Silvana Franceschetti

Summary

Affiliation: Istituto Nazionale Neurologico Carlo Besta
Country: Italy

Publications

  1. ncbi request reprint Na+-activated K+ current contributes to postexcitatory hyperpolarization in neocortical intrinsically bursting neurons
    Silvana Franceschetti
    National Neurological Institute C Besta, 20133 Milan and Department of Physiological and Pharmacological Sciences, University of Pavia, 27100 Pavia, Italy
    J Neurophysiol 89:2101-11. 2003
  2. ncbi request reprint Intellectual and language findings and their relationship to EEG characteristics in benign childhood epilepsy with centrotemporal spikes
    Daria Riva
    Developmental Neurology Division, Istituto Nazionale Neurologico C Besta, Via Celoria 11, Milan, Italy
    Epilepsy Behav 10:278-85. 2007
  3. ncbi request reprint Epileptogenic channelopathies: experimental models of human pathologies
    Giuliano Avanzini
    Department ofNeurophysiopathology, Istituto Neurologico C Besta, Milan, Italy
    Epilepsia 48:51-64. 2007
  4. doi request reprint Verbal dichotic listening performance and its relationship with EEG features in benign childhood epilepsy with centrotemporal spikes
    Sara Bulgheroni
    Developmental Neurology Division, Istituto Neurologico C Besta, Via Celoria 11, 20133 Milano, Italy
    Epilepsy Res 79:31-8. 2008
  5. ncbi request reprint Functional MRI in malformations of cortical development: activation of dysplastic tissue and functional reorganization
    Paolo Vitali
    Department of Clinical Neurophysiology, University of Genova, Genova, Italy
    J Neuroimaging 18:296-305. 2008
  6. doi request reprint The neuropsychological pattern of Unverricht-Lundborg disease
    Anna R Giovagnoli
    Neuropsychology Laboratory, C Besta National Neurological Institute, Milano, Italy
    Epilepsy Res 84:217-23. 2009
  7. doi request reprint Progressive neurocognitive decline in two children with Dravet syndrome, de novo SCN1A truncations and different epileptic phenotypes
    Daria Riva
    Developmental Neurology Unit, C Besta Foundation Neurological Institute, Milan, Italy
    Am J Med Genet A 149:2339-45. 2009
  8. ncbi request reprint Periventricular nodular heterotopia: classification, epileptic history, and genesis of epileptic discharges
    Giorgio Battaglia
    Division of Experimental Neurophysiology and Epileptology, Neurological Institute C Besta, Milan, Italy
    Epilepsia 47:86-97. 2006
  9. pmc Identification of an Nav1.1 sodium channel (SCN1A) loss-of-function mutation associated with familial simple febrile seizures
    Massimo Mantegazza
    Department of Neurophysiopathogy, Istituto Neurologico C Besta, Milan, Italy
    Proc Natl Acad Sci U S A 102:18177-82. 2005
  10. ncbi request reprint Electroencephalographic recordings of focal seizures in patients affected by periventricular nodular heterotopia: role of the heterotopic nodules in the genesis of epileptic discharges
    Giorgio Battaglia
    Division of Experimental Neurophysiology and Epileptology, Neurological Institute C Besta, Milan, Italy
    J Child Neurol 20:369-77. 2005

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Na+-activated K+ current contributes to postexcitatory hyperpolarization in neocortical intrinsically bursting neurons
    Silvana Franceschetti
    National Neurological Institute C Besta, 20133 Milan and Department of Physiological and Pharmacological Sciences, University of Pavia, 27100 Pavia, Italy
    J Neurophysiol 89:2101-11. 2003
    ....
  2. ncbi request reprint Intellectual and language findings and their relationship to EEG characteristics in benign childhood epilepsy with centrotemporal spikes
    Daria Riva
    Developmental Neurology Division, Istituto Nazionale Neurologico C Besta, Via Celoria 11, Milan, Italy
    Epilepsy Behav 10:278-85. 2007
    ....
  3. ncbi request reprint Epileptogenic channelopathies: experimental models of human pathologies
    Giuliano Avanzini
    Department ofNeurophysiopathology, Istituto Neurologico C Besta, Milan, Italy
    Epilepsia 48:51-64. 2007
    ..These findings underscore the need for further studies to address the mechanisms involved in mutated-channel dysfunctions...
  4. doi request reprint Verbal dichotic listening performance and its relationship with EEG features in benign childhood epilepsy with centrotemporal spikes
    Sara Bulgheroni
    Developmental Neurology Division, Istituto Neurologico C Besta, Via Celoria 11, 20133 Milano, Italy
    Epilepsy Res 79:31-8. 2008
    ..The aim of this study was to assess the effect of interictal EEG discharges in the peri-sylvian regions on language lateralization in BECTS...
  5. ncbi request reprint Functional MRI in malformations of cortical development: activation of dysplastic tissue and functional reorganization
    Paolo Vitali
    Department of Clinical Neurophysiology, University of Genova, Genova, Italy
    J Neuroimaging 18:296-305. 2008
    ..The aim of this work was to investigate cortical function in a heterogeneous group of patients with malformations of cortical development...
  6. doi request reprint The neuropsychological pattern of Unverricht-Lundborg disease
    Anna R Giovagnoli
    Neuropsychology Laboratory, C Besta National Neurological Institute, Milano, Italy
    Epilepsy Res 84:217-23. 2009
    ..To conclude, ULD is characterised by impaired processing and execution functions. This impairment is a strong independent predictor of ULD and may contribute to the characterisation of the diagnosis...
  7. doi request reprint Progressive neurocognitive decline in two children with Dravet syndrome, de novo SCN1A truncations and different epileptic phenotypes
    Daria Riva
    Developmental Neurology Unit, C Besta Foundation Neurological Institute, Milan, Italy
    Am J Med Genet A 149:2339-45. 2009
    ..Our observations are consistent with the hypothesis that SCN1A-mutations can be responsible not only for epilepsy, but also for early and progressive severe mental impairment...
  8. ncbi request reprint Periventricular nodular heterotopia: classification, epileptic history, and genesis of epileptic discharges
    Giorgio Battaglia
    Division of Experimental Neurophysiology and Epileptology, Neurological Institute C Besta, Milan, Italy
    Epilepsia 47:86-97. 2006
    ....
  9. pmc Identification of an Nav1.1 sodium channel (SCN1A) loss-of-function mutation associated with familial simple febrile seizures
    Massimo Mantegazza
    Department of Neurophysiopathogy, Istituto Neurologico C Besta, Milan, Italy
    Proc Natl Acad Sci U S A 102:18177-82. 2005
    ..Thus, M145T is a loss-of-function mutant. These results show that monogenic FS should also be considered a channelopathy...
  10. ncbi request reprint Electroencephalographic recordings of focal seizures in patients affected by periventricular nodular heterotopia: role of the heterotopic nodules in the genesis of epileptic discharges
    Giorgio Battaglia
    Division of Experimental Neurophysiology and Epileptology, Neurological Institute C Besta, Milan, Italy
    J Child Neurol 20:369-77. 2005
    ..The major role of heterotopic neurons in the genesis and propagation of epileptic discharges must be taken into account when planning surgery for epilepsy in patients with periventricular nodular heterotopia...
  11. ncbi request reprint Molecular biology of channelopathies: impact on diagnosis and treatment
    Giuliano Avanzini
    Istituto Nazionale Neurologico C Besta, Via Celoria 11, 20133 Milan, Italy
    Expert Rev Neurother 4:519-39. 2004
    ....
  12. doi request reprint Short and long interval cortical inhibition in patients with Unverricht-Lundborg and Lafora body disease
    Laura Canafoglia
    Dept of Neurophysiopathology and Epilepsy Centre, IRCCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, 20133 Milano, Italy
    Epilepsy Res 89:232-7. 2010
    ..These findings are probably related to the high epileptogenic propensity characterizing LBD with respect to ULD and to the more severely distorted neuronal network resulting from the pathogenesis of LBD...
  13. doi request reprint Characterization of severe action myoclonus in sialidoses
    Laura Canafoglia
    Dept of Neurophysiopathology, IRCCS Foundation Carlo Besta Neurological Institute, Milano, Italy
    Epilepsy Res 94:86-93. 2011
    ..Neurophysiological indexes indicating high EEG-EMG synchronization parallels the severity of the myoclonus...
  14. ncbi request reprint Prospects for novel antiepileptic drugs
    Giuliano Avanzini
    Istituto Nazionale Neurologico C Besta, Via Celoria 11, I 20133, Milano, Italy
    Curr Opin Investig Drugs 4:805-14. 2003
    ....
  15. ncbi request reprint Cellular biology of epileptogenesis
    Giuliano Avanzini
    Istituto Nazionale Neurologico C Besta, Milan, Italy
    Lancet Neurol 2:33-42. 2003
    ..better understanding of the role of these epileptogenic mechanisms will promote new advances in the development of selective and targeted antiepileptic drugs...
  16. ncbi request reprint A pathogenetic hypothesis of Unverricht-Lundborg disease onset and progression
    Silvana Franceschetti
    Division of Neurophysiology and Epileptology, Neurological Institute C Besta via Caloria 11, 20133 Milan, Milan, Italy
    Neurobiol Dis 25:675-85. 2007
    ..Furthermore, a greater degree of neuronal damage was observed in CSTB-deficient than in WT mice after seizures of identical grade, indicating increased susceptibility to seizure-induced cell death...
  17. doi request reprint Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy
    Jacopo C DiFrancesco
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Ospedale S Gerardo, Universita di Milano Bicocca, 20052 Monza, Italy
    J Neurosci 31:17327-37. 2011
    ..This is the first evidence in humans for a single-point, homozygous loss-of-function mutation in HCN2 potentially associated with generalized epilepsy with recessive inheritance...
  18. ncbi request reprint A pilot study of a ketogenic diet in patients with Lafora body disease
    Simonetta Cardinali
    Department of Child Neuropsychiatry, Child EEG Unit, Foundation C Mondino Institute of Neurology Via Mondino 2, 27100 Pavia, Italy
    Epilepsy Res 69:129-34. 2006
    ..We set out to assess the feasibility and tolerability of a long-term ketogenic diet (KD) in LBD patients and to make a preliminary evaluation of its effect on the disease course...
  19. ncbi request reprint Electroclinical features of a family with simple febrile seizures and temporal lobe epilepsy associated with SCN1A loss-of-function mutation
    Eleonora Colosimo
    Institute of Neurology, University Magna Graecia, Catanzaro, Italy
    Epilepsia 48:1691-6. 2007
    ..We showed that the mutation is associated with a loss of SCN1A function...
  20. ncbi request reprint Rhythmic cortical myoclonus in a case of HIV-related encephalopathy
    Laura Canafoglia
    Department of Clinical Neurophysiology Istituto Nazionale Neurologico Carlo Besta, Milan, Italy
    Mov Disord 18:1533-8. 2003
    ....
  21. ncbi request reprint Progressive myoclonus epilepsies: EPM1, EPM2A, EPM2B
    Elayne M Chan
    Program in Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Canada
    Adv Neurol 95:47-57. 2005
  22. ncbi request reprint Periodic electroencephalogram complexes in a patient with variant Creutzfeldt-Jakob disease
    Simona Binelli
    National Neurological Institute Carlo Besta, Milan, Italy
    Ann Neurol 59:423-7. 2006
    ..To verify this point, we investigated the development of the EEG changes along the course of the disease in a pateint with vCJD...
  23. ncbi request reprint Clinical and genetic findings in 26 Italian patients with Lafora disease
    Silvana Franceschetti
    Department of Clinical Neurophysiology, Istituto Nazionale Neurologico C Besta, Milan, Italy
    Epilepsia 47:640-3. 2006
    ..Genotype-phenotype correlations suggested that EPM2B patients show a slower course of the disease, with delayed age at death, compared with EPM2A patients. We herein report clinical and genetic findings of 26 Italian LD patients...
  24. pmc Self-limited hyperexcitability: functional effect of a familial hemiplegic migraine mutation of the Nav1.1 (SCN1A) Na+ channel
    Sandrine Cestele
    Department of Neurophysiopathology, Besta Neurological Institute, 20133 Milan, Italy
    J Neurosci 28:7273-83. 2008
    ..Thus, we found a possible difference in the functional effects of FHM and familial epilepsy mutations of Nav1.1...
  25. ncbi request reprint Rhythmic cortical myoclonus in Niemann-Pick disease type C
    Laura Canafoglia
    Department of Neurophysiology and Epileptology, Carlo Besta National Neurological Institute, Milan, Italy
    Mov Disord 21:1453-6. 2006
    ..EEG-EMG frequency analysis (better than jerk-locked back-averaging) demonstrated the cortical origin of the myoclonus. Our observations indicate that cortical myoclonus may occur as the main symptom of NPC...
  26. doi request reprint High-frequency rhythmic cortical myoclonus in a long-surviving patient with nonketotic hypergylcemia
    Massimo Mastrangelo
    Pediatric Neurology Unit, V Buzzi Hospital, A O ICP, Milan, Italy
    J Child Neurol 23:321-4. 2008
    ..Observation of this case suggests that rhythmic cortical myoclonus may represent a late evolution of this rare disorder...
  27. pmc Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels
    Davide Pozzi
    Department of Medical Pharmacology and Consiglio Nazionale delle Ricerche Institute of Neuroscience, University of Milano, Via Vanvitelli 32, 20129 Milan, Italy
    Proc Natl Acad Sci U S A 105:323-8. 2008
    ....
  28. ncbi request reprint Modulatory proteins can rescue a trafficking defective epileptogenic Nav1.1 Na+ channel mutant
    Raffaella Rusconi
    Department of Neurophysiopathology, Besta Neurological Institute, 20133 Milan, Italy
    J Neurosci 27:11037-46. 2007
    ..Interacting drugs may be used to rescue the mutant in vivo...
  29. ncbi request reprint Verbal and gestural communication in children with bilateral perisylvian polymicrogyria
    Veronica Saletti
    Developmental Neurology Division, Istituto Nazionale Neurologico, Besta, Milano, Italy
    J Child Neurol 22:1090-8. 2007
    ....
  30. ncbi request reprint ICTAL EEG fast activity in West syndrome: from onset to outcome
    Ferruccio Panzica
    C Besta Foundation Neurological Institute, Via Celoria 11, Milan, Italy
    Epilepsia 48:2101-10. 2007
    ..To characterize the fast EEG activities associated with infantile spasms in West syndrome, and their value in predicting the recurrence and localization of late seizures...
  31. ncbi request reprint Effects in neocortical neurons of mutations of the Na(v)1.2 Na+ channel causing benign familial neonatal-infantile seizures
    Paolo Scalmani
    Department of Neurophysiopathology, Istituto Neurologico C Besta, 20133 Milan, Italy
    J Neurosci 26:10100-9. 2006
    ..Thus, the pathogenic mechanism of BFNIS mutations is neuronal hyperexcitability caused by increased Na+ current...
  32. ncbi request reprint Block of glutamate-glutamine cycle between astrocytes and neurons inhibits epileptiform activity in hippocampus
    Alberto Bacci
    Consiglio Nazionale delle Ricerche Institute of Neuroscience, Cellular and Molecular Pharmacology, Department of Medical Pharmacology, 20129 Milano, Italy
    J Neurophysiol 88:2302-10. 2002
    ..These data point to an important role for the neuron-astrocyte metabolic interaction in sustaining episodes of intense rhythmic activity in the CNS, and thereby reveal a new potential target for antiepileptic treatments...
  33. pmc Immunotherapy responsive startle with antibodies to voltage gated potassium channels
    Carlo Antozzi
    J Neurol Neurosurg Psychiatry 78:1281-90. 2007