Alfredo Fusco

Summary

Affiliation: Istituto di Endocrinologia e Oncologia Sperimentale
Country: Italy

Publications

  1. ncbi Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma
    Teresa Guida
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:4703-9. 2005
  2. pmc The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
    Rosa Marina Melillo
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Naples, Italy
    J Clin Invest 115:1068-81. 2005
  3. ncbi RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture
    Massimo Santoro
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Via S Pansini, 5, 80131 Naples, Italy
    Eur J Endocrinol 155:645-53. 2006
  4. pmc Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues
    F de Nigris
    Br J Cancer 87:1479. 2002
  5. pmc UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas
    P Pallante
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Italy
    Br J Cancer 93:464-71. 2005
  6. pmc Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues
    F de Nigris
    Servizio di Oncologia Sperimentale E, Istituto per lo Studio e la Cura dei Tumori, Fondazione G Pascale, 80131 Naples, Italy
    Br J Cancer 86:917-23. 2002
  7. pmc FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders
    Gennaro Chiappetta
    Istituto Nazionale dei Tumori di Napoli Fondazione Senatore Pascale, Naples, Italy
    BMC Cancer 7:17. 2007
  8. pmc The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis
    Eusebio Chiefari
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Catanzaro, Italy
    BMC Biol 7:24. 2009
  9. ncbi Roles of HMGA proteins in cancer
    Alfredo Fusco
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Via Pansini, 5, 80131, Naples, Italy
    Nat Rev Cancer 7:899-910. 2007
  10. ncbi 20 years of RET/PTC in thyroid cancer: clinico-pathological correlations
    Alfredo Fusco
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale, Facoltà di Medicina e Chirurgia di Napoli, Universita Degli Studi Di Napoli, Naples, Italy
    Arq Bras Endocrinol Metabol 51:731-5. 2007

Detail Information

Publications126 found, 100 shown here

  1. ncbi Mitogenic effects of the up-regulation of minichromosome maintenance proteins in anaplastic thyroid carcinoma
    Teresa Guida
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Via S Pansini 5, 80131 Naples, Italy
    J Clin Endocrinol Metab 90:4703-9. 2005
    ..Minichromosome maintenance proteins (MCM) 2-7 are required to initiate eukaryotic DNA replication, and their overexpression has been associated with dysplasia and malignancy...
  2. pmc The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
    Rosa Marina Melillo
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Naples, Italy
    J Clin Invest 115:1068-81. 2005
    ..Thus, motile and mitogenic properties are intrinsic to transformed thyroid cells and are governed by an epistatic oncogenic signaling cascade...
  3. ncbi RET/PTC activation in papillary thyroid carcinoma: European Journal of Endocrinology Prize Lecture
    Massimo Santoro
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Via S Pansini, 5, 80131 Naples, Italy
    Eur J Endocrinol 155:645-53. 2006
    ..These findings have advanced our understanding of the processes underlying PTC formation and provide the basis for novel therapeutic approaches to this disease...
  4. pmc Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues
    F de Nigris
    Br J Cancer 87:1479. 2002
  5. pmc UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas
    P Pallante
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Italy
    Br J Cancer 93:464-71. 2005
    ..Taken together, these results would indicate that UbcH10 overexpression is involved in thyroid cell proliferation, and may represent a marker of thyroid anaplastic carcinomas...
  6. pmc Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues
    F de Nigris
    Servizio di Oncologia Sperimentale E, Istituto per lo Studio e la Cura dei Tumori, Fondazione G Pascale, 80131 Naples, Italy
    Br J Cancer 86:917-23. 2002
    ..The human SIR-T8 protein has a molecular weight of 39 kDa and is primarily located in the cytoplasm under the nuclear membrane. The SIR-T8 gene is located on chromosome 17q25-1...
  7. pmc FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders
    Gennaro Chiappetta
    Istituto Nazionale dei Tumori di Napoli Fondazione Senatore Pascale, Naples, Italy
    BMC Cancer 7:17. 2007
    ....
  8. pmc The cAMP-HMGA1-RBP4 system: a novel biochemical pathway for modulating glucose homeostasis
    Eusebio Chiefari
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Catanzaro, Italy
    BMC Biol 7:24. 2009
    ..Also, the hypothesis that increased insulin sensitivity in Hmga1-deficient mice could be related to the deficit of an insulin resistance factor is discussed...
  9. ncbi Roles of HMGA proteins in cancer
    Alfredo Fusco
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Via Pansini, 5, 80131, Naples, Italy
    Nat Rev Cancer 7:899-910. 2007
    ..Here, we focus on the role of the HMGA proteins in human neoplastic diseases, the mechanisms by which they contribute to carcinogenesis, and therapeutic strategies based on targeting HMGA proteins...
  10. ncbi 20 years of RET/PTC in thyroid cancer: clinico-pathological correlations
    Alfredo Fusco
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale, Facoltà di Medicina e Chirurgia di Napoli, Universita Degli Studi Di Napoli, Naples, Italy
    Arq Bras Endocrinol Metabol 51:731-5. 2007
    ....
  11. pmc A new mechanism of BRAF activation in human thyroid papillary carcinomas
    Alfredo Fusco
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    J Clin Invest 115:20-3. 2005
    ..The resulting AKAP9-BRAF fusion protein shows constitutive kinase activity, and it is able to transmit mitogenic signals to the MAPK pathways and to promote malignant transformation of NIH3T3 cells...
  12. ncbi Efficient inhibition of RET/papillary thyroid carcinoma oncogenic kinases by 4-amino-5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2)
    Francesca Carlomagno
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c o Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita Federico II, 80131 Naples, Italy
    J Clin Endocrinol Metab 88:1897-902. 2003
    ..Finally, PP2 blocked invasion of type I collagen matrix by TPC1 cells. Thus, pyrazolopirimidines hold promise for the treatment of human cancers sustaining oncogenic activation of RET...
  13. ncbi Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells
    Donata Vitagliano
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II c o Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Naples, Italy
    Cancer Res 64:3823-9. 2004
    ..Therefore, in thyroid cancer, RET/PTC-mediated MAPK activation contributes to p27Kip1 deregulation. This pathway is implicated in cell cycle progression and in response to small molecule kinase inhibitors...
  14. doi Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein
    Antonella Federico
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita degli Studi di Napoli Federico II, Italy
    Cancer Res 69:7079-87. 2009
    ....
  15. ncbi Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer
    Pierlorenzo Pallante
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Naples, Italy
    Cancer Res 68:6770-8. 2008
    ..In conclusion, loss of CBX7 expression correlates with a highly malignant phenotype in thyroid cancer patients...
  16. ncbi HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity
    Monica Fedele
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR and Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 80131 Naples, Italy
    Cancer Cell 9:459-71. 2006
    ..Thus, HMGA2-mediated E2F1 activation is a crucial event in the onset of these tumors in transgenic mice and probably also in human prolactinomas...
  17. pmc Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization
    Maria Letizia Motti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Am J Pathol 166:737-49. 2005
    ..Thus the PI3/AKT pathway and its effector p27(kip1) play major roles in thyroid carcinogenesis...
  18. pmc Interaction between HMGA1 and retinoblastoma protein is required for adipocyte differentiation
    Francesco Esposito
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Biol Chem 284:25993-6004. 2009
    ..Altogether these data demonstrate a key role of the interaction between HMGA1 and RB in adipocyte differentiation...
  19. ncbi Reduced E-cadherin expression contributes to the loss of p27kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas
    Maria Letizia Motti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano Facoltà di Medicina e Chirurgia, Universita Federico II, Via S Pansini 5, 80131, Napoli, Italy
    Carcinogenesis 26:1021-34. 2005
    ..In summary, our data indicate that the altered response to contact inhibition exhibited by thyroid anaplastic cancer cells is due to the failure to upregulate p27(Kip1) in response to cell-cell interactions...
  20. ncbi HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas
    Ivana De Martino
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Italy
    Cancer Res 69:1844-50. 2009
    ..Because cyclin B2 is involved in the regulation of the cell cycle, these results taken together indicate that HMGA-induced cyclin B2 overexpression gives an important contribution to experimental and human pituitary tumorigenesis...
  21. doi Tumor suppressor role of the CL2/DRO1/CCDC80 gene in thyroid carcinogenesis
    Angelo Ferraro
    Istituto per l Endocrinologia e l Oncologia Sperimentale G Salvatore, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Fondazione Pascale, 80131 Napoli, Italy
    J Clin Endocrinol Metab 98:2834-43. 2013
    ..Our previous data implicated a link between the CL2/CCDC80 gene and thyroid cancer...
  22. pmc The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma
    Rosa Marina Melillo
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita di Napoli Federico II, Via S Pansini 5, 80131 Naples, Italy
    Am J Pathol 165:511-21. 2004
    ..In conclusion, RET point mutants can behave as dominant oncogenes for thyroid follicular cells. Their transforming activity, however, is rather modest, providing a possible explanation for the rare association of MTC with PTC...
  23. doi HMGA1 protein is a novel target of the ATM kinase
    Francesca Pentimalli
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    Eur J Cancer 44:2668-79. 2008
    ....
  24. doi Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1
    Daniela D'Angelo
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Degli Studi Di Napoli, Napoli, Italy
    J Clin Endocrinol Metab 97:E1128-38. 2012
    ..MicroRNA (miRNA) are an important class of regulators of gene expression. Altered miRNA expression has been constantly found in human neoplasias and plays an important role in the process of carcinogenesis...
  25. pmc High-mobility-group A1 (HMGA1) proteins down-regulate the expression of the recombination activating gene 2 (RAG2)
    Sabrina Battista
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Via Pansini, 5, 80131 Naples, Italy
    Biochem J 389:91-7. 2005
    ..Since RAG2 is necessary for lymphoid cell development, our results suggest a novel mechanism by which HMGA1 might regulate lymphoid differentiation...
  26. ncbi Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells
    Maria Domenica Castellone
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Naples, Italy
    Oncogene 23:2188-96. 2004
    ..Thus, RET/PTC signalling triggers an autocrine loop involving OPN and CD44 that sustains proliferation and invasion of transfomed PC Cl 3 thyrocytes...
  27. doi Deregulation of microRNA expression in follicular-cell-derived human thyroid carcinomas
    Pierlorenzo Pallante
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy
    Endocr Relat Cancer 17:F91-104. 2010
    ....
  28. ncbi Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas
    Monica Fedele
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 80131 Naples, Italy
    Oncogene 24:3427-35. 2005
    ..Taken together, these data indicate an oncogenic role of the HMGA1 gene also in vivo...
  29. ncbi ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
    Francesca Carlomagno
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare Luigi Califano, University Federico II, Naples, Italy
    Cancer Res 62:7284-90. 2002
    ..Thus, targeting RET oncogenes with ZD6474 might offer a potential treatment strategy for carcinomas sustaining oncogenic activation of RET...
  30. ncbi Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes
    Maria Domenica Castellone
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c o Dipartimento di Biologia, University Federico II, Naples, Italy
    Oncogene 22:246-55. 2003
    ..In turn, Y1062 phosphorylation transmits not only mitogenic but also proapoptotic signals to thyroid cells...
  31. doi miR-191 down-regulation plays a role in thyroid follicular tumors through CDK6 targeting
    Marianna Colamaio
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Napoli, Italy
    J Clin Endocrinol Metab 96:E1915-24. 2011
    ..miR-191 expression is frequently altered in several neoplasias, being up-regulated in some cases, such as pancreatic carcinomas, and down-regulated in other carcinomas, such as melanomas...
  32. ncbi A truncated HMGA1 gene induces proliferation of the 3T3-L1 pre-adipocytic cells: a model of human lipomas
    Giovanna Maria Pierantoni
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Via Pansini 5, I 80131 Naples, Italy
    Carcinogenesis 24:1861-9. 2003
    ..These results suggest a critical role played by HMGA1 rearrangements in the generation of human lipomas...
  33. ncbi The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas
    Ivana De Martino
    Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy
    Endocr Relat Cancer 14:875-86. 2007
    ..Interestingly, Mia/Cd-rap expression inhibits their proliferation, suggesting a potential tumor suppressor role of Mia/Cd-rap in pituitary cells...
  34. doi TWIST1 plays a pleiotropic role in determining the anaplastic thyroid cancer phenotype
    Paolo Salerno
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c o Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Universita di Napoli Federico II, 80131 Naples, Italy
    J Clin Endocrinol Metab 96:E772-81. 2011
    ..Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human tumors; it is characterized by chemoresistance, local invasion, and distant metastases. ATC is invariably fatal...
  35. pmc DNA damage, homology-directed repair, and DNA methylation
    Concetta Cuozzo
    Dipartimento di Biologia e Patologia Molecolare e Cellulare, Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Universita Federico II, Naples, Italy
    PLoS Genet 3:e110. 2007
    ..Taken together, our data support a mechanistic link between HR and DNA methylation and suggest that DNA methylation in eukaryotes marks homologous recombined segments...
  36. ncbi Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation
    Rosanna Sorrentino
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Via S Pansini 5, 80131 Napoli, Italy
    J Clin Endocrinol Metab 90:928-35. 2005
    ..The block of Aurora B expression induced by RNA interference or by using an inhibitor of Aurora kinase activity significantly reduced the growth of thyroid anaplastic carcinoma cells...
  37. doi Embryonic defects and growth alteration in mice with homozygous disruption of the Patz1 gene
    Teresa Valentino
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR and Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Naples, Italy
    J Cell Physiol 228:646-53. 2013
    ..Therefore, these results indicate a critical role of PATZ1 in the control of cell growth and embryonic development...
  38. ncbi Thyrotropin regulates thyroid cell proliferation by up-regulating miR-23b and miR-29b that target SMAD3
    Vincenza Leone
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II 80131 Naples, Italy
    J Clin Endocrinol Metab 97:3292-301. 2012
    ..MicroRNA (miRNA or miR) have emerged as an important class of short endogenous RNA that act as post-transcriptional regulators of gene expression and have a critical role in cell proliferation and differentiation...
  39. doi Down-regulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2
    Francesco Esposito
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, 80131 Naples, Italy
    J Clin Endocrinol Metab 97:E710-8. 2012
    ..We have previously demonstrated that a set of micro-RNA (miRNA) is significantly down-regulated in anaplastic thyroid carcinomas with respect to normal thyroid tissues and to differentiated thyroid carcinomas...
  40. doi Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice
    Monica Fedele
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, 80131 Naples, Italy
    Endocr Relat Cancer 16:483-90. 2009
    ..Therefore, our findings suggest a dose-dependent role of p27(kip1) function in papillary thyroid cancer development...
  41. doi Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice
    Monica Fedele
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Universita degli Studi di Napoli Federico II, 80131 Naples, Italy
    Eur J Cancer 47:470-8. 2011
    ..Interestingly, the Hmga1b/T mice also develop B-cell lymphomas similar to that occurring in Hmga1-knockout mice, supporting a dominant-negative role of the Hmga1b/T mutant also in vivo...
  42. pmc Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription
    Laura Casalino
    A Buzzati Traverso Institute of Genetics and Biophysics, CNR, Naples, Italy
    EMBO J 26:1878-90. 2007
    ..Fra-1 also induced the expression of JunB, which in turn interacts with the cyclin A promoter. Hence, Fra-1 induction is important in thyroid tumorigenesis, critically regulating cyclin expression and cell-cycle progression...
  43. doi HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias
    Gennaro Chiappetta
    Istituto Nazionale dei Tumori, Fondazione Pascale, Via Mariano Semmola, 80131 Naples, Italy
    Eur J Cancer 44:1015-21. 2008
    ..Therefore, our data support the quantitative RT-PCR analysis of HMGA2 expression, rather than immunohistochemistry, as a powerful tool for the diagnosis of thyroid neoplasias...
  44. doi A TSH-CREB1-microRNA loop is required for thyroid cell growth
    Vincenza Leone
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    Mol Endocrinol 25:1819-30. 2011
    ..Hence, these data indicate that a synergistic loop involving thyrotropin, CREB1, and miRNA is required for thyroid cell proliferation...
  45. ncbi MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle
    Rosa Visone
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Via Pansini, 5, 80131 Naples, Italy
    Endocr Relat Cancer 14:791-8. 2007
    ..Therefore, the data reported here demonstrate that miR-221 and miR-222 are endogenous regulators of p27(Kip1) protein expression, and thereby, the cell cycle...
  46. pmc CBX7 is a tumor suppressor in mice and humans
    Floriana Forzati
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita di Napoli Federico II, Naples, Italy
    J Clin Invest 122:612-23. 2012
    ..These data suggest that CBX7 is a tumor suppressor and that its loss plays a key role in the pathogenesis of cancer...
  47. doi PIT1 upregulation by HMGA proteins has a role in pituitary tumorigenesis
    Dario Palmieri
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita degli Studi di Napoli Federico II, Naples, Italy
    Endocr Relat Cancer 19:123-35. 2012
    ..Taken together, our data indicate a role of Pit1 upregulation by HMGA proteins in pituitary tumours...
  48. doi The high-mobility group A1-estrogen receptor β nuclear interaction is impaired in human testicular seminomas
    Francesco Esposito
    Dipartimento di Medicina Sperimentale, II Universita di Napoli, Via Costantinopoli, Naples, Italy
    J Cell Physiol 227:3749-55. 2012
    ....
  49. ncbi UbcH10 expression on thyroid fine-needle aspirates
    Eliana Guerriero
    Department of Biomorphology Sciences, Faculty of Medicine and Surgery, University of Naples Federico II, Naples, Italy
    Cancer Cytopathol 118:157-65. 2010
    ..Here, analysis of UbcH10 expression by quantitative reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry was applied to FNAs...
  50. pmc Loss of CCDC6, the first identified RET partner gene, affects pH2AX S139 levels and accelerates mitotic entry upon DNA damage
    Francesco Merolla
    Istituto di Endocrinologia ed Oncologia Sperimentale, CNR, Naples, Italy
    PLoS ONE 7:e36177. 2012
    ..Overall, our data suggest that in primary tumours the loss of CCDC6 function could influence genome stability and thereby contribute to carcinogenesis...
  51. doi High-mobility group A1 proteins regulate p53-mediated transcription of Bcl-2 gene
    Francesco Esposito
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Università degli Studi di Napoli Federico II, Naples, Italy
    Cancer Res 70:5379-88. 2010
    ..Therefore, this study suggests a novel mechanism, based on Bcl-2 induction, by which HMGA1 overexpression contributes to the escape from apoptosis leading to neoplastic transformation...
  52. ncbi Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation
    Josefina Martinez Hoyos
    Dipartimento di Biologia e Patologia Cellulare e Molecolare e o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    Cancer Res 64:5728-35. 2004
    ....
  53. pmc Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors
    Stefania Staibano
    Istituto di Endocrinologia ed Oncologia Sperimentale, CNRZ, Via S Pansini, 5, Naples 80131, Italy
    BMC Cancer 13:433. 2013
    ..In our study we sought to determine whether CCDC6 could have a role in the patho-genesis of testicular germ cell tumors...
  54. pmc Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer
    Alfredo Fusco
    Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Naples, Italy
    Am J Pathol 160:2157-67. 2002
    ....
  55. pmc Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility
    Giovanna Maria Pierantoni
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Via Pansini 5, 80131 Naples, Italy
    J Biol Chem 286:29005-13. 2011
    ..An initial evaluation of the functional relevance of this HIPK2-mediated regulation of p27(kip1) revealed a contribution to cell motility, rather than to cell proliferation, but only in cells that do not express wild-type p53...
  56. ncbi Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
    Giuseppe Viglietto
    Istituto di Endocrinologia ed Oncologia Sperimentale, CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Naples, Italy
    Nat Med 8:1136-44. 2002
    ....
  57. pmc High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2
    Giovanna Maria Pierantoni
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Naples, Italy
    J Clin Invest 117:693-702. 2007
    ..Hence, cytoplasmic relocalization of HIPK2 induced by HMGA1 overexpression is a mechanism of inactivation of p53 apoptotic function that we believe to be novel...
  58. ncbi Transcriptional profile of Ki-Ras-induced transformation of thyroid cells
    Roberta Visconti
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, L Califano, Universita degli Studi di Napoli Federico II e o Istituto di Endocrinologia e Oncologia Sperimentale G Salvatore del CNR, Napoli, Italy
    Cancer Invest 25:256-66. 2007
    ....
  59. ncbi Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors
    Dolores Di Vizio
    Dipartimento di Scienze Biomorfologiche e Funzionali, Facolta di Medicina e Chirurgia, Universita di Napoli Federico II, Via S Pansini, 5, 80131 Napoli, Italy
    Oncogene 24:1882-94. 2005
    ....
  60. ncbi Suppression of HMGA2 protein synthesis could be a tool for the therapy of well differentiated liposarcomas overexpressing HMGA2
    Francesca Pentimalli
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita Degli Studi Di Napoli, 80131 Naples, Italy
    Cancer Res 63:7423-7. 2003
    ..On the basis of these findings, the targeting of the HMGA2 protein expression may represent a promising approach for treating the well-differentiated liposarcomas resistant to conventional therapies...
  61. ncbi Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas
    Maria D Castellone
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR G Salvatore, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, 80131 Naples, Italy
    Oncogene 23:5958-67. 2004
    ..Taken together, these results suggest that human thyroid cancers bearing RET/PTC rearrangements may use the CXCR4/SDF-1alpha receptor-ligand pathway to proliferate, survive and migrate...
  62. doi The impairment of the High Mobility Group A (HMGA) protein function contributes to the anticancer activity of trabectedin
    Daniela D'Angelo
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    Eur J Cancer 49:1142-51. 2013
    ..This result might have important clinical implications since it would suggest the use of trabectedin for the treatment of neoplasias expressing abundant HMGA levels that are frequently associated to chemoresistance and poor prognosis...
  63. pmc Identification of sumoylation sites in CCDC6, the first identified RET partner gene in papillary thyroid carcinoma, uncovers a mode of regulating CCDC6 function on CREB1 transcriptional activity
    Chiara Luise
    Istituto di Endocrinologia ed Oncologia Sperimentale, CNR, Universita Federico II, Naples, Italy
    PLoS ONE 7:e49298. 2012
    ..We believe that CCDC6 could be an important player in the dynamics of cAMP signaling by fine regulating CREB1 transcriptional activity in normal and transformed thyroid cells...
  64. pmc POZ-, AT-hook-, and zinc finger-containing protein (PATZ) interacts with human oncogene B cell lymphoma 6 (BCL6) and is required for its negative autoregulation
    Raffaela Pero
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II and Consiglio Nazionale delle Ricerche CNR, Naples, Italy
    J Biol Chem 287:18308-17. 2012
    ..Therefore, the disruption of one or both Patz1 alleles may favor lymphomagenesis by activating the BCL6 pathway...
  65. ncbi Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations
    Giuliana Salvatore
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Cancer 41:816-21. 2005
    ..Thus, in clinical practice, the detection of B-raf mutations in a thyroid follicular tumour may prove to be a valuable tool, supplementing histological examination, and allowing a differential diagnosis between PTC and HTT...
  66. ncbi Hmga1 null mice are less susceptible to chemically induced skin carcinogenesis
    Rosa Visone
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita degli Studi di Napoli Federico II, Via Pansini, 5, 80131, Naples, Italy
    Eur J Cancer 44:318-25. 2008
    ..These results suggest a lower susceptibility of Hmga1-/- mice to skin carcinogenesis induced by chemical agents...
  67. doi The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients
    Pierlorenzo Pallante
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Via Pansini 5, 80131 Naples, Italy
    Eur J Cancer 46:2304-13. 2010
    ..Therefore, the data reported here indicate that the evaluation of CBX7 expression may represent a valid tool in the prognosis of colon cancer since a reduced survival of CRC patients is associated with the loss of CBX7 expression...
  68. doi The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR-603 and miR-10b expression
    Paula Mussnich
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    Mol Oncol 7:531-42. 2013
    ..Moreover, functional studies showed that miR-10b and miR-603 regulate positively and negatively, respectively, cell proliferation and migration suggesting a role of their dysregulation in thyroid cell transformation...
  69. doi MiR-1 is a tumor suppressor in thyroid carcinogenesis targeting CCND2, CXCR4, and SDF-1alpha
    Vincenza Leone
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Centro Ingegneria Genetica and European School of Molecular Medicine, 80131 Naples, Italy
    J Clin Endocrinol Metab 96:E1388-98. 2011
    ..MiR-1 has been found down-regulated in lung, colon, and prostate cancer...
  70. ncbi UbcH10 is overexpressed in malignant breast carcinomas
    Maria Teresa Berlingieri
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Via S Pansini 5, 80131 Naples, Italy
    Eur J Cancer 43:2729-35. 2007
    ..Therefore, these results suggest the perspective of a therapy of aggressive breast carcinomas based on the suppression of the UbcH10 function...
  71. ncbi A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma
    Giuliana Salvatore
    Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Universita Parthenope, Naples, Italy
    Cancer Res 67:10148-58. 2007
    ..Thus, thyroid cell anaplastic transformation is accompanied by the overexpression of a cell proliferation/genetic instability-related gene cluster that includes PLK1 kinase, which is a potential molecular target for ATC treatment...
  72. doi Role of the high mobility group A proteins in the regulation of pituitary cell cycle
    Monica Fedele
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, 80131 Naples, Italy
    J Mol Endocrinol 44:309-18. 2010
    ..Here, we first review the role of the cell cycle in pituitary tumorigenesis, as witnessed by human pathology and transgenic mice; and then, we focus on HMGA proteins and their cell cycle-related role in pituitary tumorigenesis...
  73. ncbi Therapy of human pancreatic carcinoma based on suppression of HMGA1 protein synthesis in preclinical models
    Francesco Trapasso
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, c o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Universita di Napoli Federico II, Naples, Italy
    Cancer Gene Ther 11:633-41. 2004
    ..Therefore, suppression of HMGA1 protein synthesis by an HMGA1 antisense approach seems to be a feasible treatment strategy in pancreatic carcinomas...
  74. ncbi Molecular mechanisms of RET activation in human cancer
    Massimo Santoro
    Centro di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita di Napoli Federico II, 80131 Naples, Italy
    Ann N Y Acad Sci 963:116-21. 2002
    ..This review describes the molecular mechanisms by which the different genetic alterations cause the conversion of RET into a dominant transforming oncogene...
  75. doi UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status
    Pierlorenzo Pallante
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Via Pansini 5, Naples, Italy
    Eur J Cancer 49:1117-26. 2013
    ..The aim of this study has been to extend the analysis of UbcH10 expression to lung cancer. This neoplasia represents one of the leading cause of cancer mortality worldwide, and new tools for an accurate diagnosis/prognosis are needed...
  76. ncbi Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas
    Monica Fedele
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Federico II Università degli Studi di Napoli, Via Pansini 5, 80131 Naples, Italy
    Oncogene 21:3190-8. 2002
    ..These transgenic mice may represent an important tool for the study of this kind of neoplasia...
  77. doi Tumor suppressor activity of CBX7 in lung carcinogenesis
    Floriana Forzati
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    Cell Cycle 11:1888-91. 2012
    ..A similar mechanism is likely involved in human lung carcinogenesis, since cyclin E upregulation associated with the loss of CBX7 expression has been observed in most of the human lung carcinomas analyzed...
  78. pmc siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma
    Henri de Martimprey
    CNRS, UMR 8121, Univ Paris Sud, Institut Gustave Roussy, Naples, Italy
    Nucleic Acids Res 36:e2. 2008
    ..They have allowed to protect ret/PTC1 siRNA from in vivo degradation and leading to significant tumour growth inhibition after intratumoral administration...
  79. ncbi Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation
    Sabrina Battista
    Dipartimento di Biologia e Patologia Cellulare e Molecolare c o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Via Pansini 5, 80131 Naples, Italy
    FASEB J 17:1496-8. 2003
    ..In fact, we found that Hmga1-/- ES cells overexpress GATA-1 and that HMGA1 proteins directly control GATA-1 transcription. Taken together, these data indicate that HMGA1 proteins play a prime role in lymphohematopoietic differentiation...
  80. ncbi Cloning and molecular characterization of a novel gene strongly induced by the adenovirus E1A gene in rat thyroid cells
    Roberta Visconti
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Via Pansini 5, 80131 Naples, Italy
    Oncogene 22:1087-97. 2003
    ..Finally, CL2 gene expression was drastically downregulated in human thyroid neoplastic cell lines and tissues...
  81. ncbi The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes
    Francesca Carlomagno
    Centro di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Facolta di Medicina e Chirurgia, Universita di Napoli Federico II, 80131 Naples, Italy
    Cancer Res 62:1077-82. 2002
    ..These findings suggest targeting RET oncogenes with PP1 or related compounds as a novel treatment strategy for RET-associated neoplasms...
  82. ncbi Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1)
    Gustavo Baldassarre
    Istituto Nazionale Tumori, Via M Semmola, 80131, Naples, Italy
    Oncogene 21:1739-49. 2002
    ..Both DNA synthesis inhibition and SSEA-3 down-regulation are prevented if p27(kip1) expression is blocked by an antisense construct, which demonstrates that RET-triggered effects are mediated by p27(kip1)...
  83. ncbi Critical role of the HMGA2 gene in pituitary adenomas
    Monica Fedele
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Naples, Italy
    Cell Cycle 5:2045-8. 2006
    ..Nevertheless, other events may be also involved in this process, and are discussed here...
  84. ncbi Minireview: RET: normal and abnormal functions
    Massimo Santoro
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II c o Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Naples, Italy
    Endocrinology 145:5448-51. 2004
    ..In this report we review data on the mechanisms leading to RET oncogenic conversion and on RET targeting as a strategy in thyroid cancer treatment...
  85. doi Down-regulation of oestrogen receptor-β associates with transcriptional co-regulator PATZ1 delocalization in human testicular seminomas
    Francesco Esposito
    Dipartimento di Medicina Sperimentale, II Universita di Napoli, Naples, Italy
    J Pathol 224:110-20. 2011
    ....
  86. ncbi Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer
    Gennaro Chiappetta
    Laboratorio Oncologia Sperimentale III, Istituto Nazionale Tumori, Via M Semmola, 80131 Napoli, Italy
    Endocr Relat Cancer 14:405-20. 2007
    ..These findings indicate that Skp2 plays an important role for the development of thyroid cancer...
  87. ncbi Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells
    Silvana Libertini
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via S Pansini 5, 80131, Napoli, Italy
    Endocrinology 148:5186-94. 2007
    ..Lovastatin treatment could be exploited to increase the efficacy of oncolytic adenoviruses, and further studies are warranted to confirm the feasibility of the approach in ATC patients...
  88. ncbi SOM230, a new somatostatin analogue, is highly effective in the therapy of growth hormone/prolactin-secreting pituitary adenomas
    Monica Fedele
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR e o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Naples, Italy
    Clin Cancer Res 13:2738-44. 2007
    ..This animal model has been used to evaluate the therapeutic efficacy of SOM230, a somatostatin analogue with high affinity for the somatostatin receptor subtypes 1, 2, 3, and 5, on the growth of the pituitary adenomas...
  89. ncbi RET activation and clinicopathologic features in poorly differentiated thyroid tumors
    Massimo Santoro
    Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 80131 Naples, Italy
    J Clin Endocrinol Metab 87:370-9. 2002
    ....
  90. pmc Role of PTPRJ genotype in papillary thyroid carcinoma risk
    Rodolfo Iuliano
    Dipartimento di Medicina Sperimentale e Clinica, Facolta di Medicina e Chirurgia, Università degli Studi Magna Græcia di Catanzaro, Campus Salvatore Venuta, Viale Europa, località Germaneto, Catanzaro, Italy
    Endocr Relat Cancer 17:1001-6. 2010
    ..Therefore, the results reported here show that the homozygous genotype for Asp872 of PTPRJ is associated with an increased risk to develop PTC...
  91. pmc The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation
    Maria Domenica Castellone
    Istituto di Endocrinologia ed Oncologia Sperimentale G Salvatore, Consiglio Nazionale delle Ricerche, c o Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita Federico II, Naples, Italy
    Cancer Res 69:1867-76. 2009
    ..Thus, multiple signaling events downstream from RET/PTC converge on beta-catenin to stimulate cell proliferation...
  92. pmc Identification of a New Pathway for Tumor Progression: MicroRNA-181b Up-Regulation and CBX7 Down-Regulation by HMGA1 Protein
    Gelsomina Mansueto
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Universita di Napoli Federico II, Naples, Italy
    Genes Cancer 1:210-24. 2010
    ..These data indicate the presence of a novel pathway involving HMGA1, miR-181b, and CBX7, which leads to breast cancer progression...
  93. ncbi High-mobility group A2 gene expression is frequently induced in non-functioning pituitary adenomas (NFPAs), even in the absence of chromosome 12 polysomy
    Giovanna Maria Pierantoni
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Italy
    Endocr Relat Cancer 12:867-74. 2005
    ..However, it cannot be excluded that the HMGA2 overexpression may be due, in some NFPA patients, to the same, still mainly unknown, mechanisms responsible for HMGA2 overexpression in malignant neoplasias...
  94. pmc Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma
    Fulvio Basolo
    Dipartimento di Oncologia, Universita degli Studi di Pisa, Pisa Fondazione Senatore Pascale, Naples, Italy
    Am J Pathol 160:247-54. 2002
    ..In conclusion, we postulate that the correlation between the RET/PTC rearrangement type and the aggressiveness of human PTC is related to the efficiency with which the oncogene subtype delivers mitogenic signals to thyroid cells...
  95. doi HMGA and cancer
    Monica Fedele
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Via Pansini 5, 80131 Naples, Italy
    Biochim Biophys Acta 1799:48-54. 2010
    ..Here, we review the involvement of HMGA proteins in cancer, analyzing the mechanisms underlying their crucial role in tumorigenesis, and, finally, discuss the potentiality of a cancer treatment based on HMGA targeting...
  96. ncbi Thyroid cell transformation requires the expression of the HMGA1 proteins
    Maria Teresa Berlingieri
    Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c o Dipartimento di Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita Degli Studi Di Napoli, Via Pansini 5, 80131 Naples, Italy
    Oncogene 21:2971-80. 2002
    ..Moreover, the lack of the neoplastic phenotype in the virus-infected thyroid cells carrying the HMGA1 antisense construct correlates with the absence of induction of AP-1 transcriptional activity...
  97. ncbi The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues
    Giovanna Maria Pierantoni
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita degli Studi di Napoli Federico II, Naples, 80131, Italy
    Biochem Biophys Res Commun 290:942-7. 2002
    ..Conversely, HIPK2 is ubiquitously expressed in murine and human adult tissues. We have also found that HIPK2 expression is reduced in breast and thyroid carcinomas, suggesting a role of this gene in the process of carcinogenesis...
  98. ncbi Identification of new high mobility group A1 associated proteins
    Giovanna Maria Pierantoni
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita degli Studi di Napoli Federico II, Naples, Italy
    Proteomics 7:3735-42. 2007
    ....
  99. ncbi New drugs in thyroid cancer
    Massimo Santoro
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale, Facoltà di Medicina e Chirurgia di Napoli, Universita degli Studi di Napoli Federico II, Naples, Italy
    Arq Bras Endocrinol Metabol 51:857-61. 2007
    ..The power of this approach is witnessed by the examples of BCR-ABL, c-KIT and EGFR inhibitors in the treatment of chronic myelogenous leukemia (CML), gastro-intestinal stromal tumors (GIST) and non-small cell lung carcinoma (NSCLC)...
  100. ncbi ONYX-015 enhances radiation-induced death of human anaplastic thyroid carcinoma cells
    Giuseppe Portella
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Naples, Italy
    J Clin Endocrinol Metab 88:5027-32. 2003
    ..Our results suggest that the combination of ONYX-015 and radiotherapy should be considered for experimental trials in patients with anaplastic thyroid carcinoma...
  101. ncbi Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization
    Giuseppe Viglietto
    Instituto di Endocrinologia ed Oncologia Sperimentale, CNR and Dipartimento di Biologia e Patologie Cellulare e Molecolare, Naples, Italy
    Cell Cycle 1:394-400. 2002
    ..Finally, we review the possible clinical implications of these observations with respect to prognosis and novel anticancer therapies...