Gemma Gatta

..EUROCARE collected data from population-based cancer registries in 20 European countries. We used this data to compare childhood cancer survival time trends in Europe...

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..The burden indicators were estimated and are provided in this chapter...

..Nevertheless, a small excess risk of death persisted beyond five years after diagnosis when patients remained at risk for late treatment effects, late relapses and second primaries...

..Survival/cure rate is generally high, but there are considerable gaps in our understanding of the natural histories of these rare diseases particularly in adults...

..Adenocarcinoma of the ethmoid sinus is rare. EUROCARE data provide a good opportunity to study the survival of this rare disease in a population of continental size...

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..The project Surveillance of Rare Cancers in Europe (RARECARE) provides estimates of the incidence, prevalence and survival of rare cancers in Europe based on a new and comprehensive list of these diseases...

..We therefore aimed to characterize treatment for prostate cancer across Europe...

..We aimed to study the epidemiology of rare cancers in a large population of several countries...

..Updated recommendations for the management of these patients are here reported...

..Cancer survival in patients <25 years is poorly documented in Eastern European countries. Complete cancer registration should be a priority for these countries as an essential part of a policy for effective cancer control in Europe...

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..Three-year survival rates improved more in human papillomavirus-related than unrelated cancer sites, and women had better rates of survival than men...

..Improvements in the disease detection in its early stage and international collaborative research should be encouraged...

..Metastatic disease may be either treated with radiotherapy or palliative chemotherapy, depending on the site of metastases. For highly selected patients the employment of anti-androgen therapy is indicated...

..The objective of this study was to determine whether transatlantic differences in survival also are present in childhood cancers...

..There is no proof that postoperative chemotherapy improves the outcome. At recurrence, platinum-, nitrosourea- or temozolomide-based chemotherapy can be administered, although there is no evidence of efficacy...

..Updated recommendations for the management of these patients are here reported...

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..The loco-regional extent of the disease determines the success of cure. Surgery and radiotherapy represent the main therapeutic options. The choice between these two procedures is often controversial...

..Salvage chemotherapy in platinum-refractory patients usually results in low response rates and short survival...

..Standard therapeutic option for early stages of NPC is radiation, while an integration of radiation therapy and chemotherapy is indicated in more advanced stages...

..As a consequence, less resources of development aids are allocated to control NCDs including cancer...

..Radical surgery is indicated for patients with early stage of disease, mainly stage I and partially II. In all other cases, the aim of treatment is the palliation of different very distressing symptoms related to this neoplasm...

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..There is a need to improve completeness and standardization of detailed information collected on gastric cancer patients to allow detailed comparative analyses and interpretation...

..To estimate incidence rates of uveal melanoma in Europe from 1983 to 1994...

..This is, to our knowledge, the first worldwide analysis of cancer survival, with standard quality-control procedures and identical analytic methods for all datasets...

..This may, at least partly, be explained by the rarity of this diagnosis. Prognosis may be improved by the use of specific treatment guidelines for nephroblastoma in adults...

..We also compared our findings with data on cancer survival in the USA from the US SEER (Surveillance, Epidemiology, and End Results) programme...

..To estimate survival in patients in whom uveal melanoma was diagnosed between January 1, 1983, and December 31, 1994, in Europe...

..Biologic agents represent the major effective therapies for widespread metastatic renal cancer. An antiangiogenic strategy, the neutralization of VEGF, can slow the growth rate of advanced cancer...

..Adjuvant PCV chemotherapy increased progression-free survival but does not improve survival as compared to PCV given at recurrence. Chemotherapy with either PCV or temozolomide constitutes a standard for recurrent/progressive disease...

..At time of recurrence/progression, a nitrosourea-based chemotherapy constitutes a reasonable option, as well as a temozolomide re-challenge for patients without progression during prior temozolomide treatment...

..5 months) and quality of life with docetaxel in more than 1,600 cases...

..Therapeutic progress may be obtainable through a careful integration of chemotherapy, stem cell transplantation, and the new targeted treatments with highly specific metabolic inhibitors and humanised monoclonal antibodies...

..In recurrent disease, chemotherapy with temozolomide has been proven to be active and well-tolerated in phase II trials, but no comparative phase III trials of other cytotoxic drugs have been conducted...

..This report summarizes the most important achievements in this field and provides the readers useful suggestions for their professional practice...

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