Maria Luisa Dupuis

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. pmc Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein
    Emiliano Pavoni
    Kenton Labs, c o Sigma Tau, Via Pontina, km 30, 400, 00040 Pomezia RM, Italy
    BMC Cancer 6:41. 2006
  2. ncbi request reprint Differential effect of HIV-1 protease inhibitors on P-glycoprotein function in multidrug-resistant variants of the human CD4+ T lymphoblastoid CEM cell line
    Maria Luisa Dupuis
    Laboratorio di Immunologia, Istituto Superiore di Sanita, Rome, Italy
    Chemotherapy 49:8-16. 2003
  3. ncbi request reprint Modulation of the multidrug resistance (MDR) phenotype in CEM MDR cells simultaneously exposed to anti HIV-1 protease inhibitors (PI's) and cytotoxic drugs
    Maria Luisa Dupuis
    Laboratorio di Immunologia, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma
    Ann Ist Super Sanita 38:387-92. 2002
  4. ncbi request reprint Saquinavir induces stable and functional expression of the multidrug transporter P-glycoprotein in human CD4 T-lymphoblastoid CEMrev cells
    M L Dupuis
    Laboratorio di Immunologia, Istituto Superiore di Sanita, Rome, Italy
    HIV Med 4:338-45. 2003
  5. doi request reprint The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells
    Alessandro Ascione
    Section of Pharmacogenetics, Drug Resistance and Experimental Therapeutics, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Cancer Chemother Pharmacol 64:419-24. 2009
  6. ncbi request reprint Multidrug transporter proteins and cellular factors involved in free and mAb linked calicheamicin-gamma1 (gentuzumab ozogamicin, GO) resistance and in the selection of GO resistant variants of the HL60 AML cell line
    Maurizio Cianfriglia
    Section of Pharmacogenetics, Drug Resistance and Experimental Therapeutics, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Int J Oncol 36:1513-20. 2010
  7. doi request reprint 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer
    Giuseppe Filomeni
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Mol Cancer Ther 7:371-9. 2008
  8. ncbi request reprint Genetic construction, expression, and characterization of a single chain anti-CEA antibody fused to cytosine deaminase from yeast
    Silvia Zamboni
    Section of Pharmacogenetics, Drug Resistance and Experimental Therapeutics, Department of Drug Research and Evaluation, Istituto Superiore di Sanita, I 00161 Rome, Italy
    Int J Oncol 32:1245-51. 2008
  9. doi request reprint The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor
    Roberta Riccioni
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Blood Cells Mol Dis 45:86-92. 2010
  10. ncbi request reprint Isolation and characterization of the human monoclonal antibodies C10 in single-chain fragment variable (scFv) format to glucose oxidase from Aspergillus niger
    Alessandro Ascione
    Section of Pharmacogenetics, Drug Resistance and Experimental Therapeutics, Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Hybrid Hybridomics 23:380-4. 2004

Collaborators

Detail Information

Publications17

  1. pmc Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein
    Emiliano Pavoni
    Kenton Labs, c o Sigma Tau, Via Pontina, km 30, 400, 00040 Pomezia RM, Italy
    BMC Cancer 6:41. 2006
    ..The selection and characterization of human anti-CEA single-chain antibody fragments (scFv) is a first step toward the construction of new anticancer monoclonal antibodies designed for optimal blood clearance and tumor penetration...
  2. ncbi request reprint Differential effect of HIV-1 protease inhibitors on P-glycoprotein function in multidrug-resistant variants of the human CD4+ T lymphoblastoid CEM cell line
    Maria Luisa Dupuis
    Laboratorio di Immunologia, Istituto Superiore di Sanita, Rome, Italy
    Chemotherapy 49:8-16. 2003
    ....
  3. ncbi request reprint Modulation of the multidrug resistance (MDR) phenotype in CEM MDR cells simultaneously exposed to anti HIV-1 protease inhibitors (PI's) and cytotoxic drugs
    Maria Luisa Dupuis
    Laboratorio di Immunologia, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma
    Ann Ist Super Sanita 38:387-92. 2002
    ..The level of chemosensitization exerted by ritonavir and saquinavir suggests that these PI's may render P-glycoprotein expressing MDR cells de novo susceptible to the antineoplastic drugs vinblastine, vincristine and doxorubicyn...
  4. ncbi request reprint Saquinavir induces stable and functional expression of the multidrug transporter P-glycoprotein in human CD4 T-lymphoblastoid CEMrev cells
    M L Dupuis
    Laboratorio di Immunologia, Istituto Superiore di Sanita, Rome, Italy
    HIV Med 4:338-45. 2003
    ..P-gp substrates include HIV-1 protease inhibitors (PIs) and anticancer drugs, which are efficiently effluxed from multidrug-resistant (MDR) cells...
  5. doi request reprint The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells
    Alessandro Ascione
    Section of Pharmacogenetics, Drug Resistance and Experimental Therapeutics, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Cancer Chemother Pharmacol 64:419-24. 2009
    ..We have investigated the cytotoxic activity of the strong glutathione S-transferase (GST) inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) on AML (HL60) cell lines...
  6. ncbi request reprint Multidrug transporter proteins and cellular factors involved in free and mAb linked calicheamicin-gamma1 (gentuzumab ozogamicin, GO) resistance and in the selection of GO resistant variants of the HL60 AML cell line
    Maurizio Cianfriglia
    Section of Pharmacogenetics, Drug Resistance and Experimental Therapeutics, Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Int J Oncol 36:1513-20. 2010
    ....
  7. doi request reprint 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer
    Giuseppe Filomeni
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Mol Cancer Ther 7:371-9. 2008
    ..Therefore, NBDHEX seems a very promising compound in the search for new molecules able to overcome the ATP-binding cassette family of proteins, one of the major mechanisms of multidrug resistance in cancer cells...
  8. ncbi request reprint Genetic construction, expression, and characterization of a single chain anti-CEA antibody fused to cytosine deaminase from yeast
    Silvia Zamboni
    Section of Pharmacogenetics, Drug Resistance and Experimental Therapeutics, Department of Drug Research and Evaluation, Istituto Superiore di Sanita, I 00161 Rome, Italy
    Int J Oncol 32:1245-51. 2008
    ..This study shows the feasibility of constructing fusion proteins in a prokaryotic cell based system consisting of a human scFv antibody and yCD to convert the antifungal agent 5-FC to 5-FU, one of the widely used anticancer agent...
  9. doi request reprint The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor
    Roberta Riccioni
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Blood Cells Mol Dis 45:86-92. 2010
    ..Interestingly, nigericin and abamectin, two additional drugs identified as cancer stem cells inhibitors, also act as potent gp170 inhibitors...
  10. ncbi request reprint Isolation and characterization of the human monoclonal antibodies C10 in single-chain fragment variable (scFv) format to glucose oxidase from Aspergillus niger
    Alessandro Ascione
    Section of Pharmacogenetics, Drug Resistance and Experimental Therapeutics, Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
    Hybrid Hybridomics 23:380-4. 2004
    ..Finally, the cDNA sequence of this human scFv may be exploited to generate bispecific antibodies to target in the tumor environment-specific toxic enzymatic reaction...
  11. pmc HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein
    Maurizio Cianfriglia
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Retrovirology 4:17. 2007
    ..IINs were investigated for the inhibition and induction of the P-gp function and expression as well as for multidrug resistance (MDR) reversing ability...
  12. pmc Identification of a panel of tumor-associated antigens from breast carcinoma cell lines, solid tumors and testis cDNA libraries displayed on lambda phage
    Emiliano Pavoni
    Kenton Labs, c o Sigma Tau, Pomezia, Rome, Italy
    BMC Cancer 4:78. 2004
    ..Recent advances in molecular techniques have led to molecular definition of immunogenic tumor proteins based on their reactivity with autologous patient sera (SEREX)...
  13. ncbi request reprint [Use of phage libraries for the in vitro production of recombinant monoclonal antibodies of predetermined specificity]
    Michela Flego
    Laboratorio di Immunologia, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Roma
    Ann Ist Super Sanita 38:401-10. 2002
    ....
  14. ncbi request reprint Identification by phage display of the linear continuous MRPr1 epitope in the multidrug resistance-associated protein (MRP1)
    Michela Flego
    Laboratory of Immunology, Istituto Superiore di Sanita, Viale R Elena 299, I 00161, Rome, Italy
    Biol Chem 384:139-42. 2003
    ....
  15. ncbi request reprint Phosphatidylcholine-specific phospholipase C in mitogen-stimulated fibroblasts
    Carlo Ramoni
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Exp Cell Res 299:370-82. 2004
    ..These effects were associated with a D609-induced long-lasting cell cycle block in Go...
  16. ncbi request reprint A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells
    Paola Turella
    Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, 00133 Rome, Italy
    J Biol Chem 281:23725-32. 2006
    ..Given the low toxicity of NBDHEX in vivo, this compound may represent an attractive basis for the selective treatment of MDR1 P-glycoprotein-positive tumors...
  17. ncbi request reprint Application of a synthetic phage antibody library (ETH-2) for the isolation of single chain fragment variable (scFv) human antibodies to the pathogenic isoform of the hamster prion protein (HaPrPsc)
    Alessandro Ascione
    Section of Pharmacogenetics, Drug Resistance and Experimental Therapeutics, Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Roma, Italy
    Hybridoma (Larchmt) 24:127-32. 2005
    ....