G Lauria

Summary

Affiliation: Istituto Nazionale Neurologico Carlo Besta
Country: Italy

Publications

  1. pmc The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology
    Grazia Devigili
    Neurological Clinic, University of Ferrara, Italy
    Brain 131:1912-25. 2008
  2. doi Diagnosis of neuropathic pain: challenges and possibilities
    Giuseppe Lauria
    Carlo Besta Neurological Institute, Neuromuscular Diseases Unit, IRCCS Foundation, Via Celoria, 11, 20133, Milan, Italy 39 02 2394 2378 39 02 2394 4057
    Expert Opin Med Diagn 6:89-93. 2012
  3. doi Skin biopsy in painful and immune-mediated neuropathies
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRRCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, Milan, Italy
    J Peripher Nerv Syst 17:38-45. 2012
  4. doi Small fibre neuropathy
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
    Curr Opin Neurol 25:542-9. 2012
  5. doi Small fiber neuropathy: is skin biopsy the holy grail?
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
    Curr Diab Rep 12:384-92. 2012
  6. pmc Skin biopsy: a new tool for diagnosing peripheral neuropathy
    Giuseppe Lauria
    Neuromuscular Diseases Unit, National Neurological Institute Carlo Besta, 20133, Milan, Italy
    BMJ 334:1159-62. 2007
  7. ncbi Skin biopsy as a diagnostic tool in peripheral neuropathy
    Giuseppe Lauria
    Neuromuscular Diseases Unit, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    Nat Clin Pract Neurol 3:546-57. 2007
  8. doi Erythropoietin in amyotrophic lateral sclerosis: a pilot, randomized, double-blind, placebo-controlled study of safety and tolerability
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation, National Neurological Institute Carlo Besta, Via Celoria 11, Milan, Italy
    Amyotroph Lateral Scler 10:410-5. 2009
  9. ncbi Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies
    Giuseppe Lauria
    Neuromuscular Diseases, National Neurological Institute Carlo Besta, Milan, Italy
    J Peripher Nerv Syst 11:262-71. 2006
  10. ncbi EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy
    G Lauria
    Immunology and Muscular Pathology Unit, Department of Clinical Neurosciences, National Neurological Institute Carlo Besta, Milan, Italy
    Eur J Neurol 12:747-58. 2005

Collaborators

Detail Information

Publications46

  1. pmc The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology
    Grazia Devigili
    Neurological Clinic, University of Ferrara, Italy
    Brain 131:1912-25. 2008
    ..6% of them the clinical picture did not change. Spontaneous remission of neuropathic pain occurred in 10.9% of SFN patients, while it worsened in 30.4% of them...
  2. doi Diagnosis of neuropathic pain: challenges and possibilities
    Giuseppe Lauria
    Carlo Besta Neurological Institute, Neuromuscular Diseases Unit, IRCCS Foundation, Via Celoria, 11, 20133, Milan, Italy 39 02 2394 2378 39 02 2394 4057
    Expert Opin Med Diagn 6:89-93. 2012
    ..This editorial addresses briefly the impact of these developments on the diagnosis of neuropathic pain in clinical practice...
  3. doi Skin biopsy in painful and immune-mediated neuropathies
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRRCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, Milan, Italy
    J Peripher Nerv Syst 17:38-45. 2012
    ....
  4. doi Small fibre neuropathy
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
    Curr Opin Neurol 25:542-9. 2012
    ..This review summarizes the most recent advances in classification, diagnostic assessment, and treatment of small fibre neuropathy (SFN)...
  5. doi Small fiber neuropathy: is skin biopsy the holy grail?
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
    Curr Diab Rep 12:384-92. 2012
    ..This paper reviews usefulness and limitations of skin biopsy and the relationship between degeneration and regeneration of small nerve fibers in patients with diabetes and metabolic syndrome...
  6. pmc Skin biopsy: a new tool for diagnosing peripheral neuropathy
    Giuseppe Lauria
    Neuromuscular Diseases Unit, National Neurological Institute Carlo Besta, 20133, Milan, Italy
    BMJ 334:1159-62. 2007
  7. ncbi Skin biopsy as a diagnostic tool in peripheral neuropathy
    Giuseppe Lauria
    Neuromuscular Diseases Unit, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    Nat Clin Pract Neurol 3:546-57. 2007
    ....
  8. doi Erythropoietin in amyotrophic lateral sclerosis: a pilot, randomized, double-blind, placebo-controlled study of safety and tolerability
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation, National Neurological Institute Carlo Besta, Via Celoria 11, Milan, Italy
    Amyotroph Lateral Scler 10:410-5. 2009
    ..RhEPO treatment was safe and well tolerated in ALS patients. Our results suggest that larger studies are warranted to confirm safety of treatment and to investigate different dose schedule and efficacy...
  9. ncbi Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies
    Giuseppe Lauria
    Neuromuscular Diseases, National Neurological Institute Carlo Besta, Milan, Italy
    J Peripher Nerv Syst 11:262-71. 2006
    ..Our findings demonstrated that TRPV1 is normally expressed throughout the nociceptive pathway of PNS and that TRPV1-positive peripheral nerve fibers degenerate in painful neuropathies...
  10. ncbi EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy
    G Lauria
    Immunology and Muscular Pathology Unit, Department of Clinical Neurosciences, National Neurological Institute Carlo Besta, Milan, Italy
    Eur J Neurol 12:747-58. 2005
    ..Training in an established cutaneous nerve laboratory is recommended before using skin biopsy as a diagnostic tool in peripheral neuropathies. Quality control at all levels is mandatory...
  11. doi Skin biopsy for the diagnosis of peripheral neuropathy
    G Lauria
    Neuromuscular Diseases Unit, National Neurological Institute Carlo Besta, Milan, Italy
    Histopathology 54:273-85. 2009
    ..This review discusses the features of skin innervation in hairy and glabrous skin, the functional properties of skin nerve fibres and their changes in peripheral neuropathies...
  12. ncbi Intraepidermal nerve fiber density in rat foot pad: neuropathologic-neurophysiologic correlation
    Giuseppe Lauria
    Immunology and Muscular Pathology Unit, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    J Peripher Nerv Syst 10:202-8. 2005
    ..Our study demonstrated that IENF density quantification correlates with SNCV changes and suggests that this might represent a useful outcome measurement in experimental neuropathies...
  13. ncbi Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome
    Giuseppe Lauria
    Immunology and Muscular Pathology Unit, National Neurological Institute Carlo Besta, Via Celoria, 11, 20133 Milan, Italy
    Pain 115:332-7. 2005
    ..These findings shed light into the pathogenesis of this common disorder and could contribute to evaluate targeted therapies in patients...
  14. doi Morphometry of dermal nerve fibers in human skin
    G Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Via Celoria, 11, 20133, Milan, Italy
    Neurology 77:242-9. 2011
    ..We aimed to assess the innervation density of dermal nerves in human skin biopsies by bright-field immunohistochemistry...
  15. doi Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy
    J Peripher Nerv Syst 15:202-7. 2010
    ..002). Height, weight, or BMI did not influence the calculated 5th percentile IENF normative densities in both genders. Our study provides IENF density normative reference values at the distal leg to be used in clinical practice...
  16. doi European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Ner
    G Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
    Eur J Neurol 17:903-12, e44-9. 2010
    ..Most of the new studies focused on small fiber neuropathy (SFN), a subtype of neuropathy for which the diagnosis was first developed through skin biopsy examination. This revision focuses on the use of this technique to diagnose SFN...
  17. ncbi Epidermal nerve fiber density in sensory ganglionopathies: clinical and neurophysiologic correlations
    G Lauria
    Department of Neurology, National Neurological Institute C Besta, Via Celoria, 11, 20133 Milan, Italy
    Muscle Nerve 24:1034-9. 2001
    ....
  18. ncbi Axonal swellings predict the degeneration of epidermal nerve fibers in painful neuropathies
    G Lauria
    Department of Clinical Neuroscience, National Neurological Institute Carlo Besta, Milan, Italy
    Neurology 61:631-6. 2003
    ....
  19. doi Four novel cases of periaxin-related neuropathy and review of the literature
    C Marchesi
    Unit of Clinic of Central and Peripheral Degenerative Neuropathies, Carlo Besta Neurological Institute IRCCS Foundation, Milan, Italy
    Neurology 75:1830-8. 2010
    ..Patients with PRX mutations have early-onset autosomal recessive demyelinating Charcot-Marie-Tooth disease (CMT4F) or Déjèrine-Sottas neuropathy (DSN). Only 12 different mutations have been described thus far...
  20. ncbi Does CMT1A homozygosity cause more severe disease with root hypertrophy and higher CSF proteins?
    D Pareyson
    Division of Neurology, Carlo Besta National Neurological Institute, Milan, Italy
    Neurology 60:1721-2. 2003
  21. ncbi Reliability of clinical outcome measures in Charcot-Marie-Tooth disease
    A Solari
    Neuroepidemiology Unit, IRCCS Foundation, C Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy
    Neuromuscul Disord 18:19-26. 2008
    ..All outcome measures appear adequate for CMT assessment. Use of an immobilization device improves foot MVIC reliability, preventing biased findings in patients with greater strength...
  22. doi Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy
    R Bianchi
    Neuromuscular Disease Unit, IRCCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, 20133, Milan, Italy
    J Pharmacol Exp Ther 340:64-72. 2012
    ..The present data support a potential therapeutic effect of PKF275-055 in the treatment of rodent diabetic neuropathy...
  23. ncbi Protective effect of erythropoietin and its carbamylated derivative in experimental Cisplatin peripheral neurotoxicity
    Roberto Bianchi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Clin Cancer Res 12:2607-12. 2006
    ..We have successfully identified derivatives of erythropoietin, including carbamylated erythropoietin, which do not raise the hematocrit but retain the neuroprotective action exerted by erythropoietin...
  24. doi Painful neuropathy in subclinical hypothyroidism: clinical and neuropathological recovery after hormone replacement therapy
    Paola Penza
    Neuromuscular Diseases Unit, National Neurological Institute Carlo Besta, Via Celoria, 11, 20133, Milan, Italy
    Neurol Sci 30:149-51. 2009
    ..Subclinical hypothyroidism is a possible cause of sensory neuropathy and hormone replacement therapy can prompt nerve regeneration...
  25. doi Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy
    Giorgia Melli
    Neuromuscular Diseases Unit, IRCCS Foundation Neurological Institute Carlo Besta, Via Celoria, 11 20133, Milan, Italy
    Exp Neurol 214:276-84. 2008
    ..These findings suggest that alpha-lipoic acid might reduce the risk of developing peripheral nerve toxicity in patients undergoing chemotherapy and encourage further confirmatory clinical trials...
  26. doi Continuous buprenorphine delivery effect in streptozotocine-induced painful diabetic neuropathy in rats
    Annalisa Canta
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Milan, Italy
    J Pain 10:961-8. 2009
    ..Both doses of buprenorphine significantly reversed the diabetes-induced allodynia up to day 7 of treatment. Buprenorphine did not alter either thermal perception or NCV...
  27. doi Docetaxel-induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model
    Ilaria Roglio
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    J Peripher Nerv Syst 14:36-44. 2009
    ..Our study confirmed that neuroactive steroids exert a protective effect on peripheral nerves at different levels, suggesting that they might represent a new therapeutic frontier for patients with chemotherapy-induced neuropathy...
  28. ncbi Neurophysiological diagnosis of acquired sensory ganglionopathies
    Giuseppe Lauria
    Department of Clinical Neurosciences, National Neurological Institute Carlo Besta, Milan, Italy
    Eur Neurol 50:146-52. 2003
    ..We emphasize that distinct abnormalities allow to differentiate ganglionopathies from axonal sensory neuropathies on routine neurophysiological examination...
  29. ncbi Cisplatin-induced peripheral neuropathy: neuroprotection by erythropoietin without affecting tumour growth
    Roberto Bianchi
    Mario Negri Institute of Pharmacological Research, Milan, Italy
    Eur J Cancer 43:710-7. 2007
    ..0 and 1.5 mg/kg twice a week for four weeks) was neuroprotective without influencing the effectiveness of the treatment or tumour growth. EPO thus appears to be an effective neuroprotectant that does not interfere with tumour treatment...
  30. ncbi Tubule and neurofilament immunoreactivity in human hairy skin: markers for intraepidermal nerve fibers
    Giuseppe Lauria
    Department of Clinical Neurosciences, Division of Neuromuscular Diseases, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    Muscle Nerve 30:310-6. 2004
    ..Double-staining studies confirmed that antibodies against cytoskeletal markers can be used to reliably stain skin nerve fibers, suggesting that they might provide insight into specific axonal impairment in peripheral neuropathies...
  31. doi The Multiple Sclerosis Knowledge Questionnaire: a self-administered instrument for recently diagnosed patients
    A Giordano
    Unit of Neuroepidemiology, Foundation IRCCS Neurological Institute C Besta, Milan, Italy
    Mult Scler 16:100-11. 2010
    ..In conclusion, the MSKQ has good clinimetric properties and is sensitive to an educational intervention. We propose the MSKQ as a brief instrument for clinical practice and research...
  32. doi Altered peripheral myelination in mice lacking GABAB receptors
    Valerio Magnaghi
    Department of Endocrinology and Centre of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Mol Cell Neurosci 37:599-609. 2008
    ..In summary, our findings implicate GABA(B) receptors in the PNS myelination process and raise the possibility that PNS alterations contribute to the sensory phenotypes of GABA(B1)-deficient mice...
  33. doi "Burning tongue" and "burning tip": the diagnostic challenge of the burning mouth syndrome
    Paola Penza
    Neuromuscular Diseases Unit, IRCCS Foundation Carlo Besta National Neurological Institute, Milan, Italy
    Clin J Pain 26:528-32. 2010
    ..To investigate the clinical features of burning mouth syndrome (BMS) in a large cohort of patients and to correlate them with the results of tongue biopsy...
  34. doi The neuroprotective effect of erythropoietin in docetaxel-induced peripheral neuropathy causes no reduction of antitumor activity in 13762 adenocarcinoma-bearing rats
    Ilaria Cervellini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Neurotox Res 18:151-60. 2010
    ..Since CINP induced by DOCE reproduces the clinical utility of taxane in humans, the findings reported might provide a basis for investigating EPO as a neuroprotective agent in patients receiving therapy with DOCE...
  35. doi Short- and intermediate-term efficacy of buprenorphine TDS in chronic painful neuropathies
    Paola Penza
    Neuromuscular Diseases Unit, Fondazione IRCCS National Neurological Institute Carlo Besta, Milan, Italy
    J Peripher Nerv Syst 13:283-8. 2008
    ..In our study, which needs to be confirmed by a controlled trial, buprenorphine TDS induced clinically meaningful pain relief in about 40% of patients with chronic painful neuropathy, suggesting its use as a third-line treatment...
  36. ncbi Temporal trend and factors associated with delayed hospital admission of stroke patients
    I Casetta
    Section of Neurology, Department of Medical Surgical Sciences of Communication and Behavior, University of Ferrara, Ferrara, Italy
    Neuroepidemiology 18:255-64. 1999
    ..The finding that earliest admissions for stroke comprised patients with a previous history of cerebrovascular disease suggests that an education campaign might highlight the importance of an early admission...
  37. pmc Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): a double-blind randomised trial
    Davide Pareyson
    Clinic of Central and Peripheral Degenerative Neuropathies Unit, Department of Clinical Neurosciences, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
    Lancet Neurol 10:320-8. 2011
    ..However, in three 1-year trials, ascorbic acid had no benefit in human beings. We did a multicentre 2-year trial to test the efficacy and tolerability of ascorbic acid in patients with CMT1A...
  38. ncbi Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation
    D Pareyson
    Departments of Neurology, C Besta National Neurological Institute, Milan, Italy
    Neurology 54:1696-8. 2000
    ..The authors describe a unique combination of cranial nerve deficits in one member of a Charcot-Marie-Tooth 1 family carrying an EGR2 mutation (Arg381His). This finding further supports the role of EGR2 in cranial nerve development...
  39. ncbi Sensory neuron diseases
    Angelo Sghirlanzoni
    Neuro Oncology Unit, National Neurological Institute Carlo Besta, Milan, Italy
    Lancet Neurol 4:349-61. 2005
    ..Here we propose a comprehensive approach to the diagnosis of acquired and hereditary SND and discuss clinical, genetic, neurophysiological, neuroradiological, and neuropathological assessments...
  40. ncbi Neuroactive steroids and peripheral neuropathy
    Ilaria Roglio
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Brain Res Rev 57:460-9. 2008
    ..Therefore, neuroactive steroids, pharmacological agents able to increase their local synthesis and synthetic ligands for their receptors have a promising potential for the treatment of different forms of peripheral neuropathy...
  41. ncbi Small fibre neuropathies
    Giuseppe Lauria
    Immunology and Muscular Pathology Unit, National Neurological Institute Carlo Besta, Milan, Italy
    Curr Opin Neurol 18:591-7. 2005
    ..To summarize the recent advances in aetiology, diagnostic assessment, and treatment of small fibre neuropathies...
  42. ncbi Skin biopsy in the management of peripheral neuropathy
    Claudia Sommer
    Department of Neurology, University of Wurzburg, Germany
    Lancet Neurol 6:632-42. 2007
    ..We also review the association between morphological measures of skin innervation and function and the limits of this method in the aetiological classification of peripheral neuropathies...
  43. pmc Erythropoietin both protects from and reverses experimental diabetic neuropathy
    Roberto Bianchi
    Mario Negri Institute of Pharmacological Research, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 101:823-8. 2004
    ..These observations suggest that administration of rhEPO or its analogues may be useful in the treatment of diabetic neuropathy...
  44. ncbi IgM deposits on skin nerves in anti-myelin-associated glycoprotein neuropathy
    Raffaella Lombardi
    Neurobiology Unit, Department of Research and Neurology, University Hospital of Basel, Basel, Switzerland
    Ann Neurol 57:180-7. 2005
    ..In anti-MAG neuropathy, both large- and small-diameter nerve fibers are affected, and specific deposits of IgM are found on skin myelinated nerve fibers...
  45. ncbi Case 38-2001: paraneoplastic encephalomyelitis and sensory ganglioneuropathy
    Giuseppe Lauria
    N Engl J Med 346:1029-30; author reply 1029-30. 2002
  46. ncbi Botulinum toxin treatment for oropharyngeal dysphagia associated with diabetic neuropathy
    Domenico A Restivo
    Division of Endocrinology, Garibaldi Hospital, Via Palermo 636, Catania I 95121, Catania, Italy
    Diabetes Care 29:2650-3. 2006
    ..In the present study, we evaluated the efficacy of BoNT/A injections into the CP muscle in diabetic patients with severe oropharyngeal dysphagia associated with diabetic autonomic and/or somatic peripheral neuropathy...