G Gatta

..The objective of this study was to determine whether transatlantic differences in survival also are present in childhood cancers...

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..EUROCARE-3 collected data from 45 population-based cancer registries in 20 countries on 24 620 European children aged from 0 to 14 years diagnosed with malignancy in the period 1990-1994...

..EUROCARE collected data from population-based cancer registries in 20 European countries. We used this data to compare childhood cancer survival time trends in Europe...

..Marked differences in population based survival across Europe were found for colorectal cancers diagnosed in 1985-1989...

..We estimated the proportions of the prevalent colon cancer cases requiring initial care, terminal care and follow-up...

..The main explanatory difference is the proportion of adenocarcinoma in polyps...

..Cancer survival in patients <25 years is poorly documented in Eastern European countries. Complete cancer registration should be a priority for these countries as an essential part of a policy for effective cancer control in Europe...

..The persisting regional differences suggest there are corresponding differences in the availability of diagnostic and therapeutic facilities, and in the effectiveness of healthcare systems...

..Population based colorectal cancer survival among patients diagnosed in 1985-89 was lower in Europe than in the USA (45% v 59% five year relative survival)...

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..In 1987, about 250,000 Italian women had a present or past history of breast cancer: for the 1970-1987 period, prevalence has increased by approximately 5,500 cases per year...

..Low survival in the United Kingdom may be due to inadequate adherence to consensus treatment guidelines and greater variation in treatment...

..The burden indicators were estimated and are provided in this chapter...

..For all cancers, 5-year survival conditional to surviving 1-year was higher and varied less with region, than the overall relative survival...

..The aim of this study was to analyse survival for European head and neck cancer patients in populations covered by population-based cancer registries (CRs), in relation to tumour subsite as prognostic factor...

..CONCLUSION: Owing to aging of the population, the improvement in survival and the increasing incidence, the number of prevalent cases will increase. This phenomenon has and will have great importance for the health planning...

..Being the outcome of a number of individual, social and economical aspects, population-based survival may be thought as index for measuring the level of a country's development...

..Information on cancer prevalence is of major importance for health planning and resource allocation. However, systematic information on cancer prevalence is largely unavailable...

..Since these rare childhood malignancies were virtually untreatable until 1970, these are very welcome trends...

..Overall mortality decreased during the period, more markedly in the north and among women...

..The affluence of countries influenced overall cancer survival through the availability of adequate diagnostic and treatment procedures, and screening programmes...

..The unfavorable trend with increasing age may be due to increasing difficulty in applying complete therapy protocols as general health declines, sometimes in relation to an advanced cancer stage at diagnosis...

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..Improvements in the disease detection in its early stage and international collaborative research should be encouraged...

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..CONCLUSIONS: 70% of the prevalent patients diagnosed within 5 years prior to the prevalence date were likely to require care for cancer recurrence, while 13% of the prevalent cases required care for distant metastases...

..72% (p = 0.23) respectively for the intervention and control groups. It was concluded that sporadic educational intervention carried out during primary school years has little or no impact in preventing cigarette smoking in teenagers...

..Actually by 1976, when the Lombardy Cander Registry began its activity, the screening was diffuse throughout the province. These observations are consistent with the preventive effect of screening activity...

..Interpretation of marked variation in survival with morphology is complicated by classification inconsistencies. The completeness and standardisation of cancer registry morphology data needs to be improved...

..Updated recommendations for the management of these patients are here reported...

..Three-year survival rates improved more in human papillomavirus-related than unrelated cancer sites, and women had better rates of survival than men...

..We therefore aimed to characterize treatment for prostate cancer across Europe...

..We aimed to study the epidemiology of rare cancers in a large population of several countries...

..Adenocarcinoma of the ethmoid sinus is rare. EUROCARE data provide a good opportunity to study the survival of this rare disease in a population of continental size...

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..As a consequence, less resources of development aids are allocated to control NCDs including cancer...

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..Standard therapeutic option for early stages of NPC is radiation, while an integration of radiation therapy and chemotherapy is indicated in more advanced stages...

..There is no proof that postoperative chemotherapy improves the outcome. At recurrence, platinum-, nitrosourea- or temozolomide-based chemotherapy can be administered, although there is no evidence of efficacy...

..Updated recommendations for the management of these patients are here reported...

..Metastatic disease may be either treated with radiotherapy or palliative chemotherapy, depending on the site of metastases. For highly selected patients the employment of anti-androgen therapy is indicated...

..Salvage chemotherapy in platinum-refractory patients usually results in low response rates and short survival...

..No significant correlation was observed between exposure and either non-ethmoidal sinonasal neoplasms or ethmoidal tumours other than adenocarcinomas...

..Radical surgery is indicated for patients with early stage of disease, mainly stage I and partially II. In all other cases, the aim of treatment is the palliation of different very distressing symptoms related to this neoplasm...

..This is, to our knowledge, the first worldwide analysis of cancer survival, with standard quality-control procedures and identical analytic methods for all datasets...

..There is a need to improve completeness and standardization of detailed information collected on gastric cancer patients to allow detailed comparative analyses and interpretation...

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..This may, at least partly, be explained by the rarity of this diagnosis. Prognosis may be improved by the use of specific treatment guidelines for nephroblastoma in adults...

..To estimate incidence rates of uveal melanoma in Europe from 1983 to 1994...

..To estimate survival in patients in whom uveal melanoma was diagnosed between January 1, 1983, and December 31, 1994, in Europe...

..We also compared our findings with data on cancer survival in the USA from the US SEER (Surveillance, Epidemiology, and End Results) programme...

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..At time of recurrence/progression, a nitrosourea-based chemotherapy constitutes a reasonable option, as well as a temozolomide re-challenge for patients without progression during prior temozolomide treatment...

..Adjuvant PCV chemotherapy increased progression-free survival but does not improve survival as compared to PCV given at recurrence. Chemotherapy with either PCV or temozolomide constitutes a standard for recurrent/progressive disease...

..This report summarizes the most important achievements in this field and provides the readers useful suggestions for their professional practice...

..5 months) and quality of life with docetaxel in more than 1,600 cases...

..Biologic agents represent the major effective therapies for widespread metastatic renal cancer. An antiangiogenic strategy, the neutralization of VEGF, can slow the growth rate of advanced cancer...

..In recurrent disease, chemotherapy with temozolomide has been proven to be active and well-tolerated in phase II trials, but no comparative phase III trials of other cytotoxic drugs have been conducted...

..Therapeutic progress may be obtainable through a careful integration of chemotherapy, stem cell transplantation, and the new targeted treatments with highly specific metabolic inhibitors and humanised monoclonal antibodies...