Affiliation: Istituto Superiore di Sanit
Labbaye C, Spinello I, Quaranta M, Pelosi E, Pasquini L, Petrucci E, et al
. A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis. Nat Cell Biol. 2008;10:788-801 pubmed publisher
..Our data indicate that megakaryopoiesis is controlled by a cascade pathway, in which PLZF suppresses miR-146a transcription and thereby activates CXCR4 translation. ..
Spinello I, Saulle E, Quaranta M, Pasquini L, Pelosi E, Castelli G, et al
. The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells. Haematologica. 2018;: pubmed publisher
Spinello I, Quaranta M, Paolillo R, Pelosi E, Cerio A, Saulle E, et al
. Differential hypoxic regulation of the microRNA-146a/CXCR4 pathway in normal and leukemic monocytic cells: impact on response to chemotherapy. Haematologica. 2015;100:1160-71 pubmed publisher
Testa U, Pelosi E, Castelli G, Labbaye C. miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development. Noncoding RNA. 2017;3: pubmed publisher
..The demonstration that miR-155 overexpression plays a key pathogenic role in some lymphomas and acute myeloid leukemias has led to the development of an antagomir-based approach as a new promising therapeutic strategy. ..
Quaranta M, Olivetta E, Sanchez M, Spinello I, Paolillo R, Arenaccio C, et al
. miR-146a controls CXCR4 expression in a pathway that involves PLZF and can be used to inhibit HIV-1 infection of CD4(+) T lymphocytes. Virology. 2015;478:27-38 pubmed publisher
..Our findings improve the prospects of developing new therapeutic strategies to prevent HIV-1 entry via CXCR4 by using the PLZF/miR-146a axis. ..