experimenter handling, may reduce maternal care and in turn increase offspring's emotionality and modify social behavior and BDNF developmental trajectories...
  35. ncbi request reprint Behavioral and neurochemical vulnerability during adolescence in mice: studies with nicotine
    Walter Adriani
    Section of Behavioral Pathophysiology, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, Italy
    Neuropsychopharmacology 29:869-78. 2004
    ..These findings support neurobiological vulnerability to drugs in adolescent humans...
  36. doi request reprint Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in the rat accumbens
    Walter Adriani
    Sections of Behavioral Neuroscience and of Molecular and Cellular Imaging, Department Cell Biology and Neurosciences, Istituto Superiore di Sanita, Roma, Italy
    Int J Neuropsychopharmacol 13:1329-42. 2010
    ....
  37. ncbi request reprint Enhancement of endocannabinoid signalling during adolescence: Modulation of impulsivity and long-term consequences on metabolic brain parameters in early maternally deprived rats
    Eva Maria Marco
    Unit of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Roma, Italy
    Pharmacol Biochem Behav 86:334-45. 2007
    ..In summary, administration of URB597 during adolescence increased self-control behaviour and produced enduring brain biochemical modifications, in a model for neuropsychiatric disorders...
  38. ncbi request reprint Acetyl-L-carnitine reduces impulsive behaviour in adolescent rats
    Walter Adriani
    Behavioural Neuroscience Section, Dept Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Psychopharmacology (Berl) 176:296-304. 2004
    ..The ALC treatment increased NA levels in the CC and the 5HIAA/5HT ratio in both CC and MFC. Present data suggest that ALC, a drug devoid of psychostimulant properties, may have some beneficial effects in the treatment of ADHD children...
  39. doi request reprint Gene-environment interaction during early development in the heterozygous reeler mouse: clues for modelling of major neurobehavioral syndromes
    Giovanni Laviola
    Sect Behavioral Neuroscience, Dept Cell Biology, Istituto Superiore di Sanita, Viale Regina Elena, 299, I 00161 Roma, Italy
    Neurosci Biobehav Rev 33:560-72. 2009
    ..HZ may be used to disentangle interactions between genetic vulnerability and environmental factors. Such an approach could help to model the pathogenesis of neurodevelopmental psychiatric diseases...
  40. ncbi request reprint Short-term effects of adolescent methylphenidate exposure on brain striatal gene expression and sexual/endocrine parameters in male rats
    Walter Adriani
    Department of Cell Biology and Neurosciences, Behavioural Neuroscience Section, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Roma, Italy
    Ann N Y Acad Sci 1074:52-73. 2006
    ..Our observations suggest that adolescent MPH exposure causes only transient changes in reproductive and hormonal parameters, and a more enduring enhancement of neurobehavioral plasticity...
  41. doi request reprint Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric disorders
    Giovanni Laviola
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, Italy
    Neurobiol Dis 31:159-68. 2008
    ..Additionally we discuss why some of the effects of environmental enrichment question the validity of current animal models of mental disorders...
  42. ncbi request reprint Windows of vulnerability to psychopathology and therapeutic strategy in the adolescent rodent model
    W Adriani
    Behavioural Neuroscience Section, Dept Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Roma, Italy
    Behav Pharmacol 15:341-52. 2004
    ..In conclusion, modelling the adolescent phase in rats and mice appears to be useful for the investigation of determinants of vulnerability to addiction and to other early-onset neuropsychiatric disorders...
  43. doi request reprint Peculiar response to methylphenidate in adolescent compared to adult rats: a phMRI study
    Rossella Canese
    Molecular and Cellular Imaging Section, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161, Rome, Italy
    Psychopharmacology (Berl) 203:143-53. 2009
    ..Adolescent rodents differ markedly from adults in several neuro-behavioural parameters. Moreover, 'paradoxical' responses to psychostimulants have been reported at this age...
  44. ncbi request reprint Intrauterine position has long-term influence on brain mu-opioid receptor density and behaviour in mice
    Sara Morley-Fletcher
    Section of Behavioural Pathophysiology, Labor F O S, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Psychoneuroendocrinology 28:386-400. 2003
    ....
  45. ncbi request reprint The spontaneously hypertensive-rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopulations
    Walter Adriani
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, Roma I 00161, Italy
    Neurosci Biobehav Rev 27:639-51. 2003
    ..Present results confirm and extend previous literature, indicating that adolescent SHRs represent a suitable animal model for the preclinical investigation of the early-onset ADHD syndrome...
  46. ncbi request reprint Motor impulsivity in APP-SWE mice: a model of Alzheimer's disease
    Walter Adriani
    Behavioural Neuroscience Section, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Behav Pharmacol 17:525-33. 2006
    ..Together with recent findings, APP-SWE mice emerge as a suitable animal model, characterized by a number of specific behavioral alterations, resembling primary and secondary symptoms of human Alzheimer's disease...
  47. ncbi request reprint Restricted daily access to water and voluntary nicotine oral consumption in mice: methodological issues and individual differences
    Walter Adriani
    Behavioural Pathophysiology Section, Lab Fisiopatologia Organo Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 134:21-30. 2002
    ..In conclusion, a clear-cut preference for NIC can be easily established when the drug offer is concurrent to a restricted access to water. The present paradigm may be useful to investigate issues of NIC dependence...
  48. ncbi request reprint Single episode of maternal deprivation and adult depressive profile in mice: interaction with cannabinoid exposure during adolescence
    Simone Macri
    Department of Cell Biology and Neuroscience, Behavioural Neuroscience Section, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 154:231-8. 2004
    ..As a whole, the emergence of depressive symptoms during both adolescence and adulthood seems to be eased as a consequence of a single/prolonged episode of early maternal deprivation early in infancy...
  49. ncbi request reprint Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer's disease
    Elisa Ognibene
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Behav Brain Res 156:225-32. 2005
    ..Results clearly indicate that Tg2576 mice are characterized by a number of specific behavioral cognitive alterations, compatible with Alzheimer's disease (AD), which make them a suitable animal model for testing of novel anti-AD drugs...
  50. ncbi request reprint Altered emotionality, spatial memory and cholinergic function in caveolin-1 knock-out mice
    Laura Gioiosa
    Department Cell Biology and Neuroscience, Sect of Behavioural Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, Roma, Italy
    Behav Brain Res 188:255-62. 2008
    ..Our data confirm a distinct behavioural phenotype in CavKO mice and indicate a selective alteration in central cholinergic function...
  51. doi request reprint Resilience and vulnerability are dose-dependently related to neonatal stressors in mice
    Simone Macri
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, Italy
    Horm Behav 56:391-8. 2009
    ....
  52. ncbi request reprint Behavioral effects of 6-bromoflavanone and 5-methoxy-6,8-dibromoflavanone as anxiolytic compounds
    Elisa Ognibene
    Behavioural Neuroscience Section, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 32:128-34. 2008
    ..At the tested doses, both compounds did not induce sedative action or compulsive behaviour. These results encourage making deeper investigations on this field...
  53. ncbi request reprint Prenatal stress affects 3,4-methylenedioxymethamphetamine pharmacokinetics and drug-induced motor alterations in adolescent female rats
    Sara Morley-Fletcher
    Department Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena, 299, Rome I 00161, Italy
    Eur J Pharmacol 489:89-92. 2004
    ....
  54. doi request reprint Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas
    Eva Maria Marco
    Department Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    Brain Res 1257:25-31. 2009
    ..Insights into the developmental trajectories of this neuromodulatory system may help us to better understand and prevent outcomes of neonatal and adolescent cannabis exposure...
  55. ncbi request reprint Acute and carryover effects in mice of MDMA ("ecstasy") administration during periadolescence
    Sara Morley-Fletcher
    Section of Behavioural Pathophysiology, Labor di Fisiopatologia O S, Istituto Superiore di Sanita, Viale Regina Elena, 299 I 00161, Rome, Italy
    Eur J Pharmacol 448:31-8. 2002
    ..As a whole, these results indicate a differential long-term vulnerability to behavioural and neurotoxicant effects of MDMA as a function of the developmental stage of exposure...
  56. pmc A trouble shared is a trouble halved: social context and status affect pain in mouse dyads
    Laura Gioiosa
    Department of Cell Biology and Neuroscience, Section of Behavioral Neuroscience, Istituto Superiore di Sanita, Roma, Italy
    PLoS ONE 4:e4143. 2009
    ..The observation of a cagemate in pain significantly affected the observer's behavior. Additionally, the quality of observer's response was also modulated by the dominance/submission relationship...
  57. doi request reprint Hepatocyte growth factor, vascular endothelial growth factor, glial cell-derived neurotrophic factor and nerve growth factor are differentially affected by early chronic ethanol or red wine intake
    Marco Fiore
    Istituto di Neurobiologia e Medicina Molecolare, Rome, Italy
    Toxicol Lett 188:208-13. 2009
    ..In conclusion the present findings in the mouse show differences in ethanol-induced toxicity when ethanol is administered alone or in red wine that may be related to compounds with antioxidant properties present in the red wine...
  58. doi request reprint Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches
    Laura Ricceri
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena, Roma, Italy
    Behav Pharmacol 19:501-17. 2008
    ..Given the rare occurrence of RTT cases, transnational collaborative networks are expected to provide a deeper understanding of aetiopathology and the development of new therapeutic approaches...
  59. pmc Moderate neonatal stress decreases within-group variation in behavioral, immune and HPA responses in adult mice
    Simone Macri
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, Italy
    PLoS ONE 2:e1015. 2007
    ....
  60. doi request reprint The application of Russell and Burch 3R principle in rodent models of neurodegenerative disease: the case of Parkinson's disease
    Arianna Manciocco
    Section of Behavioral Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome I 00161, Italy
    Neurosci Biobehav Rev 33:18-32. 2009
    ..The formal inclusion in scientific papers of a section devoted to 3Rs may increase knowledge and eventually adherence to this principle by scientists...
  61. ncbi request reprint Early adversity and alcohol availability persistently modify serotonin and hypothalamic-pituitary-adrenal-axis metabolism and related behavior: what experimental research on rodents and primates can tell us
    Simone Macri
    Section of Behavioral Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Neurosci Biobehav Rev 31:172-80. 2007
    ....
  62. ncbi request reprint Health-promoting factors and animal welfare
    Maria Livia Terranova
    Dipartimento di Biologia Cellulare e Neuroscienze, Istituto di Sanità, Rome, Italy
    Ann Ist Super Sanita 40:187-93. 2004
    ....
  63. ncbi request reprint Increased ethanol intake after prenatal ethanol exposure: studies with animals
    M Gabriela Chotro
    Universidad del Pais Vasco UPV EHU, San Sebastian, Spain
    Neurosci Biobehav Rev 31:181-91. 2007
    ..Specifically, the increased ethanol intake effect may be the result of a conditioned preference for ethanol acquired by the fetus when exposed to the drug during the last days of gestation...
  64. ncbi request reprint Ontogenesis of behavioral sensitization and conditioned place preference induced by psychostimulants in laboratory rodents
    Ezio Tirelli
    Behavioral Neuroscience and Experimental Psychopharmacology Laboratory, Department of Cognitive Sciences, University of Liege, Boulevard du Rectorat B32, B 4000 Liege, Belgium
    Neurosci Biobehav Rev 27:163-78. 2003
    ..These age-related changes do imply very different degrees of vulnerability to drug addiction and several other neuropsychiatric disorders...
  65. ncbi request reprint Evidence for enhanced neurobehavioral vulnerability to nicotine during periadolescence in rats
    Walter Adriani
    Institut National de la Santé et de la Recherche Médicale U588, Université V Segalen, Bordeaux 2, Domaine de Carreire, 33077 Bordeaux, France
    J Neurosci 23:4712-6. 2003
    ..Both these changes indicated an increased sensitivity to the addictive properties of nicotine. In conclusion, adolescence seems to be a critical developmental period, characterized by enhanced neurobehavioral vulnerability to nicotine...
  66. ncbi request reprint Chronic psychosocial stress persistently alters autonomic function and physical activity in mice
    Alessandro Bartolomucci
    Dipartimento di Biologia Evolutiva e Funzionale, Universita di Parma, Parco Area delle Scienze 11A, 43100, Parma, Italy
    Physiol Behav 80:57-67. 2003
    ..No correlation emerged between the acute and the long-term autonomic responses. These results highlight the existence of a sustained autonomic activation under chronic stress, which was also affected by mice social status...
  67. ncbi request reprint Specific changes in levels of autoantibodies to glutamate and opiate receptors induced by morphine administration in rats
    Oleg Granstrem
    Department of Neurology and Neurosurgery, I P Pavlov s State Medical University, 6 8 L Tolstoy s Street, 197022 St Petersburg, Russia
    Neurosci Lett 403:1-5. 2006
    ..Therefore, together with further investigations on their potential functional consequences, we propose a thorough exploration of aAbs to MDOR and to AMPA GluR1 subunit as early biomarkers signaling opiate addiction...
  68. ncbi request reprint Effects of chronic psychosocial stress on cardiac autonomic responsiveness and myocardial structure in mice
    Tania Costoli
    Dipartimento di Biologia Evolutiva e Funzionale, Universita di Parma, Parco Area delle Scienze 11A, 43100 Parma, Italy
    Am J Physiol Heart Circ Physiol 286:H2133-40. 2004
    ..In summary, although mice appeared to adapt to chronic psychosocial stress in terms of acute cardiovascular responsiveness and heart rate rhythmicity, structural alterations occurred at the myocardial level...
  69. ncbi request reprint Behavioural, neural and cardiovascular adaptations in mice lacking the NPY Y1 receptor
    Tania Costoli
    Department of Evolutionary and Functional Biology, Universita di Parma, Parco Area delle Scienze 11A, 43100 Parma, Italy
    Neurosci Biobehav Rev 29:113-23. 2005
    ....
  70. ncbi request reprint Subchronic nicotine exposure in adolescence induces long-term effects on hippocampal and striatal cannabinoid-CB1 and mu-opioid receptors in rats
    Eva M Marco
    Dept Fisiología Fisiología Animal II, Facultad de Biologia, Universidad Complutense, Madrid, Spain
    Eur J Pharmacol 557:37-43. 2007
    ..e. cannabis and morphine/heroin when taken later in life...