Enrico Garattini

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi request reprint Atypical retinoids: an expanding series of anti-leukemia and anti-cancer agents endowed with selective apoptotic activity
    E Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    J Chemother 16:70-3. 2004
  2. pmc Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology
    Enrico Garattini
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Biochem J 372:15-32. 2003
  3. doi request reprint Inhibition of the peptidyl-prolyl-isomerase Pin1 enhances the responses of acute myeloid leukemia cells to retinoic acid via stabilization of RARalpha and PML-RARalpha
    Maurizio Gianni'
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Cancer Res 69:1016-26. 2009
  4. ncbi request reprint ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis
    Enrico Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Blood 103:194-207. 2004
  5. ncbi request reprint Mammalian aldehyde oxidases: genetics, evolution and biochemistry
    E Garattini
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan, Italy
    Cell Mol Life Sci 65:1019-48. 2008
  6. ncbi request reprint Retinoid related molecules an emerging class of apoptotic agents with promising therapeutic potential in oncology: pharmacological activity and mechanisms of action
    Enrico Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea, 62 20157 Milano, Italy
    Curr Pharm Des 10:433-48. 2004
  7. ncbi request reprint Retinoids as differentiating agents in oncology: a network of interactions with intracellular pathways as the basis for rational therapeutic combinations
    Enrico Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Curr Pharm Des 13:1375-400. 2007
  8. ncbi request reprint Cytodifferentiation: a novel approach to cancer treatment and prevention
    E Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Curr Opin Pharmacol 1:358-63. 2001
  9. ncbi request reprint Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways
    Edoardo Parrella
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milano 20157, Italy
    J Biol Chem 279:42026-40. 2004
  10. doi request reprint Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression
    Mami Kurosaki
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156, Milan, Italy
    Cell Mol Life Sci 70:1807-30. 2013

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Atypical retinoids: an expanding series of anti-leukemia and anti-cancer agents endowed with selective apoptotic activity
    E Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    J Chemother 16:70-3. 2004
    ....
  2. pmc Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology
    Enrico Garattini
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Biochem J 372:15-32. 2003
    ..At present, very little is known about the pathophysiological relevance of aldehyde oxidase, aldehyde oxidase homologue 1 and aldehyde oxidase homologue 2, which do not as yet have an accepted endogenous substrate...
  3. doi request reprint Inhibition of the peptidyl-prolyl-isomerase Pin1 enhances the responses of acute myeloid leukemia cells to retinoic acid via stabilization of RARalpha and PML-RARalpha
    Maurizio Gianni'
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Cancer Res 69:1016-26. 2009
    ..Our results add a further layer of complexity to the regulation of nuclear retinoic acid receptors and suggest that Pin1 represents an important target for strategies aimed at increasing the therapeutic index of retinoids...
  4. ncbi request reprint ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis
    Enrico Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Blood 103:194-207. 2004
    ....
  5. ncbi request reprint Mammalian aldehyde oxidases: genetics, evolution and biochemistry
    E Garattini
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan, Italy
    Cell Mol Life Sci 65:1019-48. 2008
    ..The present article provides an overview of the current knowledge of genetics, evolution, structure, enzymology, tissue distribution and regulation of mammalian aldehyde oxidases...
  6. ncbi request reprint Retinoid related molecules an emerging class of apoptotic agents with promising therapeutic potential in oncology: pharmacological activity and mechanisms of action
    Enrico Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea, 62 20157 Milano, Italy
    Curr Pharm Des 10:433-48. 2004
    ....
  7. ncbi request reprint Retinoids as differentiating agents in oncology: a network of interactions with intracellular pathways as the basis for rational therapeutic combinations
    Enrico Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Curr Pharm Des 13:1375-400. 2007
    ....
  8. ncbi request reprint Cytodifferentiation: a novel approach to cancer treatment and prevention
    E Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Curr Opin Pharmacol 1:358-63. 2001
    ..Rational ways to develop these types of agents are necessary...
  9. ncbi request reprint Phosphodiesterase IV inhibition by piclamilast potentiates the cytodifferentiating action of retinoids in myeloid leukemia cells. Cross-talk between the cAMP and the retinoic acid signaling pathways
    Edoardo Parrella
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milano 20157, Italy
    J Biol Chem 279:42026-40. 2004
    ..Initial in vivo studies conducted in severe combined immunodeficiency mice transplanted with NB4 leukemia cells indicate that the enhancing effect of piclamilast on ATRA-induced myeloid maturation translates into a therapeutic benefit...
  10. doi request reprint Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression
    Mami Kurosaki
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156, Milan, Italy
    Cell Mol Life Sci 70:1807-30. 2013
    ..We identify chimeric RNAs from the human AOX3 and AOX3L1 pseudogenes with potential to encode a novel microRNA...
  11. ncbi request reprint Bis-indols: a novel class of molecules enhancing the cytodifferentiating properties of retinoids in myeloid leukemia cells
    Claudio Pisano
    Istituto di Ricerche Farmacologiche Mario Negri, Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Milano, Italy
    Blood 100:3719-30. 2002
    ..This demonstrates an important role for the mitogen-activated protein kinase in the molecular mechanisms underlying the pharmacologic activity of the bis-indol...
  12. doi request reprint New insights into the molecular mechanisms underlying sensitivity/resistance to the atypical retinoid ST1926 in acute myeloid leukaemia cells: the role of histone H2A.Z, cAMP-dependent protein kinase A and the proteasome
    Maddalena Fratelli
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy
    Eur J Cancer 49:1491-500. 2013
    ..More importantly, they demonstrate a proactive role of the proteasome in the DNA damaging and ensuing apoptotic response observed upon the challenge of acute myeloid leukaemia cells with ST1926...
  13. pmc P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription
    Maurizio Gianni
    Laboratorio di Biologia Molecolare, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italia
    EMBO J 25:739-51. 2006
    ..We propose a model in which RARalpha transcriptional activity is regulated by SRC-3 through coordinated events that are fine-tuned by RA and p38MAPK...
  14. pmc Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse
    Mineko Terao
    Laboratory of Molecular Biology, Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy
    Mol Cell Biol 29:357-77. 2009
    ..This has correlates in the corresponding transcriptome, which shows enrichment and overall upregulation of genes involved in hypertrophic responses...
  15. ncbi request reprint Retinoids and breast cancer: from basic studies to the clinic and back again
    Enrico Garattini
    Laboratory of Molecular Biology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy Electronic address
    Cancer Treat Rev 40:739-49. 2014
    ..The information provided lays the foundation for the development of rational and retinoid-based therapeutic strategies to be used for the management of breast cancer. ..
  16. ncbi request reprint Avian and canine aldehyde oxidases. Novel insights into the biology and evolution of molybdo-flavoenzymes
    Mineko Terao
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    J Biol Chem 281:19748-61. 2006
    ..Unlike humans and most other mammals, dog and chicken are devoid of liver aldehyde oxidase activity...
  17. ncbi request reprint The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa
    Mami Kurosaki
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Biol Chem 279:50482-98. 2004
    ....
  18. doi request reprint Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: significance for the cytotoxic and antiproliferative activity
    Claudia Valli
    Laboratory of Molecular Biology, Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20157 Milan, Italy
    Mol Cancer Ther 7:2941-54. 2008
    ..Cells defective for homologous recombination are particularly sensitive to ST1926, indicating that this process is important for the protection of cells from the RRM-dependent DNA damage and cytotoxicity...
  19. doi request reprint Spinal muscular atrophy pathogenic mutations impair the axonogenic properties of axonal-survival of motor neuron
    Denise Locatelli
    Molecular Neuroanatomy and Pathogenesis Unit, Neurological Institute C Besta, Milano, Italy
    J Neurochem 121:465-74. 2012
    ..They also indicate that Tudor domain mutations are functionally relevant not only for FL-SMN but also for a-SMN, raising the possibility that also a-SMN loss of function may contribute to the pathogenic steps leading to SMA...
  20. ncbi request reprint Cytodifferentiation by retinoids, a novel therapeutic option in oncology: rational combinations with other therapeutic agents
    Enrico Garattini
    Laboratorio di Biologia Molecolare, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    Vitam Horm 75:301-54. 2007
    ..This chapter aims to summarize and critically discuss the available knowledge in the field...
  21. doi request reprint The role of aldehyde oxidase in drug metabolism
    Enrico Garattini
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy
    Expert Opin Drug Metab Toxicol 8:487-503. 2012
    ..Along with the endoplasmic cytochrome P450 system (CYP450), cytoplasmic AOX1 is the major enzyme involved in the hepatic phase I metabolism of numerous xenobiotics...
  22. pmc Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells: biological correlates and molecular targets
    Mineko Terao
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milano, Italy
    J Biol Chem 286:4027-42. 2011
    ..Evidence for ICAM-1 involvement in retinoid-dependent inhibition of MCF-7 cell motility is provided...
  23. pmc The mammalian aldehyde oxidase gene family
    Enrico Garattini
    Laboratory of Molecular Biology, Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy
    Hum Genomics 4:119-30. 2009
    ..The present paper provides an update of the available information on the evolutionary history, tissue- and cell-specific distribution and function of mammalian aldehyde oxidases...
  24. doi request reprint Aldehyde oxidase and its importance in novel drug discovery: present and future challenges
    Enrico Garattini
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via La Masa 19, 20157 Milano, Italy
    Expert Opin Drug Discov 8:641-54. 2013
    ..AOXs have broad substrate specificity and are present in the liver of humans and many experimental animals. These enzymes play an important role in Phase I metabolism of drugs and xenobiotics of toxicological interest...
  25. doi request reprint Increasing recognition of the importance of aldehyde oxidase in drug development and discovery
    Enrico Garattini
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Drug Metab Rev 43:374-86. 2011
    ..The last point is discussed in the context of the design of novel anticancer drugs, selectively activated or inactivated by this enzyme, with the final aim of achieving organ and/or tumor selectivity...
  26. ncbi request reprint Regulation and biochemistry of mouse molybdo-flavoenzymes. The DBA/2 mouse is selectively deficient in the expression of aldehyde oxidase homologues 1 and 2 and represents a unique source for the purification and characterization of aldehyde oxidase
    Ruth Vila
    Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche, Mario Negri, Via Eritrea, 62, Milano 20157, Italy
    J Biol Chem 279:8668-83. 2004
    ..Consistent with this, the levels of acetaldehyde in the livers of ethanol administered CD-1 and DBA/2 mice are similar, indicating that neither enzyme is involved in the in vivo biotransformation of acetaldehyde...
  27. pmc Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesis
    Veronica Setola
    Molecular Neuroanatomy Laboratory, Department of Experimental Neurophysiology and Epileptology, Istituto Neurologico C Besta, Milano, Italy
    Proc Natl Acad Sci U S A 104:1959-64. 2007
    ..Exons 2b and 3 are essential for the axonogenic effects. This discovery indicates an unexpected complexity of the SMN gene system and may help in understanding the pathogenesis of SMA...
  28. ncbi request reprint Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase
    M Terao
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea, 62, 20157 Milano, Italy
    J Biol Chem 275:30690-700. 2000
    ..The selective cell and tissue distribution of AOH1 and AOH2 mRNAs is consistent with the localization of the respective protein products...
  29. pmc Tissue- and cell-specific expression of mouse xanthine oxidoreductase gene in vivo: regulation by bacterial lipopolysaccharide
    M Kurosaki
    Molecular Biology Unit, Centro Daniela e Catullo Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Biochem J 306:225-34. 1995
    ....
  30. ncbi request reprint The xanthine oxidoreductase gene: structure and regulation
    M Terao
    Molecular Biology Unit, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Biochem Soc Trans 25:791-6. 1997
  31. ncbi request reprint Chromosomal mapping, isolation, and characterization of the mouse xanthine dehydrogenase gene
    G Cazzaniga
    Molecular Biology Unit, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Genomics 23:390-402. 1994
    ..Transient transfection analysis in NIH3T3, tEnd, and COS cells with an appropriate reporter gene demonstrated that a functional promoter is located within the first 268 bp preceding the transcriptional initiation site...
  32. pmc Molecular cloning of a cDNA coding for mouse liver xanthine dehydrogenase. Regulation of its transcript by interferons in vivo
    M Terao
    Molecular Biology Unit, Centro Daniela e Catullo Borgomainerio, Milano, Italy
    Biochem J 283:863-70. 1992
    ..The elevation of XD mRNA concentration is relatively fast and precedes the induction of both XD and xanthine oxidase (XO) enzymic activities...
  33. ncbi request reprint Selective localization of mouse aldehyde oxidase mRNA in the choroid plexus and motor neurons
    C Bendotti
    Laboratory of Neuropharmacology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Neuroreport 8:2343-9. 1997
    ..This localization is consistent with a possible role of AO in the pathogenesis of ALS...
  34. ncbi request reprint The mouse aldehyde oxidase gene: molecular cloning, chromosomal mapping and functional characterization of the 5'-flanking region
    S Demontis
    Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Biochim Biophys Acta 1489:207-22. 1999
    ..Deletion analysis of the 5'-flanking region defines an approximately 470 bp DNA stretch which is necessary and sufficient for the transcription of the mouse aldehyde oxidase gene...
  35. ncbi request reprint Characterization of a second promoter for the mouse liver/bone/kidney-type alkaline phosphatase gene: cell and tissue specific expression
    M Studer
    Molecular Biology Unit, Centro Daniela e Catullo Borgomainerio, Istituto di Ricerche Farmacologiche, Mario Negri, Milano, Italy
    Biochem Biophys Res Commun 179:1352-60. 1991
    ..In the whole animal, the transcript driven by the first promoter is found in most tissues albeit at different levels, while the one driven by the second promoter is specifically expressed at high levels only in the heart...
  36. ncbi request reprint Cross-talk between retinoic acid and interferons: molecular mechanisms of interaction in acute promyelocytic leukemia cells
    E Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Leuk Lymphoma 30:467-75. 1998
    ..These data may be relevant in the context of a rational use of the combination between ATRA and IFNs in the clinical management of myeloid leukemias...
  37. pmc Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone
    M Kurosaki
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    Biochem J 341:71-80. 1999
    ..Treatment of female mice with testosterone increases the amounts of AO mRNA and of the relative translation product to levels similar to those in male animals...
  38. ncbi request reprint Purification, cDNA cloning, and tissue distribution of bovine liver aldehyde oxidase
    M L Calzi
    Molecular Biology Unit, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Biol Chem 270:31037-45. 1995
    ..Aldehyde oxidase is expressed at high levels in liver, lung, and spleen, and, at a much lower level, in many other organs...
  39. ncbi request reprint Correspondence re: A. Kumar et al., cross-resistance to the synthetic retinoid CD437 in a paclitaxel-resistant human ovarian carcinoma cell line is independent of the overexpression of retinoic acid receptor-gamma. Cancer Res., 61: 7552-7555, 2001
    Enrico Garattini
    Cancer Res 62:2192-3; author reply 2193-4. 2002
  40. ncbi request reprint Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor gamma 2
    Maurizio Gianni
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Université Louis Pasteur Collège de France, BP 163, 67404 Illkirch Cedex, France
    J Biol Chem 277:24859-62. 2002
    ..Altogether these data indicate that the PI3K/Akt pathway plays an important role in retinoic acid signaling...
  41. ncbi request reprint Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamm
    Edoardo Parrella
    Institut de Genetique et Biologie Moleculaire, Illkirch, France
    Mol Pharmacol 70:909-24. 2006
    ....
  42. ncbi request reprint Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes
    Steven P Rivera
    Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, University of California, 650 Charles E Young Dr, Factor Bldg 13 230, Los Angeles, CA 90095 1732, USA
    Toxicology 207:401-9. 2005
    ..Our observations thus identify two additional xenobiotic metabolizing enzymes induced by dioxin...
  43. ncbi request reprint Synthesis and structure-activity relationships of a new series of retinoid-related biphenyl-4-ylacrylic acids endowed with antiproliferative and proapoptotic activity
    Raffaella Cincinelli
    Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy
    J Med Chem 48:4931-46. 2005
    ..Among the compounds investigated, E-3-(3'-adamantan-1-yl-4'-hydroxybiphenyl-4-yl)acrylic acid (2) was chosen for further investigation...
  44. pmc Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation
    Maurizio Gianni
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 163, 67404 Illkirch Cedex, France
    EMBO J 21:3760-9. 2002
    ..Blocking RAR gamma 2 degradation through inhibition of either the p38MAPK pathway or the 26S proteasome function impairs its RA-induced transactivation activity. Thus, the turnover of RAR gamma 2 is linked to transactivation...
  45. ncbi request reprint The AF-1 and AF-2 domains of RAR gamma 2 and RXR alpha cooperate for triggering the transactivation and the degradation of RAR gamma 2/RXR alpha heterodimers
    Maurizio Gianni
    Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC CNRS INSERM ULP, UMR 7104, BP 10142, 67404 Illkirch Cedex, France
    J Biol Chem 278:34458-66. 2003
    ..Our results underline that the AF-1 and AF-2 domains of each heterodimer partner cooperate with one other and that this cooperation is relevant for both the transcription and degradation processes...
  46. ncbi request reprint Granulocytic maturation in cultures of acute myeloid leukemia is not always accompanied by increased apoptosis
    Enrico Garattini
    Leuk Res 30:519-20. 2006
    ..Down-regulation of TRAIL is correlated to an increase in the levels of the anti-apoptotic c-FLIP(L) and Mcl-1 proteins that are likely to be involved in the suppression of caspase-8 activation and apoptosis...