Luisa Diomede

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. pmc Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy Electronic address
    Neurobiol Dis 62:521-32. 2014
  2. pmc Oleuropein aglycone protects transgenic C. elegans strains expressing Aβ42 by reducing plaque load and motor deficit
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    PLoS ONE 8:e58893. 2013
  3. ncbi request reprint Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Neurobiol Dis 40:424-31. 2010
  4. pmc Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans
    Matteo Stravalaci
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy
    J Biol Chem 287:27796-805. 2012
  5. pmc A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricovero e Cura a Carattere Scientifico Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Blood 123:3543-52. 2014
  6. ncbi request reprint Novel approaches for studying amyloidogenic peptides/proteins
    Marten Beeg
    Department of Biochemistry and Molecular Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milano, Italy
    Curr Opin Pharmacol 13:797-801. 2013
  7. pmc The efficacy of tetracyclines in peripheral and intracerebral prion infection
    Ada De Luigi
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    PLoS ONE 3:e1888. 2008
  8. ncbi request reprint Synthetic miniprion PrP106
    Valentina Bonetto
    Dulbecco Telethon Institute, Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy
    J Biol Chem 277:31327-34. 2002
  9. ncbi request reprint Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/- mice, a model of adult neuron disease
    Paolo Bigini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Neuropathol Exp Neurol 69:593-605. 2010
  10. ncbi request reprint ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis
    Enrico Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Blood 103:194-207. 2004

Collaborators

Detail Information

Publications13

  1. pmc Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy Electronic address
    Neurobiol Dis 62:521-32. 2014
    ....
  2. pmc Oleuropein aglycone protects transgenic C. elegans strains expressing Aβ42 by reducing plaque load and motor deficit
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    PLoS ONE 8:e58893. 2013
    ....
  3. ncbi request reprint Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Neurobiol Dis 40:424-31. 2010
    ..These effects were specific, dose-related and not linked to any antibiotic activity, suggesting that the drugs might offer an effective therapeutic strategy to target soluble Aβ aggregates...
  4. pmc Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans
    Matteo Stravalaci
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy
    J Biol Chem 287:27796-805. 2012
    ..The SPR-based immunoassay provides new opportunities for detection of toxic Aβ oligomers in biological samples and could be adapted to study misfolding proteins in other neurodegenerative disorders...
  5. pmc A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricovero e Cura a Carattere Scientifico Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Blood 123:3543-52. 2014
    ..In conclusion, these data indicate that this nematode-based assay is a promising surrogate model for investigating the heart-specific toxicity of amyloidogenic LCs and for a rapid screening of new therapeutic strategies. ..
  6. ncbi request reprint Novel approaches for studying amyloidogenic peptides/proteins
    Marten Beeg
    Department of Biochemistry and Molecular Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milano, Italy
    Curr Opin Pharmacol 13:797-801. 2013
    ....
  7. pmc The efficacy of tetracyclines in peripheral and intracerebral prion infection
    Ada De Luigi
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    PLoS ONE 3:e1888. 2008
    ..Median survival increased of 8.1% with doxycycline and 10% with minocycline. These data suggest that tetracyclines might have therapeutic potential for humans...
  8. ncbi request reprint Synthetic miniprion PrP106
    Valentina Bonetto
    Dulbecco Telethon Institute, Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy
    J Biol Chem 277:31327-34. 2002
    ..These features are central properties of PrP(Sc) and make sPrP106 an excellent tool for investigating the molecular basis of the conformational conversion of PrP(C) into PrP(Sc) and prion disease pathogenesis...
  9. ncbi request reprint Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/- mice, a model of adult neuron disease
    Paolo Bigini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Neuropathol Exp Neurol 69:593-605. 2010
    ....
  10. ncbi request reprint ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis
    Enrico Garattini
    Laboratory of Molecular Biology, Centro Catullo e Daniela Borgomainerio, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Blood 103:194-207. 2004
    ....
  11. pmc C. elegans expressing human β2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype
    Luisa Diomede
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    PLoS ONE 7:e52314. 2012
    ..Here we show that tetracyclines can correct this abnormality confirming that these compounds are able to protect a living organism from the proteotoxicity of human β(2)-m...
  12. ncbi request reprint Soil quality in the Lomellina area using in vitro models and ecotoxicological assays
    Diego Baderna
    Laboratory of Environmental Chemistry and Toxicology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, 20156 Milan, Italy Electronic address
    Environ Res 133:220-31. 2014
    ..Additional information on the carcinogenic potential of mixtures was provided by the cell transformation assay, strengthening the combined approach. ..
  13. ncbi request reprint Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein
    Mario Salmona
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    J Biol Chem 278:48146-53. 2003
    ..These data indicate that the intrinsic properties of PrP-(82-146) are dependent upon the integrity of the C-terminal region and account for the massive deposition of PrP amyloid in GSS...