L Laghi

Summary

Affiliation: Istituto Clinico Humanitas
Country: Italy

Publications

  1. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
  2. pmc Mast cells and the liver aging process
    Fabio Grizzi
    Department of Internal Medicine, Division of Hematology Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA
    Immun Ageing 10:9. 2013
  3. pmc Irrelevance of microsatellite instability in the epidemiology of sporadic pancreatic ductal adenocarcinoma
    Luigi Laghi
    Laboratory of Molecular Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    PLoS ONE 7:e46002. 2012
  4. doi request reprint Microsatellite instability and therapeutic consequences in colorectal cancer
    Luigi Laghi
    Molecular Gastroenterology Unit, IRCCS Istituto Clinico Humanitas, Rozzano, Italy
    Dig Dis 30:304-9. 2012
  5. doi request reprint MSH3 protein expression and nodal status in MLH1-deficient colorectal cancers
    Luigi Laghi
    Laboratory of Molecular Gastroenterology, Department of Gastroenterology, IRCCS Istituto Clinico Humanitas Rozzano, Milano, Italy
    Clin Cancer Res 18:3142-53. 2012
  6. pmc The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker
    Rosaria Cammarota
    Oncology Research Laboratory, Science and Technology Park, IRCCS Multimedica, via Fantoli 16 15, Milan, 20138, Italy
    J Transl Med 8:112. 2010
  7. pmc Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver
    Sonia Di Gioia
    Department of Pathology, Humanitas Clinical Institute of Rozzano, Milan, Italy
    BMC Cancer 6:89. 2006
  8. doi request reprint Differences and evolution of the methods for the assessment of microsatellite instability
    L Laghi
    Department of Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milano, Italy
    Oncogene 27:6313-21. 2008
  9. doi request reprint CD3+ cells at the invasive margin of deeply invading (pT3-T4) colorectal cancer and risk of post-surgical metastasis: a longitudinal study
    Luigi Laghi
    Laboratories of Molecular Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Lancet Oncol 10:877-84. 2009
  10. pmc Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer
    E Miranda
    Molecular Genetics Laboratory, Istituto Clinico Humanitas, University of Milan, Via Manzoni 56, Rozzano, Milano 20089, Italy
    Br J Cancer 95:1101-7. 2006

Collaborators

  • M Roncalli
  • Alberto Malesci
  • F Grizzi
  • L Gennari
  • A Mantovani
  • A Repici
  • Christoph Rocken
  • Carlo Capella
  • Alessandro Zerbi
  • Aldo Scarpa
  • Peter Neuhaus
  • Anna Maria Chiaravalli
  • S Costa
  • R de Franchis
  • Martijn D de Kruif
  • Armando Santoro
  • M Borzio
  • A Marchetti
  • P Bianchi
  • G Celesti
  • A Destro
  • Jerome Galon
  • Rosaria Cammarota
  • Sonia Di Gioia
  • E Miranda
  • F Marchesi
  • P Allavena
  • M Montorsi
  • G Delconte
  • D Rahal
  • G di Caro
  • F Novelli
  • M Catalano
  • G Basso
  • P Cappello
  • Anne Berger
  • Noriyuki Sato
  • Magdalena Thurin
  • Sacha Gnjatic
  • Shoichi Hazama
  • Yutaka Kawakami
  • Rejean Lapointe
  • Lotfi Chouchane
  • Richard Palmqvist
  • Fernando Vidal-Vanaclocha
  • Alessandro Lugli
  • Shuji Ogino
  • Paul Waring
  • Shilin N Shukla
  • James P Allison
  • Graham Pawelec
  • Blaise A Clarke
  • Ena Wang
  • Corrado D'Arrigo
  • Jill O'Donnell-Tormey
  • Francesco M Marincola
  • Heinz Zwierzina
  • Fabiana Tatangelo
  • Giuseppe V Masucci
  • Andreas Lundqvist
  • Martin Mihm
  • Toshihiko Torigoe
  • Peter Gibbs
  • Prabhu S Patel
  • Thomas F Gajewski
  • Harpreet Singh-Jasuja
  • Martin Asslaber
  • Christian Ottensmeier
  • Patricia A Shaw
  • Inti Zlobec
  • Robert Hawkins
  • Christine Lagorce
  • Leif Hakansson
  • Giorgio Trinchieri
  • Scott Kopetz
  • Michele Maio
  • Bernard A Fox
  • Christoph Huber
  • Frank A Sinicrope
  • Sebastian Kreiter
  • Gerardo Botti
  • Iris D Nagtegaal
  • Pamela S Ohashi
  • Cedrik M Britten
  • Hartmann Arndt
  • Kyogo Itoh
  • Bradly G Wouters
  • Carlo Bifulco
  • Helen K Angell
  • Yili Wang

Detail Information

Publications16

  1. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
    ..The results of this international validation may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune)...
  2. pmc Mast cells and the liver aging process
    Fabio Grizzi
    Department of Internal Medicine, Division of Hematology Oncology, Texas Tech University Health Sciences Center, Lubbock, TX, USA
    Immun Ageing 10:9. 2013
    ..We here briefly review the relationships between the liver aging process and mast cells, the key effectors in a more complex range of innate immune responses than originally though...
  3. pmc Irrelevance of microsatellite instability in the epidemiology of sporadic pancreatic ductal adenocarcinoma
    Luigi Laghi
    Laboratory of Molecular Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy
    PLoS ONE 7:e46002. 2012
    ..Aims of the study were to determine the prevalence of MSI in surgically resected pancreatic cancers in a multicentric, retrospective study, and to assess the occurrence of pancreatic cancer in LS...
  4. doi request reprint Microsatellite instability and therapeutic consequences in colorectal cancer
    Luigi Laghi
    Molecular Gastroenterology Unit, IRCCS Istituto Clinico Humanitas, Rozzano, Italy
    Dig Dis 30:304-9. 2012
    ..Like predictive markers of response to chemotherapy, the role of MSI is likely not exhausted, as chemotherapy regimens need to take into account the peculiar biological and clinical behavior of MSI cancers...
  5. doi request reprint MSH3 protein expression and nodal status in MLH1-deficient colorectal cancers
    Luigi Laghi
    Laboratory of Molecular Gastroenterology, Department of Gastroenterology, IRCCS Istituto Clinico Humanitas Rozzano, Milano, Italy
    Clin Cancer Res 18:3142-53. 2012
    ..Given the heterogeneity of microsatellite-unstable CRCs, we wanted to see whether any MSI-associated molecular features are specifically associated with prognosis...
  6. pmc The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker
    Rosaria Cammarota
    Oncology Research Laboratory, Science and Technology Park, IRCCS Multimedica, via Fantoli 16 15, Milan, 20138, Italy
    J Transl Med 8:112. 2010
    ....
  7. pmc Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver
    Sonia Di Gioia
    Department of Pathology, Humanitas Clinical Institute of Rozzano, Milan, Italy
    BMC Cancer 6:89. 2006
    ..While NORE1A has not been previously investigated in the human liver, recent reports have suggested that RASSF1A is frequently epigenetically methylated not only in HCC but also in the cirrhotic liver...
  8. doi request reprint Differences and evolution of the methods for the assessment of microsatellite instability
    L Laghi
    Department of Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milano, Italy
    Oncogene 27:6313-21. 2008
    ..Inaccuracies can otherwise lead to under- or overdiagnosis and inaccurate disease classification, which always have a negative impact on the clinical practice of medicine...
  9. doi request reprint CD3+ cells at the invasive margin of deeply invading (pT3-T4) colorectal cancer and risk of post-surgical metastasis: a longitudinal study
    Luigi Laghi
    Laboratories of Molecular Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Lancet Oncol 10:877-84. 2009
    ..The aim of this study was to assess the relationship between the density of CD3+ TIL and the postsurgical occurrence of distant-organ metastases in a large series of patients with deeply invading and MSI-typed colorectal cancer...
  10. pmc Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer
    E Miranda
    Molecular Genetics Laboratory, Istituto Clinico Humanitas, University of Milan, Via Manzoni 56, Rozzano, Milano 20089, Italy
    Br J Cancer 95:1101-7. 2006
    ....
  11. pmc Lack of mutation at codon 531 of SRC in advanced colorectal cancers from Italian patients
    L Laghi
    Department of Gastroenterology, Istituto Clinico Humanitas, Via Manzoni 56, Rozzano, Milan, 20089, Italy
    Br J Cancer 84:196-8. 2001
    ..Our results demonstrate that SRC Gln531AMB plays no role in the development or in the progression of colorectal cancer among Italian patients...
  12. doi request reprint Molecular heterogeneity and prognostic implications of synchronous advanced colorectal neoplasia
    A Malesci
    1 Department of gastroenterology, Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Milan, Italy 2 Department of Biotechnology and Translational Medicine, Via Vanvitelli 32, 20133 Milan, Italy
    Br J Cancer 110:1228-35. 2014
    ..As tumours with microsatellite instability (MSI) may confound the effect of S-CRC methylation on outcome, we addressed this issue in a series of CRC characterised by BRAF and MS status...
  13. ncbi request reprint K-ras and p16(INK4A)alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers
    A Destro
    Molecular Genetics Laboratory, Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milano, Italy
    Lung Cancer 44:23-32. 2004
    ....
  14. ncbi request reprint Fractional allelic loss in non-end-stage cirrhosis: correlations with hepatocellular carcinoma development during follow-up
    M Roncalli
    Departments of Pathology and Research Laboratories, Humanitas Clinical Institute of Rozzano, Milan, Italy
    Hepatology 31:846-50. 2000
    ..These data emphasize the role of early clonal changes in chronic liver disease, and their potential predictive significance for clinical use...
  15. ncbi request reprint Carriage of CARD15 variants and smoking as risk factors for resective surgery in patients with Crohn's ileal disease
    L Laghi
    Division of Gastroenterology, Istituto Clinico Humanitas, Rozzano, Italy
    Aliment Pharmacol Ther 22:557-64. 2005
    ..It is controversial whether CARD15 variants are truly associated with a more severe form of Crohn's disease. The relative role of CARD15 genotype and smoking in Crohn's disease progression is also debated...
  16. pmc Early expression of the fractalkine receptor CX3CR1 in pancreatic carcinogenesis
    G Celesti
    Laboratory of Molecular Gastroenterology, Department of Gastroenterology, Humanitas Clinical and Research Center, Via Manzoni, 56, 20089 Rozzano, Milan, Italy
    Br J Cancer 109:2424-33. 2013
    ..In pancreatic ductal adenocarcinoma (PDAC), fractalkine receptor CX3CR1 contributes to perineural invasion (PNI). We investigated whether CX3CR1 expression occurs early in PDAC and correlates with tumour features other than PNI...