E Erba

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. pmc Cell cycle phase perturbations and apoptosis in tumour cells induced by aplidine
    E Erba
    Cancer Pharmacology Laboratory, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Br J Cancer 86:1510-7. 2002
  2. ncbi request reprint Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action
    E Erba
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri Via Eritrea 62, 20157, Milan, Italy
    Eur J Cancer 37:97-105. 2001
  3. pmc Effect of Aplidin in acute lymphoblastic leukaemia cells
    E Erba
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea, 62 20157 Milan, Italy
    Br J Cancer 89:763-73. 2003
  4. pmc Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743)
    E Erba
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Br J Cancer 82:1732-9. 2000
  5. pmc Mode of action of thiocoraline, a natural marine compound with anti-tumour activity
    E Erba
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Br J Cancer 80:971-80. 1999
  6. ncbi request reprint Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4
    M Broggini
    Laboratory of Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Leukemia 17:52-9. 2003
  7. pmc Cell cycle perturbations and apoptosis induced by isohomohalichondrin B (IHB), a natural marine compound
    D Bergamaschi
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Br J Cancer 79:267-77. 1999
  8. doi request reprint Role of homologous recombination in trabectedin-induced DNA damage
    M Tavecchio
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy
    Eur J Cancer 44:609-18. 2008
  9. ncbi request reprint The unique biological features of the marine product Yondelis (ET-743, trabectedin) are shared by its analog ET-637, which lacks the C ring
    E Erba
    Department of Oncology, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Oncol Res 14:579-87. 2004
  10. pmc Role of membrane folate-binding protein in the cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cell lines in vitro
    S Sen
    Laboratory of Cancer Chemotherapy, Mario Negri Institute, Milan, Italy
    Br J Cancer 73:525-30. 1996

Collaborators

Detail Information

Publications24

  1. pmc Cell cycle phase perturbations and apoptosis in tumour cells induced by aplidine
    E Erba
    Cancer Pharmacology Laboratory, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Br J Cancer 86:1510-7. 2002
    ..Although the mechanism of action of Aplidine is still unclear, the cell cycle phase perturbations and the rapid induction of apoptosis in Molt-4 cells appear to be due to a mechanism different from that of known anticancer drugs...
  2. ncbi request reprint Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action
    E Erba
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri Via Eritrea 62, 20157, Milan, Italy
    Eur J Cancer 37:97-105. 2001
    ..The findings that G1 phase cells are hypersensitive and that NER-deficient cells are resistant to ET-743 indicate that the mode of action of ET-743 is unique and different from that of other DNA-interacting drugs...
  3. pmc Effect of Aplidin in acute lymphoblastic leukaemia cells
    E Erba
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea, 62 20157 Milan, Italy
    Br J Cancer 89:763-73. 2003
    ..Taken together these data suggest that Aplidin could be a new anticancer drug to be investigated in ALL patients resistant to available therapy...
  4. pmc Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743)
    E Erba
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Br J Cancer 82:1732-9. 2000
    ....
  5. pmc Mode of action of thiocoraline, a natural marine compound with anti-tumour activity
    E Erba
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Br J Cancer 80:971-80. 1999
    ..These studies indicate that the new anticancer drug thiocoraline probably acts by inhibiting DNA polymerase alpha activity...
  6. ncbi request reprint Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4
    M Broggini
    Laboratory of Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Leukemia 17:52-9. 2003
    ..These data demonstrate that aplidine inhibits the growth and induces apoptosis in MOLT-4 cells through the inhibition of VEGF secretion which blocks the VEGF/VEGFR-1 autocrine loop necessary for the growth of these cells...
  7. pmc Cell cycle perturbations and apoptosis induced by isohomohalichondrin B (IHB), a natural marine compound
    D Bergamaschi
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Br J Cancer 79:267-77. 1999
    ..In conclusion, IHB is a novel potent anti-tumour drug that causes delayed S-phase progression, mitotic block, tetraploidy and apoptosis in cancer cell lines...
  8. doi request reprint Role of homologous recombination in trabectedin-induced DNA damage
    M Tavecchio
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy
    Eur J Cancer 44:609-18. 2008
    ..Both were clearly detected only in the presence of an active NER, suggesting that the DSBs are not directly caused by the drug, but are formed during the processing/repair of the drug- induced lesions...
  9. ncbi request reprint The unique biological features of the marine product Yondelis (ET-743, trabectedin) are shared by its analog ET-637, which lacks the C ring
    E Erba
    Department of Oncology, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Oncol Res 14:579-87. 2004
    ..This study indicates that ET-637 acts similarly to Yondelis and demonstrates that the C ring of Yondelis may not be required for its biological activity...
  10. pmc Role of membrane folate-binding protein in the cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cell lines in vitro
    S Sen
    Laboratory of Cancer Chemotherapy, Mario Negri Institute, Milan, Italy
    Br J Cancer 73:525-30. 1996
    ..Although FBP expression is certainly one of the parameters affecting drug toxicity, taken alone it is not a sufficiently reliable predictor of cancer cell sensitivity to DDATHF...
  11. ncbi request reprint New drugs from the sea
    M D'Incalci
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan, Italy
    J Chemother 16:86-9. 2004
    ..Some of them appear to act by mechanisms different from those of conventional chemotherapeutic drugs and thus may be effective against tumors for which no active drugs are available...
  12. ncbi request reprint Synergism between fludarabine and rituximab revealed in a follicular lymphoma cell line resistant to the cytotoxic activity of either drug alone
    N Di Gaetano
    Laboratory of Molecular Immunohaematology and Department of Oncology, Istituto Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Br J Haematol 114:800-9. 2001
    ..This report gives a rational support for clinical studies with combinations of drugs, including monoclonal antibodies and fludarabine...
  13. ncbi request reprint The combination of yondelis and cisplatin is synergistic against human tumor xenografts
    M D'Incalci
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Eur J Cancer 39:1920-6. 2003
    ..The two drugs can be combined at the MTD of each drug, thus indicating there are no overlapping toxicities. These results provide a rationale for testing the combination of Yondelis and DDP in the clinic...
  14. ncbi request reprint Dynamics of cell cycle phase perturbations by trabectedin (ET-743) in nucleotide excision repair (NER)-deficient and NER-proficient cells, unravelled by a novel mathematical simulation approach
    M Tavecchio
    Department of Oncology, Flow Cytometry Unit, Istituto di Richerche Farmacologiche Marco Negri, Milan, Italy
    Cell Prolif 40:885-904. 2007
    ..The purpose of this study was to investigate whether this resistance was associated with different drug-induced cell cycle perturbations...
  15. pmc Cis dichlorodiammine platinum induced DNA interstrand cross-links in primary cultures of human ovarian cancer
    G Balconi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Br J Cancer 64:288-92. 1991
    ..These studies suggest that the long permanence of DNA-ISC in human ovarian cancer could be the basis for the high selectivity of DDP for this human malignancy...
  16. pmc Treatment with inhibitors of polyamine biosynthesis, which selectively lower intracellular spermine, does not affect the activity of alkylating agents but antagonizes the cytotoxicity of DNA topoisomerase II inhibitors
    M A Desiderio
    Istituto di Patologia Generale, , CNR, Milan, Italy
    Br J Cancer 75:1028-34. 1997
    ..Drugs that modify polyamine biosynthesis are under early clinical development as potential new anti-tumour agents. These findings illustrate the need for caution in combining such drugs with DNA topoisomerase II inhibitors...
  17. pmc Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid
    E Erba
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Br J Cancer 69:205-11. 1994
    ..In conclusion, the study highlights the modulation of DDATHF cytotoxicity by folic acid or by folinic acid and provides further rationale for in vivo clinical investigation with these combinations...
  18. pmc Synergism between 5-fluorouracil and N-methylformamide in HT29 human colon cancer line
    N Laudonio
    Instituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Br J Cancer 61:377-81. 1990
    ..These results, if confirmed on other human colon tumours, could be of clinical interest as a means of increasing the therapeutic efficacy of 5FU in patients with colon cancer...
  19. ncbi request reprint DNA Damage Induces p53-dependent Down-regulation of hCHK1
    G Damia
    Molecular Pharmacology Unit, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    J Biol Chem 276:10641-5. 2001
    ..The data suggest a strict link between p53 and hCHK1 governing the activation and repression of the G(2) checkpoint in which both proteins participate...
  20. doi request reprint The expression of the DeltaNp73beta isoform of p73 leads to tetraploidy
    E Marrazzo
    Laboratory of Molecular Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy
    Eur J Cancer 45:443-53. 2009
    ..The various C-terminal regions of DeltaNp73 may influence the final cellular phenotype and we assume that the beta one in particular could be important in both cell growth control and regulation of mitosis...
  21. doi request reprint Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents
    S Uboldi
    Department of Oncology, Mario Negri Institute, Via La Masa 19, 20156 Milan, Italy
    Int J Cancer 131:59-69. 2012
    ..The collateral sensitivity of 402-91/ET to temozolomide provides the rationale to investigate the potential use of methylating agents in MLS patients resistant to trabectedin...
  22. pmc Flow cytometric analysis of DNA content in human ovarian cancers
    E Erba
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Br J Cancer 60:45-50. 1989
    ..Prospectively collected data should be accumulated before assigning the DNA index an important role as a biological prognostic factor in ovarian cancer...
  23. ncbi request reprint Dissociation between p93B-myb and p75c-myb expression during the proliferation and differentiation of human myeloid cell lines
    M Arsura
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Blood 83:1778-90. 1994
    ..These data suggest that B-myb may function solely in the regulation of cellular proliferation, whereas c-myb has additional functions, for example, in the maintenance of an undifferentiated state...
  24. ncbi request reprint Hexamethylene bisacetamide inhibits malignant phenotype in T-ALL cell lines
    V Cecchinato
    Department of Biomedical Science and Technology, University of Milano, Via Fratelli Cervi 93, 20090 Segrate, and Transplant Immunology and Haematology Laboratory, Niguarda Ca Granda Hospital, Milano, Italy
    Leuk Res 32:791-7. 2008
    ....