M Gobbi

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi request reprint Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex
    M Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Naunyn Schmiedebergs Arch Pharmacol 360:262-9. 1999
  2. ncbi request reprint Release studies with rat brain cortical synaptosomes indicate that tramadol is a 5-hydroxytryptamine uptake blocker and not a 5-hydroxytryptamine releaser
    M Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur J Pharmacol 370:23-6. 1999
  3. ncbi request reprint Effects of repeated oral doses of dexnorfenfluramine on 5-HT levels and 5-HT uptake sites in rat brain
    M Gobbi
    Istituto di Ricerche Farmacologiche Mario Negti, Milano, Italy
    Neurosci Lett 219:5-8. 1996
  4. ncbi request reprint Down-regulation of rat brain 5-HT uptake carriers after treatment with high doses of D-fenfluramine
    M Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Brain Res 730:165-72. 1996
  5. ncbi request reprint In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters
    M Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Pharmacopsychiatry 34:S45-8. 2001
  6. ncbi request reprint Anorectic effect and brain concentrations of D-fenfluramine in the marmoset: relationship to the in vivo and in vitro effects on serotonergic mechanisms
    S Caccia
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Naunyn Schmiedebergs Arch Pharmacol 347:306-12. 1993
  7. ncbi request reprint In vitro and in vivo effects of the anorectic agent dexfenfluramine on the central serotoninergic neuronal systems of non-human primates. A comparison with the rat
    T Mennini
    Instituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Naunyn Schmiedebergs Arch Pharmacol 353:641-7. 1996
  8. ncbi request reprint p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro
    M Gobbi
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Italy
    J Neurochem 82:1435-43. 2002
  9. ncbi request reprint Chronic treatment with desipramine facilitates its effect on extracellular noradrenaline in the rat hippocampus: studies on the role of presynaptic alpha2-adrenoceptors
    G Sacchetti
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Naunyn Schmiedebergs Arch Pharmacol 363:66-72. 2001
  10. ncbi request reprint Oleamide-mediated sleep induction does not depend on perturbation of membrane homeoviscosity
    M Gobbi
    Department of Molecular Biochemistry, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157, Milan, Italy
    FEBS Lett 463:281-4. 1999

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex
    M Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Naunyn Schmiedebergs Arch Pharmacol 360:262-9. 1999
    ..Therefore other, still unknown, mechanisms are possibly involved in H. perforatum antidepressant effects...
  2. ncbi request reprint Release studies with rat brain cortical synaptosomes indicate that tramadol is a 5-hydroxytryptamine uptake blocker and not a 5-hydroxytryptamine releaser
    M Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur J Pharmacol 370:23-6. 1999
    ..In summary, (+/-)-tramadol behaved as a classical 5-HT uptake blocker (like citalopram) and not as a substrate of the 5-HT carrier with indirect 5-HT mimetic properties (like D-fenfluramine)...
  3. ncbi request reprint Effects of repeated oral doses of dexnorfenfluramine on 5-HT levels and 5-HT uptake sites in rat brain
    M Gobbi
    Istituto di Ricerche Farmacologiche Mario Negti, Milano, Italy
    Neurosci Lett 219:5-8. 1996
    ..At this longer time while the decrease in hippocampal 5-HT levels and cortical 5-HT uptake sites remained essentially constant, cortical and striatal 5-HT levels were lowered less than at 2 h, suggesting a return toward control values...
  4. ncbi request reprint Down-regulation of rat brain 5-HT uptake carriers after treatment with high doses of D-fenfluramine
    M Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Brain Res 730:165-72. 1996
    ....
  5. ncbi request reprint In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters
    M Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Pharmacopsychiatry 34:S45-8. 2001
    ....
  6. ncbi request reprint Anorectic effect and brain concentrations of D-fenfluramine in the marmoset: relationship to the in vivo and in vitro effects on serotonergic mechanisms
    S Caccia
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Naunyn Schmiedebergs Arch Pharmacol 347:306-12. 1993
    ..Unlike in rodents but similarly to primates in the striatum the pharmacology of 5-HT receptors seems to correspond to the 5-HT1D subtype.(ABSTRACT TRUNCATED AT 250 WORDS)..
  7. ncbi request reprint In vitro and in vivo effects of the anorectic agent dexfenfluramine on the central serotoninergic neuronal systems of non-human primates. A comparison with the rat
    T Mennini
    Instituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Naunyn Schmiedebergs Arch Pharmacol 353:641-7. 1996
    ..Kinetic differences in the disposition of d-F appear to have more relevance than biochemical effects in providing an explanation for the more marked brain depletion induced by d-F in primates than in rodents...
  8. ncbi request reprint p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro
    M Gobbi
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Italy
    J Neurochem 82:1435-43. 2002
    ....
  9. ncbi request reprint Chronic treatment with desipramine facilitates its effect on extracellular noradrenaline in the rat hippocampus: studies on the role of presynaptic alpha2-adrenoceptors
    G Sacchetti
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Naunyn Schmiedebergs Arch Pharmacol 363:66-72. 2001
    ....
  10. ncbi request reprint Oleamide-mediated sleep induction does not depend on perturbation of membrane homeoviscosity
    M Gobbi
    Department of Molecular Biochemistry, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157, Milan, Italy
    FEBS Lett 463:281-4. 1999
    ..There thus appears to be no causal relationship between the fluidizing effects of oleamide and its sleep-inducing properties...
  11. ncbi request reprint In vitro studies on the mechanism by which (+)-norfenfluramine induces serotonin and dopamine release from the vesicular storage pool
    M Gobbi
    Istituto di Ricerche Farmacologie Mario Negri, Milan, Italy
    Naunyn Schmiedebergs Arch Pharmacol 358:323-7. 1998
    ..We have no clear explanation why (+)-norfenfluramine has these different effects on serotoninergic and dopaminergic synaptosomes...
  12. ncbi request reprint Different components of 3H-imipramine binding in rat brain membranes: relation to serotonin uptake sites
    M Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Life Sci 42:575-83. 1988
    ....
  13. ncbi request reprint Plastic changes in neuropeptide Y receptor subtypes in experimental models of limbic seizures
    A Vezzani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Epilepsia 41:S115-21. 2000
    ..We investigated (a) whether seizures modify the NPY Y5 receptors in the hippocampus, and (b) the effect of an agonist at Y2/Y5 receptors and antagonists at Y1 receptors on acute and chronic seizure susceptibility...
  14. ncbi request reprint Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 159:1993-2000. 1997
    ..Chemokines may play a role in the trafficking of DC under resting or stimulated conditions. Chemokine receptors expressed in DC are likely to underlie HIV infection of this cell type...
  15. ncbi request reprint Biochemical characterization of a new highly cardioselective beta-adrenoceptor antagonist
    M Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Pharm Pharmacol 40:243-6. 1988
    ..These data indicate that P0160 is a potent, specific and selective beta 1-adrenoceptor antagonist, and give a molecular explanation for the cardioselective activity found in pharmacological tests...