Research Topics
| T GranataSummaryAffiliation: Istituto Nazionale Neurologico Carlo Besta Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Rasmussen's encephalitis: early characteristics allow diagnosisT Granata
Division of Child Neurology, Istituto Nazionale Neurologico C Besta, Milan, Italy
Neurology 60:422-5. 2003..To identify early manifestations of Rasmussen encephalitis (RE) that can prompt early and reasonably secure diagnosis, allowing medical or surgical therapies at an early stage when they may be more effective in slowing the disease...
Rasmussen encephalitisTiziana Granata
Department of Pediatric Neuroscience, Carlo Besta Neurological Institute, Milan, Italy Electronic address
Handb Clin Neurol 111:511-9. 2013..Given that the severity of symptoms varies among different patients and phases, the therapeutic strategy, including medical and surgical options, must be tailored to the need of each patient...- Schizencephaly: clinical spectrum, epilepsy, and pathogenesisTiziana Granata
Division of Child Neurology, IRCCS Istituto Nazionale Neurologico C Besta, Milan, Italy
J Child Neurol 20:313-8. 2005.... - Comprehensive care of children with Dravet syndromeTiziana Granata
Department of Pediatric Neuroscience, IRCCS Foundation Neurological Institute C Besta, Milano, Italy
Epilepsia 52:90-4. 2011.... 
Immune-mediated epilepsiesTiziana Granata
Department of Child Neurology, Carlo Besta Neurological Institute, Milan, Italy
Epilepsia 52:5-11. 2011..We highlight future directions for preclinical and clinical research that are required for improved diagnosis and treatment of immune-mediated epilepsies...- Epilepsy in type 1 Chiari malformationTiziana Granata
Department of Paediatric Neuroscience, IRCCS Foundation Neurological Institute C Besta, Via Celoria 11, 20133, Milan, Italy
Neurol Sci 32:S303-6. 2011..Epileptic seizures must be accurately differentiated by potentially harmful paroxysmal events due to compression of the medulla, particularly by the cerebellar fits characterized by drop attacks, abnormal extensor posturing and apnea... - Experience with immunomodulatory treatments in Rasmussen's encephalitisT Granata
Division of Child Neurology, Istituto Nazionale Neurologico C Besta, Milan, Italy
Neurology 61:1807-10. 2003.... - Diagnostic imaging in 13 cases of Rasmussen's encephalitis: can early MRI suggest the diagnosis?L Chiapparini
Department of Neuroradiology, Istituto Nazionale Neurologico C Besta, Via Celoria 11, 20133 Milano, Italy
Neuroradiology 45:171-83. 2003..Early diagnosis of RE may be crucial for selecting patients for aggressive medical therapy or major surgical interventions such as hemispherectomy... - Positive response to immunomodulatory therapy in an adult patient with Rasmussen's encephalitisF Villani
Division of Clinical Neurophysiology and Epileptology, Istituto Nazionale Neurologico C Besta, Milan, Italy
Neurology 56:248-50. 2001..High-dose corticosteroids and plasmapheresis were not effective. She improved with high-dose therapy with human IV immunoglobulin... - Labeling of rat neurons by anti-GluR3 IgG from patients with Rasmussen encephalitisC Frassoni
Department of Experimental Neurophysiology and Epileptology, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy
Neurology 57:324-7. 2001..These findings show that anti-GluR3 antibodies purified from patients with RE bind to specific regions of the CNS but do not act through an excitotoxic mechanism... - Epileptic phenotypes associated with mitochondrial disordersL Canafoglia
Department of Clinical Neurophysiology, Epilepsy Center, Istituto Nazionale Neurologico C. Besta, Milan, Italy
Neurology 56:1340-6. 2001..Except for those with an A8344G mitochondrial DNA point mutation, most of our patients had partial seizures or EEG signs indicating a focal origin... - Spectral properties of EEG fast activity ictal discharges associated with infantile spasmsF Panzica
Department of Neurophysiology, C Besta Neurological Institute, Milan, Italy
Clin Neurophysiol 110:593-603. 1999..The aim of this study was to evaluate the characteristics of the ictal EEG event accompanying infantile spasms... - Subcortical nodular heterotopia: a functional MRI and somatosensory evoked potentials studyF Villani
Division of Clinical Neurophysiology and Epilepsy Centre, Istituto Nazionale Neurologico C Besta, Via Celoria 11, I 20133 Milan, Italy
Neurol Sci 25:225-9. 2004.... - Electroencephalographic recordings of focal seizures in patients affected by periventricular nodular heterotopia: role of the heterotopic nodules in the genesis of epileptic dischargesGiorgio Battaglia
Division of Experimental Neurophysiology and Epileptology, Neurological Institute C Besta, Milan, Italy
J Child Neurol 20:369-77. 2005..The major role of heterotopic neurons in the genesis and propagation of epileptic discharges must be taken into account when planning surgery for epilepsy in patients with periventricular nodular heterotopia... - ICTAL EEG fast activity in West syndrome: from onset to outcomeFerruccio Panzica
C Besta Foundation Neurological Institute, Via Celoria 11, Milan, Italy
Epilepsia 48:2101-10. 2007..To characterize the fast EEG activities associated with infantile spasms in West syndrome, and their value in predicting the recurrence and localization of late seizures... - Management of the patient with medically refractory epilepsyTiziana Granata
Department of Neurology, Cleveland, OH, USA and Department of Child Neurology, Carlo Besta Neurological Institute, Milan, Italy
Expert Rev Neurother 9:1791-802. 2009..A promising approach is the use of corticosteroids that may have a dual beneficial effect. Resective brain surgery remains the ultimate and highly successful approach to multiple drug resistance in epileptic patients... - Periventricular nodular heterotopia: classification, epileptic history, and genesis of epileptic dischargesGiorgio Battaglia
Division of Experimental Neurophysiology and Epileptology, Neurological Institute C Besta, Milan, Italy
Epilepsia 47:86-97. 2006.... - Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizuresRenato Mantegazza
Immunology and Muscular Pathology Unit, Istituto Nazionale Neurologico Carlo Besta, Via Celoria 11, Milan, Italy
J Neuroimmunol 131:179-85. 2002..Antibodies against GluR3B peptide were significantly associated with frequent seizures compared to occasional or drug-controlled seizures... - Epileptic and imaging findings in perinatal hypoxic-ischemic encephalopathy with ulegyriaFlavio Villani
Istituto Nazionale Neurologico, Via Celoria 11, Milan, Italy
Epilepsy Res 55:235-43. 2003..Drug refractoriness was an almost constant correlate of this form of symptomatic epilepsy... - Intellectual and language findings and their relationship to EEG characteristics in benign childhood epilepsy with centrotemporal spikesDaria Riva
Developmental Neurology Division, Istituto Nazionale Neurologico C Besta, Via Celoria 11, Milan, Italy
Epilepsy Behav 10:278-85. 2007.... - Similar binding to glutamate receptors by Rasmussen and partial epilepsy patients' seraP Bernasconi
Immunology and Muscular Pathology Unit, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy
Neurology 59:1998-2001. 2002..Histoblot analysis showed a positive staining in GluR3- and NMDA-specific regions of rat brain, providing a comprehensive CNS immunolocalization... - Rasmussen's syndromeT Granata
Department of Child Neurology, National Neurological Institute C. Besta, Milan, Italy
Neurol Sci 24:S239-43. 2003..The use of intravenous immunoglobulins has produced encouraging results in adult-onset RE but further studies are needed to assess the effect, dosage, and schedules in childhood-onset RE... - Adult-onset Rasmussen's encephalitis: anatomical-electrographic-clinical features of 7 Italian casesFlavio Villani
Division of Clinical Epileptology, Istituto Nazionale Neurologico, C Besta, Milan, Italy
Epilepsia 47:41-6. 2006..The aim of this study was to verify the clinical features of A-RE, and outline a noninvasive approach that may allow its early diagnosis and treatment... - Brain inflammation in epilepsy: experimental and clinical evidenceAnnamaria Vezzani
Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Epilepsia 46:1724-43. 2005..The elucidation of this aspect may open new perspectives for the pharmacologic treatment of seizures... - Joubert syndrome with bilateral polymicrogyria: clinical and neuropathological findings in two brothersL Giordano
Division of Child Neurology, Spedali Civili di Brescia, Brescia, Italy
Am J Med Genet A 149:1511-5. 2009..No mutations were detected in the AHI1 gene, the only so far associated with the JS + PMG phenotype. Moreover, linkage analysis allowed excluding all known gene loci, suggesting further genetic heterogeneity... - Single-dose pharmacokinetics of lamotrigine in children: influence of age and antiepileptic comedicationD Battino
Carlo Besta Neurological Institute, Milan; and Clinical Pharmacology Unit, University of Pavia, Pavia, Italy
Ther Drug Monit 23:217-22. 2001..On the other hand, the lower plasma lamotrigine levels in children than in adolescents and older patients may not be explainable solely by differences in metabolic rate... - The genesis of epileptogenic cerebral heterotopia: clues from experimental modelsGiorgio Battaglia
Department of Experimental Neurophysiology, Neurological Institute C Besta, Milano, Italy
Epileptic Disord 5:S51-8. 2003..On this basis, we suggest a neurogenetic scheme for MAM-induced heterotopia that can also explain the origin and intrinsic epileptogenicity of periventricular nodular heterotopia in humans... - Seizure-promoting effect of blood-brain barrier disruptionNicola Marchi
Cerebrovascular Research Center, Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Epilepsia 48:732-42. 2007..However, evidences also suggest that BBB failure may be an etiological factor contributing to the development of seizures... - Familial occurrence of febrile seizures and epilepsy in severe myoclonic epilepsy of infancy (SMEI) patients with SCN1A mutationsMaria Margherita Mancardi
Laboratory of Neurogenetics, Unit of Muscular and Neurodegenerative Disease, Institute G Gaslini, Genova, Italy
Epilepsia 47:1629-35. 2006..We explored the genetic background of SMEI patients carrying SCN1A mutations to further shed light on the genetics of this disorder... - Polymicrogyria and deletion 22q11.2 syndrome: window to the etiology of a common cortical malformationNathaniel H Robin
Department of Genetics, University of Alabama at Birmingham, USA
Am J Med Genet A 140:2416-25. 2006..Although this was not the focus of the present study, mild cerebellar anomalies are probably the most common brain malformation associated with DEL22q11... - Suppressive efficacy by a commercially available blue lens on PPR in 610 photosensitive epilepsy patientsGiuseppe Capovilla
Epilepsy Center, Department of Child Neuropsychiatry, C Poma Hospital, Mantova, Italy
Epilepsia 47:529-33. 2006..Nonpharmacologic treatment using blue sunglasses is effective and safe in controlling photosensitivity, but large series of patients have never been studied...