Gianluigi Forloni

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi request reprint In vivo application of beta amyloid oligomers: a simple tool to evaluate mechanisms of action and new therapeutic approaches
    Claudia Balducci
    IRCCS Istitituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 2156 Milano, Italy
    Curr Pharm Des 20:2491-505. 2014
  2. ncbi request reprint Therapy in prion diseases
    Gianluigi Forloni
    IRCCS Istituto di Ricerche Farmacologiche Mario Negri Via La Masa 19, 20156 Milano, Italy
    Curr Top Med Chem 13:2465-76. 2013
  3. pmc The neurodegeneration in Alzheimer disease and the prion protein
    Gianluigi Forloni
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Prion 7:60-5. 2013
  4. ncbi request reprint Tetracyclines and prion infectivity
    Gianluigi Forloni
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Infect Disord Drug Targets 9:23-30. 2009
  5. ncbi request reprint Protein misfolding in Alzheimer's and Parkinson's disease: genetics and molecular mechanisms
    Gianluigi Forloni
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Neurobiol Aging 23:957-76. 2002
  6. pmc Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein
    Claudia Balducci
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan 20156, Italy
    Proc Natl Acad Sci U S A 107:2295-300. 2010
  7. ncbi request reprint Association study to evaluate the serotonin transporter and apolipoprotein E genes in frontotemporal lobar degeneration in Italy
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy
    J Hum Genet 53:1029-33. 2008
  8. ncbi request reprint Neurotoxic and gliotrophic activity of a synthetic peptide homologous to Gerstmann-Sträussler-Scheinker disease amyloid protein
    Luana Fioriti
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Neurosci 27:1576-83. 2007
  9. ncbi request reprint The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-epsilon4 non-carriers in the Italian Alzheimer's disease population and does not affect the plasma Abeta(1-42) level
    Marzia Pesaresi
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Neurobiol Dis 25:609-13. 2007
  10. doi request reprint JNK regulates APP cleavage and degradation in a model of Alzheimer's disease
    Alessio Colombo
    Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy
    Neurobiol Dis 33:518-25. 2009

Detail Information

Publications59

  1. ncbi request reprint In vivo application of beta amyloid oligomers: a simple tool to evaluate mechanisms of action and new therapeutic approaches
    Claudia Balducci
    IRCCS Istitituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 2156 Milano, Italy
    Curr Pharm Des 20:2491-505. 2014
    ..We also examined the proposed involvement of cellular prion protein as a mediator of the oligomer-induced memory impairment...
  2. ncbi request reprint Therapy in prion diseases
    Gianluigi Forloni
    IRCCS Istituto di Ricerche Farmacologiche Mario Negri Via La Masa 19, 20156 Milano, Italy
    Curr Top Med Chem 13:2465-76. 2013
    ..However, in common with the other oligomeropathies, early diagnosis allowing to treat at risk population in a preclinical stage represent the more realistic perspective for efficient TSE therapy. ..
  3. pmc The neurodegeneration in Alzheimer disease and the prion protein
    Gianluigi Forloni
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Prion 7:60-5. 2013
    ..Even more important however is the relevance of this interaction in the context of the disease, so as to develop valid therapeutic strategies...
  4. ncbi request reprint Tetracyclines and prion infectivity
    Gianluigi Forloni
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Infect Disord Drug Targets 9:23-30. 2009
    ..This article analyzes the development of tetracyclines as a therapeutic tool in TSE in the light of recent results obtained in our laboratories...
  5. ncbi request reprint Protein misfolding in Alzheimer's and Parkinson's disease: genetics and molecular mechanisms
    Gianluigi Forloni
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Neurobiol Aging 23:957-76. 2002
    ..We also reported data obtained with synthetic peptides and other experimental models, for evaluation of the pathogenic role of mutations in terms of protein misfolding...
  6. pmc Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein
    Claudia Balducci
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan 20156, Italy
    Proc Natl Acad Sci U S A 107:2295-300. 2010
    ..However, PrP-expressing and PrP knock-out mice were equally susceptible to this impairment. These data suggest that Abeta(1-42) oligomers are responsible for cognitive impairment in AD and that PrP(C) is not required...
  7. ncbi request reprint Association study to evaluate the serotonin transporter and apolipoprotein E genes in frontotemporal lobar degeneration in Italy
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy
    J Hum Genet 53:1029-33. 2008
    ..A significant correlation [P = 0.018, OR (95% CI): 2.1 (1.1-3.9)] between rs4795541 S-allele presence and FTLD susceptibility was found. In summary, the rs4795541 might be important for FTLD susceptibility in the Italian population...
  8. ncbi request reprint Neurotoxic and gliotrophic activity of a synthetic peptide homologous to Gerstmann-Sträussler-Scheinker disease amyloid protein
    Luana Fioriti
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Neurosci 27:1576-83. 2007
    ..Prnp0/0 astrocytes were insensitive to the proliferative stimulus of PrP 82-146. These results underline the role of cerebral accumulation of abnormally folded PrP fragments and indicate that cellular PrP governs the pathogenic process...
  9. ncbi request reprint The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-epsilon4 non-carriers in the Italian Alzheimer's disease population and does not affect the plasma Abeta(1-42) level
    Marzia Pesaresi
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Neurobiol Dis 25:609-13. 2007
    ..Our data support a role for PLAU_1 as an independent genetic risk factor for AD in the Italian population for those subjects who do not have the APOE-epsilon4 allele...
  10. doi request reprint JNK regulates APP cleavage and degradation in a model of Alzheimer's disease
    Alessio Colombo
    Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy
    Neurobiol Dis 33:518-25. 2009
    ..All together our results suggest an important link between APP metabolism and the JNK pathway and contribute to shed light on the molecular signalling pathway of this disease indicating JNK as an innovative target for AD therapy...
  11. ncbi request reprint Analysis of the cerebellar proteome in a transgenic mouse model of inherited prion disease reveals preclinical alteration of calcineurin activity
    Emiliano Biasini
    Prion Unit, Dulbecco Telethon Institute, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea, Milano, Italy
    Proteomics 6:2823-34. 2006
    ....
  12. doi request reprint The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian case-control cohorts
    Letizia Polito
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy Golgi Cenci Foundation, Abbiategrasso, Italy
    Alzheimers Dement 9:392-9. 2013
    ..This study investigated whether genetic variants in two members of the sirtuin family, SIRT2 and SIRT3, affected AD susceptibility...
  13. doi request reprint The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, Milan 20156, Italy
    J Neurochem 110:1445-56. 2009
    ....
  14. doi request reprint Serotonin transporter gene polymorphic element 5-HTTLPR increases the risk of sporadic Parkinson's disease in Italy
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur Neurol 62:120-3. 2009
    ..5], p = 0.002) was found. The rs25531 and the haplotype 5-HTTLPR/rs25531 did not associate with risk of PD. Our data indicate that the 5-HTTLPR polymorphic element within the SLC6A4 promoter may govern the genetic risk of PD in Italians...
  15. pmc The efficacy of tetracyclines in peripheral and intracerebral prion infection
    Ada De Luigi
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    PLoS ONE 3:e1888. 2008
    ..Median survival increased of 8.1% with doxycycline and 10% with minocycline. These data suggest that tetracyclines might have therapeutic potential for humans...
  16. pmc c-Jun N-terminal kinase regulates soluble Aβ oligomers and cognitive impairment in AD mouse model
    Alessandra Sclip
    Neuronal Death and Neuroprotection Laboratory, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano 20156, Italy
    J Biol Chem 286:43871-80. 2011
    ..In conclusion, by regulating key pathogenic mechanisms of AD, JNK might hold promise as innovative therapeutic target...
  17. pmc A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    BMC Geriatr 9:19. 2009
    ..In humans, IGF-1 level has an age-related modulation with a lower concentration in the elderly, depending on hormonal and genetic factors affecting the IGF-1 receptor gene (IGF-1R)...
  18. doi request reprint The serotonin transporter promoter polymorphic region is not a risk factor for Alzheimer's disease related behavioral disturbances
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Alzheimers Dis 18:125-30. 2009
    ..We conclude that 5-HTTLPR and rs25531 are not major genetic modulators of BPSD development in AD...
  19. doi request reprint Early-onset Alzheimer disease in an Italian family with presenilin-1 double mutation E318G and G394V
    Sara Batelli
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, Milan, Italy
    Alzheimer Dis Assoc Disord 22:184-7. 2008
    ..We did not find any modification of the A beta(1-42)/A beta(1-40) ratio, suggesting that this double mutation might be involved in early-onset AD etiopathogenesis by affecting a PSEN-1 function other than gamma-secretase activity...
  20. ncbi request reprint The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species
    Luana Fioriti
    Dulbecco Telethon Institute, Istituto di Ricerche Farmacologiche Mario Negri, Milan 20157, Italy
    Mol Cell Neurosci 28:165-76. 2005
    ..These results indicate that PrP106-126 interferes with a PrP function that requires only low protein levels, and is not impaired by a pathogenic insertion in the octapeptide region...
  21. ncbi request reprint Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Neurobiol Aging 28:1682-8. 2007
    ..05, Mann-Whitney test) in the Abeta(1-42)/Abeta(1-40) ratio in PSEN-1 [E318G] carriers, suggesting a peculiar biochemical effect of this mutation...
  22. ncbi request reprint Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein
    Mario Salmona
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    J Biol Chem 278:48146-53. 2003
    ..These data indicate that the intrinsic properties of PrP-(82-146) are dependent upon the integrity of the C-terminal region and account for the massive deposition of PrP amyloid in GSS...
  23. pmc DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70
    Sara Batelli
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    PLoS ONE 3:e1884. 2008
    ..DJ-1 (PARK7), another family-PD-linked gene causing an autosomal recessive form of the pathology, shows antioxidant and chaperone-like activities too...
  24. ncbi request reprint Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model
    Marco Gobbi
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Biol Chem 281:843-9. 2006
    ..e. the locking steps) appear to be faster and easier with PrP82-146 than with Abeta40. Such differences suggest that PrP82-146 has a greater propensity to polymerize and greater stability of the aggregates...
  25. ncbi request reprint Role of VEGF gene variability in longevity: a lesson from the Italian population
    Roberto Del Bo
    Department of Neurological Sciences, Dino Ferrari Centre, University of Milan, IRCCS Foundation Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Padiglione Ponti, Milano, Italy
    Neurobiol Aging 29:1917-22. 2008
    ..These results suggest that VEGF gene variability can be inserted among the genetic factors influencing the lifespan...
  26. ncbi request reprint Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations
    Luana Fioriti
    Dulbecco Telethon Institute DTI and Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano 20157, Italy
    J Biol Chem 280:11320-8. 2005
    ....
  27. pmc Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit
    Assunta Senatore
    Dulbecco Telethon Institute, 20156 Milan, Italy
    Neuron 74:300-13. 2012
    ..These results link intracellular PrP retention to synaptic dysfunction, indicating new modalities of neurotoxicity and potential therapeutic strategies...
  28. ncbi request reprint Proteasome inhibition and aggregation in Parkinson's disease: a comparative study in untransfected and transfected cells
    Emiliano Biasini
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri Milano, Italy
    J Neurochem 88:545-53. 2004
    ....
  29. doi request reprint Polymeric nanoparticle system to target activated microglia/macrophages in spinal cord injury
    Simonetta Papa
    IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Dipartimento di Neuroscienze, Via La Masa 19, 20156 Milan, Italy
    J Control Release 174:15-26. 2014
    ....
  30. ncbi request reprint JNK signalling: a possible target to prevent neurodegeneration
    Tiziana Borsello
    Biol Neurodeg Disorders Lab, Istituto di Ricerche Farmacologiche, Mario Negri, Milano, Italy
    Curr Pharm Des 13:1875-86. 2007
    ..In this review we examine in detail the role of JNK in neurodegeneration, particularly in Alzheimer's and Parkinson's disease. The possibility of intervention on the JNK pathway as a therapeutic approach is also illustrated...
  31. doi request reprint JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models
    Cristina Ploia
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Alzheimers Dis 26:315-29. 2011
    ..Similarly, D-JNKI-1 reduced p-tau at S202/T205 in an in vivo model of AD (TgCRND8 mice). Our findings support the fundamental role of JNK in the regulation of tau hyperphosphorylation and subsequently in AD pathogenesis...
  32. pmc Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)"
    Diego Albani
    Department of Neuroscience, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156, Milan, Italy
    Age (Dordr) 36:469-78. 2014
    ..We found an increased level of SIRT3 in subjects homozygous for the (T) allele. We suggest that SIRT3 genetic variability might be relevant for the modulation of human longevity in the Italian population. ..
  33. doi request reprint A new face for old antibiotics: tetracyclines in treatment of amyloidoses
    Tatiana Stoilova
    IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156 Milano, Italy
    J Med Chem 56:5987-6006. 2013
    ....
  34. doi request reprint Replication study to confirm the role of CYP2D6 polymorphism rs1080985 on donepezil efficacy in Alzheimer's disease patients
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Alzheimers Dis 30:745-9. 2012
    ..74 [1.01-3.00], p = 0.04). Rs1080985 might be useful as predictor of poor response to short-term donepezil treatment...
  35. doi request reprint Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva--TRELONG)
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa, Milan, Italy
    Aging Male 14:257-64. 2011
    ..These findings sustain the hypothesis that sex-specific longevity relies on detectable differences in genetic and biochemical parameters between males and females...
  36. pmc A novel study and meta-analysis of the genetic variation of the serotonin transporter promoter in the italian population do not support a large effect on Alzheimer's disease risk
    Letizia Polito
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, 20156 Milan, Italy
    Int J Alzheimers Dis 2011:312341. 2011
    ..85 (associated P value = .08). Overall, our findings are not supportive of a large genetic effect of the explored polymorphisms on AD risk...
  37. pmc Tetracyclines affect prion infectivity
    Gianluigi Forloni
    Istituto di Ricerche Farmacologiche Mario Negri, Istituto Nazionale Neurologico Carlo Besta, and Istituto di Microbiologia e Immunologia Veterinaria, Universita degli Studi, 20100 Milano, Italy
    Proc Natl Acad Sci U S A 99:10849-54. 2002
    ..Our data suggest that these well characterized antibiotics reduce prion infectivity through a direct interaction with PrP(Sc) and are potentially useful for inactivation of BSE- or vCJD-contaminated products and prevention strategies...
  38. pmc Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156, Milan, Italy
    Age (Dordr) 31:155-62. 2009
    ..05, Tukey's test) was also noticed. We suggest a sex-specific pattern for genetic variability linked to inflammatory response and longevity, consistent with the age-related increase in IL-6...
  39. doi request reprint A new fluorogenic peptide determines proteasome activity in single cells
    Silvana A M Urru
    Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan 20156, Italy
    J Med Chem 53:7452-60. 2010
    ..This reporter is an innovative tool for monitoring proteasomal proteolytic activities in physiological and pathological conditions...
  40. pmc Role of plasminogen in propagation of scrapie
    Mario Salmona
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Virol 79:11225-30. 2005
    ..In conclusion, our data indicate that plasminogen has no major effect on the survival of scrapie agent-infected mice...
  41. doi request reprint Neuroprotective properties of resveratrol in different neurodegenerative disorders
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Biofactors 36:370-6. 2010
    ..Here, we summarize the in vitro and in vivo experimental results highlighting the possible role of resveratrol as neuroprotective biofactor with a particular focus on AD...
  42. ncbi request reprint Hydrogel-based nanocomposites and mesenchymal stem cells: a promising synergistic strategy for neurodegenerative disorders therapy
    Diego Albani
    IRCCS Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy
    ScientificWorldJournal 2013:270260. 2013
    ..The use of hydrogel-based nanocomposites and mesenchymal stem cells as a synergistic strategy for nervous tissue applications will be then discussed. ..
  43. ncbi request reprint Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70
    Diego Albani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    FASEB J 18:1713-5. 2004
    ..The implications for alpha-syn-mediated neurotoxicity and for PD pathogenesis and progression are discussed...
  44. ncbi request reprint Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression
    Luigi Cervo
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    J Neurosci 25:8165-72. 2005
    ..Interstrain comparisons could probably be a useful strategy for understanding the mechanisms underlying the response to selective serotonin reuptake inhibitors...
  45. pmc β-amyloid oligomers and prion protein: Fatal attraction?
    Gianluigi Forloni
    Biology of Neurodegenerative Diseases Lab, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Prion 5:10-5. 2011
    ..Similarly, in two other studies the LTP alterations induced by Aβ 1-42 oligomers was not influenced by the absence of PrP. Possible explanations of these contradictory results are discussed...
  46. doi request reprint Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence
    Diego Albani
    Laboratory of Biology of Neurodegenerative Disorders, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Alzheimers Dis 19:11-26. 2010
    ....
  47. doi request reprint ST1859 reduces prion infectivity and increase survival in experimental scrapie
    Laura Colombo
    Istituto di Ricerche Farmacologiche Mario Negri, Via G La Masa 19, Milan, Italy
    Arch Virol 154:1539-44. 2009
    ..Similar results were found with the analogue ST1745. Our data indicate that ST1859 reduces prion infectivity and can exert a therapeutic effect in experimental scrapie...
  48. ncbi request reprint A novel PSENEN mutation in a patient with complaints of memory loss and a family history of dementia
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Alzheimers Dement 3:235-8. 2007
    ..Although our data do not definitively support a pathogenetic role for this mutation, it does not appear to be a common polymorphism. Further follow-up is warranted in this family...
  49. ncbi request reprint Cognitive deficits associated with alteration of synaptic metaplasticity precede plaque deposition in AβPP23 transgenic mice
    Claudia Balducci
    Department of Neuroscience, Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Alzheimers Dis 21:1367-81. 2010
    ..These results indicate a general impairment of synaptic function and learning and memory in young AβPP23tg mice with Aβ oligomers but no amyloid plaques...
  50. ncbi request reprint The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice
    Claudia Balducci
    Laboratory of Biology of Neurodegenerative Disorders, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Alzheimers Dis 24:799-816. 2011
    ..We conclude that the beneficial effects of CHF5074 treatment in young transgenic mice occurred at a stage that precedes plaque formation and were associated with a reduction in intraneuronal AβPP/Aβ and hyperphosphorylated tau...
  51. pmc Hydrogels in spinal cord injury repair strategies
    Giuseppe Perale
    Department of Chemistry, Materials and Chemical Engineering Giulio Natta, Politecnico di Milano, Via Mancinelli 7, 20131 Milan, Italy Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156, Milan, Italy
    ACS Chem Neurosci 2:336-45. 2011
    ..Here, different hydrogel applications are underlined, together with their different nature, in order to have a clearer view of what is happening in one of the most sparkling fields of regenerative medicine...
  52. ncbi request reprint Current options for drug delivery to the spinal cord
    Filippo Rossi
    Dipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy
    Expert Opin Drug Deliv 10:385-96. 2013
    ..Here, drug administration is severely limited by the blood-spinal cord barrier (BSCB) that impedes to reach the cord from the bloodstream. So, developing a suitable delivery route is mandatory to increase medical chances...
  53. pmc Multiplex assessment of a panel of 16 serum molecules for the differential diagnosis of Alzheimer's disease
    Gloria Biella
    Department of Neuroscience, Istituto di Ricerche Famacologiche Mario Negri IRCCS Milan, Italy
    Am J Neurodegener Dis 2:40-5. 2013
    ..63 and 0.66 for EGF and TRAIL-R4, respectively). Finally, we tried to find a diagnostic classifier by a multivariate algorithm. We found indication of diagnostic evidence for AD only, while NAD samples did not show a diagnostic pattern...
  54. doi request reprint APP transgenic mice: their use and limitations
    Claudia Balducci
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G La Masa, 19, 20156, Milan, Italy
    Neuromolecular Med 13:117-37. 2011
    ..Neuronal cell death and NFTs typical of AD are much harder to replicate in these mice, which thus offer a fundamental but still imperfect tool for understanding and solving dementia pathology...
  55. ncbi request reprint Plasma levels of beta-amyloid (1-42) in Alzheimer's disease and mild cognitive impairment
    Marzia Pesaresi
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Neurobiol Aging 27:904-5. 2006
    ..Thus, the reduction in beta-amyloid 1-42 may be a marker for AD status, specifically, a transition from normal status or MCI to AD, rather than a marker for neurodegenerative processes occurring in the disease...
  56. ncbi request reprint Tumor necrosis factor alpha polymorphism C-850T is not associated with Alzheimer's disease and vascular dementia in an Italian population
    Liana Terreni
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Neurosci Lett 344:135-7. 2003
    ..The influence of TNF-alpha polymorphism on dementia has not been confirmed in this segment of the Italian population...
  57. doi request reprint Selective nanovector mediated treatment of activated proinflammatory microglia/macrophages in spinal cord injury
    Simonetta Papa
    Dipartimento di Neuroscienze, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy
    ACS Nano 7:9881-95. 2013
    ..The nanocarrier drug delivery tool developed here shows potential advantages over the conventionally administered anti-inflammatory therapy, maximizing therapeutic efficiency and reducing side effects. ..
  58. ncbi request reprint Synthetic miniprion PrP106
    Valentina Bonetto
    Dulbecco Telethon Institute, Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy
    J Biol Chem 277:31327-34. 2002
    ..These features are central properties of PrP(Sc) and make sPrP106 an excellent tool for investigating the molecular basis of the conformational conversion of PrP(C) into PrP(Sc) and prion disease pathogenesis...
  59. ncbi request reprint Effect of beta-amyloid on endothelial cells: lack of direct toxicity, enhancement of MTT-induced cell death and intracellular accumulation
    Francesc X Soriano
    Laboratory of Biology of Neurodegenerative Disorders, Istituto di Ricerche Fannacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy
    Neurochem Int 43:251-61. 2003
    ..In our condition, the exposure of EC to betaA induced an intracellular accumulation of the peptide and a vasoactive effect that did not appear associated with direct toxic activity...